Published in J Biol Chem on July 21, 2003
Nonpolarized signaling reveals two distinct modes of 3D cell migration. J Cell Biol (2012) 2.76
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Mol Cell (2011) 2.32
Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells. J Cell Biol (2005) 2.24
SUMOylation of the GTPase Rac1 is required for optimal cell migration. Nat Cell Biol (2010) 1.95
14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins. Cell (2013) 1.90
Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell. Biophys J (2006) 1.58
ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinases. Neuroscientist (2007) 1.38
Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P2 pools. Biochem J (2006) 1.37
Ras acylation, compartmentalization and signaling nanoclusters (Review). Mol Membr Biol (2008) 1.33
Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET. EMBO J (2007) 1.31
How cells integrate complex stimuli: the effect of feedback from phosphoinositides and cell shape on cell polarization and motility. PLoS Comput Biol (2012) 1.22
Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells. Blood (2007) 1.13
Phospholipase D signaling: orchestration by PIP2 and small GTPases. Naunyn Schmiedebergs Arch Pharmacol (2007) 1.09
Modelling cell polarization driven by synthetic spatially graded Rac activation. PLoS Comput Biol (2012) 1.03
Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. Mol Cell Biol (2005) 1.02
Rac1 recruits the adapter protein CMS/CD2AP to cell-cell contacts. J Biol Chem (2010) 1.00
The small GTPase RhoG mediates glioblastoma cell invasion. Mol Cancer (2012) 0.98
Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking. Small GTPases (2014) 0.93
A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis. Arthritis Res Ther (2010) 0.91
Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium. PLoS One (2010) 0.91
Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation. J Cell Biol (2010) 0.88
Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts. J Cell Sci (2012) 0.87
Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation. J Biol Chem (2010) 0.87
Identification of CrkL-SH3 binding proteins from embryonic murine brain: implications for Reelin signaling during brain development. J Proteome Res (2011) 0.83
The Rac1 hypervariable region in targeting and signaling: a tail of many stories. Small GTPases (2013) 0.83
Single-molecule tracking of small GTPase Rac1 uncovers spatial regulation of membrane translocation and mechanism for polarized signaling. Proc Natl Acad Sci U S A (2015) 0.83
Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. Coli and Y. Pseudotuberculosis. J Signal Transduct (2012) 0.80
The presence of alpha-catenin in the VE-cadherin complex is required for efficient transendothelial migration of leukocytes. Int J Biol Sci (2009) 0.80
Activation of Cdc42 is necessary for sustained oscillations of Ca2+ and PIP2 stimulated by antigen in RBL mast cells. Biol Open (2014) 0.77
Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis. Elife (2016) 0.77
Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1. PLoS One (2014) 0.77
Nucleophosmin1 is a negative regulator of the small GTPase Rac1. PLoS One (2013) 0.75
Extracting Diffusive States of Rho GTPase in Live Cells: Towards In Vivo Biochemistry. PLoS Comput Biol (2015) 0.75
p104 binds to Rac1 and reduces its activity during myotube differentiation of C2C12 cell. ScientificWorldJournal (2014) 0.75
Suppression of Rac1 Signaling by Influenza A Virus NS1 Facilitates Viral Replication. Sci Rep (2016) 0.75
Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. J Immunol (2016) 0.75
Breast cancer-associated gene 3 interacts with Rac1 and augments NF-κB signaling in vitro, but has no effect on RANKL-induced bone resorption in vivo. Int J Mol Med (2017) 0.75
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell (2003) 3.36
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol (2010) 2.72
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration. Am J Physiol Cell Physiol (2003) 2.37
Calcium signaling regulates translocation and activation of Rac. J Biol Chem (2003) 1.94
PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions. J Cell Sci (2009) 1.75
Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells. J Cell Sci (2002) 1.72
Rap2A links intestinal cell polarity to brush border formation. Nat Cell Biol (2012) 1.71
P-selectin glycoprotein ligand-1 is expressed on endothelial cells and mediates monocyte adhesion to activated endothelium. Arterioscler Thromb Vasc Biol (2007) 1.63
Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases. J Leukoc Biol (2008) 1.57
Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J Immunol (2008) 1.56
Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta. Mol Cell (2006) 1.55
The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling. Genes Cells (2002) 1.53
Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis. Nature (2012) 1.48
Proline-rich tyrosine kinase 2 (Pyk2) mediates vascular endothelial-cadherin-based cell-cell adhesion by regulating beta-catenin tyrosine phosphorylation. J Biol Chem (2005) 1.45
Visualization of PtdIns3P dynamics in living plant cells. Plant J (2006) 1.44
Identification of adiponectin as a novel hemopoietic stem cell growth factor. J Immunol (2007) 1.32
Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET. EMBO J (2007) 1.31
Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway. J Cell Sci (2010) 1.31
Signaling in leukocyte transendothelial migration. Arterioscler Thromb Vasc Biol (2004) 1.28
Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of beta1 and beta2 integrins. J Leukoc Biol (2006) 1.26
Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate. J Cell Biol (2007) 1.25
Rac1 mediates collapse of microvilli on chemokine-activated T lymphocytes. J Immunol (2004) 1.23
The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration. J Cell Sci (2011) 1.23
The role of ubiquitylation and degradation in RhoGTPase signalling. J Cell Sci (2010) 1.22
Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm. BMC Biol (2006) 1.19
Intravital imaging of fluorescent markers and FRET probes by DNA tattooing. BMC Biotechnol (2007) 1.19
Activation of Wnt signaling in hematopoietic regeneration. Stem Cells (2008) 1.18
PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways. Eur J Cell Biol (2008) 1.17
Leukocyte-endothelium interaction promotes SDF-1-dependent polarization of CXCR4. J Biol Chem (2003) 1.17
Epac1-Rap1 signaling regulates monocyte adhesion and chemotaxis. J Leukoc Biol (2006) 1.16
Wnt signaling in the stem cell niche. Curr Opin Hematol (2004) 1.15
Evaluation and optimization of ZIC-HILIC-RP as an alternative MudPIT strategy. J Proteome Res (2007) 1.15
Wnt signaling in normal and malignant hematopoiesis. Cold Spring Harb Perspect Biol (2013) 1.14
A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning. Dev Cell (2008) 1.13
Migration of human hematopoietic progenitor cells across bone marrow endothelium is regulated by vascular endothelial cadherin. J Immunol (2002) 1.13
Real-time imaging of the dynamics and secretory behavior of Weibel-Palade bodies. Arterioscler Thromb Vasc Biol (2003) 1.11
cAMP signaling in leukocyte transendothelial migration. Arterioscler Thromb Vasc Biol (2007) 1.09
Mesenchymal stromal cell migration: possibilities to improve cellular therapy. Stem Cells Dev (2011) 1.09
Linking lipids to chromatin. Curr Opin Genet Dev (2004) 1.09
Filamin B mediates ICAM-1-driven leukocyte transendothelial migration. J Biol Chem (2008) 1.09
Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. J Biol Chem (2010) 1.08
PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha. Biochem J (2010) 1.07
The composition of the mesenchymal stromal cell compartment in human bone marrow changes during development and aging. Haematologica (2011) 1.06
Endothelial signaling by Ig-like cell adhesion molecules. Arterioscler Thromb Vasc Biol (2007) 1.05
Monocyte scintigraphy in rheumatoid arthritis: the dynamics of monocyte migration in immune-mediated inflammatory disease. PLoS One (2009) 1.05
An emerging role for PtdIns(4,5)P2-mediated signalling in human disease. Trends Pharmacol Sci (2005) 1.04
The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion. PLoS One (2012) 1.03
Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C. J Biol Chem (2005) 1.03
Nuclear phosphoinositides and their impact on nuclear functions. FEBS J (2013) 1.02
Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling. Curr Biol (2002) 1.02
A proinflammatory monocyte response is associated with myocardial injury and impaired functional outcome in patients with ST-segment elevation myocardial infarction: monocytes and myocardial infarction. Am Heart J (2011) 1.01
Recovery and functional activity of mononuclear bone marrow and peripheral blood cells after different cell isolation protocols used in clinical trials for cell therapy after acute myocardial infarction. EuroIntervention (2008) 1.00
Rac1 recruits the adapter protein CMS/CD2AP to cell-cell contacts. J Biol Chem (2010) 1.00
Endothelial adapter proteins in leukocyte transmigration. Thromb Haemost (2009) 1.00
Identification of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins by neomycin extraction. Mol Cell Proteomics (2010) 0.99
Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics. J Cell Sci (2010) 0.98
Targeting and localized signalling by small GTPases. Biol Cell (2007) 0.98
The regulation of leucocyte transendothelial migration by endothelial signalling events. Cardiovasc Res (2010) 0.98
A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis. Curr Biol (2006) 0.96
The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation. Mol Biol Cell (2012) 0.96
Nuclear receptors Nur77 and Nurr1 modulate mesenchymal stromal cell migration. Stem Cells Dev (2011) 0.95
Cytoplasmic targeting of the proto-oncogene SET promotes cell spreading and migration. FEBS Lett (2012) 0.95
The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation. Mol Biol Cell (2012) 0.94
Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults. Dev Biol (2007) 0.93
Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1. Mol Ther Nucleic Acids (2013) 0.93
Structure-activity relationship of diacylglycerol kinase theta. Biochim Biophys Acta (2004) 0.92
The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta. J Biol Chem (2005) 0.91
Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium. PLoS One (2010) 0.91
A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis. Arthritis Res Ther (2010) 0.91
Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach. J Lipid Res (2006) 0.91
Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development. Proc Natl Acad Sci U S A (2013) 0.90
The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization. J Biol Chem (2012) 0.90
Phosphatidylinositol 5-phosphate links dehydration stress to the activity of ARABIDOPSIS TRITHORAX-LIKE factor ATX1. PLoS One (2010) 0.90
Toward understanding RhoGTPase specificity: structure, function and local activation. Small GTPases (2014) 0.89
Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration. Biochem J (2012) 0.89
Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression. Cancer Res (2013) 0.88
Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress. Sci Signal (2012) 0.88
Biodistribution and radiation dosimetry of 99mTc-HMPAO-labeled monocytes in patients with rheumatoid arthritis. J Nucl Med (2008) 0.88
Phosphoinositide signalling in the nucleus. Adv Enzyme Regul (2010) 0.88
PtdIns5P is an oxidative stress-induced second messenger that regulates PKB activation. FASEB J (2012) 0.88
Small GTP-binding protein Ral is involved in cAMP-mediated release of von Willebrand factor from endothelial cells. Arterioscler Thromb Vasc Biol (2004) 0.88
Functional analysis of single amino-acid mutations in the thrombopoietin-receptor Mpl underlying congenital amegakaryocytic thrombocytopenia. Br J Haematol (2008) 0.88
Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts. J Cell Sci (2012) 0.87