Published in Nat Cell Biol on May 26, 2013
Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly. Mol Cell (2014) 1.38
Molecular architecture and mechanism of the anaphase-promoting complex. Nature (2014) 1.36
Spatiotemporal regulation of the anaphase-promoting complex in mitosis. Nat Rev Mol Cell Biol (2015) 1.25
Atomic structure of the APC/C and its mechanism of protein ubiquitination. Nature (2015) 1.22
Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template. Genes Dev (2013) 1.00
RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex. Proc Natl Acad Sci U S A (2015) 0.95
Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition. Curr Biol (2015) 0.92
The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium. Elife (2014) 0.91
Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation. Mol Cell (2016) 0.88
Modulation of cell cycle control during oocyte-to-embryo transitions. EMBO J (2013) 0.87
Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell (2016) 0.86
Structural insights into the catalysis and regulation of E3 ubiquitin ligases. Nat Rev Mol Cell Biol (2016) 0.84
The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation. FEBS Open Bio (2014) 0.79
Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis. Virology (2013) 0.79
Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex. Mol Cell (2016) 0.78
In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis. Oncogene (2016) 0.78
Active transport can greatly enhance Cdc20:Mad2 formation. Int J Mol Sci (2014) 0.77
EMI1, a three-in-one ubiquitylation inhibitor. Nat Struct Mol Biol (2013) 0.76
Insights into APC/C: from cellular function to diseases and therapeutics. Cell Div (2016) 0.75
An E2 Accessory Domain Increases Affinity for the Anaphase-promoting Complex and Ensures E2 Competition. J Biol Chem (2015) 0.75
The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat Rev Mol Cell Biol (2006) 10.76
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Mol Cell (2008) 4.09
Mitotic regulation of the APC activator proteins CDC20 and CDH1. Mol Biol Cell (2000) 4.01
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Nat Cell Biol (2002) 3.46
Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Cell (2001) 3.36
The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell (2006) 2.91
Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science (2009) 2.69
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2. Cell (2011) 2.58
Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates. Cell (2009) 2.40
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev (2006) 2.16
UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex. Proc Natl Acad Sci U S A (2010) 2.15
Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor. Nature (2010) 2.11
The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC. Mol Cell (2008) 1.52
Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes. J Biol Chem (2011) 1.16
Unique D box and KEN box sequences limit ubiquitination of Acm1 and promote pseudosubstrate inhibition of the anaphase-promoting complex. J Biol Chem (2008) 1.08
Emi2 inhibition of the anaphase-promoting complex/cyclosome absolutely requires Emi2 binding via the C-terminal RL tail. Mol Biol Cell (2010) 1.01
Processive ubiquitin chain formation by the anaphase-promoting complex. Semin Cell Dev Biol (2011) 0.95
Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism. Mol Biol Cell (2010) 0.93
Substrate-specific regulation of ubiquitination by the anaphase-promoting complex. Cell Cycle (2011) 0.86
A novel yeast mutant that is defective in regulation of the Anaphase-Promoting Complex by the spindle damage checkpoint. Mol Genet Genomics (2003) 0.86
Rescuing US biomedical research from its systemic flaws. Proc Natl Acad Sci U S A (2014) 14.78
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc Natl Acad Sci U S A (2003) 10.82
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science (2012) 6.79
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature (2002) 6.26
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol (2002) 5.58
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol (2003) 4.89
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell (2004) 4.21
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
Cell growth and size homeostasis in proliferating animal cells. Science (2009) 3.89
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature (2004) 3.63
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature (2004) 3.62
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature (2012) 3.44
The incoherent feedforward loop can provide fold-change detection in gene regulation. Mol Cell (2009) 3.38
An actin-based wave generator organizes cell motility. PLoS Biol (2007) 3.36
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell (2006) 2.91
Using buoyant mass to measure the growth of single cells. Nat Methods (2010) 2.67
Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol (2004) 2.36
Direct observation of mammalian cell growth and size regulation. Nat Methods (2012) 2.34
Purification and architecture of the ubiquitous Wave complex. Proc Natl Acad Sci U S A (2004) 2.25
UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex. Proc Natl Acad Sci U S A (2010) 2.15
Phosphorylation analysis by mass spectrometry: myths, facts, and the consequences for qualitative and quantitative measurements. Mol Cell Proteomics (2005) 2.12
Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Mol Cell (2009) 2.11
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol (2004) 2.11
Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A (2004) 2.08
Activation of the WAVE complex by coincident signals controls actin assembly. Mol Cell (2009) 2.08
Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Mol Cell (2005) 2.05
Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions. Nature (2013) 2.02
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol (2004) 1.99
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J (2003) 1.98
Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell (2007) 1.97
A general lack of compensation for gene dosage in yeast. Mol Syst Biol (2010) 1.96
Self-assembly of filopodia-like structures on supported lipid bilayers. Science (2010) 1.87
Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS. Proc Natl Acad Sci U S A (2005) 1.83
Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. Proc Natl Acad Sci U S A (2003) 1.77
Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility. Dev Cell (2011) 1.76
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes Dev (2010) 1.74
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell (2003) 1.56
Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature (2013) 1.50
A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J Biol Chem (2002) 1.40
Optimizing optical flow cytometry for cell volume-based sorting and analysis. PLoS One (2011) 1.39
Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. J Cell Biol (2004) 1.39
Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev (2010) 1.38
The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm. Development (2003) 1.35
Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis. Proc Natl Acad Sci U S A (2008) 1.34
Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts. Mol Cell (2010) 1.25
Need-based up-regulation of protein levels in response to deletion of their duplicate genes. PLoS Biol (2010) 1.24
Kinetic responses of β-catenin specify the sites of Wnt control. Science (2012) 1.23
Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays. Proc Natl Acad Sci U S A (2009) 1.23
A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis. Development (2005) 1.20
Timing of events in mitosis. Curr Biol (2002) 1.20
The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus. Development (2009) 1.15
Gap 1 phase length and mouse embryonic stem cell self-renewal. Proc Natl Acad Sci U S A (2012) 1.15
FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides. J Proteome Res (2009) 1.15
Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem Biol (2006) 1.12
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. J Biol Chem (2012) 1.12
Remodeling of the metabolome during early frog development. PLoS One (2011) 1.12
Profiling of ubiquitin-like modifications reveals features of mitotic control. Cell (2013) 1.12
Cell cycle adaptations of embryonic stem cells. Proc Natl Acad Sci U S A (2011) 1.11
Size homeostasis in adherent cells studied by synthetic phase microscopy. Proc Natl Acad Sci U S A (2013) 1.07
Graded positional information: interpretation for both fate and guidance. Cell (2003) 1.05
The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. J Cell Sci (2007) 1.04
Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrula. Development (2003) 1.02
Anaphase specific auto-cleavage of separase. FEBS Lett (2002) 1.01
The relationship between evolutionary and physiological variation in hemoglobin. Proc Natl Acad Sci U S A (2007) 1.01
Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster. Anal Chem (2012) 0.98
Domain structure of separase and its binding to securin as determined by EM. Nat Struct Mol Biol (2005) 0.98
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9. Proc Natl Acad Sci U S A (2013) 0.96
SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Rep (2013) 0.93
Exploiting polypharmacology for drug target deconvolution. Proc Natl Acad Sci U S A (2014) 0.93
Identification of ubiquitin ligase substrates by in vitro expression cloning. Methods Enzymol (2005) 0.89
Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Dev Cell (2005) 0.88
In vitro reconstitution of cdc42-mediated actin assembly using purified components. Methods Enzymol (2006) 0.87
Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts. Methods Enzymol (2006) 0.87
Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated. J Am Chem Soc (2014) 0.84
Protein microarrays for genome-wide posttranslational modification analysis. Wiley Interdiscip Rev Syst Biol Med (2010) 0.84
Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. Proc Natl Acad Sci U S A (2013) 0.83
Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway. Cancer Res (2002) 0.80
Post-Translational Modification Profiling-a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems. Curr Protoc Protein Sci (2014) 0.76