Published in Mol Cell on May 09, 2008
p53 dynamics control cell fate. Science (2012) 3.30
Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96
Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription. Nat Cell Biol (2009) 2.46
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell (2010) 2.40
Cancer systems biology: a network modeling perspective. Carcinogenesis (2009) 2.22
The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends Genet (2012) 2.13
The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer (2009) 2.13
Functional motifs in biochemical reaction networks. Annu Rev Phys Chem (2010) 2.04
Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol (2011) 2.02
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell (2010) 1.95
Functional roles of pulsing in genetic circuits. Science (2013) 1.84
Two-phase dynamics of p53 in the DNA damage response. Proc Natl Acad Sci U S A (2011) 1.65
New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy. J Biomed Biotechnol (2012) 1.57
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol Biol Cell (2011) 1.53
Cell fate decision mediated by p53 pulses. Proc Natl Acad Sci U S A (2009) 1.53
Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells. Nat Rev Cancer (2011) 1.51
Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner. Blood (2015) 1.46
Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53. EMBO J (2011) 1.42
A novel mathematical model of ATM/p53/NF- κB pathways points to the importance of the DDR switch-off mechanisms. BMC Syst Biol (2016) 1.41
Distinct mechanisms act in concert to mediate cell cycle arrest. Proc Natl Acad Sci U S A (2009) 1.37
Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Mol Cell (2011) 1.27
USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. EMBO J (2011) 1.26
Regulation of the Wip1 phosphatase and its effects on the stress response. Front Biosci (Landmark Ed) (2012) 1.24
Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4. Proc Natl Acad Sci U S A (2012) 1.23
Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression. EMBO J (2009) 1.22
Fourier analysis and systems identification of the p53 feedback loop. Proc Natl Acad Sci U S A (2010) 1.19
We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells. Curr Opin Genet Dev (2011) 1.18
Programming biological models in Python using PySB. Mol Syst Biol (2013) 1.15
Activation and control of p53 tetramerization in individual living cells. Proc Natl Acad Sci U S A (2013) 1.12
Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways. PLoS One (2011) 1.09
Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response. Cancer Res (2009) 1.07
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control. BMC Biol (2013) 1.06
Computational modeling of mammalian signaling networks. Wiley Interdiscip Rev Syst Biol Med (2010) 1.04
Ionizing radiation-induced responses in human cells with differing TP53 status. Int J Mol Sci (2013) 1.04
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold. BMC Biol (2013) 1.02
Stress-specific response of the p53-Mdm2 feedback loop. BMC Syst Biol (2010) 0.99
HIF-2α suppresses p53 to enhance the stemness and regenerative potential of human embryonic stem cells. Stem Cells (2012) 0.99
Phosphatases in the cellular response to DNA damage. Cell Commun Signal (2010) 0.97
Measurement and modeling of signaling at the single-cell level. Biochemistry (2012) 0.96
Can case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?". ALTEX (2011) 0.95
Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway. PLoS One (2011) 0.95
Coordination between cell cycle progression and cell fate decision by the p53 and E2F1 pathways in response to DNA damage. J Biol Chem (2010) 0.95
Adjusting phenotypes by noise control. PLoS Comput Biol (2012) 0.94
The versatile functions of ATM kinase. Biomed J (2014) 0.94
TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity. Genome Res (2014) 0.93
A synthetic-natural hybrid oscillator in human cells. Proc Natl Acad Sci U S A (2010) 0.92
Identification of novel targets for breast cancer by exploring gene switches on a genome scale. BMC Genomics (2011) 0.92
Complex dynamics of transcription regulation. Biochim Biophys Acta (2012) 0.92
Mechanisms that enhance sustainability of p53 pulses. PLoS One (2013) 0.91
Dual delayed feedback provides sensitivity and robustness to the NF-κB signaling module. PLoS Comput Biol (2013) 0.90
Spontaneous γH2AX Foci in Human Solid Tumor-Derived Cell Lines in Relation to p21WAF1 and WIP1 Expression. Int J Mol Sci (2015) 0.89
A mathematical model for the detection mechanism of DNA double-strand breaks depending on autophosphorylation of ATM. PLoS One (2009) 0.88
A two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities. PLoS One (2012) 0.88
Modeling the role of p53 pulses in DNA damage- induced cell death decision. BMC Bioinformatics (2009) 0.88
Minichromosome maintenance 2 bound with retroviral Gp70 is localized to cytoplasm and enhances DNA-damage-induced apoptosis. PLoS One (2012) 0.86
Schedule-dependent interaction between anticancer treatments. Science (2016) 0.85
Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation. J Biol Chem (2010) 0.85
Decision making of the p53 network: death by integration. J Theor Biol (2010) 0.85
Wip1 suppresses apoptotic cell death through direct dephosphorylation of BAX in response to γ-radiation. Cell Death Dis (2013) 0.84
Down-regulation of wild-type p53-induced phosphatase 1 (Wip1) plays a critical role in regulating several p53-dependent functions in premature senescent tumor cells. J Biol Chem (2013) 0.84
Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol. Mol Biol Rep (2013) 0.84
Modeling the basal dynamics of p53 system. PLoS One (2011) 0.83
Predicted functions of MdmX in fine-tuning the response of p53 to DNA damage. PLoS Comput Biol (2010) 0.83
Sources of dynamic variability in NF-κB signal transduction: a mechanistic model. Bioessays (2015) 0.83
Nested autoinhibitory feedbacks alter the resistance of homeostatic adaptive biochemical networks. J R Soc Interface (2013) 0.82
Tension and robustness in multitasking cellular networks. PLoS Comput Biol (2012) 0.82
p53 Pulses Diversify Target Gene Expression Dynamics in an mRNA Half-Life-Dependent Manner and Delineate Co-regulated Target Gene Subnetworks. Cell Syst (2016) 0.82
Regulation of the DNA damage response by p53 cofactors. Biophys J (2012) 0.81
A novel p53 phosphorylation site within the MDM2 ubiquitination signal: I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function. J Biol Chem (2010) 0.81
Redefining Signaling Pathways with an Expanding Single-Cell Toolbox. Trends Biotechnol (2016) 0.80
Rbf1 degron dysfunction enhances cellular DNA replication. Cell Cycle (2012) 0.80
Stochastic and Deterministic Models of Cellular p53 Regulation. Front Oncol (2013) 0.80
Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2. Proc Natl Acad Sci U S A (2016) 0.80
Correlation between oncogenic mutations and parameter sensitivity of the apoptosis pathway model. PLoS Comput Biol (2014) 0.79
The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation. PLoS One (2013) 0.79
A protein turnover signaling motif controls the stimulus-sensitivity of stress response pathways. PLoS Comput Biol (2013) 0.79
Constant rate of p53 tetramerization in response to DNA damage controls the p53 response. Mol Syst Biol (2014) 0.79
MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells. PLoS Comput Biol (2015) 0.79
An acetyl-methyl switch drives a conformational change in p53. Structure (2015) 0.78
Stochasticity of intranuclear biochemical reaction processes controls the final decision of cell fate associated with DNA damage. PLoS One (2014) 0.78
A suppressive role of ionizing radiation-responsive miR-29c in the development of liver carcinoma via targeting WIP1. Oncotarget (2015) 0.78
Chemical memory reactions induced bursting dynamics in gene expression. PLoS One (2013) 0.78
Dynamics of posttranslational modifications of p53. Comput Math Methods Med (2014) 0.78
Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage. Mol Biol Cell (2016) 0.78
Computational analysis of signaling patterns in single cells. Semin Cell Dev Biol (2014) 0.78
Census and evaluation of p53 target genes. Oncogene (2017) 0.77
Design principles for robust oscillatory behavior. Syst Synth Biol (2015) 0.77
Involvement of miR-605 and miR-34a in the DNA damage response promotes apoptosis induction. Biophys J (2014) 0.77
Significance of p53 dynamics in regulating apoptosis in response to ionizing radiation, and polypharmacological strategies. Sci Rep (2014) 0.77
Transcriptional regulation underlying recovery from a DNA damage-induced arrest. Transcription (2012) 0.77
Noise amplification in human tumor suppression following gamma irradiation. PLoS One (2011) 0.76
New insights into the link between DNA damage and apoptosis. Antioxid Redox Signal (2012) 0.76
Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability. Cell Stem Cell (2015) 0.76
On the limitations of biological knowledge. Curr Genomics (2012) 0.76
Image-predicated sorting of adherent cells using photopatterned hydrogels. Adv Healthc Mater (2012) 0.75
Studying Cellular Signal Transduction with OMIC Technologies. J Mol Biol (2015) 0.75
Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System. PLoS Comput Biol (2016) 0.75
State feedback control design for Boolean networks. BMC Syst Biol (2016) 0.75
p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression. Oncotarget (2016) 0.75
Influence of parameter values on the oscillation sensitivities of two p53-Mdm2 models. Syst Synth Biol (2015) 0.75
A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol (1952) 160.83
Mdm2 promotes the rapid degradation of p53. Nature (1997) 21.26
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13
Regulation of p53 stability by Mdm2. Nature (1997) 18.20
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (1998) 11.90
The p53-mdm-2 autoregulatory feedback loop. Genes Dev (1993) 11.19
Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89
The p53 pathway: positive and negative feedback loops. Oncogene (2005) 9.75
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Curr Opin Cell Biol (2003) 8.91
Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet (2004) 8.30
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol (2005) 8.27
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell (2004) 8.18
mdm2 expression is induced by wild type p53 activity. EMBO J (1993) 8.01
An excitable gene regulatory circuit induces transient cellular differentiation. Nature (2006) 6.03
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci U S A (2000) 5.64
Oscillations and variability in the p53 system. Mol Syst Biol (2006) 4.59
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res (1998) 4.52
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol (2007) 4.14
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev (2001) 4.06
Oscillatory behavior in enzymatic control processes. Adv Enzyme Regul (1965) 3.77
Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci U S A (2000) 3.74
Oscillatory expression of Hes1, p53, and NF-kappaB driven by transcriptional time delays. Curr Biol (2003) 3.54
MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner. Cancer Res (2006) 3.26
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc Natl Acad Sci U S A (1997) 3.19
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci U S A (1999) 3.13
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J (2004) 3.10
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res (2000) 3.06
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.87
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev (2005) 2.85
Modeling the cell division cycle: cdc2 and cyclin interactions. Proc Natl Acad Sci U S A (1991) 2.80
Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem (2006) 2.76
Steady states and oscillations in the p53/Mdm2 network. Cell Cycle (2005) 2.45
Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell (2006) 2.39
A plausible model for the digital response of p53 to DNA damage. Proc Natl Acad Sci U S A (2005) 2.32
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell (2007) 2.32
ATM regulates ATR chromatin loading in response to DNA double-strand breaks. J Exp Med (2006) 2.31
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. EMBO J (2004) 2.19
Small-molecule antagonists of p53-MDM2 binding: research tools and potential therapeutics. Cell Cycle (2004) 2.15
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase. Cell Death Differ (2005) 1.98
Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex. Oncogene (2006) 1.93
A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells. Cancer Res (2007) 1.67
Exploring mechanisms of the DNA-damage response: p53 pulses and their possible relevance to apoptosis. Cell Cycle (2007) 1.37
Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imaging. Cancer Res (2006) 1.34
The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase. Oncogene (2006) 1.34
p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback. Syst Biol (Stevenage) (2005) 1.15
The strength of indecisiveness: oscillatory behavior for better cell fate determination. Sci STKE (2004) 1.12
Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells. J Biol Chem (1999) 1.12
p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A. Mol Cell Biol (1996) 1.08
The negative role of cyclin G in ATM-dependent p53 activation. Oncogene (2004) 1.03
Circular RNAs are a large class of animal RNAs with regulatory potency. Nature (2013) 8.54
Oscillations and variability in the p53 system. Mol Syst Biol (2006) 4.59
Cell growth and size homeostasis in proliferating animal cells. Science (2009) 3.89
p53 dynamics control cell fate. Science (2012) 3.30
Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat Methods (2006) 2.94
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell (2010) 2.40
The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer (2009) 2.13
Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol (2011) 2.02
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell (2010) 1.95
Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase. Mol Cell (2012) 1.91
High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis. Cell Stem Cell (2013) 1.86
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol Biol Cell (2011) 1.53
Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature (2013) 1.50
Acute Lower Gastrointestinal Bleeding. N Engl J Med (2017) 1.39
Distinct mechanisms act in concert to mediate cell cycle arrest. Proc Natl Acad Sci U S A (2009) 1.37
Fourier analysis and systems identification of the p53 feedback loop. Proc Natl Acad Sci U S A (2010) 1.19
Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J (2004) 1.18
We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells. Curr Opin Genet Dev (2011) 1.18
Activation and control of p53 tetramerization in individual living cells. Proc Natl Acad Sci U S A (2013) 1.12
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold. BMC Biol (2013) 1.02
A synthetic-natural hybrid oscillator in human cells. Proc Natl Acad Sci U S A (2010) 0.92
Differential protein occupancy profiling of the mRNA transcriptome. Genome Biol (2014) 0.92
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol Cell Biol (2010) 0.83
Dynamics of the DNA damage response: insights from live-cell imaging. Brief Funct Genomics (2013) 0.82
Decoding the insulin signal. Mol Cell (2012) 0.82
Cellular conference call: external feedback affects cell-fate decisions. Cell (2006) 0.79
Signal transduction and signaling networks. Mol Biol Cell (2013) 0.77
Suppressing variation in synthetic circuits. Mol Syst Biol (2011) 0.76