Published in Cell on April 11, 2013
Necroptosis. N Engl J Med (2014) 2.71
Necroptosis drives motor neuron death in models of both sporadic and familial ALS. Neuron (2014) 1.56
Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog (2014) 1.51
Zebrafish models in translational research: tipping the scales toward advancements in human health. Dis Model Mech (2014) 1.50
Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment. Cell Host Microbe (2015) 1.47
Programmed necrosis in the cross talk of cell death and inflammation. Annu Rev Immunol (2014) 1.27
Tuberculosis drug discovery in the post-post-genomic era. EMBO Mol Med (2014) 1.20
Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2014) 1.17
Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections. Immunology (2015) 1.17
Macrophage defense mechanisms against intracellular bacteria. Immunol Rev (2015) 1.17
Turning 21: Induction of miR-21 as a Key Switch in the Inflammatory Response. Front Immunol (2015) 1.16
Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics. Eur J Immunol (2014) 1.15
Coupling heme and iron metabolism via ferritin H chain. Antioxid Redox Signal (2013) 1.08
Necroptosis: is there a role for mitochondria? Front Physiol (2014) 1.08
Reactive oxygen species and mitochondria: A nexus of cellular homeostasis. Redox Biol (2015) 1.03
Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model. Dis Model Mech (2014) 1.02
Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death. Oncogene (2015) 0.99
Host-directed therapeutics for tuberculosis: can we harness the host? Microbiol Mol Biol Rev (2013) 0.97
B cells and antibodies in the defense against Mycobacterium tuberculosis infection. Immunol Rev (2015) 0.97
Necroptosis in development, inflammation and disease. Nat Rev Mol Cell Biol (2016) 0.96
Are reactive oxygen species always detrimental to pathogens? Antioxid Redox Signal (2013) 0.95
Striking the Right Balance Determines TB or Not TB. Front Immunol (2014) 0.93
Investigating the causes for decreased levels of glutathione in individuals with type II diabetes. PLoS One (2015) 0.92
Inflammatory signaling in human tuberculosis granulomas is spatially organized. Nat Med (2016) 0.92
Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies. Semin Immunopathol (2015) 0.91
TB: the Yin and Yang of lipid mediators. Curr Opin Pharmacol (2013) 0.91
Computational modeling predicts IL-10 control of lesion sterilization by balancing early host immunity-mediated antimicrobial responses with caseation during mycobacterium tuberculosis infection. J Immunol (2014) 0.91
NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation. Cell Death Dis (2014) 0.91
An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. PLoS One (2013) 0.90
New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeutics. Immunol Rev (2015) 0.90
Understanding and overcoming the barriers to T cell-mediated immunity against tuberculosis. Semin Immunol (2014) 0.90
Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle. J Biol Chem (2014) 0.90
Mechanisms of Control of Mycobacterium tuberculosis by NK Cells: Role of Glutathione. Front Immunol (2015) 0.89
MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosis. Immunol Rev (2015) 0.89
ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question. Front Cell Infect Microbiol (2013) 0.89
The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Dis Model Mech (2015) 0.87
Macrophages and Iron Metabolism. Immunity (2016) 0.86
Fit for consumption: zebrafish as a model for tuberculosis. Dis Model Mech (2014) 0.86
Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma. Immunol Rev (2015) 0.86
Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis. Immunity (2014) 0.86
Protection and pathology in TB: learning from the zebrafish model. Semin Immunopathol (2015) 0.85
The Iron age of host-microbe interactions. EMBO Rep (2015) 0.85
Interaction of Mycobacterium tuberculosis with host cell death pathways. Cold Spring Harb Perspect Med (2014) 0.84
Neutrophils in host defense: new insights from zebrafish. J Leukoc Biol (2015) 0.84
CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease. PLoS Pathog (2016) 0.83
A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis. Cell Host Microbe (2014) 0.83
Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis. BMC Med (2016) 0.83
TNFR1/phox interaction and TNFR1 mitochondrial translocation Thwart silica-induced pulmonary fibrosis. J Immunol (2014) 0.82
Insights into battles between Mycobacterium tuberculosis and macrophages. Protein Cell (2014) 0.82
Immune vulnerability of infants to tuberculosis. Clin Dev Immunol (2013) 0.82
Cell-autonomous effector mechanisms against mycobacterium tuberculosis. Cold Spring Harb Perspect Med (2014) 0.82
Utilization of zebrafish for intravital study of eukaryotic pathogen-host interactions. Dev Comp Immunol (2014) 0.82
Infection of human monocytes by Chlamydia pneumoniae and Chlamydia trachomatis: an in vitro comparative study. BMC Res Notes (2014) 0.81
The involvement of NADPH oxidase-mediated ROS in cytokine secretion from macrophages induced by Mycobacterium tuberculosis ESAT-6. Inflammation (2014) 0.81
From mouth to macrophage: mechanisms of innate immune subversion by Mycobacterium avium subsp. paratuberculosis. Vet Res (2014) 0.81
Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages. Am J Physiol Lung Cell Mol Physiol (2015) 0.81
Repositioning drugs for inflammatory disease - fishing for new anti-inflammatory agents. Dis Model Mech (2014) 0.80
TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis. J Neuroinflammation (2015) 0.80
Role of B cells and antibodies in acquired immunity against Mycobacterium tuberculosis. Cold Spring Harb Perspect Med (2014) 0.80
Novel adjunctive therapies for the treatment of tuberculosis. Curr Mol Med (2014) 0.80
Modeling mucosal candidiasis in larval zebrafish by swimbladder injection. J Vis Exp (2014) 0.79
Perspectives on antigen presenting cells in zebrafish. Dev Comp Immunol (2014) 0.79
CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections. Dis Model Mech (2015) 0.79
ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts. Cell Death Dis (2015) 0.79
Mechanisms of RIPK3-induced inflammation. Immunol Cell Biol (2016) 0.79
Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis. Front Immunol (2016) 0.79
The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum. Infect Immun (2015) 0.78
The Function of Fish Cytokines. Biology (Basel) (2016) 0.78
The Transcriptional Foundations of Sp110-mediated Macrophage (RAW264.7) Resistance to Mycobacterium tuberculosis H37Ra. Sci Rep (2016) 0.78
Mycobacteria counteract a TLR-mediated nitrosative defense mechanism in a zebrafish infection model. PLoS One (2014) 0.78
Annonaceous acetogenin mimic AA005 induces cancer cell death via apoptosis inducing factor through a caspase-3-independent mechanism. BMC Cancer (2015) 0.78
Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. J Neuroinflammation (2017) 0.78
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome. Nat Commun (2017) 0.78
Fine-tuning of macrophage activation using synthetic rocaglate derivatives. Sci Rep (2016) 0.78
Mycobacterial Dormancy Systems and Host Responses in Tuberculosis. Front Immunol (2017) 0.77
The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages. Sci Rep (2016) 0.77
Etanercept exacerbates inflammation and pathology in a rabbit model of active pulmonary tuberculosis. J Interferon Cytokine Res (2014) 0.77
Microbial egress: a hitchhiker's guide to freedom. PLoS Pathog (2014) 0.77
Animal models of tuberculosis: zebrafish. Cold Spring Harb Perspect Med (2014) 0.77
Bcl-xL mediates RIPK3-dependent necrosis in M. tuberculosis-infected macrophages. Mucosal Immunol (2017) 0.76
Hypoxia Sensing and Persistence Genes Are Expressed during the Intragranulomatous Survival of Mycobacterium tuberculosis. Am J Respir Cell Mol Biol (2017) 0.76
The Zebrafish Breathes New Life into the Study of Tuberculosis. Front Immunol (2016) 0.76
Host directed therapies (HDTs) and immune response signatures: insights into a role for interleukin-32. Ann Transl Med (2015) 0.76
Protein Thiol Redox Signaling in Monocytes and Macrophages. Antioxid Redox Signal (2016) 0.76
Host-Directed Therapies for Tuberculosis. Cold Spring Harb Perspect Med (2015) 0.76
Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. Biochem J (2016) 0.76
Changing T-cell enigma: cancer killing or cancer control? Cell Cycle (2013) 0.76
Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress. Thorax (2015) 0.76
A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling. Immunity (2016) 0.76
Cortisol-treated zebrafish embryos develop into pro-inflammatory adults with aberrant immune gene regulation. Biol Open (2016) 0.76
Identification of a Transcription Factor That Regulates Host Cell Exit and Virulence of Mycobacterium tuberculosis. PLoS Pathog (2016) 0.76
Nrf2: new insight in cell apoptosis. Cell Death Dis (2015) 0.75
Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization. Sci Rep (2016) 0.75
Participation of Necroptosis in the Host Response to Acute Bacterial Pneumonia. J Innate Immun (2017) 0.75
xCT increases tuberculosis susceptibility by regulating antimicrobial function and inflammation. Oncotarget (2016) 0.75
Mycobacterium tuberculosis Zinc Metalloprotease-1 Assists Mycobacterial Dissemination in Zebrafish. Front Microbiol (2016) 0.75
Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages. Proc Natl Acad Sci U S A (2015) 0.75
The Role of Reactive Oxygen Species in Modulating the Caenorhabditis elegans Immune Response. PLoS Pathog (2016) 0.75
Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish. Dis Model Mech (2016) 0.75
Targeting Tuberculosis and HIV Infection-Specific Regulatory T Cells with MEK/ERK Signaling Pathway Inhibitors. PLoS One (2015) 0.75
Optimal alignments in linear space. Comput Appl Biosci (1988) 38.10
Population genomics of human gene expression. Nat Genet (2007) 24.49
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell (2009) 11.36
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell (2009) 11.26
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature (2005) 11.22
Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N Engl J Med (2004) 10.14
Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J Exp Med (1992) 10.08
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science (2009) 9.29
Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol (2008) 9.24
Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature (2005) 8.51
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol (2000) 8.49
Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci U S A (1997) 7.90
Pyroptosis: host cell death and inflammation. Nat Rev Microbiol (2009) 7.63
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell (2012) 6.56
Mitochondrial dynamics and apoptosis. Genes Dev (2008) 6.07
Mitochondria: in sickness and in health. Cell (2012) 6.05
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell (2008) 5.67
The role of the granuloma in expansion and dissemination of early tuberculous infection. Cell (2009) 4.79
TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell (2007) 4.53
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell (2012) 4.37
Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol (2007) 3.90
Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. J Biol Chem (1992) 3.76
The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. Cell (2010) 3.64
Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis. J Immunol (1988) 3.64
Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell (2012) 3.54
RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome. Immunity (2011) 3.53
More than one way to die: apoptosis, necrosis and reactive oxygen damage. Oncogene (1999) 3.42
Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochem J (1988) 3.41
Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish. Cell Host Microbe (2007) 3.09
Revisiting the role of the granuloma in tuberculosis. Nat Rev Immunol (2012) 2.86
Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism. EMBO Mol Med (2010) 2.26
Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium. Nat Immunol (2012) 2.25
Macrophage apoptosis in response to high intracellular burden of Mycobacterium tuberculosis is mediated by a novel caspase-independent pathway. J Immunol (2006) 2.22
Mycobacterial survival strategies in the phagosome: defence against host stresses. Cell Microbiol (2009) 2.18
Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase. Nature (2009) 2.13
Effect of corticosteroids on intracranial pressure, computed tomographic findings, and clinical outcome in young children with tuberculous meningitis. Pediatrics (1997) 2.09
Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages. Cell Host Microbe (2012) 1.94
Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model. J Pathol (2012) 1.93
Programmed necrosis from molecules to health and disease. Int Rev Cell Mol Biol (2011) 1.58
Link between mitochondria and NADPH oxidase 1 isozyme for the sustained production of reactive oxygen species and cell death. J Biol Chem (2006) 1.47
Ceramide mediates caspase-independent programmed cell death. FASEB J (2005) 1.36
Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages. PLoS One (2011) 1.31
Nitration of the mitochondrial complex I subunit NDUFB8 elicits RIP1- and RIP3-mediated necrosis. Free Radic Biol Med (2009) 1.30
Reconsidering adjuvant immunotherapy for tuberculosis. Clin Infect Dis (2005) 1.28
TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis. Oncogene (2006) 1.18
The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects in Col6a1-/- myopathic mice. Br J Pharmacol (2009) 1.16
An in vivo platform for rapid high-throughput antitubercular drug discovery. Cell Rep (2012) 1.11
New insights on the use of desipramine as an inhibitor for acid ceramidase. FEBS Lett (2006) 1.10
Protection of Mycobacterium tuberculosis from reactive oxygen species conferred by the mel2 locus impacts persistence and dissemination. Infect Immun (2009) 1.00
Differential regulation of primitive myelopoiesis in the zebrafish by Spi-1/Pu.1 and C/ebp1. Zebrafish (2007) 0.98
Tumor necrosis factor and anti-tumor necrosis factor therapies. J Rheumatol Suppl (2010) 0.98
Induction of cell death after localization to the host cell mitochondria by the Mycobacterium tuberculosis PE_PGRS33 protein. Microbiology (2010) 0.98
NecroX as a novel class of mitochondrial reactive oxygen species and ONOO⁻ scavenger. Arch Pharm Res (2010) 0.97
Insights into tuberculosis from the zebrafish model. Trends Mol Med (2012) 0.94
The cyclophilin inhibitor alisporivir prevents hepatitis C virus-mediated mitochondrial dysfunction. Hepatology (2012) 0.91
The Mycobacterium marinum mel2 locus displays similarity to bacterial bioluminescence systems and plays a role in defense against reactive oxygen and nitrogen species. BMC Microbiol (2007) 0.89
Targeting of Mycobacterium tuberculosis heparin-binding hemagglutinin to mitochondria in macrophages. PLoS Pathog (2011) 0.88
Real-time measurement of intracellular reactive oxygen species using Mito tracker orange (CMH2TMRos). Biosci Rep (2001) 0.88
The role of the granuloma in expansion and dissemination of early tuberculous infection. Cell (2009) 4.79
Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium. Science (2009) 3.71
The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. Cell (2010) 3.64
Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell (2012) 3.54
Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos. Immunity (2002) 3.48
Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism. Cell (2011) 3.42
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. Genome Res (2008) 3.26
Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death. Immunity (2008) 3.24
The secret lives of the pathogenic mycobacteria. Annu Rev Microbiol (2003) 3.15
Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinant. PLoS Biol (2004) 3.12
Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish. Cell Host Microbe (2007) 3.09
Superinfecting mycobacteria home to established tuberculous granulomas. Nat Immunol (2004) 2.87
Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis. Cell Microbiol (2008) 2.11
Why is long-term therapy required to cure tuberculosis? PLoS Med (2007) 2.03
Mycobacterium marinum infection of adult zebrafish causes caseating granulomatous tuberculosis and is moderated by adaptive immunity. Infect Immun (2006) 1.99
Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages. Cell Host Microbe (2012) 1.94
Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection. Proc Natl Acad Sci U S A (2002) 1.70
Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos. Cell Microbiol (2009) 1.45
Mycobacterium marinum Erp is a virulence determinant required for cell wall integrity and intracellular survival. Infect Immun (2006) 1.39
Zebrafish and frog models of Mycobacterium marinum infection. Curr Protoc Microbiol (2006) 1.32
Insights into early mycobacterial pathogenesis from the zebrafish. Curr Opin Microbiol (2008) 1.23
Multiplex fluorescent in situ hybridization in zebrafish embryos using tyramide signal amplification. Zebrafish (2005) 1.20
Do mycobacteria produce endospores? Proc Natl Acad Sci U S A (2009) 1.13
An in vivo platform for rapid high-throughput antitubercular drug discovery. Cell Rep (2012) 1.11
New models for the study of Mycobacterium-host interactions. Curr Opin Immunol (2004) 1.09
Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish. Nat Protoc (2013) 1.06
Trafficking of superinfecting Mycobacterium organisms into established granulomas occurs in mammals and is independent of the Erp and ESX-1 mycobacterial virulence loci. J Infect Dis (2008) 1.04
Leptospira interrogans stably infects zebrafish embryos, altering phagocyte behavior and homing to specific tissues. PLoS Negl Trop Dis (2009) 1.04
Insights into tuberculosis from the zebrafish model. Trends Mol Med (2012) 0.94
TB: the Yin and Yang of lipid mediators. Curr Opin Pharmacol (2013) 0.91
An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. PLoS One (2013) 0.90
"The very pulse of the machine": the tuberculous granuloma in motion. Immunity (2008) 0.86
Antimicrobial efflux pumps and Mycobacterium tuberculosis drug tolerance: evolutionary considerations. Curr Top Microbiol Immunol (2013) 0.83
The Acetobacteraceae: extending the spectrum of human pathogens. PLoS Pathog (2006) 0.77