Published in Nature on July 25, 2004
Mechanism and regulation of class switch recombination. Annu Rev Immunol (2008) 5.98
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity (2008) 4.59
A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res (2006) 4.49
The AID/APOBEC family of nucleic acid mutators. Genome Biol (2008) 3.25
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell (2010) 2.92
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol (2010) 2.80
Antiviral protein APOBEC3G localizes to ribonucleoprotein complexes found in P bodies and stress granules. J Virol (2006) 2.50
ATM is required for efficient recombination between immunoglobulin switch regions. J Exp Med (2004) 2.30
PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. Proc Natl Acad Sci U S A (2005) 2.13
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse. J Exp Med (2005) 2.13
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (2011) 1.95
Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc Natl Acad Sci U S A (2006) 1.95
The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice. J Exp Med (2006) 1.92
Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation. J Exp Med (2005) 1.85
MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes. J Exp Med (2005) 1.80
Immunoglobulin class-switch DNA recombination: induction, targeting and beyond. Nat Rev Immunol (2012) 1.80
Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med (2008) 1.78
AID and somatic hypermutation. Adv Immunol (2010) 1.74
Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination. Nat Immunol (2009) 1.69
A coming-of-age story: activation-induced cytidine deaminase turns 10. Nat Immunol (2009) 1.68
tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma. Proc Natl Acad Sci U S A (2013) 1.66
Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination. Nat Immunol (2010) 1.62
Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA. DNA Repair (Amst) (2007) 1.57
RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle. Cell Rep (2013) 1.53
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A (2009) 1.50
Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination. PLoS One (2013) 1.46
Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation. J Exp Med (2007) 1.46
Nibrin functions in Ig class-switch recombination. Proc Natl Acad Sci U S A (2005) 1.41
14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination. Nat Struct Mol Biol (2010) 1.41
Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination. Proc Natl Acad Sci U S A (2005) 1.40
Complex regulation and function of activation-induced cytidine deaminase. Trends Immunol (2011) 1.36
Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex. Proc Natl Acad Sci U S A (2007) 1.34
Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells. Proc Natl Acad Sci U S A (2005) 1.34
The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability. DNA Repair (Amst) (2014) 1.33
Fine-structure analysis of activation-induced deaminase accessibility to class switch region R-loops. Mol Cell Biol (2005) 1.32
AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity. Nat Struct Mol Biol (2009) 1.31
The elongation factor RfaH and the initiation factor sigma bind to the same site on the transcription elongation complex. Proc Natl Acad Sci U S A (2008) 1.29
AID-dependent histone acetylation is detected in immunoglobulin S regions. J Exp Med (2006) 1.26
Structural mechanism of RPA loading on DNA during activation of a simple pre-replication complex. EMBO J (2006) 1.25
Regulation of AID, the B-cell genome mutator. Genes Dev (2013) 1.21
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil. J Exp Med (2005) 1.21
The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA. Nat Immunol (2010) 1.20
Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions. Proc Natl Acad Sci U S A (2008) 1.20
Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination. Crit Rev Immunol (2007) 1.19
T cells contain an RNase-insensitive inhibitor of APOBEC3G deaminase activity. PLoS Pathog (2007) 1.19
Sub1 and RPA associate with RNA polymerase II at different stages of transcription. Mol Cell (2011) 1.18
Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA. Mol Cell Biol (2005) 1.18
DNA repair in antibody somatic hypermutation. Trends Immunol (2006) 1.17
Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase. J Biol Chem (2008) 1.16
The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination. Mol Cell Biol (2006) 1.15
The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription. J Exp Med (2009) 1.12
Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair. Adv Immunol (2014) 1.11
Regulation of Aicda expression and AID activity. Autoimmunity (2013) 1.11
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response. Cell Res (2014) 1.10
Influence of switch region length on immunoglobulin class switch recombination. Proc Natl Acad Sci U S A (2005) 1.10
AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner. Mol Cell Biol (2006) 1.09
Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB. J Exp Med (2007) 1.06
The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions. J Exp Med (2005) 1.06
AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected]. J Immunol (2011) 1.06
V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment. Proc Natl Acad Sci U S A (2009) 1.05
Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase. Mol Cell (2008) 1.05
Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation. J Exp Med (2006) 1.03
GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA. J Biol Chem (2010) 1.02
AID targeting is dependent on RNA polymerase II pausing. Semin Immunol (2012) 1.01
Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID. Mol Cell Biol (2007) 1.01
NusG-Spt5 proteins-Universal tools for transcription modification and communication. Chem Rev (2013) 1.01
A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination. Nat Immunol (2013) 1.01
Deaminase activity on single-stranded DNA (ssDNA) occurs in vitro when APOBEC3G cytidine deaminase forms homotetramers and higher-order complexes. J Biol Chem (2011) 1.00
Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase. J Exp Med (2012) 1.00
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation. Proc Natl Acad Sci U S A (2011) 0.99
Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein. J Biol Chem (2011) 0.98
Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes. Immunology (2009) 0.98
AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID. Mol Immunol (2008) 0.96
Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions. Proc Natl Acad Sci U S A (2010) 0.96
Stochastic properties of processive cytidine DNA deaminases AID and APOBEC3G. Philos Trans R Soc Lond B Biol Sci (2009) 0.95
Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus. Proc Natl Acad Sci U S A (2008) 0.93
53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma. Mol Cell (2013) 0.93
AID and Apobec3G haphazard deamination and mutational diversity. Cell Mol Life Sci (2012) 0.93
Biochemical basis of immunological and retroviral responses to DNA-targeted cytosine deamination by activation-induced cytidine deaminase and APOBEC3G. J Biol Chem (2009) 0.93
Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA. PLoS One (2011) 0.93
Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias. Mol Immunol (2007) 0.93
Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation. Mol Cell Biol (2010) 0.92
Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions. Proc Natl Acad Sci U S A (2008) 0.91
APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication. Cell Rep (2016) 0.90
Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination. Microbiol Spectr (2015) 0.90
Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase. Proc Natl Acad Sci U S A (2012) 0.90
AID/APOBEC deaminases and cancer. Oncoscience (2015) 0.89
Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications. Semin Immunol (2012) 0.89
Metabolic regulation of apoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factor. Nucleic Acids Res (2006) 0.89
Hypermutation at A/T sites during G.U mismatch repair in vitro by human B-cell lysates. J Biol Chem (2008) 0.88
Identification of core DNA elements that target somatic hypermutation. J Immunol (2012) 0.88
Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes. BMC Immunol (2005) 0.87
Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching. J Exp Med (2008) 0.86
GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy. Nat Commun (2013) 0.86
Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers. Immune Netw (2012) 0.85
AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination. Front Immunol (2014) 0.85
Sense transcription through the S region is essential for immunoglobulin class switch recombination. EMBO J (2011) 0.84
MicroRNAs miR-155 and miR-16 Decrease AID and E47 in B Cells from Elderly Individuals. J Immunol (2015) 0.84
The mechanisms regulating the subcellular localization of AID. Nucleus (2010) 0.84
Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion. Mol Immunol (2007) 0.83
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
The mechanism and regulation of chromosomal V(D)J recombination. Cell (2002) 6.28
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
DNA repair, genome stability, and aging. Cell (2005) 5.52
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell (2003) 5.26
Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature (2003) 5.20
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol (2006) 4.32
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol (2004) 4.14
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol (2004) 4.04
Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell (2012) 4.02
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell (2011) 3.81
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 3.46
SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol (2011) 3.21
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab (2005) 3.15
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12
Activating Notch1 mutations in mouse models of T-ALL. Blood (2005) 3.08
Mechanism and control of class-switch recombination. Trends Immunol (2002) 2.95
Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol (2007) 2.94
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature (2003) 2.92
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell (2007) 2.88
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol (2008) 2.85
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74
Calorie restriction alters mitochondrial protein acetylation. Aging Cell (2009) 2.73
The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst) (2004) 2.72
The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev (2003) 2.72
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature (2005) 2.63
CTCF-binding elements mediate control of V(D)J recombination. Nature (2011) 2.62
Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol Cell (2002) 2.49
Antibody class switching mediated by yeast endonuclease-generated DNA breaks. Science (2006) 2.49
The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev (2004) 2.44
Control of sister chromatid recombination by histone H2AX. Mol Cell (2004) 2.43
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol (2004) 2.38
The influence of transcriptional orientation on endogenous switch region function. Nat Immunol (2003) 2.38
Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. J Exp Med (2003) 2.36
Mechanisms promoting translocations in editing and switching peripheral B cells. Nature (2009) 2.27
Unraveling V(D)J recombination; insights into gene regulation. Cell (2004) 2.25
Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Adv Immunol (2005) 2.19
Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer. Proc Natl Acad Sci U S A (2006) 2.17
H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity. Cell Cycle (2004) 2.16
Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med (2003) 2.15
S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity (2007) 2.11
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. J Exp Med (2008) 2.10
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell (2003) 2.08
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell (2013) 2.05
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J (2003) 1.98
Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med (2003) 1.98
An evolutionarily conserved target motif for immunoglobulin class-switch recombination. Nat Immunol (2004) 1.98
Microbial colonization influences early B-lineage development in the gut lamina propria. Nature (2013) 1.96
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (2011) 1.95
Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell (2008) 1.91
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell (2009) 1.86
p63 and p73 are not required for the development and p53-dependent apoptosis of T cells. Cancer Cell (2004) 1.86
Elucidation of IgH intronic enhancer functions via germ-line deletion. Proc Natl Acad Sci U S A (2005) 1.85
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med (2010) 1.85
IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity (2002) 1.85
Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Genes Dev (2004) 1.84
Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A (2010) 1.84
Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv Immunol (2012) 1.83
Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol (2004) 1.79
Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes Dev (2004) 1.77
The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol (2010) 1.77
Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF. Mol Cell Biol (2004) 1.76
Mechanisms that promote and suppress chromosomal translocations in lymphocytes. Annu Rev Immunol (2011) 1.75
A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity (2002) 1.74
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat Med (2009) 1.70
Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus. Adv Immunol (2008) 1.70
Proapoptotic BID is required for myeloid homeostasis and tumor suppression. Genes Dev (2003) 1.70
Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proc Natl Acad Sci U S A (2007) 1.69
Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nat Immunol (2007) 1.68
ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature (2010) 1.64
Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation. Nat Immunol (2002) 1.63
Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations. Blood (2007) 1.61
WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo. J Leukoc Biol (2005) 1.59
Innate immune response to encephalomyocarditis virus infection mediated by CD1d. Immunology (2003) 1.57
Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire. Immunity (2013) 1.56
Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proc Natl Acad Sci U S A (2004) 1.53
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A (2009) 1.50
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A (2010) 1.49
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice. Proc Natl Acad Sci U S A (2003) 1.49
Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. J Exp Med (2008) 1.47
Hypomorphic Rag mutations can cause destructive midline granulomatous disease. Blood (2010) 1.47
The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood (2011) 1.45
DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med (2008) 1.44