Published in Proc Natl Acad Sci U S A on June 07, 2012
Identification of cardiolipin binding sites on cytochrome c oxidase at the entrance of proton channels. Sci Rep (2013) 1.14
Multiscale simulations reveal conserved patterns of lipid interactions with aquaporins. Structure (2013) 1.00
Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel. Biochemistry (2012) 0.96
Human Aquaporin-4 and Molecular Modeling: Historical Perspective and View to the Future. Int J Mol Sci (2016) 0.88
Water permeability of aquaporin-4 channel depends on bilayer composition, thickness, and elasticity. Biophys J (2012) 0.88
Molecular dynamics simulations of the bacterial UraA H+-uracil symporter in lipid bilayers reveal a closed state and a selective interaction with cardiolipin. PLoS Comput Biol (2015) 0.86
Intact and N- or C-terminal end truncated AQP0 function as open water channels and cell-to-cell adhesion proteins: end truncation could be a prelude for adjusting the refractive index of the lens to prevent spherical aberration. Biochim Biophys Acta (2014) 0.85
Three-dimensional stress field around a membrane protein: atomistic and coarse-grained simulation analysis of gramicidin A. Biophys J (2013) 0.82
Lipid interaction sites on channels, transporters and receptors: Recent insights from molecular dynamics simulations. Biochim Biophys Acta (2016) 0.81
A sliding selectivity scale for lipid binding to membrane proteins. Curr Opin Struct Biol (2016) 0.81
Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges. Membranes (Basel) (2015) 0.80
Characterization of 3D Voronoi tessellation nearest neighbor lipid shells provides atomistic lipid disruption profile of protein containing lipid membranes. Biophys Chem (2015) 0.76
Molecular dynamics simulations of membrane proteins and their interactions: from nanoscale to mesoscale. Curr Opin Struct Biol (2016) 0.76
Mutual Interactions between Aquaporins and Membrane Components. Front Plant Sci (2016) 0.76
Localization and Ordering of Lipids Around Aquaporin-0: Protein and Lipid Mobility Effects. Front Physiol (2017) 0.75
Cardiolipin puts the seal on ATP synthase. Proc Natl Acad Sci U S A (2016) 0.75
Insights into the molecular basis for substrate binding and specificity of the wild-type L-arginine/agmatine antiporter AdiC. Proc Natl Acad Sci U S A (2016) 0.75
GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. J Chem Theory Comput (2008) 34.90
GROMACS: fast, flexible, and free. J Comput Chem (2005) 27.22
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat Rev Microbiol (2005) 13.69
SNAREs--engines for membrane fusion. Nat Rev Mol Cell Biol (2006) 12.74
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature (2007) 12.35
Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature (2005) 5.44
Emerging roles for lipids in shaping membrane-protein function. Nature (2009) 4.14
Structure of the rotor of the V-Type Na+-ATPase from Enterococcus hirae. Science (2005) 3.46
Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature (2004) 2.94
Lipids in membrane protein structures. Biochim Biophys Acta (2004) 2.67
Structures and physiological roles of 13 integral lipids of bovine heart cytochrome c oxidase. EMBO J (2007) 2.28
Specific roles of protein-phospholipid interactions in the yeast cytochrome bc1 complex structure. EMBO J (2001) 2.24
The structure of bacteriorhodopsin at 3.0 A resolution based on electron crystallography: implication of the charge distribution. J Mol Biol (1999) 2.07
Protein modulation of lipids, and vice-versa, in membranes. Biochim Biophys Acta (2008) 1.95
Lipid-dependent membrane protein topogenesis. Annu Rev Biochem (2009) 1.91
Membrane proteins: molecular dynamics simulations. Curr Opin Struct Biol (2008) 1.86
Lipids on the move: simulations of membrane pores, domains, stalks and curves. Biochim Biophys Acta (2008) 1.76
Let's go bananas: revisiting the endocytic BAR code. EMBO J (2011) 1.66
Interplay of proteins and lipids in generating membrane curvature. Curr Opin Cell Biol (2010) 1.64
Lipids and membrane protein structures. Curr Opin Struct Biol (2008) 1.58
Assembly of bacterial inner membrane proteins. Annu Rev Biochem (2011) 1.54
Principles of membrane protein interactions with annular lipids deduced from aquaporin-0 2D crystals. EMBO J (2010) 1.38
Biological membranes: the importance of molecular detail. Trends Biochem Sci (2011) 1.33
Electron crystallography as a technique to study the structure on membrane proteins in a lipidic environment. Annu Rev Biophys (2009) 1.23
Membrane proteins diffuse as dynamic complexes with lipids. J Am Chem Soc (2010) 1.21
Interactions of lipids with aquaporin-0 and other membrane proteins. Pflugers Arch (2007) 1.14
Revival of electron crystallography. Curr Opin Struct Biol (2007) 1.13
Lipids and topological rules of membrane protein assembly: balance between long and short range lipid-protein interactions. J Biol Chem (2011) 0.99
Electron spin resonance in membrane research: protein-lipid interactions from challenging beginnings to state of the art. Eur Biophys J (2009) 0.98
Electron crystallography of proteins in membranes. Curr Opin Struct Biol (2008) 0.97
The potassium channel KcsA: a model protein in studying membrane protein oligomerization and stability of oligomeric assembly? Arch Biochem Biophys (2011) 0.86
Electron crystallography and aquaporins. Methods Enzymol (2010) 0.82
Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution. Science (2008) 8.04
A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science (2006) 7.84
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Cell (2002) 7.03
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell (2009) 6.92
Negative Staining and Image Classification - Powerful Tools in Modern Electron Microscopy. Biol Proced Online (2004) 6.14
Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature (2005) 5.44
Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature (2002) 5.32
Multiple associated proteins regulate proteasome structure and function. Mol Cell (2002) 4.97
Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature (2004) 4.48
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell (2012) 4.29
Structure of the human transferrin receptor-transferrin complex. Cell (2004) 3.64
Latent TGF-β structure and activation. Nature (2011) 3.42
Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol Cell (2010) 3.33
Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. Immunity (2006) 3.11
Structure of integrin alpha5beta1 in complex with fibronectin. EMBO J (2003) 2.99
Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature (2004) 2.94
Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. J Mol Biol (2002) 2.92
ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. Mol Cell (2005) 2.82
Ligand docking and binding site analysis with PyMOL and Autodock/Vina. J Comput Aided Mol Des (2010) 2.67
Implications of the aquaporin-4 structure on array formation and cell adhesion. J Mol Biol (2005) 2.50
Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions. Neuron (2004) 2.49
Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell (2007) 2.48
Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation. Cell (2005) 2.47
Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5. Cell (2012) 2.34
A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1. Cell (2009) 2.24
Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat Struct Mol Biol (2011) 2.23
Structure and different conformational states of native AMPA receptor complexes. Nature (2005) 2.22
Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles. EMBO J (2006) 2.19
Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol (2006) 2.17
Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nat Struct Mol Biol (2005) 2.12
Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. FASEB J (2008) 2.10
The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering. Cell (2006) 2.10
The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat Struct Mol Biol (2010) 2.08
Structural basis of Dscam isoform specificity. Nature (2007) 2.02
Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition. Proc Natl Acad Sci U S A (2011) 1.99
Predicting free energy changes using structural ensembles. Nat Methods (2009) 1.93
The structure of aquaporins. Q Rev Biophys (2006) 1.90
Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assembly. Mol Cell (2007) 1.89
Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores. J Mol Biol (2003) 1.81
Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature (2004) 1.81
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle. Nat Struct Mol Biol (2005) 1.78
The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes. PLoS Pathog (2011) 1.78
Scrutinizing molecular mechanics force fields on the submicrosecond timescale with NMR data. Biophys J (2010) 1.75
Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes. EMBO J (2002) 1.68
Mechanism of selectivity in aquaporins and aquaglyceroporins. Proc Natl Acad Sci U S A (2008) 1.67
Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex. Structure (2011) 1.63
Aquaporin-0 membrane junctions form upon proteolytic cleavage. J Mol Biol (2004) 1.63
Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain. J Biol Chem (2004) 1.60
RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner. Mol Cell (2013) 1.57
Structural transitions of complement component C3 and its activation products. Proc Natl Acad Sci U S A (2006) 1.57
Structural and functional characterization of the integral membrane protein VDAC-1 in lipid bilayer nanodiscs. J Am Chem Soc (2009) 1.55
Structure and function of water channels. Curr Opin Struct Biol (2002) 1.55
Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1. Mol Cell (2007) 1.53
The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell (2010) 1.48
Functional and structural stability of the epidermal growth factor receptor in detergent micelles and phospholipid nanodiscs. Biochemistry (2008) 1.48
Structure of a VEGF-VEGF receptor complex determined by electron microscopy. Nat Struct Mol Biol (2007) 1.48
Quaternary ammonium compounds as water channel blockers. Specificity, potency, and site of action. J Biol Chem (2006) 1.46
Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor. Nat Struct Mol Biol (2011) 1.45
An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis. Biochemistry (2004) 1.43
Kinetics, statistics, and energetics of lipid membrane electroporation studied by molecular dynamics simulations. Biophys J (2008) 1.43
Structural and functional analysis of essential pre-mRNA splicing factor Prp19p. Mol Cell Biol (2005) 1.42
Molecular electron microscopy: state of the art and current challenges. ACS Chem Biol (2008) 1.41
Crystal structure of a yeast aquaporin at 1.15 angstrom reveals a novel gating mechanism. PLoS Biol (2009) 1.41
Principles of membrane protein interactions with annular lipids deduced from aquaporin-0 2D crystals. EMBO J (2010) 1.38
Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques. J Mol Biol (2005) 1.38
Molecular architecture of the vesicular stomatitis virus RNA polymerase. Proc Natl Acad Sci U S A (2010) 1.35
Monolayer purification: a rapid method for isolating protein complexes for single-particle electron microscopy. Proc Natl Acad Sci U S A (2008) 1.34
A pH-regulated dimeric bouquet in the structure of von Willebrand factor. EMBO J (2011) 1.34
Protein thermostability calculations using alchemical free energy simulations. Biophys J (2010) 1.33
Self-consistent residual dipolar coupling based model-free analysis for the robust determination of nanosecond to microsecond protein dynamics. J Biomol NMR (2008) 1.33
Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments. Proc Natl Acad Sci U S A (2012) 1.33
Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta. Neurobiol Dis (2005) 1.32
Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2. Proc Natl Acad Sci U S A (2010) 1.32
Huntingtin facilitates polycomb repressive complex 2. Hum Mol Genet (2009) 1.32
Computational electrophysiology: the molecular dynamics of ion channel permeation and selectivity in atomistic detail. Biophys J (2011) 1.30
Collaborative EM image processing with the IPLT image processing library and toolbox. J Struct Biol (2006) 1.29
Structural insight into pre-B cell receptor function. Science (2007) 1.29
Structural characterization of the fission yeast U5.U2/U6 spliceosome complex. Proc Natl Acad Sci U S A (2007) 1.28
Does CO2 permeate through aquaporin-1? Biophys J (2006) 1.28
Detection of functional modes in protein dynamics. PLoS Comput Biol (2009) 1.27
Oligomeric states of bacteriophage T7 gene 4 primase/helicase. J Mol Biol (2006) 1.26
Geometry-based sampling of conformational transitions in proteins. Structure (2007) 1.26
The supramolecular architecture of junctional microdomains in native lens membranes. EMBO Rep (2006) 1.26
Sequence and structure relationships within von Willebrand factor. Blood (2012) 1.26
The Affinity Grid: a pre-fabricated EM grid for monolayer purification. J Mol Biol (2008) 1.26
Assembly of a functional Machupo virus polymerase complex. Proc Natl Acad Sci U S A (2010) 1.24
Speeding up parallel GROMACS on high-latency networks. J Comput Chem (2007) 1.23
Electron crystallography as a technique to study the structure on membrane proteins in a lipidic environment. Annu Rev Biophys (2009) 1.23
Abeta protofibrils possess a stable core structure resistant to hydrogen exchange. Biochemistry (2003) 1.23
OpenStructure: a flexible software framework for computational structural biology. Bioinformatics (2010) 1.22
Cell-free expressed bacteriorhodopsin in different soluble membrane mimetics: biophysical properties and NMR accessibility. Structure (2013) 1.19
Projection structure of a member of the amino acid/polyamine/organocation transporter superfamily. J Biol Chem (2008) 1.19
Junction-forming aquaporins. Curr Opin Struct Biol (2008) 1.19
Molecular organization of the COG vesicle tethering complex. Nat Struct Mol Biol (2010) 1.17
Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Mol Cell (2008) 1.17
Voltage-dependent and -independent titration of specific residues accounts for complex gating of a ClC chloride channel by extracellular protons. J Physiol (2009) 1.16
Molecular architecture of the TRAPPII complex and implications for vesicle tethering. Nat Struct Mol Biol (2010) 1.16
Interactions of lipids with aquaporin-0 and other membrane proteins. Pflugers Arch (2007) 1.14