Published in Mol Biol Evol on November 01, 1990
Inferring weak selection from patterns of polymorphism and divergence at "silent" sites in Drosophila DNA. Genetics (1995) 7.19
Protective immune responses to apical membrane antigen 1 of Plasmodium chabaudi involve recognition of strain-specific epitopes. Infect Immun (1996) 3.64
Divergent patterns of progression to AIDS after infection from the same source: human immunodeficiency virus type 1 evolution and antiviral responses. J Virol (1997) 2.16
Natural selection drives Drosophila immune system evolution. Genetics (2003) 2.13
Reliabilities of identifying positive selection by the branch-site and the site-prediction methods. Proc Natl Acad Sci U S A (2009) 1.94
Evolutionary inferences from DNA variation at the 6-phosphogluconate dehydrogenase locus in natural populations of drosophila: selection and geographic differentiation. Genetics (1994) 1.93
Why must T cells be cross-reactive? Nat Rev Immunol (2012) 1.88
Hypervariability generated by natural selection in an extracellular complement-inhibiting protein of serotype M1 strains of group A Streptococcus. Proc Natl Acad Sci U S A (1998) 1.85
Adaptive evolution in two large families of ubiquitin-ligase adapters in nematodes and plants. Genome Res (2006) 1.84
Excess nonsynonymous substitution of shared polymorphic sites among self-incompatibility alleles of Solanaceae. Proc Natl Acad Sci U S A (1991) 1.82
Extraordinary divergence and positive Darwinian selection in a fusagenic protein coating the acrosomal process of abalone spermatozoa. Proc Natl Acad Sci U S A (1995) 1.70
Positive selection drives the evolution of the Acp29AB accessory gland protein in Drosophila. Genetics (1999) 1.60
Circumsporozoite protein genes of malaria parasites (Plasmodium spp.): evidence for positive selection on immunogenic regions. Genetics (1991) 1.60
Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties. BMC Evol Biol (2008) 1.59
Molecular evolution of the intimin gene in O111 clones of pathogenic Escherichia coli. J Bacteriol (2002) 1.50
Widespread adaptive evolution in the human immunodeficiency virus type 1 genome. J Mol Evol (2003) 1.49
Evidence for positive selection in foot-and-mouth disease virus capsid genes from field isolates. Genetics (2001) 1.49
Recombination and selection at Brassica self-incompatibility loci. Genetics (1999) 1.41
Duplication and selection in the evolution of primate beta-defensin genes. Genome Biol (2003) 1.37
Adaptive diversification within a large family of recently duplicated, placentally expressed genes. Proc Natl Acad Sci U S A (2000) 1.32
Tracking human migrations by the analysis of the distribution of HLA alleles, lineages and haplotypes in closed and open populations. Philos Trans R Soc Lond B Biol Sci (2012) 1.28
Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics (2006) 1.27
The exchangeability of amino acids in proteins. Genetics (2005) 1.23
Duplicate gene evolution and expression in the wake of vertebrate allopolyploidization. BMC Evol Biol (2008) 1.22
The ompA gene in Chlamydia trachomatis differs in phylogeny and rate of evolution from other regions of the genome. Infect Immun (2006) 1.22
Detecting site-specific physicochemical selective pressures: applications to the Class I HLA of the human major histocompatibility complex and the SRK of the plant sporophytic self-incompatibility system. J Mol Evol (2005) 1.19
Adaptive evolution in the SRZ chemoreceptor families of Caenorhabditis elegans and Caenorhabditis briggsae. Proc Natl Acad Sci U S A (2005) 1.16
Diversity and linkage of genes in the self-incompatibility gene family in Arabidopsis lyrata. Genetics (2003) 1.14
Molecular evolution of Puumala hantavirus. J Virol (2001) 1.13
Molecular evolution of imprinted genes: no evidence for antagonistic coevolution. Proc Biol Sci (1997) 1.11
Large number of replacement polymorphisms in rapidly evolving genes of Drosophila. Implications for genome-wide surveys of DNA polymorphism. Genetics (1999) 1.11
A depauperate immune repertoire precedes evolution of sociality in bees. Genome Biol (2015) 1.11
Multiple mechanisms promote the retained expression of gene duplicates in the tetraploid frog Xenopus laevis. PLoS Genet (2006) 1.11
Neutral evolution of the sex-determining gene transformer in Drosophila. Genetics (2000) 1.11
Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor. PLoS One (2012) 1.07
Positive Darwinian selection on two homologous fertilization proteins: what is the selective pressure driving their divergence? J Mol Evol (1997) 1.06
Linkage disequilibrium and recombination rate estimates in the self-incompatibility region of Arabidopsis lyrata. Genetics (2007) 1.05
Haplotype variation in bovine Toll-like receptor 4 and computational prediction of a positively selected ligand-binding domain. Proc Natl Acad Sci U S A (2003) 1.04
Evolutionary ecology of the marine Roseobacter clade. Microbiol Mol Biol Rev (2014) 1.04
Contrasting roles of interallelic recombination at the HLA-A and HLA-B loci. Genetics (1993) 1.03
Are radical and conservative substitution rates useful statistics in molecular evolution? J Mol Evol (2003) 1.02
Adaptive evolution in humans revealed by the negative correlation between the polymorphism and fixation phases of evolution. Proc Natl Acad Sci U S A (2007) 1.00
HLA and disease. Eur J Epidemiol (2005) 1.00
Rapid sequence evolution of transcription factors controlling neuron differentiation in Caenorhabditis. Mol Biol Evol (2009) 1.00
Adaptive selection on bracovirus genomes drives the specialization of Cotesia parasitoid wasps. PLoS One (2013) 0.98
Purifying selection in mitochondria, free-living and obligate intracellular proteobacteria. BMC Evol Biol (2007) 0.96
Evolutionary analysis of a streamlined lineage of surface ocean Roseobacters. ISME J (2014) 0.96
Prdm9 polymorphism unveils mouse evolutionary tracks. DNA Res (2014) 0.93
Molecular evolution of the primate antiviral restriction factor tetherin. PLoS One (2010) 0.92
Selective pressures on Drosophila chemosensory receptor genes. J Mol Evol (2007) 0.91
Episodic positive selection in the evolution of avian toll-like receptor innate immunity genes. PLoS One (2014) 0.91
Identification of genes with fast-evolving regions in microbial genomes. Nucleic Acids Res (2004) 0.91
Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance. BMC Evol Biol (2008) 0.90
Characterizing sequence variation in the VP1 capsid proteins of foot and mouth disease virus (serotype 0) with respect to virion structure. J Mol Evol (1998) 0.90
Evolution and divergence of the mammalian SAMD9/SAMD9L gene family. BMC Evol Biol (2013) 0.86
Long-term and short-term evolutionary impacts of transposable elements on Drosophila. Genetics (2012) 0.85
Evolutionary genetics of insect innate immunity. Brief Funct Genomics (2015) 0.85
Detecting clusters of mutations. PLoS One (2008) 0.84
The T cell antigen receptor: the Swiss army knife of the immune system. Clin Exp Immunol (2015) 0.82
Characterizing molecular adaptation: a hierarchical approach to assess the selective influence of amino acid properties. Bioinformatics (2010) 0.81
Rapid evolution of the trophoblast kunitz domain proteins (TKDPs)-a multigene family in ruminant ungulates. J Mol Evol (2006) 0.80
Diversifying selection in a parasitoid's symbiotic virus among genes involved in inhibiting host immunity. Immunogenetics (2003) 0.79
A simple method for predicting the functional differentiation of duplicate genes and its application to MIKC-type MADS-box genes. Nucleic Acids Res (2005) 0.79
Expression and evolutionary divergence of the non-conventional olfactory receptor in four species of fig wasp associated with one species of fig. BMC Evol Biol (2009) 0.79
Patterns of historical balancing selection on the salmonid major histocompatibility complex class II beta gene. J Mol Evol (2007) 0.79
Characterisation and expression analysis of interleukin 2 (IL-2) and IL-21 homologues in the Japanese pufferfish, Fugu rubripes, following their discovery by synteny. Immunogenetics (2004) 0.78
Adaptive evolution of the chrysanthemyl diphosphate synthase gene involved in irregular monoterpene metabolism. BMC Evol Biol (2012) 0.78
Chinese origin rhesus macaque major histocompatibility complex class I molecules promiscuously present epitopes from SIV associated with molecules of Indian origin; implications for immunodominance and viral escape. Immunogenetics (2011) 0.78
Lineage-specific differences in the amino acid substitution process. J Mol Biol (2010) 0.78
Detecting selection in the blue crab, Callinectes sapidus, using DNA sequence data from multiple nuclear protein-coding genes. PLoS One (2014) 0.77
Codon-based detection of positive selection can be biased by heterogeneous distribution of polar amino acids along protein sequences. Comput Syst Bioinformatics Conf (2006) 0.76
The use of evolutionary approaches to understand single cell genomes. Front Microbiol (2015) 0.76
MHC class I genes in the owl monkey: mosaic organisation, convergence and loci diversity. Immunogenetics (2005) 0.76
Directional Darwinian Selection in proteins. BMC Bioinformatics (2013) 0.76
Tandem repetitive D domains of the sperm ligand zonadhesin evolve faster in the paralogue than in the orthologue comparison. J Mol Evol (2006) 0.76
Human Leukocyte Antigen Diversity: A Southern African Perspective. J Immunol Res (2015) 0.75
Structure and function of the non-classical major histocompatibility complex molecule MR1. Immunogenetics (2016) 0.75
Bayesian factor models in characterizing molecular adaptation. J Appl Stat (2013) 0.75
Excess of non-conservative amino acid changes in marine bacterioplankton lineages with reduced genomes. Nat Microbiol (2017) 0.75
The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol (1987) 266.90
Mathematical model for studying genetic variation in terms of restriction endonucleases. Proc Natl Acad Sci U S A (1979) 41.08
MEGA2: molecular evolutionary genetics analysis software. Bioinformatics (2001) 38.50
Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. Mol Biol Evol (1993) 38.03
MEGA: Molecular Evolutionary Genetics Analysis software for microcomputers. Comput Appl Biosci (1994) 28.25
Analysis of gene diversity in subdivided populations. Proc Natl Acad Sci U S A (1973) 26.31
Statistical studies on protein polymorphism in natural populations. I. Distribution of single locus heterozygosity. Genetics (1977) 17.08
Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection. Nature (1988) 15.05
Phylogenetic test of the molecular clock and linearized trees. Mol Biol Evol (1995) 14.60
Gene differences between Caucasian, Negro, and Japanese populations. Science (1972) 12.11
Sampling variances of heterozygosity and genetic distance. Genetics (1974) 11.91
A new method of inference of ancestral nucleotide and amino acid sequences. Genetics (1995) 10.23
DNA polymorphism detectable by restriction endonucleases. Genetics (1981) 10.13
The theory of genetic distance and evolution of human races. Jinrui Idengaku Zasshi (1978) 8.80
Relationships between gene trees and species trees. Mol Biol Evol (1988) 8.63
Mutational pressure as the main cause of molecular evolution and polymorphism. Nature (1974) 8.03
Preliminary criteria for classification of adult Still's disease. J Rheumatol (1992) 7.53
Accuracy of estimated phylogenetic trees from molecular data. II. Gene frequency data. J Mol Evol (1983) 7.45
Limitations of the evolutionary parsimony method of phylogenetic analysis. Mol Biol Evol (1990) 5.92
F-statistics and analysis of gene diversity in subdivided populations. Ann Hum Genet (1977) 5.89
Estimation of fixation indices and gene diversities. Ann Hum Genet (1983) 5.67
Genetic structure of human populations. II. Differentiation of blood group gene frequencies among isolated populations. Heredity (Edinb) (1966) 5.55
Positive Darwinian selection after gene duplication in primate ribonuclease genes. Proc Natl Acad Sci U S A (1998) 5.54
Maximum likelihood estimation of the number of nucleotide substitutions from restriction sites data. Genetics (1983) 5.48
Estimation of evolutionary distance between nucleotide sequences. Mol Biol Evol (1984) 5.39
Linkage disequilibrium in subdivided populations. Genetics (1973) 5.22
On the stochastic model for estimation of mutational distance between homologous proteins. J Mol Evol (1972) 5.16
Allelic genealogy under overdominant and frequency-dependent selection and polymorphism of major histocompatibility complex loci. Genetics (1990) 5.11
Genetic distances and reconstruction of phylogenetic trees from microsatellite DNA. Genetics (1996) 4.55
Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection. Proc Natl Acad Sci U S A (1989) 4.52
On the constancy of the evolutionary rate of cistrons. J Mol Evol (1971) 4.49
Drift variances of heterozygosity and genetic distance in transient states. Genet Res (1975) 4.45
Molecular phylogeny and divergence times of drosophilid species. Mol Biol Evol (1995) 4.33
Pseudogenes as a paradigm of neutral evolution. Nature (1981) 4.33
Genetic distance and electrophoretic identity of proteins between taxa. J Mol Evol (1973) 4.19
Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res (2001) 4.03
Modification of linkage intensity by natural selection. Genetics (1967) 3.99
Non-random association between electromorphs and inversion chromosomes in finite populations. Genet Res (1980) 3.69
Gene genealogy and variance of interpopulational nucleotide differences. Genetics (1985) 3.64
Infinite allele model with varying mutation rate. Proc Natl Acad Sci U S A (1976) 3.56
The average number of generations until extinction of an individual mutant gene in a finite population. Genetics (1969) 3.49
Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO Rep (2001) 3.47
Estimation of average number of nucleotide substitutions when the rate of substitution varies with nucleotide. J Mol Evol (1982) 3.45
Population dynamics of sex-determining alleles in honey bees and self-incompatibility alleles in plants. Genetics (1979) 3.27
Spin Seebeck insulator. Nat Mater (2010) 3.01
Probability of identical monomorphism in related species. Genet Res (1975) 2.91
Efficiencies of fast algorithms of phylogenetic inference under the criteria of maximum parsimony, minimum evolution, and maximum likelihood when a large number of sequences are used. Mol Biol Evol (2000) 2.86
Detrimental genes with partial selfing and effects on a neutral locus. Genet Res (1974) 2.79
Genetic variability maintained by mutation and overdominant selection in finite populations. Genetics (1981) 2.79
Genic variation within and between the three major races of man, Caucasoids, Negroids, and Mongoloids. Am J Hum Genet (1974) 2.77
The frequency distribution of lethal chromosomes in finite populations. Proc Natl Acad Sci U S A (1968) 2.76
Statistical Studies on Protein Polymorphism in Natural Populations. III. Distribution of Allele Frequencies and the Number of Alleles per Locus. Genetics (1980) 2.76
Theoretical foundation of the minimum-evolution method of phylogenetic inference. Mol Biol Evol (1993) 2.74
Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res (1998) 2.63
Positive selection is a general phenomenon in the evolution of abalone sperm lysin. Mol Biol Evol (1995) 2.63
Letters to the editors: Lewontin-Krakauer test for neutral genes. Genetics (1975) 2.59
Models of evolution of reproductive isolation. Genetics (1983) 2.58
Phylogenetic analysis of polymorphic DNA sequences at the Adh locus in Drosophila melanogaster and its sibling species. J Mol Evol (1985) 2.48
Interior-branch and bootstrap tests of phylogenetic trees. Mol Biol Evol (1995) 2.45
Testing the neutral mutation hypothesis by distribution of single locus heterozygosity. Nature (1976) 2.37
Accumulation of mutations in sexual and asexual populations. Genet Res (1987) 2.30
Genetic structure of human populations. I. Local differentiation of blood group gene frequencies in Japan. Heredity (Edinb) (1966) 2.26
The number of nucleotides required to determine the branching order of three species, with special reference to the human-chimpanzee-gorilla divergence. J Mol Evol (1986) 2.25
Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET. Neurology (2009) 2.23
Accuracies of ancestral amino acid sequences inferred by the parsimony, likelihood, and distance methods. J Mol Evol (1997) 2.23
Identity of genes by descent within and between populations under mutation and migration pressures. Theor Popul Biol (1972) 2.19
Positive darwinian selection observed at the variable-region genes of immunoglobulins. Mol Biol Evol (1989) 2.17
Estimation of mutation rate from rare protein variants. Am J Hum Genet (1977) 2.15
Evolution of human races at the gene level. Prog Clin Biol Res (1982) 2.13
Statistical Studies on Protein Polymorphism in Natural Populations II. Gene Differentiation between Populations. Genetics (1978) 2.13
Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries. Genomics (2000) 2.09
Note on genetic drift and estimation of effective population size. Genetics (1984) 2.07
Relative efficiencies of the maximum parsimony and distance-matrix methods in obtaining the correct phylogenetic tree. Mol Biol Evol (1988) 2.03
Total number of individuals affected by a single deleterious mutation in a finite population. Am J Hum Genet (1972) 1.98
Small-sample tests of episodic adaptive evolution: a case study of primate lysozymes. Mol Biol Evol (1997) 1.97
Linkage modifications and sex difference in recombination. Genetics (1969) 1.96
Stable linkage disequilibrium without epistasis in subdivided populations. Theor Popul Biol (1974) 1.93
Extinction time of deleterious mutant genes in large populations. Theor Popul Biol (1971) 1.87
Polymorphism and evolution of influenza A virus genes. Mol Biol Evol (1986) 1.86
Gene duplication and nucleotide substitution in evolution. Nature (1969) 1.85
Efficiencies of different genes and different tree-building methods in recovering a known vertebrate phylogeny. Mol Biol Evol (1996) 1.84
Mean and variance of FST in a finite number of incompletely isolated populations. Theor Popul Biol (1977) 1.79
Divergent evolution and evolution by the birth-and-death process in the immunoglobulin VH gene family. Mol Biol Evol (1994) 1.77
Effective population size when fertility is inherited. Genet Res (1966) 1.76
SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J Pharmacol Exp Ther (2001) 1.72
Variability and heritability of human fertility. Ann Hum Genet (1970) 1.71
The transient distribution of allele frequencies under mutation pressure. Genet Res (1976) 1.70
Expression of endothelin 3 by mesenchymal cells of embryonic mouse caecum. Gut (1999) 1.66
Associative overdominance caused by linked detrimental mutations. Genet Res (1971) 1.66
A note on positive identification of paternity by using genetic markers. Hum Hered (1983) 1.66
Probability of fixation of a mutant gene in a finite population when selective advantage decreases with time. Genetics (1970) 1.65
Statistical analyses of Drosophila and human protein polymorphisms. Proc Natl Acad Sci U S A (1975) 1.63
Evolution of Antennapedia-class homeobox genes. Genetics (1996) 1.63
Probability of fixation and mean fixation time of an overdominant mutation. Genetics (1973) 1.57
Variance and covariances of the numbers of synonymous and nonsynonymous substitutions per site. Mol Biol Evol (1994) 1.57
Relative efficiencies of the maximum-likelihood, neighbor-joining, and maximum-parsimony methods when substitution rate varies with site. Mol Biol Evol (1994) 1.57
Evolution of the major histocompatibility complex: independent origin of nonclassical class I genes in different groups of mammals. Mol Biol Evol (1989) 1.56
Persistence of common alleles in two related populations or species. Genetics (1977) 1.54
Evolutionary change of linkage intensity. Nature (1968) 1.54
Relative efficiencies of the maximum-parsimony and distance-matrix methods of phylogeny construction for restriction data. Mol Biol Evol (1991) 1.53