Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study.

PubWeight™: 1.10‹?› | Rank: Top 10%

🔗 View Article (PMC 4135488)

Published in Am J Clin Nutr on June 18, 2014

Authors

Carolyn A Miller1, Karen D Corbin1, Kerry-Ann da Costa1, Shucha Zhang1, Xueqing Zhao1, Joseph A Galanko1, Tondra Blevins1, Brian J Bennett1, Annalouise O'Connor1, Steven H Zeisel1

Author Affiliations

1: From the Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC (CAM, KDC, SZ, XZ, TB, BJB, AO, and SHZ), and the Department of Nutrition, School of Public Health and School of Medicine (K-AdC and SHZ) and Departments of Medicine (JAG) and Genetics (BJB), University of North Carolina at Chapel Hill, Chapel Hill, NC.

Associated clinical trials:

Plasma and Urine TMAO Formation and Changes to Oxidized LDL After Ingestion of Different Amounts of Egg | NCT01906554

Study of the Role of Pomegranate Juice Ellagitannins in the Modulation of Inflammation in Inflammatory Bowel Diseases (POME2016) | NCT03000101

A Pilot Study to Investigate the Effect of Water-soluble Tomato Extract on TMAO | NCT04160481

Plant-Based Meat vs Animal "Red" Meat Trial (FOOD-1) | NCT04510324

Articles citing this

The contributory role of gut microbiota in cardiovascular disease. J Clin Invest (2014) 1.57

Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide. MBio (2015) 1.26

Characterization and detection of a widely distributed gene cluster that predicts anaerobic choline utilization by human gut bacteria. MBio (2015) 0.92

Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr (2015) 0.89

Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease. PLoS One (2016) 0.86

Bioactive Egg Components and Inflammation. Nutrients (2015) 0.85

Intestinal Microbiota-Generated Metabolite Trimethylamine-N-Oxide and 5-Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE-Like Patient Cohort. J Am Heart Assoc (2016) 0.83

Egg phospholipids and cardiovascular health. Nutrients (2015) 0.83

Eggs as a dietary source for gut microbial production of trimethylamine-N-oxide. Am J Clin Nutr (2014) 0.81

Egg consumption and risk of type 2 diabetes among African Americans: The Jackson Heart Study. Clin Nutr (2015) 0.80

Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease. Drug Metab Dispos (2016) 0.79

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Curr Diab Rep (2016) 0.78

Choline metabolites: gene by diet interactions. Curr Opin Lipidol (2016) 0.78

Emerging roles of flavin monooxygenase 3 in cholesterol metabolism and atherosclerosis. Curr Opin Lipidol (2015) 0.78

Differential effects of oral and intravenous l-carnitine on serum lipids: is the microbiota the answer? Clin Kidney J (2014) 0.76

Cardiovascular disease and type 2 diabetes in evolutionary perspective: a critical role for helminths? Evol Med Public Health (2016) 0.76

Choline, Its Potential Role in Nonalcoholic Fatty Liver Disease, and the Case for Human and Bacterial Genes. Adv Nutr (2016) 0.76

Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease. Dig Dis Sci (2015) 0.76

Egg Consumption and Incidence of Heart Failure: A Meta-Analysis of Prospective Cohort Studies. Front Nutr (2017) 0.75

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA). J Am Heart Assoc (2016) 0.75

Trimethylamine-N-oxide and its biological variations in vegetarians. Eur J Nutr (2016) 0.75

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies. Nutrients (2017) 0.75

Articles cited by this

A rapid method of total lipid extraction and purification. Can J Biochem Physiol (1959) 173.74

A new equation to estimate glomerular filtration rate. Ann Intern Med (2009) 71.41

Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A (2005) 33.66

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med (2013) 9.44

Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med (2013) 8.21

The core gut microbiome, energy balance and obesity. J Physiol (2009) 4.45

Concentrations of choline-containing compounds and betaine in common foods. J Nutr (2003) 4.12

Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation (2004) 3.44

Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab (2013) 3.01

Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometry. Anal Chem (2002) 2.35

Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr (2007) 1.76

Formation of methylamines from ingested choline and lecithin. J Pharmacol Exp Ther (1983) 1.51

Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. BMC Cardiovasc Disord (2007) 1.47

Amine metabolism and the small bowel in uraemia. Lancet (1976) 1.20

Fish consumption and cardiovascular disease in the physicians' health study: a prospective study. Am J Epidemiol (1995) 1.16

Prospective study on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women. Eur J Clin Nutr (2007) 1.15

The measurement of dimethylamine, trimethylamine, and trimethylamine N-oxide using capillary gas chromatography-mass spectrometry. Anal Biochem (1990) 1.07

Nutrition in pregnancy: the argument for including a source of choline. Int J Womens Health (2013) 0.98

Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities. Biochem Pharmacol (2013) 0.98

Whole egg consumption improves lipoprotein profiles and insulin sensitivity to a greater extent than yolk-free egg substitute in individuals with metabolic syndrome. Metabolism (2012) 0.98

Increase in human exposure to methylamine precursors of N-nitrosamines after eating fish. Cancer Res (1986) 0.89

Effects of oral choline administration on serum and CSF choline levels in patients with Huntington's disease. J Neurochem (1977) 0.88

Effects of egg ingestion on endothelial function in adults with coronary artery disease: a randomized, controlled, crossover trial. Am Heart J (2014) 0.84

An in vitro study of choline uptake by intestine from neonatal and adult rats. Pediatr Res (1986) 0.82

Choline and lecithin administration to patients with tardive dyskinesia. Trans Am Neurol Assoc (1978) 0.79