Published in Proc Natl Acad Sci U S A on March 19, 2014
A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell (2014) 1.44
On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development. Dev Cell (2015) 1.00
Systems biology approaches for advancing the discovery of effective drug combinations. J Cheminform (2015) 0.90
Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders. Annu Rev Pharmacol Toxicol (2015) 0.89
Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment. PLoS One (2015) 0.84
Composition and applications of focus libraries to phenotypic assays. Front Pharmacol (2014) 0.82
Inhibitory effect of traditional oriental medicine-derived monoamine oxidase B inhibitor on radioresistance of non-small cell lung cancer. Sci Rep (2016) 0.80
Drug combination therapy increases successful drug repositioning. Drug Discov Today (2016) 0.80
An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer. BMC Genomics (2015) 0.77
Identifying kinase dependency in cancer cells by integrating high-throughput drug screening and kinase inhibition data. Bioinformatics (2015) 0.77
Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology. Angew Chem Int Ed Engl (2015) 0.76
Regularization Paths for Generalized Linear Models via Coordinate Descent. J Stat Softw (2010) 38.65
Cell migration: integrating signals from front to back. Science (2003) 29.13
A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol (2008) 14.74
Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer (2009) 11.25
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science (2007) 10.60
Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol (2008) 8.51
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature (2012) 8.13
Global mapping of pharmacological space. Nat Biotechnol (2006) 4.99
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat Cell Biol (2011) 4.59
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol (2011) 3.72
Autocrine PDGFR signaling promotes mammary cancer metastasis. J Clin Invest (2006) 2.68
EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. Nat Med (2011) 2.46
Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Res (2008) 2.37
TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. Mol Cell (2011) 2.13
A systems view of epithelial-mesenchymal transition signaling states. Clin Exp Metastasis (2010) 1.95
Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin. Cancer Res (2010) 1.94
Target deconvolution strategies in drug discovery. Nat Rev Drug Discov (2007) 1.94
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. Nat Cell Biol (2009) 1.55
Receptor tyrosine kinase coactivation networks in cancer. Cancer Res (2010) 1.46
EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme. Cancer Cell (2013) 1.44
Polypharmacology - foe or friend? J Med Chem (2013) 1.42
Gini coefficient: a new way to express selectivity of kinase inhibitors against a family of kinases. J Med Chem (2007) 1.28
Target deconvolution techniques in modern phenotypic profiling. Curr Opin Chem Biol (2013) 1.08
A simplified method for quantifying cell migration/wound healing in 96-well plates. J Biomol Screen (2010) 1.08
ErbB4 increases the proliferation potential of human lung cancer cells and its blockage can be used as a target for anti-cancer therapy. Int J Cancer (2006) 1.05
Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest. Mutagenesis (2010) 0.96
Discoidin domain receptor 2 is a critical regulator of epithelial-mesenchymal transition. Matrix Biol (2011) 0.90
Measurement of chondrocyte chemotaxis using a Boyden chamber: a model of receptor-mediated cell migration combined with cell sedimentation. Math Med Biol (2012) 0.78
A method and server for predicting damaging missense mutations. Nat Methods (2010) 78.53
Rescuing US biomedical research from its systemic flaws. Proc Natl Acad Sci U S A (2014) 14.78
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc Natl Acad Sci U S A (2003) 10.82
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science (2012) 6.79
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature (2002) 6.26
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol (2002) 5.58
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol (2003) 4.89
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell (2004) 4.21
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
Cell growth and size homeostasis in proliferating animal cells. Science (2009) 3.89
Rapidly retargetable approaches to de-identification in medical records. J Am Med Inform Assoc (2007) 3.82
A public resource facilitating clinical use of genomes. Proc Natl Acad Sci U S A (2012) 3.72
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature (2004) 3.63
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature (2004) 3.62
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature (2012) 3.44
The incoherent feedforward loop can provide fold-change detection in gene regulation. Mol Cell (2009) 3.38
An actin-based wave generator organizes cell motility. PLoS Biol (2007) 3.36
Roundup: a multi-genome repository of orthologs and evolutionary distances. Bioinformatics (2006) 3.28
Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature (2011) 3.19
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell (2006) 2.91
Using buoyant mass to measure the growth of single cells. Nat Methods (2010) 2.67
Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol (2004) 2.36
Direct observation of mammalian cell growth and size regulation. Nat Methods (2012) 2.34
Purification and architecture of the ubiquitous Wave complex. Proc Natl Acad Sci U S A (2004) 2.25
UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex. Proc Natl Acad Sci U S A (2010) 2.15
Phosphorylation analysis by mass spectrometry: myths, facts, and the consequences for qualitative and quantitative measurements. Mol Cell Proteomics (2005) 2.12
Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Mol Cell (2009) 2.11
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol (2004) 2.11
Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A (2004) 2.08
Activation of the WAVE complex by coincident signals controls actin assembly. Mol Cell (2009) 2.08
Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Mol Cell (2005) 2.05
Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions. Nature (2013) 2.02
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol (2004) 1.99
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J (2003) 1.98
Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell (2007) 1.97
A general lack of compensation for gene dosage in yeast. Mol Syst Biol (2010) 1.96
Self-assembly of filopodia-like structures on supported lipid bilayers. Science (2010) 1.87
Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS. Proc Natl Acad Sci U S A (2005) 1.83
Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. Proc Natl Acad Sci U S A (2003) 1.77
Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility. Dev Cell (2011) 1.76
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes Dev (2010) 1.74
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell (2003) 1.56
Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature (2013) 1.50
A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J Biol Chem (2002) 1.40
Optimizing optical flow cytometry for cell volume-based sorting and analysis. PLoS One (2011) 1.39
Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. J Cell Biol (2004) 1.39
Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev (2010) 1.38
The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm. Development (2003) 1.35
Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis. Proc Natl Acad Sci U S A (2008) 1.34
Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts. Mol Cell (2010) 1.25
Need-based up-regulation of protein levels in response to deletion of their duplicate genes. PLoS Biol (2010) 1.24
Kinetic responses of β-catenin specify the sites of Wnt control. Science (2012) 1.23
Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays. Proc Natl Acad Sci U S A (2009) 1.23
Effects of temperature on gene expression in embryos of the coral Montastraea faveolata. BMC Genomics (2009) 1.21
A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis. Development (2005) 1.20
Timing of events in mitosis. Curr Biol (2002) 1.20
The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus. Development (2009) 1.15
FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides. J Proteome Res (2009) 1.15
Gap 1 phase length and mouse embryonic stem cell self-renewal. Proc Natl Acad Sci U S A (2012) 1.15
Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem Biol (2006) 1.12
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. J Biol Chem (2012) 1.12
Remodeling of the metabolome during early frog development. PLoS One (2011) 1.12
Profiling of ubiquitin-like modifications reveals features of mitotic control. Cell (2013) 1.12
Cell cycle adaptations of embryonic stem cells. Proc Natl Acad Sci U S A (2011) 1.11
Size homeostasis in adherent cells studied by synthetic phase microscopy. Proc Natl Acad Sci U S A (2013) 1.07
Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex. Nat Cell Biol (2013) 1.06
Graded positional information: interpretation for both fate and guidance. Cell (2003) 1.05
The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. J Cell Sci (2007) 1.04
Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrula. Development (2003) 1.02
Anaphase specific auto-cleavage of separase. FEBS Lett (2002) 1.01
The relationship between evolutionary and physiological variation in hemoglobin. Proc Natl Acad Sci U S A (2007) 1.01
Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster. Anal Chem (2012) 0.98
Domain structure of separase and its binding to securin as determined by EM. Nat Struct Mol Biol (2005) 0.98
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9. Proc Natl Acad Sci U S A (2013) 0.96
SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Rep (2013) 0.93
Identification of ubiquitin ligase substrates by in vitro expression cloning. Methods Enzymol (2005) 0.89
Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Dev Cell (2005) 0.88
In vitro reconstitution of cdc42-mediated actin assembly using purified components. Methods Enzymol (2006) 0.87
Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts. Methods Enzymol (2006) 0.87
Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated. J Am Chem Soc (2014) 0.84
Protein microarrays for genome-wide posttranslational modification analysis. Wiley Interdiscip Rev Syst Biol Med (2010) 0.84
Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. Proc Natl Acad Sci U S A (2013) 0.83
Vascular disrupting agent drug classes differ in effects on the cytoskeleton. PLoS One (2012) 0.81
Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway. Cancer Res (2002) 0.80
Post-Translational Modification Profiling-a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems. Curr Protoc Protein Sci (2014) 0.76
Toward an unbiased evolutionary platform for unraveling Xenopus developmental gene networks. Genesis (2012) 0.75