Published in Proc Natl Acad Sci U S A on June 25, 2012
Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL. Nat Cell Biol (2016) 1.51
Lysosomal physiology. Annu Rev Physiol (2015) 1.34
Phosphoinositides regulate ion channels. Biochim Biophys Acta (2014) 1.09
Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics. Proc Natl Acad Sci U S A (2013) 1.09
Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification. Cell Rep (2015) 1.03
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation. Nat Cell Biol (2016) 1.02
The role of TRPMLs in endolysosomal trafficking and function. Cell Calcium (2014) 0.99
Phosphoinositide regulation of TRP channels. Handb Exp Pharmacol (2014) 0.97
The intracellular Ca²⁺ channels of membrane traffic. Channels (Austin) (2012) 0.93
Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane. J Biol Chem (2013) 0.90
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nat Commun (2016) 0.89
Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes. J Physiol (2013) 0.87
ROS and intracellular ion channels. Cell Calcium (2016) 0.83
Lipid agonism: The PIP2 paradigm of ligand-gated ion channels. Biochim Biophys Acta (2015) 0.83
A non-inactivating high-voltage-activated two-pore Na⁺ channel that supports ultra-long action potentials and membrane bistability. Nat Commun (2014) 0.82
Diabetes mellitus accelerates Aβ pathology in brain accompanied by enhanced GAβ generation in nonhuman primates. PLoS One (2015) 0.81
Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx. J Cell Sci (2016) 0.78
Calcium signaling in membrane repair. Semin Cell Dev Biol (2015) 0.78
Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice. PLoS One (2016) 0.78
Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression. Oncotarget (2016) 0.77
A painful TR(i)P to lysosomes. J Cell Biol (2016) 0.75
Biphasic regulation of lysosomal exocytosis by oxidative stress. Cell Calcium (2016) 0.75
Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel. Nat Struct Mol Biol (2017) 0.75
Specific stabilization of CFTR by phosphatidylserine. Biochim Biophys Acta (2016) 0.75
Regulation of lysosomal ion homeostasis by channels and transporters. Sci China Life Sci (2016) 0.75
Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. J Exp Med (2016) 0.75
Direct interaction of the Golgi V-ATPase a-subunit isoform with PI(4)P drives localization of Golgi V-ATPases in yeast. Mol Biol Cell (2017) 0.75
The 5-phosphatase OCRL in Lowe syndrome and Dent disease 2. Nat Rev Nephrol (2017) 0.75
Phosphoinositides in cell regulation and membrane dynamics. Nature (2006) 14.00
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature (2005) 6.85
Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science (2006) 5.10
The complex and intriguing lives of PIP2 with ion channels and transporters. Sci STKE (2001) 4.45
PIP2 is a necessary cofactor for ion channel function: how and why? Annu Rev Biophys (2008) 3.89
Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2. Nature (2011) 3.14
The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature (2008) 2.76
Transcriptional activation of lysosomal exocytosis promotes cellular clearance. Dev Cell (2011) 2.71
Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium. Cell (2011) 2.69
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci (2006) 2.58
The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Neuron (2006) 2.50
Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel. Hum Mol Genet (2000) 2.43
Ca2+ entry through plasma membrane IP3 receptors. Science (2006) 2.43
Regulation of ion transport proteins by membrane phosphoinositides. Nat Rev Neurosci (2007) 2.21
Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A (2007) 1.99
Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic. Traffic (2006) 1.92
Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomes. Traffic (2006) 1.84
Kinetic analysis of receptor-activated phosphoinositide turnover. J Cell Biol (2003) 1.81
Phosphoinositides: lipid regulators of membrane proteins. J Physiol (2010) 1.72
Mucolipins: Intracellular TRPML1-3 channels. FEBS Lett (2010) 1.49
Modulation of high-voltage activated Ca(2+) channels by membrane phosphatidylinositol 4,5-bisphosphate. Neuron (2010) 1.44
Small molecule activators of TRPML3. Chem Biol (2010) 1.37
Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. J Biol Chem (2009) 1.32
TRP channels of intracellular membranes. J Neurochem (2010) 1.30
Luminal chloride-dependent activation of endosome calcium channels: patch clamp study of enlarged endosomes. J Biol Chem (2007) 1.28
Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls magnesium gatekeeper TRPM6 activity. Sci Rep (2011) 1.18
Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes. J Physiol (2008) 1.04
Life and death of sensory hair cells expressing constitutively active TRPML3. J Biol Chem (2009) 0.98
An exciting release on TRPM7. Neuron (2006) 0.82
The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature (2008) 2.76
PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun (2010) 2.54
Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci (2004) 2.41
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35
TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell (2010) 2.32
A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. Cell (2015) 2.24
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat Cell Biol (2015) 1.88
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release. Nat Commun (2012) 1.85
A superfamily of voltage-gated sodium channels in bacteria. J Biol Chem (2003) 1.84
TRP ion channels in the nervous system. Curr Opin Neurobiol (2004) 1.78
Mucolipins: Intracellular TRPML1-3 channels. FEBS Lett (2010) 1.49
A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis. Dev Cell (2013) 1.36
Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. J Biol Chem (2009) 1.32
TRP channels of intracellular membranes. J Neurochem (2010) 1.30
The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A (2011) 1.29
The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. Proc Natl Acad Sci U S A (2004) 1.28
Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics. Proc Natl Acad Sci U S A (2013) 1.09
Lysosomal delivery of a lipophilic gemcitabine prodrug using novel acid-sensitive micelles improved its antitumor activity. Bioconjug Chem (2012) 1.00
Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders. Future Med Chem (2010) 0.98
SLOW WALKER2, a NOC1/MAK21 homologue, is essential for coordinated cell cycle progression during female gametophyte development in Arabidopsis. Plant Physiol (2009) 0.97
Permeation of antigen protein-conjugated nanoparticles and live bacteria through microneedle-treated mouse skin. Int J Nanomedicine (2011) 0.96
Few-layered CoHPO4 · 3H2O ultrathin nanosheets for high performance of electrode materials for supercapacitors. Nanoscale (2013) 0.95
Performance map of a cluster detection test using extended power. Int J Health Geogr (2013) 0.92
Microneedle-mediated transcutaneous immunization with plasmid DNA coated on cationic PLGA nanoparticles. J Control Release (2012) 0.92
Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes. J Physiol (2013) 0.87
Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP. J Physiol (2002) 0.87
Correlated evolution of transcription factors and their binding sites. Bioinformatics (2011) 0.87
Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts. Hum Mol Genet (2012) 0.85
TRPML1: an ion channel in the lysosome. Handb Exp Pharmacol (2014) 0.85
Gating of inward rectifier K(+) channels by proton-mediated interactions of intracellular protein domains. Trends Cardiovasc Med (2002) 0.83
Extrasegmental analgesia of heterotopic electroacupuncture stimulation on visceral pain rats. Brain Res (2010) 0.81
Solid lipid nanoparticle formulations of docetaxel prepared with high melting point triglycerides: in vitro and in vivo evaluation. Mol Pharm (2014) 0.80
Control of solid tumor growth in mice using EGF receptor-targeted RNA replicase-based plasmid DNA. Nanomedicine (Lond) (2012) 0.80
The extent of the uptake of plasmid into the skin determines the immune responses induced by a DNA vaccine applied topically onto the skin. J Pharm Pharmacol (2011) 0.79
Spatial heterogeneity of type I error for local cluster detection tests. Int J Health Geogr (2014) 0.78
An empiric weight computation for record linkage using linearly combined fields' similarity scores. Conf Proc IEEE Eng Med Biol Soc (2014) 0.78
AppA C-terminal plays an important role in its thermostability in Escherichia coli. Curr Microbiol (2012) 0.76
Transcutaneous DNA immunization following waxing-based hair depilation elicits both humoral and cellular immune responses. Eur J Pharm Biopharm (2012) 0.76
Alkalophilic adaptation of XynB endoxylanase from Aspergillus niger via rational design of pKa of catalytic residues. J Biosci Bioeng (2013) 0.76
N-trimethyl chitosan-coated multivesicular liposomes for oxymatrine oral delivery. Drug Dev Ind Pharm (2009) 0.76
A nanoparticle depot formulation of 4-(N)-stearoyl gemcitabine shows a strong anti-tumour activity. J Pharm Pharmacol (2012) 0.75
Effects of atrioventricular nodal ablation on permanent atrial fibrillation patients with cardiac resynchronization therapy: a systematic review and meta-analysis. Clin Cardiol (2014) 0.75
Relationship between Escherichia coli AppA phytase's thermostability and salt bridges. J Biosci Bioeng (2013) 0.75
Ferric phosphate hydroxide microcrystals for highly efficient visible-light-driven photocatalysts. Chemphyschem (2013) 0.75
Uniform M3PMo12O40·nH2O (M = NH4+, K+, Cs+) rhombic dodecahedral nanocrystals for effective antibacterial agents. Dalton Trans (2013) 0.75
Exact confidence intervals for the average causal effect on a binary outcome. Stat Med (2016) 0.75
TPZ, a bright centrosymmetric two-photon scaffold for bioimaging. Chem Commun (Camb) (2017) 0.75
Long-term phase-locking technique for locking the repetition rate of an optical frequency comb laser with 1.67 × 10<sup>-19</sup> precision. Appl Opt (2016) 0.75