Published in Nat Cell Biol on July 29, 2012
Tunable signal processing through modular control of transcription factor translocation. Science (2013) 2.11
A novel single-cell screening platform reveals proteome plasticity during yeast stress responses. J Cell Biol (2013) 1.56
Proteasome-mediated processing of Def1, a critical step in the cellular response to transcription stress. Cell (2013) 1.46
Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1. Nat Commun (2016) 1.41
DNA Damage Response Checkpoint Activation Drives KP1019 Dependent Pre-Anaphase Cell Cycle Delay in S. cerevisiae. PLoS One (2015) 1.41
The yeast deletion collection: a decade of functional genomics. Genetics (2014) 1.15
Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition. EMBO J (2015) 1.11
A chemostat array enables the spatio-temporal analysis of the yeast proteome. Proc Natl Acad Sci U S A (2013) 1.10
Spliceosome-mediated decay (SMD) regulates expression of nonintronic genes in budding yeast. Genes Dev (2013) 1.00
Global analysis of SUMO chain function reveals multiple roles in chromatin regulation. J Cell Biol (2013) 0.98
Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase. J Proteomics (2014) 0.96
Organelle acidification is important for localisation of vacuolar proteins in Saccharomyces cerevisiae. Protoplasma (2013) 0.96
Translation of CGA codon repeats in yeast involves quality control components and ribosomal protein L1. RNA (2013) 0.95
MitoMiner v3.1, an update on the mitochondrial proteomics database. Nucleic Acids Res (2015) 0.94
The yeast environmental stress response regulates mutagenesis induced by proteotoxic stress. PLoS Genet (2013) 0.94
Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. Nat Commun (2015) 0.91
The role of post-translational modifications in fine-tuning BLM helicase function during DNA repair. DNA Repair (Amst) (2014) 0.91
Examining the virulence of Candida albicans transcription factor mutants using Galleria mellonella and mouse infection models. Front Microbiol (2015) 0.90
Comprehensive analysis of interacting proteins and genome-wide location studies of the Sas3-dependent NuA3 histone acetyltransferase complex. FEBS Open Bio (2014) 0.89
How the nucleus copes with proteotoxic stress. Curr Biol (2014) 0.89
Learning gene networks under SNP perturbations using eQTL datasets. PLoS Comput Biol (2014) 0.88
Heritability and genetic basis of protein level variation in an outbred population. Genome Res (2014) 0.88
Altering nuclear pore complex function impacts longevity and mitochondrial function in S. cerevisiae. J Cell Biol (2015) 0.88
A SUMO-targeted ubiquitin ligase is involved in the degradation of the nuclear pool of the SUMO E3 ligase Siz1. Mol Biol Cell (2013) 0.87
Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit. Cell Rep (2016) 0.87
Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork. G3 (Bethesda) (2013) 0.86
Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proc Natl Acad Sci U S A (2014) 0.86
Transcriptomic responses of the basidiomycete yeast Sporobolomyces sp. to the mycotoxin patulin. BMC Genomics (2016) 0.84
LoQAtE--Localization and Quantitation ATlas of the yeast proteomE. A new tool for multiparametric dissection of single-protein behavior in response to biological perturbations in yeast. Nucleic Acids Res (2013) 0.84
Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae. Nucleic Acids Res (2013) 0.84
Length-dependent processing of telomeres in the absence of telomerase. Nucleic Acids Res (2014) 0.83
A reversible and highly selective inhibitor of the proteasomal ubiquitin receptor rpn13 is toxic to multiple myeloma cells. J Am Chem Soc (2015) 0.83
Yeast gene CMR1/YDL156W is consistently co-expressed with genes participating in DNA-metabolic processes in a variety of stringent clustering experiments. J R Soc Interface (2013) 0.83
Building a KATalogue of acetyllysine targeting and function. Brief Funct Genomics (2015) 0.83
Assembly of Slx4 signaling complexes behind DNA replication forks. EMBO J (2015) 0.83
MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches. Front Physiol (2014) 0.82
The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species. Microbiol Mol Biol Rev (2016) 0.82
Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells. DNA Repair (Amst) (2014) 0.82
Classifying and segmenting microscopy images with deep multiple instance learning. Bioinformatics (2016) 0.82
Novel connections between DNA replication, telomere homeostasis, and the DNA damage response revealed by a genome-wide screen for TEL1/ATM interactions in Saccharomyces cerevisiae. Genetics (2013) 0.82
The yeast 14-3-3 proteins BMH1 and BMH2 differentially regulate rapamycin-mediated transcription. Biosci Rep (2014) 0.82
The GCKIII kinase Sps1 and the 14-3-3 isoforms, Bmh1 and Bmh2, cooperate to ensure proper sporulation in Saccharomyces cerevisiae. PLoS One (2014) 0.81
Sen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae. PLoS One (2013) 0.81
Separate responses of karyopherins to glucose and amino acid availability regulate nucleocytoplasmic transport. Mol Biol Cell (2014) 0.81
Plasmids for C-terminal tagging in Saccharomyces cerevisiae that contain improved GFP proteins, Envy and Ivy. Yeast (2015) 0.81
Stress-induced nuclear RNA degradation pathways regulate yeast bromodomain factor 2 to promote cell survival. PLoS Genet (2014) 0.81
Granules harboring translationally active mRNAs provide a platform for P-body formation following stress. Cell Rep (2014) 0.80
A system based network approach to ethanol tolerance in Saccharomyces cerevisiae. BMC Syst Biol (2014) 0.80
Break-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and transcription. Genome Res (2015) 0.80
Concise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease. Stem Cells Transl Med (2013) 0.80
Conditional genetic interactions of RTT107, SLX4, and HRQ1 reveal dynamic networks upon DNA damage in S. cerevisiae. G3 (Bethesda) (2014) 0.79
Changes in SAM2 expression affect lactic acid tolerance and lactic acid production in Saccharomyces cerevisiae. Microb Cell Fact (2014) 0.79
Chromatin remodeling factors Isw2 and Ino80 regulate checkpoint activity and chromatin structure in S phase. Genetics (2015) 0.79
An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes. G3 (Bethesda) (2015) 0.79
Connecting chromatin modifying factors to DNA damage response. Int J Mol Sci (2013) 0.79
A conserved and essential basic region mediates tRNA binding to the Elp1 subunit of the Saccharomyces cerevisiae Elongator complex. Mol Microbiol (2014) 0.79
Nuclear localization of Haa1, which is linked to its phosphorylation status, mediates lactic acid tolerance in Saccharomyces cerevisiae. Appl Environ Microbiol (2014) 0.79
Application of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulans. PLoS One (2014) 0.79
A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe. PLoS One (2013) 0.79
Single-cell phenomics in budding yeast. Mol Biol Cell (2015) 0.79
Termination of Replication Stress Signaling via Concerted Action of the Slx4 Scaffold and the PP4 Phosphatase. Genetics (2015) 0.79
Leveraging DNA damage response signaling to identify yeast genes controlling genome stability. G3 (Bethesda) (2015) 0.78
Synthetic physical interactions map kinetochore regulators and regions sensitive to constitutive Cdc14 localization. Proc Natl Acad Sci U S A (2015) 0.78
Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. Genes Dev (2016) 0.78
Fgk3 glycogen synthase kinase is important for development, pathogenesis, and stress responses in Fusarium graminearum. Sci Rep (2015) 0.78
Genetic basis of haloperidol resistance in Saccharomyces cerevisiae is complex and dose dependent. PLoS Genet (2014) 0.78
MTE1 Functions with MPH1 in Double-Strand Break Repair. Genetics (2016) 0.78
The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. J Mol Biol (2015) 0.78
SW1PerS: Sliding windows and 1-persistence scoring; discovering periodicity in gene expression time series data. BMC Bioinformatics (2015) 0.78
Proteomic analyses reveal that Sky1 modulates apoptosis and mitophagy in Saccharomyces cerevisiae cells exposed to cisplatin. Int J Mol Sci (2014) 0.77
WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage. PLoS One (2016) 0.77
Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates. Cell Rep (2016) 0.77
Genetic Regulation of Dna2 Localization During the DNA Damage Response. G3 (Bethesda) (2015) 0.77
An Unsupervised kNN Method to Systematically Detect Changes in Protein Localization in High-Throughput Microscopy Images. PLoS One (2016) 0.77
Recruitment of Saccharomyces cerevisiae Cmr1/Ydl156w to Coding Regions Promotes Transcription Genome Wide. PLoS One (2016) 0.77
A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast. G3 (Bethesda) (2013) 0.77
Automated analysis of high-content microscopy data with deep learning. Mol Syst Biol (2017) 0.77
Comprehensive analysis of forty yeast microarray datasets reveals a novel subset of genes (APha-RiB) consistently negatively associated with ribosome biogenesis. BMC Bioinformatics (2014) 0.77
Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1. Genes Dev (2016) 0.77
Chemical suppression of defects in mitotic spindle assembly, redox control, and sterol biosynthesis by hydroxyurea. G3 (Bethesda) (2014) 0.77
Synthetic protein interactions reveal a functional map of the cell. Elife (2016) 0.77
Phosphatase complex Pph3/Psy2 is involved in regulation of efficient non-homologous end-joining pathway in the yeast Saccharomyces cerevisiae. PLoS One (2014) 0.76
Cell biology of mitotic recombination. Cold Spring Harb Perspect Biol (2015) 0.76
Examining the condition-specific antisense transcription in S. cerevisiae and S. paradoxus. BMC Genomics (2014) 0.76
Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiae. Physiol Genomics (2015) 0.76
The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and DNA replication-coupled nucleosome assembly in budding yeast. J Biol Chem (2014) 0.76
Unidirectional P-body transport during the yeast cell cycle. PLoS One (2014) 0.76
Proteomic Analysis of Dhh1 Complexes Reveals a Role for Hsp40 Chaperone Ydj1 in Yeast P-Body Assembly. G3 (Bethesda) (2015) 0.76
Fluorescent foci quantitation for high-throughput analysis. J Biol Methods (2015) 0.76
The Set3 Complex Antagonizes the MYST Acetyltransferase Esa1 in the DNA Damage Response. Mol Cell Biol (2015) 0.76
The LSH/DDM1 Homolog MUS-30 Is Required for Genome Stability, but Not for DNA Methylation in Neurospora crassa. PLoS Genet (2016) 0.76
A Genome-Wide Screen with Nicotinamide to Identify Sirtuin-Dependent Pathways in Saccharomyces cerevisiae. G3 (Bethesda) (2015) 0.76
Protein aggregation as a mechanism of adaptive cellular responses. Curr Genet (2016) 0.76
Big Data in Caenorhabditis elegans: quo vadis? Mol Biol Cell (2015) 0.75
Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: New pathways and metabolic cross-talk. Biochim Biophys Acta (2016) 0.75
IRES-dependent translated genes in fungi: computational prediction, phylogenetic conservation and functional association. BMC Genomics (2015) 0.75
Analysis of the Physiological Activities of Scd6 through Its Interaction with Hmt1. PLoS One (2016) 0.75
Time-Course Analysis of Gene Expression During the Saccharomyces cerevisiae Hypoxic Response. G3 (Bethesda) (2016) 0.75
Inappropriate expression of the translation elongation factor 1A disrupts genome stability and metabolism. J Cell Sci (2016) 0.75
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (1999) 36.25
Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell (2000) 36.09
Global analysis of protein localization in budding yeast. Nature (2003) 33.22
Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics (2010) 26.76
Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast (1998) 23.00
Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. Science (2009) 20.75
The genetic landscape of a cell. Science (2010) 16.52
Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software. Bioinformatics (2011) 12.98
Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise. Nature (2006) 12.92
Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science (2003) 12.90
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
A proteomics approach to understanding protein ubiquitination. Nat Biotechnol (2003) 10.51
Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell (2004) 9.74
REVIGO summarizes and visualizes long lists of gene ontology terms. PLoS One (2011) 8.65
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol (2003) 8.55
Global analysis of protein phosphorylation in yeast. Nature (2005) 7.46
Enrichment map: a network-based method for gene-set enrichment visualization and interpretation. PLoS One (2010) 6.61
Getting started with yeast. Methods Enzymol (2002) 6.60
Processing bodies require RNA for assembly and contain nontranslating mRNAs. RNA (2005) 6.54
Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Mol Biol Cell (2001) 6.39
GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function. Genome Biol (2008) 5.94
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science (2005) 5.75
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol (2003) 5.60
Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev (1996) 4.98
Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase. EMBO J (1999) 4.64
Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev (2001) 4.28
A central role for DNA replication forks in checkpoint activation and response. Mol Cell (2003) 4.15
Principles of ubiquitin and SUMO modifications in DNA repair. Nature (2009) 4.10
Rewiring of genetic networks in response to DNA damage. Science (2010) 4.03
Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae. J Cell Biol (2007) 3.98
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A (2002) 3.46
P bodies promote stress granule assembly in Saccharomyces cerevisiae. J Cell Biol (2008) 3.45
Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents. Proc Natl Acad Sci U S A (2002) 2.72
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale. Nat Methods (2010) 2.67
RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nat Cell Biol (2009) 2.67
Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet (2007) 2.63
A dynamic model of proteome changes reveals new roles for transcript alteration in yeast. Mol Syst Biol (2011) 2.44
Analysis of P-body assembly in Saccharomyces cerevisiae. Mol Biol Cell (2007) 2.37
Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways. Proc Natl Acad Sci U S A (2003) 2.24
Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools. J Biol Chem (2003) 2.17
RACK1, A multifaceted scaffolding protein: Structure and function. Cell Commun Signal (2011) 2.16
Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage. EMBO Rep (2003) 1.96
The ubiquitous role of ubiquitin in the DNA damage response. DNA Repair (Amst) (2010) 1.94
Ino80 chromatin remodeling complex promotes recovery of stalled replication forks. Curr Biol (2008) 1.89
Delayed correlation of mRNA and protein expression in rapamycin-treated cells and a role for Ggc1 in cellular sensitivity to rapamycin. Mol Cell Proteomics (2009) 1.76
Lsm1 promotes genomic stability by controlling histone mRNA decay. EMBO J (2011) 1.73
Synthetic genetic array (SGA) analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Methods Enzymol (2010) 1.73
Pat1 contains distinct functional domains that promote P-body assembly and activation of decapping. Mol Cell Biol (2007) 1.64
Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes. Mol Cell Biol (2007) 1.52
The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptation. Exp Cell Res (2006) 1.52
Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci (2009) 1.49
Global analysis of the yeast osmotic stress response by quantitative proteomics. Mol Biosyst (2009) 1.49
The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components. PLoS Genet (2011) 1.41
Choreography of recombination proteins during the DNA damage response. DNA Repair (Amst) (2009) 1.40
Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis. J Cell Biol (2010) 1.36
Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype. EMBO J (2012) 1.35
A consensus of core protein complex compositions for Saccharomyces cerevisiae. Mol Cell (2010) 1.19
Methylated DNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or DNA single-strand breaks and results in DNA damage. J Mol Biol (2010) 1.16
Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents. Proc Natl Acad Sci U S A (2011) 1.12
Reduction and loss of the iron center in the reaction of the small subunit of mouse ribonucleotide reductase with hydroxyurea. Biochemistry (1993) 1.06
Role of the iron mobilization and oxidative stress regulons in the genomic response of yeast to hydroxyurea. Mol Genet Genomics (2005) 1.03
Roles for oxidative stress and poly(ADP-ribosyl)ation in the killing of cultured hepatocytes by methyl methanesulfonate. Biochem Pharmacol (1993) 0.99
A Rab escort protein integrates the secretion system with TOR signaling and ribosome biogenesis. Genes Dev (2009) 0.98
Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae. Mutat Res (2005) 0.95
Saccharomyces cerevisiae Cmr1 protein preferentially binds to UV-damaged DNA in vitro. J Microbiol (2012) 0.89
CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol (2006) 32.51
Global mapping of the yeast genetic interaction network. Science (2004) 21.34
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The genetic landscape of a cell. Science (2010) 16.52
A high-resolution atlas of nucleosome occupancy in yeast. Nat Genet (2007) 12.21
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell (2006) 11.48
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell (2005) 10.41
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science (2008) 8.52
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21
A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules. Science (2001) 7.08
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
Most "dark matter" transcripts are associated with known genes. PLoS Biol (2010) 6.60
An empirical framework for binary interactome mapping. Nat Methods (2008) 6.59
Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell (2006) 6.42
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol (2003) 5.60
Role of formins in actin assembly: nucleation and barbed-end association. Science (2002) 5.47
Exploration of essential gene functions via titratable promoter alleles. Cell (2004) 5.21
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. Proc Natl Acad Sci U S A (2009) 5.15
Quantitative phenotyping via deep barcode sequencing. Genome Res (2009) 5.13
Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proc Natl Acad Sci U S A (2004) 5.10
Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics (2005) 5.08
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell (2005) 4.95
Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. Nat Genet (2007) 4.59
Assigning function to yeast proteins by integration of technologies. Mol Cell (2003) 4.58
A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell (2008) 4.49
Synthetic genetic array analysis in Saccharomyces cerevisiae. Methods Mol Biol (2006) 4.45
A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol Cell (2003) 4.04
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell (2006) 4.03
Identification of a bacterial type III effector family with G protein mimicry functions. Cell (2006) 3.47
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A (2002) 3.46
Combining biological networks to predict genetic interactions. Proc Natl Acad Sci U S A (2004) 3.18
Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation. Nat Cell Biol (2008) 3.16
A specificity map for the PDZ domain family. PLoS Biol (2008) 3.16
Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase. Science (2008) 3.09
The synthetic genetic interaction spectrum of essential genes. Nat Genet (2005) 3.06
eSGA: E. coli synthetic genetic array analysis. Nat Methods (2008) 3.01
BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates. Proc Natl Acad Sci U S A (2006) 3.00
Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast. Nat Cell Biol (2002) 2.95
Genotype to phenotype: a complex problem. Science (2010) 2.92
Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol Microbiol (2003) 2.84
The Ndc80 kinetochore complex forms load-bearing attachments to dynamic microtubule tips via biased diffusion. Cell (2009) 2.79
Formin leaky cap allows elongation in the presence of tight capping proteins. Curr Biol (2003) 2.69
Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell (2011) 2.68
Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network. J Biol (2005) 2.68
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale. Nat Methods (2010) 2.67
The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast. Nat Genet (2007) 2.58
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature (2013) 2.49
Functional genomics and proteomics: charting a multidimensional map of the yeast cell. Trends Cell Biol (2003) 2.46
Systematic mapping of genetic interaction networks. Annu Rev Genet (2009) 2.43
The Dam1 kinetochore complex harnesses microtubule dynamics to produce force and movement. Proc Natl Acad Sci U S A (2006) 2.40
Identifying transcription factor functions and targets by phenotypic activation. Proc Natl Acad Sci U S A (2006) 2.39
Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures. Nat Protoc (2007) 2.36
RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J (2005) 2.34
Identification of protein complexes required for efficient sister chromatid cohesion. Mol Biol Cell (2004) 2.34
Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. PLoS Genet (2005) 2.32
Formins: signaling effectors for assembly and polarization of actin filaments. J Cell Sci (2003) 2.31
Signature-tagged mutagenesis: barcoding mutants for genome-wide screens. Nat Rev Genet (2006) 2.30
Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast. Nat Cell Biol (2002) 2.27
Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol (2011) 2.26
An integrated platform of genomic assays reveals small-molecule bioactivities. Nat Chem Biol (2008) 2.21
Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples. Nucleic Acids Res (2010) 2.20
The Yeast Resource Center Public Data Repository. Nucleic Acids Res (2005) 2.19
Mechanism of formin-induced nucleation of actin filaments. Biochemistry (2003) 2.18
Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA. Nature (2009) 2.14
Tension applied through the Dam1 complex promotes microtubule elongation providing a direct mechanism for length control in mitosis. Nat Cell Biol (2007) 2.05
Elg1 forms an alternative RFC complex important for DNA replication and genome integrity. EMBO J (2003) 2.03
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Proc Natl Acad Sci U S A (2008) 2.01
Combination chemical genetics. Nat Chem Biol (2008) 1.98
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes Dev (2008) 1.97
A unique and universal molecular barcode array. Nat Methods (2006) 1.96
Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p. Nat Cell Biol (2004) 1.94
Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B. J Cell Biol (2010) 1.94
Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation. J Cell Biol (2008) 1.92
Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet (2009) 1.90