Signal transduction and signaling networks.

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol (2013) 1.73

Oscillations and variability in the p53 system. Mol Syst Biol (2006) 4.59

Cell growth and size homeostasis in proliferating animal cells. Science (2009) 3.89

p53 dynamics control cell fate. Science (2012) 3.30

Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96

Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat Methods (2006) 2.94

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell (2008) 2.70

Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell (2010) 2.40

The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer (2009) 2.13

Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol (2011) 2.02

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell (2010) 1.95

Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase. Mol Cell (2012) 1.91

High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis. Cell Stem Cell (2013) 1.86

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol Biol Cell (2011) 1.53

Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature (2013) 1.50

Distinct mechanisms act in concert to mediate cell cycle arrest. Proc Natl Acad Sci U S A (2009) 1.37

Fourier analysis and systems identification of the p53 feedback loop. Proc Natl Acad Sci U S A (2010) 1.19

We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells. Curr Opin Genet Dev (2011) 1.18

Activation and control of p53 tetramerization in individual living cells. Proc Natl Acad Sci U S A (2013) 1.12

The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold. BMC Biol (2013) 1.02

A synthetic-natural hybrid oscillator in human cells. Proc Natl Acad Sci U S A (2010) 0.92

Decoding the insulin signal. Mol Cell (2012) 0.82

Dynamics of the DNA damage response: insights from live-cell imaging. Brief Funct Genomics (2013) 0.82

Cellular conference call: external feedback affects cell-fate decisions. Cell (2006) 0.79

Suppressing variation in synthetic circuits. Mol Syst Biol (2011) 0.76