Insulin concentration modulates hepatic lipid accumulation in mice in part via transcriptional regulation of fatty acid transport proteins.

PubWeight™: 0.79‹?›

🔗 View Article (PMC 3380053)

Published in PLoS One on June 20, 2012

Authors

Samir Softic1, Michelle Kirby, Nicholas G Berger, Noah F Shroyer, Stephen C Woods, Rohit Kohli

Author Affiliations

1: Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.

Articles cited by this

Nonalcoholic fatty liver disease. N Engl J Med (2002) 22.41

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest (1999) 6.99

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell (2000) 5.92

Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell (1994) 4.33

High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology (2010) 4.11

Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology (2004) 3.23

Insulin signaling in health and disease. Science (2003) 2.93

Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo. Diabetes (1999) 2.87

Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. J Clin Invest (2005) 2.14

A family of fatty acid transporters conserved from mycobacterium to man. Proc Natl Acad Sci U S A (1998) 2.12

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. J Clin Invest (1997) 2.11

SREBPs suppress IRS-2-mediated insulin signalling in the liver. Nat Cell Biol (2004) 2.09

A novel, noninvasive method for the measurement of intestinal fat absorption. Gastroenterology (2004) 2.02

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo. J Biol Chem (2000) 1.95

Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. Cell Metab (2008) 1.86

Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology (2010) 1.86

Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J (2001) 1.78

The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Mol Cell Biol (2009) 1.69

Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes. Dev Cell (2002) 1.67

Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. J Cell Sci (2006) 1.52

Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis. Gastroenterology (2006) 1.45

Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling. Cell Metab (2005) 1.43

Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36. Diabetes (2002) 1.38

Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia. J Biol Chem (2008) 1.32

Very-long-chain acyl-CoA synthetases. J Biol Chem (2007) 1.30

FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase. Am J Physiol Endocrinol Metab (2010) 1.26

The double life of Irs. Cell Metab (2008) 1.26

Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice. Exp Gerontol (2005) 1.23

Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet. J Hepatol (2004) 1.19

Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the phosphatidylinositol 3-kinase cell survival pathway. J Biol Chem (2007) 1.17

Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity. Gastroenterology (2006) 1.16

Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease in patients with type 1 diabetes. J Hepatol (2010) 1.16

Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2. J Clin Endocrinol Metab (2003) 1.15

Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast. J Biol Chem (2005) 1.15

Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice. J Biol Chem (2009) 1.14

Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis. Liver Int (2010) 1.12

Fatty acid transport and activation and the expression patterns of genes involved in fatty acid trafficking. Arch Biochem Biophys (2008) 1.11

Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease. Hepatol Res (2008) 1.08

Mechanisms and clinical implications of hepatocyte lipoapoptosis. Clin Lipidol (2010) 1.07

Thiazolidinediones (PPARgamma agonists) but not PPARalpha agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes. FASEB J (2001) 1.00

Abnormal liver function tests in patients with Type 1 diabetes mellitus: prevalence, clinical correlations and underlying pathologies. Diabet Med (2009) 0.90

A very long-chain acyl-CoA synthetase-deficient mouse and its relevance to X-linked adrenoleukodystrophy. Hum Mol Genet (2003) 0.90

Gas chromatography of unesterified fatty acids using polyester columns treated with phosphoric acid. Nature (1960) 0.86

A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration. Biochem J (2005) 0.86

Cbl, IRS-1, and IRS-2 mediate effects of rosiglitazone on PI3K, PKC-lambda, and glucose transport in 3T3/L1 adipocytes. Endocrinology (2002) 0.84

A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis. Horm Metab Res (2010) 0.84

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice. Diabetologia (2006) 0.84

Regulation of IRS-2 tyrosine phosphorylation in fasting and diabetes. Mol Cell Endocrinol (2001) 0.82

Characterization of the murine fatty acid transport protein gene and its insulin response sequence. J Biol Chem (1998) 0.81

Lipoprotein lipase activator NO-1886 improves fatty liver caused by high-fat feeding in streptozotocin-induced diabetic rats. Metabolism (2004) 0.76

Articles by these authors

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature (2010) 10.60

Hypothalamic mTOR signaling regulates food intake. Science (2006) 8.62

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature (2010) 5.81

High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology (2010) 4.11

The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest (2007) 2.97

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab (2008) 2.86

Cloned mice have an obese phenotype not transmitted to their offspring. Nat Med (2002) 2.68

Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes (2006) 2.62

Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. Gastroenterology (2011) 2.45

Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status. Endocrinology (2005) 2.43

A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery. Endocrinology (2013) 2.39

Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats. Endocrinology (2007) 2.37

A role for central nervous system PPAR-γ in the regulation of energy balance. Nat Med (2011) 2.34

Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. Diabetes (2008) 2.33

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol (2011) 2.21

Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. Am J Physiol Endocrinol Metab (2004) 2.21

Is the energy homeostasis system inherently biased toward weight gain? Diabetes (2003) 2.14

Gastrointestinal hormones and food intake. Gastroenterology (2005) 2.00

The catabolic action of insulin in the brain is mediated by melanocortins. J Neurosci (2002) 1.95

Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1). Proc Natl Acad Sci U S A (2012) 1.83

Differential sensitivity to central leptin and insulin in male and female rats. Diabetes (2003) 1.80

Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. Gastroenterology (2010) 1.80

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol (2009) 1.79

Atonal homolog 1 is a tumor suppressor gene. PLoS Biol (2009) 1.76

The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. J Neurosci (2008) 1.71

IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice. Hepatology (2014) 1.69

SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells. Exp Cell Res (2009) 1.64

Sleeve gastrectomy in rats improves postprandial lipid clearance by reducing intestinal triglyceride secretion. Gastroenterology (2011) 1.64

Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats. Diabetes (2007) 1.62

Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy. Gastroenterology (2007) 1.61

Insulin and leptin as adiposity signals. Recent Prog Horm Res (2004) 1.60

Cooperation between brain and islet in glucose homeostasis and diabetes. Nature (2013) 1.59

Monitoring of stored and available fuel by the CNS: implications for obesity. Nat Rev Neurosci (2003) 1.55

Improved rodent maternal metabolism but reduced intrauterine growth after vertical sleeve gastrectomy. Sci Transl Med (2013) 1.54

Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J Neurosci (2009) 1.54

Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function. J Neurosci (2011) 1.54

Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. Am J Physiol Gastrointest Liver Physiol (2010) 1.54

Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells. Gastroenterology (2010) 1.52

Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet. Am J Physiol Regul Integr Comp Physiol (2004) 1.49

Improvement in liver histology is associated with reduction in dyslipidemia in children with nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr (2015) 1.46

Intestinal development and differentiation. Exp Cell Res (2011) 1.44

Vertebrate intestinal endoderm development. Dev Dyn (2011) 1.41

Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats. Diabetes (2008) 1.39

Perinatal exposure to bisphenol-a and the development of metabolic syndrome in CD-1 mice. Endocrinology (2010) 1.38

Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. Hepatology (2009) 1.37

Mechanisms of lipotoxicity in NAFLD and clinical implications. J Pediatr Gastroenterol Nutr (2011) 1.35

Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis. Gut (2011) 1.33

Pleasurable behaviors reduce stress via brain reward pathways. Proc Natl Acad Sci U S A (2010) 1.33

Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium. Am J Physiol Gastrointest Liver Physiol (2006) 1.30

Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system. Am J Physiol Regul Integr Comp Physiol (2007) 1.27

Stem cell-derived human intestinal organoids as an infection model for rotaviruses. MBio (2012) 1.27

The timing of meals. Psychol Rev (2004) 1.26

The role of GM-CSF in adipose tissue inflammation. Am J Physiol Endocrinol Metab (2008) 1.26

Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nat Neurosci (2010) 1.25

The renin angiotensin system and the metabolic syndrome. Physiol Behav (2010) 1.25

Dynamic body weight and body composition changes in response to subordination stress. Physiol Behav (2007) 1.24

Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. Am J Physiol Regul Integr Comp Physiol (2005) 1.23

Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity. Cell Metab (2012) 1.23

Assessment of feeding behavior in laboratory mice. Cell Metab (2010) 1.22

Eating elicited by orexin-a, but not melanin-concentrating hormone, is opioid mediated. Endocrinology (2002) 1.22

Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Physiol Behav (2006) 1.21

Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A. Blood (2008) 1.21

Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes (2013) 1.20

Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis. Am J Physiol Endocrinol Metab (2008) 1.20

Insulin and leptin combine additively to reduce food intake and body weight in rats. Endocrinology (2002) 1.18

GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature mice. Gastroenterology (2011) 1.18

Social stress and recovery: implications for body weight and body composition. Am J Physiol Regul Integr Comp Physiol (2007) 1.16

Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats. Physiol Behav (2011) 1.15

Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats. Diabetes (2010) 1.15

A multidisciplinary clinical program is effective in stabilizing BMI and reducing transaminase levels in pediatric patients with NAFLD. J Pediatr Gastroenterol Nutr (2013) 1.15

Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats. Endocrinology (2012) 1.15

Notch in the intestine: regulation of homeostasis and pathogenesis. Annu Rev Physiol (2012) 1.15

Metabolic and endocrine consequences of social stress in a visible burrow system. Physiol Behav (2004) 1.14

Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner. Obesity (Silver Spring) (2013) 1.13

Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology. Obesity (Silver Spring) (2011) 1.12

Mice lacking the syndecan-3 gene are resistant to diet-induced obesity. J Clin Invest (2004) 1.11

Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats. Diabetes (2009) 1.10

Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity. Nat Med (2002) 1.09

Characterization of mice lacking the gene for cholecystokinin. Am J Physiol Regul Integr Comp Physiol (2007) 1.09

The effect of fat removal on glucose tolerance is depot specific in male and female mice. Am J Physiol Endocrinol Metab (2007) 1.08

Meal-anticipatory glucagon-like peptide-1 secretion in rats. Endocrinology (2009) 1.08

Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion. Proc Natl Acad Sci U S A (2012) 1.08

Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells. Blood (2009) 1.07

Consumption of a high-fat diet induces central insulin resistance independent of adiposity. Physiol Behav (2011) 1.07

The evaluation of hepatic fibrosis scores in children with nonalcoholic fatty liver disease. Dig Dis Sci (2014) 1.07

Acute exposure to a high-fat diet alters meal patterns and body composition. Physiol Behav (2010) 1.07

Acute third ventricular administration of insulin decreases food intake in two paradigms. Pharmacol Biochem Behav (2002) 1.07

Overview of animal models of obesity. Curr Protoc Pharmacol (2012) 1.06

Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. Endocrinology (2013) 1.05

Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism. Obesity (Silver Spring) (2009) 1.04

The regulation of the lymphatic secretion of glucagon-like peptide-1 (GLP-1) by intestinal absorption of fat and carbohydrate. Am J Physiol Gastrointest Liver Physiol (2007) 1.04

Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans. J Neurosci (2011) 1.04

Effect of vertical sleeve gastrectomy on food selection and satiation in rats. Am J Physiol Endocrinol Metab (2012) 1.04

High-fat-diet exposure induces IgG accumulation in hypothalamic microglia. Dis Model Mech (2012) 1.03