Published in Mol Biol Cell on June 13, 2012
Rho-GTPase signaling in leukocyte extravasation: an endothelial point of view. Cell Adh Migr (2014) 1.03
Endothelial cells use dynamic actin to facilitate lymphocyte transendothelial migration and maintain the monolayer barrier. Mol Biol Cell (2014) 0.92
Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans. Circulation (2016) 0.91
Intercellular adhesion molecules (ICAMs) and spermatogenesis. Hum Reprod Update (2013) 0.90
Function and regulation of the Rho guanine nucleotide exchange factor Trio. Small GTPases (2014) 0.86
The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis. PLoS One (2013) 0.85
Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. J Cereb Blood Flow Metab (2014) 0.85
Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation. Mediators Inflamm (2015) 0.82
Rho GAPs and GEFs: controling switches in endothelial cell adhesion. Cell Adh Migr (2014) 0.82
F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling. Nat Commun (2016) 0.82
Cortactin regulates the activity of small GTPases and ICAM-1 clustering in endothelium: Implications for the formation of docking structures. Tissue Barriers (2013) 0.78
The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2. Biol Open (2013) 0.78
Leukocyte transendothelial migration: A local affair. Small GTPases (2016) 0.77
Nanoscale Imaging Reveals a Tetraspanin-CD9 Coordinated Elevation of Endothelial ICAM-1 Clusters. PLoS One (2016) 0.76
Local Arp2/3 dependent actin assembly modulates applied traction force during apCAM adhesion site maturation. Mol Biol Cell (2016) 0.75
Supervillin binds the Rac/Rho-GEF Trio and increases Trio-mediated Rac1 activation. Cytoskeleton (Hoboken) (2015) 0.75
Small Rho GTPase-mediated actin dynamics at endothelial adherens junctions. Small GTPases (2016) 0.75
Intercellular adhesion molecule-1 augments myoblast adhesion and fusion through homophilic trans-interactions. Sci Rep (2017) 0.75
Endothelial CD2AP Binds the Receptor ICAM-1 To Control Mechanosignaling, Leukocyte Adhesion, and the Route of Leukocyte Diapedesis In Vitro. J Immunol (2017) 0.75
Atherosclerosis--an inflammatory disease. N Engl J Med (1999) 59.28
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 57.23
Inflammation in atherosclerosis. Nature (2002) 28.92
Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol (2007) 17.18
A third-generation lentivirus vector with a conditional packaging system. J Virol (1998) 16.07
Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci U S A (2004) 7.24
A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J Cell Biol (2004) 3.66
Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J Cell Biol (2002) 3.16
The small GTPase RalA targets filamin to induce filopodia. Proc Natl Acad Sci U S A (1999) 2.87
Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system. Nat Immunol (2007) 2.85
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol (2010) 2.72
ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. J Immunol (2007) 2.66
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis. Mol Biol Cell (2004) 2.49
Analysis of activated GAPs and GEFs in cell lysates. Methods Enzymol (2006) 2.45
The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc Natl Acad Sci U S A (1996) 2.32
Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells. J Cell Biol (1993) 2.23
Adhesion and signaling molecules controlling the transmigration of leukocytes through endothelium. Immunol Rev (2007) 2.22
Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway. J Immunol (1999) 2.03
Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actinin. J Cell Biol (1992) 2.02
Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1. J Cell Sci (1998) 1.99
Endothelial cells proactively form microvilli-like membrane projections upon intercellular adhesion molecule 1 engagement of leukocyte LFA-1. J Immunol (2003) 1.95
ICAM-1-coupled cytoskeletal rearrangements and transendothelial lymphocyte migration involve intracellular calcium signaling in brain endothelial cell lines. J Immunol (2000) 1.92
Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. Mol Biol Cell (2003) 1.90
Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. Curr Biol (2004) 1.87
Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration. J Exp Med (2004) 1.85
Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins. Mol Cell Biol (2000) 1.83
Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering. J Cell Biol (1999) 1.75
Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration. J Cell Sci (2008) 1.74
RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. J Cell Biol (2007) 1.71
RhoG signals in parallel with Rac1 and Cdc42. J Biol Chem (2002) 1.70
The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin. Nat Cell Biol (2000) 1.61
ICAM-1 signaling pathways associated with Rho activation in microvascular brain endothelial cells. J Immunol (1998) 1.56
TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG. J Cell Sci (2000) 1.54
Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration. J Immunol (2006) 1.51
p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. Blood (2008) 1.48
Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells. J Biol Chem (1994) 1.46
SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. Mol Biol Cell (2004) 1.42
Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact. Acta Neuropathol (2004) 1.39
Filamins regulate cell spreading and initiation of cell migration. PLoS One (2009) 1.36
Molecular cloning of human ABPL, an actin-binding protein homologue. Biochem Biophys Res Commun (1998) 1.26
Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo. J Exp Med (2011) 1.25
The Src-cortactin pathway is required for clustering of E-selectin and ICAM-1 in endothelial cells. FASEB J (2002) 1.23
Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration. J Immunol (2003) 1.21
Analysis of the roles of ICAM-1 in neutrophil transmigration using a reconstituted mammalian cell expression model: implication of ICAM-1 cytoplasmic domain and Rho-dependent signaling pathway. J Immunol (2001) 1.16
Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo. Blood (2010) 1.15
A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem Biol (2009) 1.15
Multiple novel isoforms of Trio are expressed in the developing rat brain. Gene (2005) 1.11
Filamin B plays a key role in vascular endothelial growth factor-induced endothelial cell motility through its interaction with Rac-1 and Vav-2. J Biol Chem (2010) 1.11
Neisseria meningitidis infection of human endothelial cells interferes with leukocyte transmigration by preventing the formation of endothelial docking structures. J Cell Biol (2006) 1.10
Filamin B mediates ICAM-1-driven leukocyte transendothelial migration. J Biol Chem (2008) 1.09
Endothelial domes encapsulate adherent neutrophils and minimize increases in vascular permeability in paracellular and transcellular emigration. PLoS One (2008) 1.05
The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion. PLoS One (2012) 1.03
Endothelial adapter proteins in leukocyte transmigration. Thromb Haemost (2009) 1.00
RKIKK motif in the intracellular domain is critical for spatial and dynamic organization of ICAM-1: functional implication for the leukocyte adhesion and transmigration. Mol Biol Cell (2007) 0.99
Filamin B serves as a molecular scaffold for type I interferon-induced c-Jun NH2-terminal kinase signaling pathway. Mol Biol Cell (2008) 0.98
Evidence of a functional role for interaction between ICAM-1 and nonmuscle alpha-actinins in leukocyte diapedesis. J Immunol (2006) 0.95
Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium. PLoS One (2010) 0.91
Nano-surgery at the leukocyte-endothelial docking site. Pflugers Arch (2007) 0.88
Analysis of low molecular weight GTPase activity in endothelial cell cultures. Methods Enzymol (2008) 0.87
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol (2010) 2.72
ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. J Immunol (2007) 2.66
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration. Am J Physiol Cell Physiol (2003) 2.37
Calcium signaling regulates translocation and activation of Rac. J Biol Chem (2003) 1.94
In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma. Cancer Cell (2010) 1.94
Domain-wide regulation of gene expression in the human genome. Genome Res (2007) 1.86
Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells. J Cell Sci (2002) 1.72
Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells. Proc Natl Acad Sci U S A (2009) 1.66
P-selectin glycoprotein ligand-1 is expressed on endothelial cells and mediates monocyte adhesion to activated endothelium. Arterioscler Thromb Vasc Biol (2007) 1.63
A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis. Arterioscler Thromb Vasc Biol (2010) 1.63
Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases. J Leukoc Biol (2008) 1.57
Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J Immunol (2008) 1.56
Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly. J Cell Sci (2003) 1.52
Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. J Cell Biol (2002) 1.47
The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity. J Biol Chem (2003) 1.45
Proline-rich tyrosine kinase 2 (Pyk2) mediates vascular endothelial-cadherin-based cell-cell adhesion by regulating beta-catenin tyrosine phosphorylation. J Biol Chem (2005) 1.45
LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation. EMBO J (2011) 1.34
Diabetes mellitus induces bone marrow microangiopathy. Arterioscler Thromb Vasc Biol (2009) 1.34
Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET. EMBO J (2007) 1.31
Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway. J Cell Sci (2010) 1.31
Signaling in leukocyte transendothelial migration. Arterioscler Thromb Vasc Biol (2004) 1.28
Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of beta1 and beta2 integrins. J Leukoc Biol (2006) 1.26
Rac1 mediates collapse of microvilli on chemokine-activated T lymphocytes. J Immunol (2004) 1.23
The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration. J Cell Sci (2011) 1.23
The role of ubiquitylation and degradation in RhoGTPase signalling. J Cell Sci (2010) 1.22
PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways. Eur J Cell Biol (2008) 1.17
Leukocyte-endothelium interaction promotes SDF-1-dependent polarization of CXCR4. J Biol Chem (2003) 1.17
Retinoic acid induces blood-brain barrier development. J Neurosci (2013) 1.17
Epac1-Rap1 signaling regulates monocyte adhesion and chemotaxis. J Leukoc Biol (2006) 1.16
Granulocyte colony-stimulating factor inhibits the mitochondria-dependent activation of caspase-3 in neutrophils. Blood (2002) 1.15
Susceptibility of recently transmitted subtype B human immunodeficiency virus type 1 variants to broadly neutralizing antibodies. J Virol (2007) 1.14
Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus. Mol Biol Cell (2003) 1.14
Migration of human hematopoietic progenitor cells across bone marrow endothelium is regulated by vascular endothelial cadherin. J Immunol (2002) 1.13
Real-time imaging of the dynamics and secretory behavior of Weibel-Palade bodies. Arterioscler Thromb Vasc Biol (2003) 1.11
cAMP signaling in leukocyte transendothelial migration. Arterioscler Thromb Vasc Biol (2007) 1.09
Trading spaces: Rap, Rac, and Rho as architects of transendothelial migration. Curr Opin Hematol (2005) 1.09
Filamin B mediates ICAM-1-driven leukocyte transendothelial migration. J Biol Chem (2008) 1.09
The composition of the mesenchymal stromal cell compartment in human bone marrow changes during development and aging. Haematologica (2011) 1.06
Endothelial signaling by Ig-like cell adhesion molecules. Arterioscler Thromb Vasc Biol (2007) 1.05
The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma. Exp Cell Res (2008) 1.05
Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors. Antiviral Res (2010) 1.05
The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion. PLoS One (2012) 1.03
Comparison of RNAi efficiency mediated by tetracycline-responsive H1 and U6 promoter variants in mammalian cell lines. Nucleic Acids Res (2007) 1.01
Rac1 recruits the adapter protein CMS/CD2AP to cell-cell contacts. J Biol Chem (2010) 1.00
MYCN-regulated miRNA-92 inhibits secretion of the tumor suppressor DICKKOPF-3 (DKK3) in neuroblastoma. Carcinogenesis (2011) 1.00
Endothelial adapter proteins in leukocyte transmigration. Thromb Haemost (2009) 1.00
Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene. Cancer Res (2010) 0.99
Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics. J Cell Sci (2010) 0.98
Targeting and localized signalling by small GTPases. Biol Cell (2007) 0.98
The regulation of leucocyte transendothelial migration by endothelial signalling events. Cardiovasc Res (2010) 0.98
Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55. J Immunol (2013) 0.97
Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs. J Natl Cancer Inst (2013) 0.96
The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits. Matrix Biol (2002) 0.96
Tumor infiltrating macrophages reduce development of peritoneal colorectal carcinoma metastases. Cancer Lett (2008) 0.95
Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma. FASEB J (2012) 0.95
Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex. Acta Neuropathol (2012) 0.95
Cytoplasmic targeting of the proto-oncogene SET promotes cell spreading and migration. FEBS Lett (2012) 0.95
The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation. Mol Biol Cell (2012) 0.94
A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis. Arthritis Res Ther (2010) 0.91
Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium. PLoS One (2010) 0.91
Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier. J Neuroinflammation (2012) 0.91
FHL2 protein is a novel co-repressor of nuclear receptor Nur77. J Biol Chem (2011) 0.90
The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization. J Biol Chem (2012) 0.90
Brain endothelial barrier passage by monocytes is controlled by the endothelin system. J Neurochem (2011) 0.89
Toward understanding RhoGTPase specificity: structure, function and local activation. Small GTPases (2014) 0.89
Myeloid ecotropic viral integration site 1 (MEIS) 1 involvement in embryonic implantation. Hum Reprod (2008) 0.89
Escape of human immunodeficiency virus type 1 from broadly neutralizing antibodies is not associated with a reduction of viral replicative capacity in vitro. Virology (2007) 0.89
The many faces of the guanine-nucleotide exchange factor trio. Cell Adh Migr (2012) 0.89
Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration. Biochem J (2012) 0.89
HOXA/PBX3 knockdown impairs growth and sensitizes cytogenetically normal acute myeloid leukemia cells to chemotherapy. Haematologica (2013) 0.89
MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3. Cancer Lett (2009) 0.89
Inhibition of HIV-1 replication with stable RNAi-mediated knockdown of autophagy factors. Virol J (2012) 0.88
Small GTP-binding protein Ral is involved in cAMP-mediated release of von Willebrand factor from endothelial cells. Arterioscler Thromb Vasc Biol (2004) 0.88
Cell cycle and tissue of origin contribute to the migratory behaviour of human fetal and adult mesenchymal stromal cells. Br J Haematol (2009) 0.87
Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts. J Cell Sci (2012) 0.87
Osteoprotegerin expression in triple-negative breast cancer cells promotes metastasis. Cancer Med (2014) 0.87
Control of Rho GTPase function by BAR-domains. Small GTPases (2012) 0.87
Inhibition of GTPase Rac1 in endothelium by 6-mercaptopurine results in immunosuppression in nonimmune cells: new target for an old drug. J Immunol (2014) 0.86
A model for phospho-caveolin-1-driven turnover of focal adhesions. Cell Adh Migr (2011) 0.86
Distribution of the human intracellular serpin protease inhibitor 8 in human tissues. J Histochem Cytochem (2002) 0.86
Transendothelial migration drives dissociation of plateletmonocyte complexes. Thromb Haemost (2008) 0.85
Endothelial CD81 is a marker of early human atherosclerotic plaques and facilitates monocyte adhesion. Cardiovasc Res (2008) 0.85
Endothelial junction regulation: a prerequisite for leukocytes crossing the vessel wall. J Innate Immun (2013) 0.85