Published in Nat Rev Mol Cell Biol on March 01, 2008
Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A (2008) 33.65
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer (2009) 18.53
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88
miRiad roles for the miR-17-92 cluster in development and disease. Cell (2008) 8.02
The genetic signatures of noncoding RNAs. PLoS Genet (2009) 6.72
A three-dimensional view of the molecular machinery of RNA interference. Nature (2009) 6.31
miRNAs in human cancer. J Pathol (2010) 6.02
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83
Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nat Rev Genet (2008) 5.83
MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science (2010) 5.77
MicroRNA control of signal transduction. Nat Rev Mol Cell Biol (2010) 5.74
A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell (2009) 5.28
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nat Neurosci (2009) 5.27
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med (2010) 4.71
On the road to reading the RNA-interference code. Nature (2009) 4.33
Predicting effective microRNA target sites in mammalian mRNAs. Elife (2015) 4.30
TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN. Nat Cell Biol (2009) 4.05
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron (2010) 3.96
Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia (2010) 3.93
MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat Rev Cancer (2011) 3.91
Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression. Cell Cycle (2009) 3.68
Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell (2009) 3.68
Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation. J Biol Chem (2009) 3.62
Regulation of OsSPL14 by OsmiR156 defines ideal plant architecture in rice. Nat Genet (2010) 3.56
Noncoding RNA in development. Mamm Genome (2008) 3.42
A microRNA signature for a BMP2-induced osteoblast lineage commitment program. Proc Natl Acad Sci U S A (2008) 3.29
MicroRNA-mediated control of oligodendrocyte differentiation. Neuron (2010) 3.24
MicroRNAs in human cancer. Adv Exp Med Biol (2013) 3.19
Toward microRNA-based therapeutics for heart disease: the sense in antisense. Circ Res (2008) 3.18
Exosomes from human saliva as a source of microRNA biomarkers. Oral Dis (2009) 3.11
Molecular architecture of a miRNA-regulated 3' UTR. RNA (2008) 3.11
RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries. RNA (2011) 3.00
Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1. J Biol Chem (2008) 3.00
Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer. Breast Cancer Res (2010) 2.98
Identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes. J Neurosci (2008) 2.95
Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs. Nat Struct Mol Biol (2011) 2.85
Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development. Genome Biol (2009) 2.81
Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev (2009) 2.73
MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev (2010) 2.70
miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development (2008) 2.59
Distinct microRNA alterations characterize high- and low-grade bladder cancer. Cancer Res (2009) 2.58
MicroRNA function is globally suppressed in mouse oocytes and early embryos. Curr Biol (2010) 2.57
Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity. Genome Res (2008) 2.52
MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev (2010) 2.51
MicroRNAs and cardiac pathology. Nat Rev Cardiol (2009) 2.50
DGCR8-dependent microRNA biogenesis is essential for skin development. Proc Natl Acad Sci U S A (2008) 2.49
MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Res (2010) 2.44
MicroRNA and cancer--focus on apoptosis. J Cell Mol Med (2009) 2.44
snoRNA, a novel precursor of microRNA in Giardia lamblia. PLoS Pathog (2008) 2.36
The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation. J Clin Invest (2009) 2.36
MicroRNA expression profiles predictive of human renal allograft status. Proc Natl Acad Sci U S A (2009) 2.36
The mammalian ovary from genesis to revelation. Endocr Rev (2009) 2.31
miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging. Aging Cell (2010) 2.31
Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice. Hepatology (2009) 2.29
Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression. Proc Natl Acad Sci U S A (2009) 2.28
Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein. Mol Cell (2009) 2.27
A transcriptional sketch of a primary human breast cancer by 454 deep sequencing. BMC Genomics (2009) 2.27
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J (2008) 2.25
MicroRNA target prediction by expression analysis of host genes. Genome Res (2008) 2.21
miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2. Blood (2008) 2.21
miRTRAP, a computational method for the systematic identification of miRNAs from high throughput sequencing data. Genome Biol (2010) 2.18
MicroRNA-144 dysregulates the transforming growth factor-β signaling cascade and contributes to the development of bronchiolitis obliterans syndrome after human lung transplantation. J Heart Lung Transplant (2015) 2.18
Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1. Cancer Cell (2012) 2.04
Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family. EMBO J (2011) 2.03
An elegant miRror: microRNAs in stem cells, developmental timing and cancer. Chromosoma (2009) 1.99
MicroRNAs both promote and antagonize longevity in C. elegans. Curr Biol (2010) 1.99
Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO J (2009) 1.94
New insights of epithelial-mesenchymal transition in cancer metastasis. Acta Biochim Biophys Sin (Shanghai) (2008) 1.94
Roles of small RNAs in tumor formation. Trends Mol Med (2010) 1.89
Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions. J Biol Chem (2010) 1.89
Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer. Oncogene (2008) 1.88
ATM is down-regulated by N-Myc-regulated microRNA-421. Proc Natl Acad Sci U S A (2010) 1.85
The role of incoherent microRNA-mediated feedforward loops in noise buffering. PLoS Comput Biol (2011) 1.84
Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system. Dev Dyn (2009) 1.83
The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. Kidney Int (2011) 1.82
miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells. Cell Death Differ (2009) 1.82
A microRNA regulatory mechanism of osteoblast differentiation. Proc Natl Acad Sci U S A (2009) 1.80
Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. BMC Biol (2010) 1.80
MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts. Circ Res (2013) 1.80
MicroRNAs and their role in progressive kidney diseases. Clin J Am Soc Nephrol (2009) 1.77
miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol (2010) 1.75
MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by down-regulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN). J Biol Chem (2009) 1.74
Evolution under canalization and the dual roles of microRNAs: a hypothesis. Genome Res (2009) 1.72
Identification of a microRNA signature in renal fibrosis: role of miR-21. Am J Physiol Renal Physiol (2011) 1.70
Circulating microRNAs in patients with active pulmonary tuberculosis. J Clin Microbiol (2011) 1.70
MicroRNA-127 modulates fetal lung development. Physiol Genomics (2009) 1.68
MicroRNA profiling and head and neck cancer. Comp Funct Genomics (2009) 1.68
The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation. Aging (Albany NY) (2011) 1.65
Repertoire and evolution of miRNA genes in four divergent nematode species. Genome Res (2009) 1.64
Birth and expression evolution of mammalian microRNA genes. Genome Res (2012) 1.64
The microRNA-processing enzyme dicer maintains juxtaglomerular cells. J Am Soc Nephrol (2010) 1.60
microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci U S A (2011) 1.60
miR-34: from bench to bedside. Oncotarget (2014) 1.59
Editing of Epstein-Barr virus-encoded BART6 microRNAs controls their dicer targeting and consequently affects viral latency. J Biol Chem (2010) 1.59
Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet (2011) 1.55
NEAT1 long noncoding RNA and paraspeckle bodies modulate HIV-1 posttranscriptional expression. MBio (2013) 1.55
The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/Lhx1. Development (2009) 1.54
MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence. Aging (Albany NY) (2010) 1.53
Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer (2006) 46.47
RAS is regulated by the let-7 microRNA family. Cell (2005) 30.24
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science (2010) 9.78
The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res (2007) 9.32
The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR. Genes Dev (2004) 8.42
The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target. Dev Cell (2003) 6.74
The let-7 family of microRNAs. Trends Cell Biol (2008) 6.24
OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature (2010) 5.73
Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer (2011) 5.12
A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res (2008) 5.05
The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle (2008) 4.95
let-7 microRNAs in development, stem cells and cancer. Trends Mol Med (2008) 4.29
The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter. Dev Biol (2003) 3.92
MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. Cancer Res (2007) 3.68
Micro-RNAs: small is plentiful. J Cell Biol (2002) 2.95
The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans. Dev Cell (2005) 2.81
Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development. Genome Biol (2009) 2.81
microRNAs and cancer: an overview. Cell Cycle (2008) 2.80
Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol Ther (2011) 2.75
Architecture of a validated microRNA::target interaction. Chem Biol (2004) 2.36
The evolution of animal microRNA function. Curr Opin Genet Dev (2007) 2.22
A KRAS-variant in ovarian cancer acts as a genetic marker of cancer risk. Cancer Res (2010) 2.15
Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis. Dev Dyn (2005) 2.14
miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma. Cancer Res (2012) 2.13
An elegant miRror: microRNAs in stem cells, developmental timing and cancer. Chromosoma (2009) 1.99
MicroRNA signatures differentiate melanoma subtypes. Cell Cycle (2011) 1.99
MicroRNAs both promote and antagonize longevity in C. elegans. Curr Biol (2010) 1.99
Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma. Proc Natl Acad Sci U S A (2012) 1.91
microRNAs: small molecules with big roles - C. elegans to human cancer. Biol Cell (2008) 1.82
MicroRNA in cancer prognosis. N Engl J Med (2008) 1.66
Rare BRCA1 haplotypes including 3'UTR SNPs associated with breast cancer risk. Cell Cycle (2011) 1.64
FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep (2012) 1.63
MicroRNAs and their roles in aging. J Cell Sci (2012) 1.60
The role of microRNAs in cancer. Yale J Biol Med (2006) 1.54
C. elegans sym-1 is a downstream target of the hunchback-like-1 developmental timing transcription factor. Cell Cycle (2009) 1.50
Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells. Cancer Biol Ther (2011) 1.50
kin-19/casein kinase Iα has dual functions in regulating asymmetric division and terminal differentiation in C. elegans epidermal stem cells. Cell Cycle (2010) 1.49
The Caenorhabditis elegans pumilio homolog, puf-9, is required for the 3'UTR-mediated repression of the let-7 microRNA target gene, hbl-1. Dev Biol (2007) 1.46
MicroRNA predictors of longevity in Caenorhabditis elegans. PLoS Genet (2011) 1.39
The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans. Dev Biol (2008) 1.36
The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure. Cell Cycle (2008) 1.32
Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans. RNA (2011) 1.31
MicroRNAs in the ionizing radiation response and in radiotherapy. Curr Opin Genet Dev (2013) 1.30
Longevity and stress in Caenorhabditis elegans. Aging (Albany NY) (2011) 1.28
miRNA modulation of the cellular stress response. Future Oncol (2008) 1.25
Epstein-Barr virus-mediated dysregulation of human microRNA expression. Cell Cycle (2008) 1.25
MicroRNA control of lifespan and metabolism. Cell Cycle (2006) 1.20
Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans. PLoS Biol (2013) 1.18
A truth serum for cancer--microRNAs have major potential as cancer biomarkers. Cell Res (2008) 1.16
Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes. Dev Cell (2005) 1.11
MicroRNAs in mutagenesis, genomic instability, and DNA repair. Semin Oncol (2011) 1.09
microRNA-mediated silencing inside P-bodies. RNA Biol (2006) 1.08
The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation. Cell Cycle (2008) 1.07
Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation. Cell Cycle (2015) 1.05
A developmental timing switch promotes axon outgrowth independent of known guidance receptors. PLoS Genet (2010) 1.04
Inhibiting microRNA function in vivo. Nat Methods (2009) 1.04
Identification of specific let-7 microRNA binding complexes in Caenorhabditis elegans. RNA (2008) 1.02
Developmental biomarkers of aging in Caenorhabditis elegans. Dev Dyn (2010) 1.02
Transcription of the C. elegans let-7 microRNA is temporally regulated by one of its targets, hbl-1. Dev Biol (2009) 1.02
Potential microRNA therapies targeting Ras, NFkappaB and p53 signaling. Curr Opin Mol Ther (2010) 1.01
The duality of oncomiR addiction in the maintenance and treatment of cancer. Cancer J (2012) 0.99
Canonical and non-canonical barriers facing antimiR cancer therapeutics. Curr Med Chem (2013) 0.98
The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition. Dev Biol (2010) 0.97
Transcriptional control of microRNA expression in C. elegans: promoting better understanding. RNA Biol (2009) 0.94
Ageing and the small, non-coding RNA world. Ageing Res Rev (2012) 0.93
Biases and errors on allele frequency estimation and disease association tests of next-generation sequencing of pooled samples. Genet Epidemiol (2012) 0.93
MicroRNA therapeutics in preclinical cancer models. Lancet Oncol (2011) 0.93
The age of high-throughput microRNA profiling. Nat Methods (2004) 0.92
Ribosomal protein RPS-14 modulates let-7 microRNA function in Caenorhabditis elegans. Dev Biol (2009) 0.90
Micromanagement: a role for microRNAs in mRNA stability. ACS Chem Biol (2006) 0.87
And now introducing mammalian mirtrons. Dev Cell (2007) 0.87
Estrogen withdrawal, increased breast cancer risk and the KRAS-variant. Cell Cycle (2015) 0.86
C. elegans microRNAs. WormBook (2005) 0.85
KRAS alleles: the LCS6 3'UTR variant and KRAS coding sequence mutations in the NCI-60 panel. Cell Cycle (2012) 0.84
The POU transcription factor UNC-86 controls the timing and ventral guidance of Caenorhabditis elegans axon growth. Dev Dyn (2011) 0.83
Joint analysis of expression profiles from multiple cancers improves the identification of microRNA-gene interactions. Bioinformatics (2013) 0.82
MicroRNAs and cancer: a meeting summary of the eponymous Keystone Conference. Epigenetics (2010) 0.81
siRNA. A guide for RNA silencing. Chem Biol (2002) 0.81
Stem cells: Big roles for small RNAs. Nature (2010) 0.80
A 'pivotal' new rule for microRNA-mRNA interactions. Nat Struct Mol Biol (2012) 0.80
Transcriptional (dys)regulation and aging in Caenorhabditis elegans. Genome Biol (2008) 0.79
Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis. Pulm Med (2011) 0.79
The Inescapable Influence of Noncoding RNAs in Cancer. Cancer Res (2015) 0.79
KRAS rs61764370 in Epithelial Ovarian Cancer-Letter. Clin Cancer Res (2011) 0.78
Arresting the Culprit: Targeted Antagomir Delivery to Sequester Oncogenic miR-221 in HCC. Mol Ther Nucleic Acids (2012) 0.78
MiR-33 connects cholesterol to the cell cycle. Cell Cycle (2012) 0.78
Targeting noncoding RNAs in disease. J Clin Invest (2017) 0.78
Small RNAs deliver a blow to ovarian cancer. Cancer Discov (2013) 0.77
Temporal and spatial patterning of an organ by a single transcription factor. Genome Biol (2005) 0.77
MicroRNAs circulate around Alzheimer's disease. Genome Biol (2013) 0.75
MicroRNAs micromanage themselves. Circ Res (2012) 0.75
Robust and specific inhibition of microRNAs in Caenorhabditis elegans. J Biol (2010) 0.75