Published in Curr Opin Genet Dev on October 15, 2011
Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. Cell (2015) 4.42
Single-cell RNA-seq reveals dynamic paracrine control of cellular variation. Nature (2014) 3.86
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold. BMC Biol (2013) 1.02
Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes. Sci Signal (2014) 0.99
Cell-to-cell variability analysis dissects the plasticity of signaling of common γ chain cytokines in T cells. Sci Signal (2013) 0.97
Mechanisms that enhance sustainability of p53 pulses. PLoS One (2013) 0.91
Single-cell genome-wide studies give new insight into nongenetic cell-to-cell variability in animals. Histochem Cell Biol (2016) 0.88
Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing. Nat Commun (2014) 0.83
Dynamics of the DNA damage response: insights from live-cell imaging. Brief Funct Genomics (2013) 0.82
Strength in numbers: quantitative single-molecule RNA detection assays. Wiley Interdiscip Rev Dev Biol (2015) 0.81
A direct look at RNAi screens. Mol Syst Biol (2012) 0.79
Diversity training for signal transduction: leveraging cell-to-cell variability to dissect cellular signaling, differentiation and death. Curr Opin Biotechnol (2013) 0.79
The metabolic response to excitotoxicity - lessons from single-cell imaging. J Bioenerg Biomembr (2014) 0.78
A millifluidic study of cell-to-cell heterogeneity in growth-rate and cell-division capability in populations of isogenic cells of Chlamydomonas reinhardtii. PLoS One (2015) 0.78
Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway. PLoS Comput Biol (2016) 0.75
Computational Analysis of AMPK-Mediated Neuroprotection Suggests Acute Excitotoxic Bioenergetics and Glucose Dynamics Are Regulated by a Minimal Set of Critical Reactions. PLoS One (2016) 0.75
p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression. Oncotarget (2016) 0.75
Origins of variation in conducted vasomotor responses. Pflugers Arch (2014) 0.75
Calcium response of KCl-excited populations of ventricular myocytes from the European sea bass (Dicentrarchus labrax): a promising approach to integrate cell-to-cell heterogeneity in studying the cellular basis of fish cardiac performance. J Comp Physiol B (2015) 0.75
Bacterial persistence as a phenotypic switch. Science (2004) 15.80
Nature, nurture, or chance: stochastic gene expression and its consequences. Cell (2008) 12.13
Visualization of single RNA transcripts in situ. Science (1998) 10.51
Imaging individual mRNA molecules using multiple singly labeled probes. Nat Methods (2008) 10.40
Oscillations in NF-kappaB signaling control the dynamics of gene expression. Science (2004) 8.44
Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet (2004) 8.30
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature (2008) 7.60
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature (2009) 7.24
Functional roles for noise in genetic circuits. Nature (2010) 6.96
Dynamic and quantitative Ca2+ measurements using improved cameleons. Proc Natl Acad Sci U S A (1999) 6.63
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Methods (2008) 6.51
Stochastic switching as a survival strategy in fluctuating environments. Nat Genet (2008) 5.87
Dynamic proteomics of individual cancer cells in response to a drug. Science (2008) 5.43
Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature (2010) 5.27
Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR. Proc Natl Acad Sci U S A (2006) 5.21
Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels. Genome Res (2005) 4.98
Oscillations and variability in the p53 system. Mol Syst Biol (2006) 4.59
Cellular decision making and biological noise: from microbes to mammals. Cell (2011) 4.44
Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature (2006) 4.00
Image-based multivariate profiling of drug responses from single cells. Nat Methods (2007) 3.90
Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol Cell (2008) 3.88
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proc Natl Acad Sci U S A (2001) 3.77
Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci U S A (2000) 3.74
Oscillatory expression of Hes1, p53, and NF-kappaB driven by transcriptional time delays. Curr Biol (2003) 3.54
The incoherent feedforward loop can provide fold-change detection in gene regulation. Mol Cell (2009) 3.38
Single-cell transcriptional analysis of neuronal progenitors. Neuron (2003) 3.38
Population context determines cell-to-cell variability in endocytosis and virus infection. Nature (2009) 3.37
Mapping normal and cancer cell signalling networks: towards single-cell proteomics. Nat Rev Cancer (2006) 3.24
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat Methods (2006) 2.94
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proc Natl Acad Sci U S A (2001) 2.77
Fundamental limits on the suppression of molecular fluctuations. Nature (2010) 2.75
Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell (2008) 2.70
Single-cell microarray analysis in hippocampus CA1: demonstration and validation of cellular heterogeneity. J Neurosci (2003) 2.60
Imaging intracellular RNA distribution and dynamics in living cells. Nat Methods (2009) 2.56
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell (2010) 2.40
Non-genetic heterogeneity from stochastic partitioning at cell division. Nat Genet (2010) 2.32
Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response. Mol Syst Biol (2010) 2.21
Origins of regulated cell-to-cell variability. Nat Rev Mol Cell Biol (2011) 2.15
Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol (2011) 2.02
Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res (2011) 1.99
In vivo imaging in cancer. Cold Spring Harb Perspect Biol (2010) 1.76
Population robustness arising from cellular heterogeneity. Proc Natl Acad Sci U S A (2010) 1.66
Variability and robustness in biomolecular systems. Mol Cell (2007) 1.61
A fluorescent reporter of AMPK activity and cellular energy stress. Cell Metab (2011) 1.55
Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template. Mol Syst Biol (2011) 1.53
Cell-to-cell variability of alternative RNA splicing. Mol Syst Biol (2011) 1.38
Reporting from the field: genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems. Annu Rev Biochem (2011) 1.30
Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Curr Biol (2011) 1.18
Spatio-temporal protein dynamics in single living cells. Curr Opin Biotechnol (2008) 0.96
Transcriptional feedbacks in mammalian signal transduction pathways facilitate rapid and reliable protein induction. Mol Biosyst (2010) 0.87
Generation of double-labeled reporter cell lines for studying co-dynamics of endogenous proteins in individual human cells. PLoS One (2010) 0.80
Oscillations and variability in the p53 system. Mol Syst Biol (2006) 4.59
Cell growth and size homeostasis in proliferating animal cells. Science (2009) 3.89
p53 dynamics control cell fate. Science (2012) 3.30
Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96
Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat Methods (2006) 2.94
Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell (2008) 2.70
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell (2010) 2.40
The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer (2009) 2.13
Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol (2011) 2.02
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell (2010) 1.95
Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase. Mol Cell (2012) 1.91
High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis. Cell Stem Cell (2013) 1.86
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol Biol Cell (2011) 1.53
Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature (2013) 1.50
Distinct mechanisms act in concert to mediate cell cycle arrest. Proc Natl Acad Sci U S A (2009) 1.37
Fourier analysis and systems identification of the p53 feedback loop. Proc Natl Acad Sci U S A (2010) 1.19
Activation and control of p53 tetramerization in individual living cells. Proc Natl Acad Sci U S A (2013) 1.12
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold. BMC Biol (2013) 1.02
A synthetic-natural hybrid oscillator in human cells. Proc Natl Acad Sci U S A (2010) 0.92
Decoding the insulin signal. Mol Cell (2012) 0.82
Dynamics of the DNA damage response: insights from live-cell imaging. Brief Funct Genomics (2013) 0.82
Cellular conference call: external feedback affects cell-fate decisions. Cell (2006) 0.79
Signal transduction and signaling networks. Mol Biol Cell (2013) 0.77
Suppressing variation in synthetic circuits. Mol Syst Biol (2011) 0.76