A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells.

PubWeight™: 1.49‹?› | Rank: Top 4%

🔗 View Article (PMID 21822311)

Published in Oncogene on August 08, 2011

Authors

G Zhu1, Y Wang, B Huang, J Liang, Y Ding, A Xu, W Wu

Author Affiliations

1: Protein Science Laboratory of the Ministry of Education, School of Life Sciences, Tsinghua University, Beijing, China.

Articles citing this

The many faces and functions of β-catenin. EMBO J (2012) 3.85

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression. EBioMedicine (2015) 1.49

PAK signaling in cancer. Cell Logist (2012) 1.27

Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer. Gut (2014) 1.18

Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells. Cancer Res (2013) 1.09

Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways. Mol Cancer Res (2012) 1.06

SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis. EMBO Mol Med (2013) 0.95

Tumour suppressor TRIM33 targets nuclear β-catenin degradation. Nat Commun (2015) 0.94

Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models. Front Pharmacol (2013) 0.93

An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis. Oncogene (2015) 0.93

A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation. PLoS One (2012) 0.93

Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Genes Dev (2014) 0.92

CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer Res (2014) 0.91

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1. Oncotarget (2015) 0.91

Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin. J Cell Sci (2012) 0.90

DNA damage induces the accumulation of Tiam1 by blocking β-TrCP-dependent degradation. J Biol Chem (2014) 0.90

Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers. Clin Cancer Res (2014) 0.89

The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity. PLoS One (2015) 0.88

Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis. Hepatology (2013) 0.88

Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1. Biochem Pharmacol (2012) 0.88

The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer. EMBO Mol Med (2014) 0.87

The role of the Wnt signaling pathway in incretin hormone production and function. Front Physiol (2012) 0.84

A PAK6-IQGAP1 complex promotes disassembly of cell-cell adhesions. Cell Mol Life Sci (2013) 0.84

Monitoring interactions and dynamics of endogenous beta-catenin with intracellular nanobodies in living cells. Mol Cell Proteomics (2015) 0.84

Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion. Adv Exp Med Biol (2015) 0.83

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish. Dis Model Mech (2013) 0.83

p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways. Am J Physiol Gastrointest Liver Physiol (2013) 0.81

Differential mRNA expression levels of human histone-modifying enzymes in normal karyotype B cell pediatric acute lymphoblastic leukemia. Int J Mol Sci (2013) 0.79

Merlin/NF2 Suppresses Pancreatic Tumor Growth and Metastasis by Attenuating the FOXM1-Mediated Wnt/β-Catenin Signaling. Cancer Res (2015) 0.79

Krüppel-like factor 5 incorporates into the β-catenin/TCF complex in response to LPA in colon cancer cells. Cell Signal (2015) 0.79

p21-activated kinase interacts with Wnt signaling to regulate tissue polarity and gene expression. Proc Natl Acad Sci U S A (2012) 0.78

Essential oil of Pinus koraiensis inhibits cell proliferation and migration via inhibition of p21-activated kinase 1 pathway in HCT116 colorectal cancer cells. BMC Complement Altern Med (2014) 0.78

New insight into the mechanisms underlying the function of the incretin hormone glucagon-like peptide-1 in pancreatic β-cells: the involvement of the Wnt signaling pathway effector β-catenin. Islets (2012) 0.78

Mutation of Vav1 adaptor region reveals a new oncogenic activation. Oncotarget (2015) 0.78

Structure, biochemistry, and biology of PAK kinases. Gene (2016) 0.77

VE-cadherin cleavage by ovarian cancer microparticles induces β-catenin phosphorylation in endothelial cells. Oncotarget (2016) 0.77

PAK1 confers chemoresistance and poor outcome in non-small cell lung cancer via β-catenin-mediated stemness. Sci Rep (2016) 0.76

Identification of Wnt Pathway Target Genes Regulating the Division and Differentiation of Larval Seam Cells and Vulval Precursor Cells in Caenorhabditis elegans. G3 (Bethesda) (2015) 0.76

PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta (2015) 0.76

RhoA GTPase interacts with beta-catenin signaling in clinorotated osteoblasts. J Bone Miner Metab (2013) 0.76

A Critical Role for β-Catenin in Modulating Levels of Insulin Secretion from β-Cells by Regulating Actin Cytoskeleton and Insulin Vesicle Localization. J Biol Chem (2016) 0.75

The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Cell Res (2016) 0.75

Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells. BMC Cancer (2016) 0.75

Overexpression of PAK-1 is an independent predictor of disease recurrence in colorectal carcinoma. Int J Clin Exp Pathol (2015) 0.75

Republished: tracing PAKs from GI inflammation to cancer. Postgrad Med J (2014) 0.75

Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation. Cell Death Differ (2016) 0.75

Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells. J Cancer (2016) 0.75

Synchronization by Daytime Restricted Food Access Modulates the Presence and Subcellular Distribution of β-Catenin and Its Phosphorylated Forms in the Rat Liver. Front Endocrinol (Lausanne) (2017) 0.75

Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells. Physiol Rep (2014) 0.75

Entamoeba histolytica RacC selectively engages p21-activated kinase effectors. Biochemistry (2015) 0.75

CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo. Oncotarget (2016) 0.75

Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signalling pathway effector Tcf7l2. Cell Death Dis (2017) 0.75

An anti-cancer WxxxE-containing azurin polypeptide inhibits Rac1-dependent STAT3 and ERK/GSK-3β signaling in breast cancer cells. Oncotarget (2017) 0.75

Articles by these authors

(truncated to the top 100)

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79

Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet (2005) 24.57

Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J (1982) 17.98

Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics. J Bacteriol (1997) 12.21

Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. Proc Natl Acad Sci U S A (1996) 11.80

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell (1998) 11.54

Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet (2011) 9.20

The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care (1999) 9.16

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res (1994) 9.00

Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med (2000) 8.47

Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet (2014) 8.04

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature (1998) 8.02

Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science (1997) 7.95

The frequency of chimeric molecules as a consequence of PCR co-amplification of 16S rRNA genes from different bacterial species. Microbiology (1996) 7.78

Genomics. Genome project standards in a new era of sequencing. Science (2009) 7.72

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature (2001) 7.44

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron (1996) 7.20

Frequency of formation of chimeric molecules as a consequence of PCR coamplification of 16S rRNA genes from mixed bacterial genomes. Appl Environ Microbiol (1997) 7.09

A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature (1996) 7.04

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science (1999) 6.93

TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. Biochem Biophys Res Commun (1999) 6.33

Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: outcomes at 66 months of age in the Seychelles Child Development Study. JAMA (1998) 6.30

Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet (1998) 6.04

Readmission after hospitalization for congestive heart failure among Medicare beneficiaries. Arch Intern Med (1997) 5.93

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol Cell Biol (1998) 5.66

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation. Proc Natl Acad Sci U S A (1992) 5.60

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem Biol (1997) 5.49

Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science (1992) 5.46

Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med (2001) 5.43

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res (1998) 5.41

High-resolution inkjet printing of all-polymer transistor circuits. Science (2000) 5.35

Genetic diversity and disease control in rice. Nature (2000) 5.34

Paralyzed flagella mutants of Chlamydomonas reinhardtii. Defective for axonemal doublet microtubule arms. J Biol Chem (1979) 5.32

A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function. Nat Cell Biol (2000) 5.29

Racial differences in the use of cardiac catheterization after acute myocardial infarction. N Engl J Med (2001) 5.29

Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex. Science (2000) 5.27

Flagellar mutants of Chlamydomonas: studies of radial spoke-defective strains by dikaryon and revertant analysis. Proc Natl Acad Sci U S A (1977) 4.91

Sociodemographic and psychopathologic predictors of first incidence of DSM-IV substance use, mood and anxiety disorders: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. Mol Psychiatry (2008) 4.70

Differential signaling via the same axon of neocortical pyramidal neurons. Proc Natl Acad Sci U S A (1998) 4.59

POWER_SAGE: comparing statistical tests for SAGE experiments. Bioinformatics (2000) 4.56

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci (2001) 4.54

Two-dimensional analysis of flagellar proteins from wild-type and paralyzed mutants of Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A (1977) 4.46

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A (1996) 4.45

Do "America's Best Hospitals" perform better for acute myocardial infarction? N Engl J Med (1999) 4.30

Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09

Broadly protective vaccine for Staphylococcus aureus based on an in vivo-expressed antigen. Science (1999) 4.08

Single-molecule fluorescence spectroscopy of enzyme conformational dynamics and cleavage mechanism. Proc Natl Acad Sci U S A (1999) 4.05

Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing. Proc Natl Acad Sci U S A (1994) 3.85

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A (1996) 3.78

Suppressor mutations in Chlamydomonas reveal a regulatory mechanism for Flagellar function. Cell (1982) 3.77

Temperature-sensitive mutations affecting flagellar assembly and function in Chlamydomonas reinhardtii. J Cell Biol (1977) 3.69

Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet (1997) 3.69

The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron (2001) 3.68

Signal timing across the macaque visual system. J Neurophysiol (1998) 3.66

Radial spokes of Chlamydomonas flagella: genetic analysis of assembly and function. J Cell Biol (1981) 3.61

The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells. Proc Natl Acad Sci U S A (1999) 3.53

Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. J Med Genet (2004) 3.45

The ica locus of Staphylococcus epidermidis encodes production of the capsular polysaccharide/adhesin. Infect Immun (1998) 3.44

Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell (1994) 3.41

Focal adhesion kinase is involved in mechanosensing during fibroblast migration. Proc Natl Acad Sci U S A (2001) 3.41

A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature (1999) 3.40

Midzone microtubule bundles are continuously required for cytokinesis in cultured epithelial cells. J Cell Biol (1996) 3.36

Criteria and recommendations for vitamin C intake. JAMA (1999) 3.32

Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet (2001) 3.27

Central-pair microtubular complex of Chlamydomonas flagella: polypeptide composition as revealed by analysis of mutants. J Cell Biol (1981) 3.23

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature (1996) 3.21

Male fertility potential in terms of semen quality: a review of the past, a study of the present. Fertil Steril (1979) 3.19

Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3. J Biol Chem (1987) 3.19

The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris. Circulation (1978) 3.19

Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite. Bone (2005) 3.13

Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids. Toxicol In Vitro (2014) 3.10

Renoprotective role of the vitamin D receptor in diabetic nephropathy. Kidney Int (2007) 3.06

Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proc Natl Acad Sci U S A (1998) 3.05

Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival. Leukemia (2008) 3.04

Radial spokes of Chlamydomonas flagella: polypeptide composition and phosphorylation of stalk components. J Cell Biol (1981) 3.00

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci (2000) 3.00

Changes in reliability of synaptic function as a mechanism for plasticity. Nature (1994) 2.97

Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques. Nat Med (1996) 2.96

Facilitation and depression at single central synapses. Neuron (1995) 2.95

Vam3p structure reveals conserved and divergent properties of syntaxins. Nat Struct Biol (2001) 2.92

Effectiveness of laser therapy and topical desensitising agents in treating dentine hypersensitivity: a systematic review. J Oral Rehabil (2011) 2.91

Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J Natl Cancer Inst Monogr (2010) 2.91

A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science (1997) 2.90

Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest (2001) 2.90

Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. J Biol Chem (2000) 2.89

Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J Control Release (2001) 2.84

Coronectomy vs. total removal for third molar extraction: a systematic review. J Dent Res (2012) 2.84

Management of heartburn in a large, randomized, community-based study: comparison of four therapeutic strategies. Am J Gastroenterol (2001) 2.77

Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells. J Cell Sci (2001) 2.76

Adolescents' perceptions of social status: development and evaluation of a new indicator. Pediatrics (2001) 2.76

Phytochelatin synthesis and glutathione levels in response to heavy metals in tomato cells. Plant Physiol (1987) 2.76

Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet (2001) 2.75

Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors. Nature (2000) 2.73

Distinct types of rRNA operons exist in the genome of the actinomycete Thermomonospora chromogena and evidence for horizontal transfer of an entire rRNA operon. J Bacteriol (1999) 2.72

Predictors of readmission among elderly survivors of admission with heart failure. Am Heart J (2000) 2.71

National use and effectiveness of beta-blockers for the treatment of elderly patients after acute myocardial infarction: National Cooperative Cardiovascular Project. JAMA (1998) 2.70

A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. Clin Cancer Res (1999) 2.69

Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J Exp Med (1998) 2.69

Feasibility of a high-speed gamma-camera design using the high-yield-pileup-event-recovery method. J Nucl Med (2001) 2.69

A high-affinity iron permease essential for Candida albicans virulence. Science (2000) 2.68