Published in J Biol Chem on July 09, 2015
P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate. PLoS One (2016) 0.77
Clinicopathological signature of p21-activated kinase 1 in prostate cancer and its regulation of proliferation and autophagy via the mTOR signaling pathway. Oncotarget (2017) 0.75
Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov (2005) 11.46
A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature (1994) 9.18
Biology of the p21-activated kinases. Annu Rev Biochem (2003) 7.63
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol (1999) 6.18
Inhibition of myosin light chain kinase by p21-activated kinase. Science (1999) 5.41
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol (1997) 4.91
p21-activated kinases in cancer. Nat Rev Cancer (2006) 4.24
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell (2000) 4.21
p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. J Cell Biol (1999) 2.84
The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1. J Biol Chem (1996) 2.45
Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. J Biol Chem (1999) 2.36
Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck. Curr Biol (1997) 2.24
Interaction of the Nck adapter protein with p21-activated kinase (PAK1). J Biol Chem (1996) 2.21
PAK signalling during the development and progression of cancer. Nat Rev Cancer (2014) 2.21
Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. EMBO J (1998) 2.18
Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol Cell (2001) 2.07
Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2. Biochim Biophys Acta (2007) 2.07
Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. J Biol Chem (1998) 2.06
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. Mol Cell (2002) 2.00
The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. J Biol Chem (2001) 1.96
Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells. Oncogene (2010) 1.91
Structure of Cdc42 bound to the GTPase binding domain of PAK. Nat Struct Biol (2000) 1.65
p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J Biol Chem (2000) 1.61
Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP. Mol Cell (2003) 1.53
Nuclear localization of protein kinase CK2 catalytic subunit (CK2alpha) is associated with poor prognostic factors in human prostate cancer. Eur J Cancer (2007) 1.38
p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate. EMBO Rep (2004) 1.34
PAK signaling in cancer. Cell Logist (2012) 1.27
Overexpression of nuclear protein kinase CK2 α catalytic subunit (CK2α) as a poor prognosticator in human colorectal cancer. PLoS One (2011) 1.26
Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1. J Biol Chem (2000) 1.25
The role of EZH2 in the regulation of the activity of matrix metalloproteinases in prostate cancer cells. PLoS One (2012) 1.25
p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling. J Biol Chem (2003) 1.22
Association of PI-3 kinase with PAK1 leads to actin phosphorylation and cytoskeletal reorganization. Mol Biol Cell (2002) 1.21
The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein. Mol Cell Biol (2005) 1.18
Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair. Cell Mol Life Sci (2009) 1.15
Protein kinase CK2 regulates cytoskeletal reorganization during ionizing radiation-induced senescence of human mesenchymal stem cells. Cancer Res (2009) 1.08
Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2. J Biol Chem (2000) 1.08
P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion. J Biol Chem (2012) 1.07
The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein. J Biol Chem (2006) 1.04
WAVE2 is regulated by multiple phosphorylation events within its VCA domain. Cell Motil Cytoskeleton (2009) 1.02
Phosphoinositides are essential coactivators for p21-activated kinase 1. Mol Cell (2010) 1.00
The Pleckstrin homology domain of CK2 interacting protein-1 is required for interactions and recruitment of protein kinase CK2 to the plasma membrane. J Biol Chem (2004) 0.98
Growth factor-stimulated phosphorylation of Akt and p70(S6K) is differentially inhibited by LY294002 and Wortmannin. Endocrinology (2001) 0.93
Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation. Mol Cell Biol (2004) 0.93
Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration. Sci Rep (2012) 0.92
Untangling the complexity of PAK1 dynamics: The future challenge. Cell Logist (2012) 0.85
Evidence for a novel mechanism of the PAK1 interaction with the Rho-GTPases Cdc42 and Rac. PLoS One (2013) 0.83
CKIP-1: a scaffold protein and potential therapeutic target integrating multiple signaling pathways and physiological functions. Ageing Res Rev (2012) 0.83
CKIP-1 regulates mammalian and zebrafish myoblast fusion. J Cell Sci (2012) 0.81
Integrated analysis of genomics and proteomics reveals that CKIP-1 is a novel macrophage migration regulator. Biochem Biophys Res Commun (2013) 0.79
Protein kinase CK2 phosphorylates and activates p21-activated kinase 1. Mol Biol Cell (2013) 0.78