Published in N Engl J Med on March 22, 2011
PROphylaxis for ThromboEmbolism in Critical Care Trial (PROTECT) | NCT00182143
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Procedure-specific venous thromboembolism prophylaxis: a paradigm from colectomy surgery. Surgery (2012) 1.11
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A comparative study of varying doses of enoxaparin for thromboprophylaxis in critically ill patients: a double-blinded, randomised controlled trial. Crit Care (2013) 0.88
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A Survey of the Knowledge of Venous Thromboembolism Prophylaxis among the Medical Staff of Intensive Care Units in North China. PLoS One (2015) 0.81
Thrombo-prophylaxis in acutely ill medical and critically ill patients. Indian J Crit Care Med (2014) 0.81
Prevalence of deep vein thrombosis in acutely admitted ambulatory non-surgical intensive care unit patients. BMC Res Notes (2014) 0.78
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Competing Risk Analysis for Evaluation of Dalteparin Versus Unfractionated Heparin for Venous Thromboembolism in Medical-Surgical Critically Ill Patients. Medicine (Baltimore) (2015) 0.78
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Prevention of venous thromboembolism in hospitalized acutely ill medical patients: focus on the clinical utility of (low-dose) fondaparinux. Drug Des Devel Ther (2013) 0.75
Does dalteparin PROTECT better than heparin? Crit Care (2011) 0.75
Pharmacological and Mechanical Thromboprophylaxis in Critically Ill Patients: a Network Meta-Analysis of 12 Trials. J Korean Med Sci (2016) 0.75
Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial. Trials (2014) 0.75
The Perception of Evidence for Venous Thromboembolism Prophylaxis Current Practices after Cardiac Surgery: A Canadian Cross-Sectional Survey. Thrombosis (2015) 0.75
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The impact of deep vein thrombosis in critically ill patients: a meta-analysis of major clinical outcomes. Blood Transfus (2015) 0.75
A feasible strategy for preventing blood clots in critically ill patients with acute kidney injury (FBI): study protocol for a randomized controlled trial. Trials (2014) 0.75
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Use of Low Molecular Weight Heparins in Patients with Renal Failure; Time to Re-evaluate Our Preconceptions. J Gen Intern Med (2016) 0.75
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial. Trials (2015) 0.75
Risk factors for and prediction of mortality in critically ill medical-surgical patients receiving heparin thromboprophylaxis. Ann Intensive Care (2016) 0.75
Dalteparin in critically ill patients. N Engl J Med (2011) 0.75
ACP Journal Club. Dalteparin did not differ from unfractionated heparin for reducing proximal DVT in critically ill patients. Ann Intern Med (2011) 0.75
Dalteparin in critically ill patients. N Engl J Med (2011) 0.75
Dalteparin and heparin-induced thrombocytopenia. N Engl J Med (2011) 0.75
The safety profile of preoperative administration of heparin for thromboprophylaxis in Chinese patients intended for thoracoscopic major thoracic surgery: a pilot randomized controlled study. J Thorac Dis (2017) 0.75
Bilateral spontaneous, simultaneous lower extremity hematomas in a patient on dalteparin. Int J Surg Case Rep (2013) 0.75
Practice Patterns of Venous Thromboembolism Prophylaxis in Underweight, Critically Ill Patients with Neurologic Injury. Neurocrit Care (2017) 0.75
Association between aspirin use and deep venous thrombosis in mechanically ventilated ICU patients. J Thromb Thrombolysis (2017) 0.75
Prevention of venous thromboembolism in the critically ill patient. J Intensive Care Soc (2015) 0.75
Pediatric intensive care stress ulcer prevention (PIC-UP): a protocol for a pilot randomized trial. Pilot Feasibility Stud (2017) 0.75
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Intensive versus conventional glucose control in critically ill patients. N Engl J Med (2009) 26.30
Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet (2008) 13.15
Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA (2009) 13.00
One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med (2003) 11.77
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39
Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med (2011) 9.96
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet (2011) 9.31
American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken) (2012) 9.25
A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med (2013) 8.94
Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism. N Engl J Med (2003) 8.55
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Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med (2015) 7.73
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Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA (2012) 6.69
A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome. N Engl J Med (2003) 6.57
The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood (2011) 6.50
Hypoglycemia and risk of death in critically ill patients. N Engl J Med (2012) 6.17
Aspirin in patients undergoing noncardiac surgery. N Engl J Med (2014) 6.10
Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N Engl J Med (2008) 6.00
Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA (2010) 5.90
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Systematic overview of warfarin and its drug and food interactions. Arch Intern Med (2005) 5.86
An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations. Am J Respir Crit Care Med (2006) 5.29
A Trial of Wound Irrigation in the Initial Management of Open Fracture Wounds. N Engl J Med (2015) 5.28
A systematic review and meta-analysis of studies comparing mortality rates of private for-profit and private not-for-profit hospitals. CMAJ (2002) 4.84
Post-randomisation exclusions: the intention to treat principle and excluding patients from analysis. BMJ (2002) 4.70
Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. JAMA (2012) 4.58
Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel. Transfusion (2004) 4.48
Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med (2007) 4.42
Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2009) 4.41
Toothbrushing for critically ill mechanically ventilated patients: a systematic review and meta-analysis of randomized trials evaluating ventilator-associated pneumonia. Crit Care Med (2013) 4.29
Evaluating the teaching of evidence-based medicine. JAMA (2002) 4.01
Fluid resuscitation in sepsis: a systematic review and network meta-analysis. Ann Intern Med (2014) 3.96
Clinical experts or methodologists to write clinical guidelines? Lancet (2009) 3.91
Interventions to reduce unintended pregnancies among adolescents: systematic review of randomised controlled trials. BMJ (2002) 3.90
Predicting survival after extracorporeal membrane oxygenation for severe acute respiratory failure. The Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) score. Am J Respir Crit Care Med (2014) 3.78
GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations. J Clin Epidemiol (2013) 3.58
Publication bias in editorial decision making. JAMA (2002) 3.52
The vexing problem of guidelines and conflict of interest: a potential solution. Ann Intern Med (2010) 3.47
Meta-analyses of therapies for postmenopausal osteoporosis. IX: Summary of meta-analyses of therapies for postmenopausal osteoporosis. Endocr Rev (2002) 3.46
Longer- Versus Shorter-Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent Placement: A Systematic Review and Meta-analysis. Ann Intern Med (2015) 3.41
Aspirin versus low-molecular-weight heparin for extended venous thromboembolism prophylaxis after total hip arthroplasty: a randomized trial. Ann Intern Med (2013) 3.40
Patients at the center: in our practice, and in our use of language. ACP J Club (2004) 3.32
Where to now with carbon monoxide poisoning? Emerg Med Australas (2004) 3.30
Randomized controlled trials of surgical interventions. Ann Surg (2010) 3.30
Outcomes of patients treated with noninvasive ventilation by a medical emergency team on the wards. Respir Care (2013) 3.28
Naturopathic medicine for the prevention of cardiovascular disease: a randomized clinical trial. CMAJ (2013) 3.25
Tips for learning and teaching evidence-based medicine: introduction to the series. CMAJ (2004) 3.23
Quality of care in for-profit and not-for-profit nursing homes: systematic review and meta-analysis. BMJ (2009) 3.22
Acute kidney injury after cardiac surgery: focus on modifiable risk factors. Circulation (2009) 3.10
Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials. BMJ (2007) 3.06
The safety of long-acting beta-agonists among patients with asthma using inhaled corticosteroids: systematic review and metaanalysis. Am J Respir Crit Care Med (2008) 3.01
Randomized trial of reamed and unreamed intramedullary nailing of tibial shaft fractures. J Bone Joint Surg Am (2008) 3.01
Characteristics and short-term prognosis of perioperative myocardial infarction in patients undergoing noncardiac surgery: a cohort study. Ann Intern Med (2011) 2.80
The Very Elderly Admitted to ICU: A Quality Finish? Crit Care Med (2015) 2.77
Payments for care at private for-profit and private not-for-profit hospitals: a systematic review and meta-analysis. CMAJ (2004) 2.76
Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis. Thromb Haemost (2011) 2.75
Facilitating clinician adherence to guidelines in the intensive care unit: A multicenter, qualitative study. Crit Care Med (2007) 2.72
Specific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid. J Clin Epidemiol (2011) 2.69
Credibility of claims of subgroup effects in randomised controlled trials: systematic review. BMJ (2012) 2.69
A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med (2013) 2.68
Clinician predictions of intensive care unit mortality. Crit Care Med (2004) 2.65
Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP. Proc Natl Acad Sci U S A (2002) 2.64
An observational study found that authors of randomized controlled trials frequently use concealment of randomization and blinding, despite the failure to report these methods. J Clin Epidemiol (2004) 2.58
Helicobacter pylori eradication in functional dyspepsia: HEROES trial. Arch Intern Med (2011) 2.57
Ischemic Limb Gangrene with Pulses. N Engl J Med (2015) 2.57
Is a pre-operative brain natriuretic peptide or N-terminal pro-B-type natriuretic peptide measurement an independent predictor of adverse cardiovascular outcomes within 30 days of noncardiac surgery? A systematic review and meta-analysis of observational studies. J Am Coll Cardiol (2009) 2.56
Indications, complications, and management of inferior vena cava filters: the experience in 952 patients at an academic hospital with a level I trauma center. JAMA Intern Med (2013) 2.52
Cooling for neonatal hypoxic ischemic encephalopathy: do we have the answer? Pediatrics (2007) 2.51
Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardiovascular disease: a meta-analysis of randomized trials. Arch Intern Med (2007) 2.50
Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 2.50
Meta-analyses of therapies for postmenopausal osteoporosis. II. Meta-analysis of alendronate for the treatment of postmenopausal women. Endocr Rev (2002) 2.49
Antiphospholipid syndrome. Lancet (2010) 2.47
Comparative responsiveness of generic and specific quality-of-life instruments. J Clin Epidemiol (2003) 2.47
GRADE guidelines: 15. Going from evidence to recommendation-determinants of a recommendation's direction and strength. J Clin Epidemiol (2013) 2.46
Use of non-invasive ventilation to wean critically ill adults off invasive ventilation: meta-analysis and systematic review. BMJ (2009) 2.44
Evidence based medicine has come a long way. BMJ (2004) 2.42