Published in J Immunol on July 23, 2012
mTOR is a key modulator of ageing and age-related disease. Nature (2013) 5.40
Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res (2015) 1.53
Immunometabolism governs dendritic cell and macrophage function. J Exp Med (2015) 1.41
Regulation of innate immune cell function by mTOR. Nat Rev Immunol (2015) 1.27
Dendritic cell metabolism. Nat Rev Immunol (2015) 1.21
Immunosuppressants in cancer prevention and therapy. Oncoimmunology (2013) 1.17
Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells. Proc Natl Acad Sci U S A (2013) 1.08
mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function. J Immunol (2014) 1.04
Blockade of mTOR signaling via rapamycin combined with immunotherapy augments antiglioma cytotoxic and memory T-cell functions. Mol Cancer Ther (2014) 1.02
Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4+CD25+FoxP3+ Treg. Blood (2015) 0.99
mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition. Proc Natl Acad Sci U S A (2014) 0.98
Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition. Neoplasia (2013) 0.95
mTOR Inhibition: From Aging to Autism and Beyond. Scientifica (Cairo) (2013) 0.94
Metabolic control of dendritic cell activation and function: recent advances and clinical implications. Front Immunol (2014) 0.92
Immunometabolism: Cellular Metabolism Turns Immune Regulator. J Biol Chem (2015) 0.91
Priming dendritic cells for th2 polarization: lessons learned from helminths and implications for metabolic disorders. Front Immunol (2014) 0.86
Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function. J Immunol (2014) 0.85
β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10. Proc Natl Acad Sci U S A (2015) 0.85
New perspectives on mTOR inhibitors (rapamycin, rapalogs and TORKinibs) in transplantation. Br J Clin Pharmacol (2016) 0.83
The Concept of Hormesis in Cancer Therapy - Is Less More? Cureus (2015) 0.82
Roles of mTOR complexes in the kidney: implications for renal disease and transplantation. Nat Rev Nephrol (2016) 0.82
Post-transplantation malignancies: here today, gone tomorrow? Nat Rev Clin Oncol (2015) 0.81
Dendritic cell-based immunization ameliorates pulmonary infection with highly virulent Cryptococcus gattii. Infect Immun (2015) 0.80
Antitumor cytotoxicity induced by bone-marrow-derived antigen-presenting cells is facilitated by the tumor suppressor protein p53 via regulation of IL-12. Oncoimmunology (2015) 0.75
Metabolic reprogramming of the immune response in the tumor microenvironment. Cancer Biol Ther (2013) 0.75
Intratumoral delivery of mTORC2-deficient dendritic cells inhibits B16 melanoma growth by promoting CD8(+) effector T cell responses. Oncoimmunology (2016) 0.75
Dynamic Metabolism in Immune Response. J Immunol Res Ther (2016) 0.75
Microfilariae of Brugia malayi Inhibit the mTOR Pathway and Induce Autophagy in Human Dendritic Cells. Infect Immun (2016) 0.75
mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections. Mediators Inflamm (2016) 0.75
The role of nitric oxide in metabolic regulation of Dendritic cell immune function. Cancer Lett (2017) 0.75
Energy metabolic pathways control the fate and function of myeloid immune cells. J Leukoc Biol (2017) 0.75
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
Growing roles for the mTOR pathway. Curr Opin Cell Biol (2005) 11.66
Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell (2010) 7.61
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell (2010) 7.59
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci U S A (2008) 6.84
The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis. Immunity (2007) 4.74
mTOR, translation initiation and cancer. Oncogene (2006) 4.68
Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab (2007) 4.59
Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol (2006) 4.55
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab (2010) 4.44
The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity (2008) 4.44
Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer. Cancer (2009) 4.12
With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab (2010) 4.11
Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood (2010) 3.98
Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. Proc Natl Acad Sci U S A (1993) 3.25
Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs. Blood (2002) 3.19
mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol (2009) 2.57
Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood (2008) 2.53
Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival. Am J Transplant (2005) 2.32
Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab (2009) 2.20
Rapamycin inhibits IL-4--induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood (2003) 2.12
Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. Immunity (2010) 2.05
Taming cancer by inducing immunity via dendritic cells. Immunol Rev (2007) 1.92
Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol (2002) 1.92
The multiple facets of mTOR in immunity. Trends Immunol (2009) 1.89
Suppression of Th2 cell development by Notch ligands Delta1 and Delta4. J Immunol (2008) 1.45
A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation. J Immunol (2010) 1.42
Nutrient sensing in the mTOR/S6K1 signalling pathway. Biochem Soc Trans (2007) 1.39
Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression. Blood (2002) 1.26
IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells. J Immunol (2008) 1.22
Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway. J Biol Chem (2008) 1.21
Cap- and IRES-independent scanning mechanism of translation initiation as an alternative to the concept of cellular IRESs. Mol Cells (2010) 1.21
Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation. EMBO J (2000) 1.16
Dendritic cells undergo rapid apoptosis in vitro during antigen-specific interaction with CD4+ T cells. J Immunol (1999) 1.15
Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression. FASEB J (2009) 1.14
Th2 differentiation is unaffected by Jagged2 expression on dendritic cells. J Immunol (2008) 1.11
Enhancement of dendritic cell-based vaccine potency by anti-apoptotic siRNAs targeting key pro-apoptotic proteins in cytotoxic CD8(+) T cell-mediated cell death. Immunol Lett (2009) 0.99
The evolving role of mTOR inhibition in transplantation tolerance. J Am Soc Nephrol (2011) 0.96
p16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms. PLoS One (2011) 0.94
Building on dendritic cell subsets to improve cancer vaccines. Curr Opin Immunol (2010) 0.93
Nutrient sensing: TOR's Ragtime. Nat Cell Biol (2008) 0.89
Augmentation of the migratory ability of DC-based vaccine into regional lymph nodes by efficient CCR7 gene transduction. Gene Ther (2005) 0.89
Update on prostate cancer vaccines. Cancer J (2011) 0.88
Dendritic cell-based vaccine in advanced melanoma: update of clinical outcome. Melanoma Res (2011) 0.87
Enhancement of DC vaccine potency by activating the PI3K/AKT pathway with a small interfering RNA targeting PTEN. Immunol Lett (2010) 0.86
Modification of dendritic cells with interferon-gamma-inducible protein-10 gene to enhance vaccine potency. J Gene Med (2009) 0.86
Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors. BMC Biol (2011) 0.82
Helminth infections: the great neglected tropical diseases. J Clin Invest (2008) 6.92
Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell (2013) 6.30
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity (2011) 5.43
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol (2009) 4.28
Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood (2010) 3.98
T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J Exp Med (2009) 3.40
Metabolic pathways in immune cell activation and quiescence. Immunity (2013) 3.09
IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge. J Immunol (2009) 2.74
Memory CD4+ T cells induce innate responses independently of pathogen. Nat Med (2010) 2.61
Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung. J Exp Med (2009) 2.51
Regulation of pathogenesis and immunity in helminth infections. J Exp Med (2009) 2.39
Helminth antigens modulate TLR-initiated dendritic cell activation. J Immunol (2004) 2.21
Metabolic switching and fuel choice during T-cell differentiation and memory development. Immunol Rev (2012) 2.03
CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol (2004) 2.03
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proc Natl Acad Sci U S A (2013) 1.90
Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood (2012) 1.89
Schistosomiasis delays lesion resolution during Leishmania major infection by impairing parasite killing by macrophages. Parasite Immunol (2002) 1.80
Long-term suppression of cathepsin B levels by RNA interference retards schistosome growth. Mol Biochem Parasitol (2005) 1.73
Regulatory T cell responses develop in parallel to Th responses and control the magnitude and phenotype of the Th effector population. J Immunol (2006) 1.73
TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoni. PLoS Pathog (2007) 1.68
Immunology of parasitic helminth infections. Infect Immun (2002) 1.62
Cutting edge: Th2 response induction by dendritic cells: a role for CD40. J Immunol (2002) 1.60
An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth. Cancer Biol Ther (2003) 1.52
Functional inactivation of immature dendritic cells by the intracellular parasite Toxoplasma gondii. J Immunol (2004) 1.49
Review series on helminths, immune modulation and the hygiene hypothesis: mechanisms underlying helminth modulation of dendritic cell function. Immunology (2009) 1.48
Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo. J Immunol (2007) 1.47
Suppression of Th2 cell development by Notch ligands Delta1 and Delta4. J Immunol (2008) 1.45
Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni. J Infect Dis (2001) 1.44
Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression. J Clin Invest (2009) 1.43
piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni. FASEB J (2007) 1.42
Functional plasticity in memory T helper cell responses. J Immunol (2007) 1.38
IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung. J Exp Med (2007) 1.34
Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor. J Exp Med (2012) 1.32
Cutting edge: CNS CD11c+ cells from mice with encephalomyelitis polarize Th17 cells and support CD25+CD4+ T cell-mediated immunosuppression, suggesting dual roles in the disease process. J Immunol (2007) 1.32
TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development. J Immunol (2005) 1.27
Cutting edge: polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells. J Immunol (2002) 1.26
Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover. PLoS Pathog (2010) 1.26
Combined TLR2 and TLR4 ligation in the context of bacterial or helminth extracts in human monocyte derived dendritic cells: molecular correlates for Th1/Th2 polarization. BMC Immunol (2009) 1.21
Genetic manipulation of schistosomes. Int J Parasitol (2007) 1.17
HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells. PLoS One (2011) 1.16
Chronic helminth infections protect against allergic diseases by active regulatory processes. Curr Allergy Asthma Rep (2010) 1.15
Th2 differentiation is unaffected by Jagged2 expression on dendritic cells. J Immunol (2008) 1.11
Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction. J Immunol (2002) 1.11
Suppression of early IL-4 production underlies the failure of CD4 T cells activated by TLR-stimulated dendritic cells to differentiate into Th2 cells. J Immunol (2007) 1.07
Schistosoma mansoni egg antigen-mediated modulation of Toll-like receptor (TLR)-induced activation occurs independently of TLR2, TLR4, and MyD88. Infect Immun (2008) 1.05
Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation. J Biol Chem (2009) 1.05
Transgene expression in Schistosoma mansoni: introduction of RNA into schistosomula by electroporation. Mol Biochem Parasitol (2004) 1.05
Th2 responses in schistosomiasis. Semin Immunopathol (2012) 1.04
Transfection of Schistosoma mansoni by electroporation and the description of a new promoter sequence for transgene expression. Int J Parasitol (2007) 1.03
Fatty acid oxidation is essential for egg production by the parasitic flatworm Schistosoma mansoni. PLoS Pathog (2012) 1.01
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood (2010) 1.01
CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses. J Immunol (2003) 1.01
IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease. PLoS Pathog (2012) 1.00
Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways. PLoS Pathog (2013) 1.00
Tegumental expression of a novel type II receptor serine/threonine kinase (SmRK2) in Schistosoma mansoni. Mol Biochem Parasitol (2004) 0.98
IL-12 driven upregulation of P-selectin ligand on myelin-specific T cells is a critical step in an animal model of autoimmune demyelination. J Neuroimmunol (2006) 0.97
Dendritic cell-intrinsic expression of NF-kappa B1 is required to promote optimal Th2 cell differentiation. J Immunol (2005) 0.97
Transposon-mediated chromosomal integration of transgenes in the parasitic nematode Strongyloides ratti and establishment of stable transgenic lines. PLoS Pathog (2012) 0.96
Cutting edge: requirement for TRAF6 in the induction of T cell anergy. J Immunol (2008) 0.95
Cell death and reproductive regression in female Schistosoma mansoni. PLoS Negl Trop Dis (2012) 0.94
Central role for interleukin-4 in regulating nitric oxide-mediated inhibition of T-cell proliferation and gamma interferon production in schistosomiasis. Infect Immun (2002) 0.93
Transforming growth factor-beta and insulin-like signalling pathways in parasitic helminths. Int J Parasitol (2002) 0.92
Memory CD4 T cells enhance primary CD8 T-cell responses. Infect Immun (2007) 0.92
Lack of C3 affects Th2 response development and the sequelae of chemotherapy in schistosomiasis. J Immunol (2003) 0.89
Cutting edge: Helminth infection induces IgE in the absence of mu- or delta-chain expression. J Immunol (2008) 0.89
Schistosomiasis. Curr Protoc Immunol (2013) 0.89
Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo. Eur J Immunol (2006) 0.88
A bone morphogenetic protein homologue in the parasitic flatworm, Schistosoma mansoni. Int J Parasitol (2008) 0.88
Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. Proc Natl Acad Sci U S A (2012) 0.87
Th1 and Th2 cells help CD8 T-cell responses. Infect Immun (2007) 0.87
Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis. J Clin Invest (2015) 0.86
Uncoupling of induced protein processing from maturation in dendritic cells exposed to a highly antigenic preparation from a helminth parasite. J Immunol (2008) 0.86
14-3-3 proteins in Schistosoma mansoni; identification of a second epsilon isoform. Int J Parasitol (2002) 0.85
Interleukin-4-inducing principle from Schistosoma mansoni eggs contains a functional C-terminal nuclear localization signal necessary for nuclear translocation in mammalian cells but not for its uptake. Infect Immun (2011) 0.84
Growth factors and chemotactic factors from parasitic helminths: molecular evidence for roles in host-parasite interactions versus parasite development. Int J Parasitol (2010) 0.84
Eukaryotic initiation factor 2 alpha subunit associates with TGF beta receptors and 14-3-3 epsilon and acts as a modulator of the TGF beta response. Biochemistry (2002) 0.83