Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation.

PubWeight™: 0.83‹?›

🔗 View Article (PMC 3442524)

Published in J Biol Chem on July 28, 2012

Authors

Hong-Gyum Kim1, Dong Joon Kim, Shengqing Li, Kun Yeong Lee, Xiang Li, Ann M Bode, Zigang Dong

Author Affiliations

1: Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA.

Articles cited by this

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature (1999) 12.60

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature (2003) 12.06

Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer (2006) 11.48

Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet (2004) 11.31

The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol (2007) 8.57

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J (2004) 7.32

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev (2007) 6.77

Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol (2006) 6.06

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev (1999) 5.35

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice. Cell (1991) 5.02

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature (2004) 4.82

The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function. Annu Rev Genet (1995) 4.03

The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development (2001) 3.46

pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev (2007) 3.31

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell (2007) 3.16

Arsenic: health effects, mechanisms of actions, and research issues. Environ Health Perspect (1999) 3.07

Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol Cell Biol (2008) 2.57

Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila. Dev Cell (2008) 2.41

Polycomb group protein-mediated repression of transcription. Trends Biochem Sci (2010) 2.37

Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. J Biol Chem (2006) 1.93

Role of polycomb group proteins in stem cell self-renewal and cancer. DNA Cell Biol (2005) 1.89

Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy. Mol Cancer Ther (2003) 1.84

Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicol Appl Pharmacol (2005) 1.59

A quantitative system for assay of malignant transformation by chemical carcinogens using a clone derived from BALB-3T3. Int J Cancer (1973) 1.58

Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. Epigenomics (2010) 1.56

Arsenite alters global histone H3 methylation. Carcinogenesis (2008) 1.53

Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer cells. Cancer Res (2009) 1.50

Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. PLoS One (2009) 1.47

EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer. Breast Cancer Res (2008) 1.42

Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. Free Radic Biol Med (2008) 1.39

Arsenic and drinking water contamination. Science (1999) 1.27

Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung cancer in A/J mice. Toxicol Sci (2006) 1.26

Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformation. Cancer Res (2008) 1.20

Requirement of Erk, but not JNK, for arsenite-induced cell transformation. J Biol Chem (1999) 1.18

PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation. Environ Health Perspect (2008) 1.06

Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation. Cancer Res (2008) 1.02

Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells. Hum Pathol (2006) 0.99

Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells. Toxicol Appl Pharmacol (2006) 0.98

Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer. PLoS One (2009) 0.95

Neoplastic transformation of human small airway epithelial cells induced by arsenic. Mol Med (2008) 0.95

Mechanisms of acquired androgen independence during arsenic-induced malignant transformation of human prostate epithelial cells. Environ Health Perspect (2006) 0.94

The repressive effect of NF-kappaB on p53 by mot-2 is involved in human keratinocyte transformation induced by low levels of arsenite. Toxicol Sci (2010) 0.91

SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia. Genes Chromosomes Cancer (2010) 0.89

Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation. Biochem J (2011) 0.79

p16Ink4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation. J Thorac Oncol (2011) 0.79

Comparison of sensitivity to arsenic compounds between a Bhas 42 cell transformation assay and a BALB/c 3T3 cell transformation assay. Mutat Res (2009) 0.76

Articles by these authors

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc Natl Acad Sci U S A (2007) 7.96

Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer (2004) 6.67

Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol Cell (2006) 3.62

Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science (2012) 2.50

A prospective nationwide study of drug-induced liver injury in Korea. Am J Gastroenterol (2012) 2.43

Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J Biol Chem (2003) 2.30

Structure-based modeling of the functional HIV-1 intasome and its inhibition. Proc Natl Acad Sci U S A (2010) 2.16

Mitogen-activated protein kinase activation in UV-induced signal transduction. Sci STKE (2003) 2.12

Organization of the core structure of the postsynaptic density. Proc Natl Acad Sci U S A (2008) 2.06

The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase. J Virol (2009) 1.99

Development of genome-wide DNA polymorphism database for map-based cloning of rice genes. Plant Physiol (2004) 1.98

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells. J Biol Chem (2005) 1.89

Diffusion-tensor MR imaging and fiber tractography: a new method of describing aberrant fiber connections in developmental CNS anomalies. Radiographics (2005) 1.86

Electronic signatures of all four DNA nucleosides in a tunneling gap. Nano Lett (2010) 1.83

Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res (2002) 1.77

The functional contrariety of JNK. Mol Carcinog (2007) 1.77

Genomic evidence for ameiotic evolution in the bdelloid rotifer Adineta vaga. Nature (2013) 1.76

Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: association with gleason score and chromosome 8p deletion. Cancer Res (2006) 1.76

How human location-specific contact patterns impact spatial transmission between populations? Sci Rep (2013) 1.74

Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals. Mol Cell (2008) 1.71

Molecular targets of phytochemicals for cancer prevention. Nat Rev Cancer (2011) 1.69

Light-induced rescue of breathing after spinal cord injury. J Neurosci (2008) 1.68

KNN/BNT composite lead-free films for high-frequency ultrasonic transducer applications. IEEE Trans Ultrason Ferroelectr Freq Control (2011) 1.65

Evolution of scaling emergence in large-scale spatial epidemic spreading. PLoS One (2011) 1.64

Application of the HALF index obviates the need for liver biopsy in half of all patients with chronic hepatitis B. J Gastroenterol Hepatol (2011) 1.63

Prevalence of and racial differences in pterygium: a multiethnic population study in Asians. Ophthalmology (2012) 1.63

Protein kinase A type I and type II define distinct intracellular signaling compartments. Circ Res (2008) 1.62

NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy. Kidney Int (2013) 1.61

(-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78. Cancer Res (2006) 1.60

Congenital lethal motor neuron disease with a novel defect in ribosome biogenesis. Neurology (2014) 1.59

Development of integrated preamplifier for high-frequency ultrasonic transducers and low-power handheld receiver. IEEE Trans Ultrason Ferroelectr Freq Control (2011) 1.58

A nationwide seroepidemiology of hepatitis C virus infection in South Korea. Liver Int (2013) 1.57

Three common TP53 polymorphisms in susceptibility to breast cancer, evidence from meta-analysis. Breast Cancer Res Treat (2009) 1.56

Hepatocellular carcinoma screening in a hepatitis B virus-infected Korean population. Dig Dis Sci (2012) 1.55

Serum protein S100A9, SOD3, and MMP9 as new diagnostic biomarkers for pulmonary tuberculosis by iTRAQ-coupled two-dimensional LC-MS/MS. Proteomics (2014) 1.55

Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells. Gastroenterology (2007) 1.51

Ceramide-enriched membrane domains--structure and function. Biochim Biophys Acta (2008) 1.49

Phosphorylation of Sox2 cooperates in reprogramming to pluripotent stem cells. Stem Cells (2010) 1.48

Revision and update on clinical practice guideline for liver cirrhosis. Korean J Hepatol (2012) 1.47

Integrated intravascular optical coherence tomography ultrasound imaging system. J Biomed Opt (2010) 1.47

Intron 3 16 bp duplication polymorphism of TP53 contributes to cancer susceptibility: a meta-analysis. Carcinogenesis (2010) 1.47

Increased intestinal permeability as a predictor of bacterial infections in patients with decompensated liver cirrhosis and hemorrhage. J Gastroenterol Hepatol (2011) 1.47

Subcellular organelle lipidomics in TLR-4-activated macrophages. J Lipid Res (2010) 1.46

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5. Biochem J (2006) 1.46

Preventive effects of NSAIDs, NO-NSAIDs, and NSAIDs plus difluoromethylornithine in a chemically induced urinary bladder cancer model. Cancer Prev Res (Phila) (2013) 1.45

Functional and clinical evidence for NDRG2 as a candidate suppressor of liver cancer metastasis. Cancer Res (2008) 1.45

Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation. Mol Biol Cell (2005) 1.45

[Factors associated with liver stiffness in chronic liver disease]. Korean J Hepatol (2009) 1.44

The enigmatic effects of caffeine in cell cycle and cancer. Cancer Lett (2006) 1.43

Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen Aspergillus fumigatus. Chembiochem (2007) 1.42

Photocatalytic oxidation of arsenite over TiO2: is superoxide the main oxidant in normal air-saturated aqueous solutions? Environ Sci Technol (2011) 1.42

Y-configuration double-stent-assisted coiling using two closed-cell stents for wide-neck basilar tip aneurysms. Acta Neurochir (Wien) (2014) 1.42

Patient-specific dose estimation for pediatric chest CT. Med Phys (2008) 1.41

Rapid detection of the ACMG/ACOG-recommended 23 CFTR disease-causing mutations using ion torrent semiconductor sequencing. J Biomol Tech (2012) 1.40

MicroRNAome of porcine pre- and postnatal development. PLoS One (2010) 1.40

Stent-assisted coil embolization of intracranial wide-necked aneurysms. Neuroradiology (2005) 1.39

The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects. Crit Rev Oncol Hematol (2002) 1.37

Role of Wnt/beta-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-1alpha. Int J Urol (2007) 1.36

Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity. PLoS Pathog (2013) 1.36

Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization. Biomed Opt Express (2011) 1.35

Reduction of false positives by internal features for polyp detection in CT-based virtual colonoscopy. Med Phys (2005) 1.34

The intermediate filament protein vimentin is a new target for epigallocatechin gallate. J Biol Chem (2005) 1.34

PSD-95 is required to sustain the molecular organization of the postsynaptic density. J Neurosci (2011) 1.33

Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation. Cancer Res (2007) 1.33

Nitrogen-doped porous carbon nanofiber webs as anodes for lithium ion batteries with a superhigh capacity and rate capability. Adv Mater (2012) 1.33

High-resolution coregistered intravascular imaging with integrated ultrasound and optical coherence tomography probe. Appl Phys Lett (2010) 1.32

Gold biomineralization by a metallophore from a gold-associated microbe. Nat Chem Biol (2013) 1.31

Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia. Hypertension (2012) 1.31

ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4. Nat Struct Mol Biol (2012) 1.30

Incidence and risk factors of recurrence after endovascular treatment of intracranial vertebrobasilar dissecting aneurysms. Stroke (2011) 1.30

Isolation and characterization of a new ginsenoside from the fresh root of Panax Ginseng. Molecules (2010) 1.30

Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine. Cancer Res (2008) 1.30

miR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPKα1. Mol Cancer Ther (2012) 1.29

Myricetin suppresses UVB-induced skin cancer by targeting Fyn. Cancer Res (2008) 1.29

An improved electronic colon cleansing method for detection of colonic polyps by virtual colonoscopy. IEEE Trans Biomed Eng (2006) 1.28

Roles of mixing patterns in cooperation on a scale-free networked game. Phys Rev E Stat Nonlin Soft Matter Phys (2007) 1.27

Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity. J Virol (2008) 1.27

Inducible covalent posttranslational modification of histone H3. Sci STKE (2005) 1.26

Tpl2 is a key mediator of arsenite-induced signal transduction. Cancer Res (2009) 1.26

[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer Res (2009) 1.26

Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. J Biol Chem (2008) 1.26

Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t. Eur J Immunol (2008) 1.26

NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. Cancer Res (2002) 1.25

Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging. J Biomed Opt (2011) 1.25

A randomized trial of mesenchymal stem cells in multiple system atrophy. Ann Neurol (2012) 1.24