Published in Science on February 21, 2003
Pharmacogenetic Morphine Spine Study | NCT01839461
Patient Controlled Analgesia Pharmacogenetic Study | NCT01731873
Comprehensive Study of Post-surgical Pain After Pectus or Spine Surgery | NCT04031716
Placebo effects on human mu-opioid activity during pain. Proc Natl Acad Sci U S A (2007) 3.33
Biological processes in prevention and intervention: the promotion of self-regulation as a means of preventing school failure. Dev Psychopathol (2008) 2.93
Genetic variation in human NPY expression affects stress response and emotion. Nature (2008) 2.65
Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders. J Clin Invest (2007) 2.58
Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome. JAMA (2013) 2.34
Variation in dopamine genes influences responsivity of the human reward system. Proc Natl Acad Sci U S A (2008) 2.13
Frontiers in pruritus research: scratching the brain for more effective itch therapy. J Clin Invest (2006) 1.90
Pharmacogenetic approaches to the treatment of alcohol addiction. Nat Rev Neurosci (2011) 1.74
Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia. Arthritis Res Ther (2007) 1.73
Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain (2006) 1.72
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Genetic predictors for acute experimental cold and heat pain sensitivity in humans. J Med Genet (2006) 1.62
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Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain (2006) 1.57
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Preclinical and early clinical investigations related to monoaminergic pain modulation. Neurotherapeutics (2009) 1.26
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Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women. Pain (2008) 1.22
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Differential methylation of the TRPA1 promoter in pain sensitivity. Nat Commun (2014) 1.19
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Genetic approaches to functional gastrointestinal disorders. Gastroenterology (2010) 1.18
Variations in catechol-O-methyltransferase gene interact with parenting to influence attention in early development. Neuroscience (2009) 1.16
Consequences of variations in genes that affect dopamine in prefrontal cortex. Cereb Cortex (2007) 1.16
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Fibromyalgia syndrome: etiology, pathogenesis, diagnosis, and treatment. Pain Res Treat (2012) 1.15
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Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism. PLoS One (2009) 1.12
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Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice. Genes Brain Behav (2010) 1.09
Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase. Cell Mol Neurobiol (2006) 1.09
Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction. Pain (2012) 1.09
CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques. Arch Gen Psychiatry (2008) 1.09
Personality trait predictors of placebo analgesia and neurobiological correlates. Neuropsychopharmacology (2012) 1.09
Catechol O-methyltransferase haplotype predicts immediate musculoskeletal neck pain and psychological symptoms after motor vehicle collision. J Pain (2010) 1.08
A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia. Behav Brain Res (2008) 1.07
The impact of placebo, psychopathology, and expectations on the response to acupuncture needling in patients with chronic low back pain. J Pain (2010) 1.07
Genetic contributions to clinical pain and analgesia: avoiding pitfalls in genetic research. J Pain (2009) 1.07
The comorbidity of insomnia, chronic pain, and depression: dopamine as a putative mechanism. Sleep Med Rev (2012) 1.07
Biopsychosocial influence on exercise-induced delayed onset muscle soreness at the shoulder: pain catastrophizing and catechol-o-methyltransferase (COMT) diplotype predict pain ratings. Clin J Pain (2008) 1.06
Central pain mechanisms in the rheumatic diseases: future directions. Arthritis Rheum (2013) 1.06
Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures. PLoS One (2011) 1.06
Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions. Expert Rev Neurother (2012) 1.05
Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children. Am J Psychiatry (2009) 1.05
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Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome. Arthritis Res Ther (2006) 1.04
Normal genetic variation, cognition, and aging. Behav Cogn Neurosci Rev (2003) 1.04
Influence of sympathetic nervous system on sensorimotor function: whiplash associated disorders (WAD) as a model. Eur J Appl Physiol (2006) 1.03
Opioid neuropeptide genotypes in relation to heroin abuse: dopamine tone contributes to reversed mesolimbic proenkephalin expression. Proc Natl Acad Sci U S A (2008) 1.03
The establishment of the GENEQOL consortium to investigate the genetic disposition of patient-reported quality-of-life outcomes. Twin Res Hum Genet (2009) 1.03
Genome-wide association study of acute post-surgical pain in humans. Pharmacogenomics (2009) 1.03
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COMT moderates the relation of daily maladaptive coping and pain in fibromyalgia. Pain (2010) 1.02
Pain modality- and sex-specific effects of COMT genetic functional variants. Pain (2013) 1.02
Co-occurrence of musculoskeletal pain among female kitchen workers. Int Arch Occup Environ Health (2006) 1.01
Orthodontic Treatment, Genetic Factors and Risk of Temporomandibular Disorder. Semin Orthod (2008) 1.01
Positron emission tomography measures of endogenous opioid neurotransmission and impulsiveness traits in humans. Arch Gen Psychiatry (2009) 1.00
A clinical genetic method to identify mechanisms by which pain causes depression and anxiety. Mol Pain (2006) 0.99
Influence of catechol-O-methyltransferase (COMT) gene polymorphisms in pain sensibility of Brazilian fibromialgia patients. Rheumatol Int (2010) 0.98
No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study. BMC Musculoskelet Disord (2006) 0.98
Genetically determined dopamine availability predicts disposition for depression. Brain Behav (2011) 0.98
The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli. PLoS One (2011) 0.97
Genetic influences on the dynamics of pain and affect in fibromyalgia. Health Psychol (2010) 0.97
Genetics of emotion. Trends Cogn Sci (2011) 0.97
Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophrenia. J Abnorm Psychol (2008) 0.97
Genetic contributions to pain: a review of findings in humans. Oral Dis (2008) 0.96
Transcriptional profiling of C57 and DBA strains of mice in the absence and presence of morphine. BMC Genomics (2007) 0.95
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[Predictors of chronic pain following surgery. What do we know?]. Schmerz (2010) 0.94
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Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assay. Psychopharmacology (Berl) (2004) 0.94
Genes and epigenetic processes as prospective pain targets. Genome Med (2013) 0.93
Epigenetics and the transition from acute to chronic pain. Pain Med (2012) 0.93
Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med (2013) 24.88
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell (2003) 12.50
Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab (2007) 11.79
Serotonin transporter genetic variation and the response of the human amygdala. Science (2002) 9.31
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet (2006) 6.27
Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet (2004) 5.87
Trends in access to health services and financial protection in China between 2003 and 2011: a cross-sectional study. Lancet (2012) 4.98
An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry (2008) 4.91
Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation. BMJ (2013) 4.17
Placebo effects mediated by endogenous opioid activity on mu-opioid receptors. J Neurosci (2005) 4.00
Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI. Neurobiol Aging (2009) 3.97
An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res (2005) 3.94
A family cluster of infections by a newly recognized bunyavirus in eastern China, 2007: further evidence of person-to-person transmission. Clin Infect Dis (2011) 3.91
Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study. Lancet (2013) 3.74
Gait speed in Parkinson disease correlates with cholinergic degeneration. Neurology (2013) 3.56
Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses. Arch Gen Psychiatry (2008) 3.47
Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry (2006) 3.44
Neurobiological mechanisms of the placebo effect. J Neurosci (2005) 3.41
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med (2006) 3.38
Coping with out-of-pocket health payments: empirical evidence from 15 African countries. Bull World Health Organ (2008) 3.33
The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core. Alzheimers Dement (2010) 3.30
Addictions biology: haplotype-based analysis for 130 candidate genes on a single array. Alcohol Alcohol (2008) 3.13
To retain or remove user fees?: reflections on the current debate in low- and middle-income countries. Appl Health Econ Health Policy (2006) 3.06
Validation of a polysomnographic score for REM sleep behavior disorder. Sleep (2005) 3.02
Individual differences in reward responding explain placebo-induced expectations and effects. Neuron (2007) 2.96
FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease. Brain (2007) 2.96
Amyloid deposition, hypometabolism, and longitudinal cognitive decline. Ann Neurol (2012) 2.84
Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry (2003) 2.82
Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Neuroimage (2009) 2.80
Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain (2006) 2.75
Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet (2004) 2.71
Genetic variation in human NPY expression affects stress response and emotion. Nature (2008) 2.65
A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet (2002) 2.60
Preventing impoverishment through protection against catastrophic health expenditure. Bull World Health Organ (2002) 2.56
A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry (2002) 2.51
Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biol Psychiatry (2004) 2.49
A 160-kilobit molecular electronic memory patterned at 10(11) bits per square centimetre. Nature (2007) 2.48
Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain (2010) 2.41
Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson's disease. Brain (2010) 2.37
Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry (2006) 2.31
Universal coverage of health services: tailoring its implementation. Bull World Health Organ (2008) 2.30
The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med (2009) 2.20
The financial burden from non-communicable diseases in low- and middle-income countries: a literature review. Health Res Policy Syst (2013) 2.20
Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain (2004) 2.17
Positron emission tomography of monoaminergic vesicular binding in aging and Parkinson disease. J Cereb Blood Flow Metab (2006) 2.16
Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations. Arch Gen Psychiatry (2004) 2.12
Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry (2006) 2.09
Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci (2005) 2.04
MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2. Cell Res (2010) 2.04
A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature (2010) 2.00
Using ancestry-informative markers to define populations and detect population stratification. J Psychopharmacol (2006) 1.98
Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates. Arch Gen Psychiatry (2004) 1.98
Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study. Arch Neurol (2003) 1.94
Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission. Arch Gen Psychiatry (2003) 1.89
Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biol (2009) 1.81
Clinical outcomes after transcatheter aortic valve replacement using valve academic research consortium definitions: a weighted meta-analysis of 3,519 patients from 16 studies. J Am Coll Cardiol (2012) 1.80
Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function. Biol Psychiatry (2008) 1.79
Variations in the human pain stress experience mediated by ventral and dorsal basal ganglia dopamine activity. J Neurosci (2006) 1.79
Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample size. Anesthesiology (2004) 1.78
mu-opioid receptor-mediated antinociceptive responses differ in men and women. J Neurosci (2002) 1.77
Reduced brainstem inhibition during anticipated pelvic visceral pain correlates with enhanced brain response to the visceral stimulus in women with irritable bowel syndrome. J Neurosci (2008) 1.77
Regional gray matter density changes in brains of patients with irritable bowel syndrome. Gastroenterology (2010) 1.75
New caged coumarin fluorophores with extraordinary uncaging cross sections suitable for biological imaging applications. J Am Chem Soc (2004) 1.74
Pharmacogenetic approaches to the treatment of alcohol addiction. Nat Rev Neurosci (2011) 1.74
Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease. Neuroimage (2008) 1.74
BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. Neuropsychopharmacology (2005) 1.74
Reducing between scanner differences in multi-center PET studies. Neuroimage (2009) 1.73
Down-regulation of miR-141 in gastric cancer and its involvement in cell growth. J Gastroenterol (2009) 1.73
Impact of in-hospital major bleeding on late clinical outcomes after primary percutaneous coronary intervention in acute myocardial infarction the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) trial. J Am Coll Cardiol (2011) 1.72
Neurobiological mechanisms of placebo responses. Ann N Y Acad Sci (2009) 1.72
Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proc Natl Acad Sci U S A (2004) 1.71
Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohort. Am J Psychiatry (2009) 1.70
Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. Am J Psychiatry (2002) 1.70
Genetic approaches to addiction: genes and alcohol. Addiction (2008) 1.70
A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction. Proc Natl Acad Sci U S A (2010) 1.70
3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects. Neurobiol Aging (2010) 1.70
β-Amyloid and postural instability and gait difficulty in Parkinson's disease at risk for dementia. Mov Disord (2012) 1.69
Influenza-associated mortality in temperate and subtropical Chinese cities, 2003-2008. Bull World Health Organ (2012) 1.69
Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide. Neuropsychopharmacology (2010) 1.68