Published in Curr Biol on January 22, 2002
Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev (2002) 3.37
Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase. Genes Dev (2005) 2.56
PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase. J Cell Biol (2007) 2.39
The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch. Nat Cell Biol (2013) 1.46
Commitment to a cellular transition precedes genome-wide transcriptional change. Mol Cell (2011) 1.31
Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts. Mol Cell (2010) 1.25
Systems biology by the rules: hybrid intelligent systems for pathway modeling and discovery. BMC Syst Biol (2007) 1.13
Mechanism of APC/CCDC20 activation by mitotic phosphorylation. Proc Natl Acad Sci U S A (2016) 0.96
Vitamin K-dependent proteins in Ciona intestinalis, a basal chordate lacking a blood coagulation cascade. Proc Natl Acad Sci U S A (2006) 0.92
Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches. Proc Natl Acad Sci U S A (2012) 0.89
Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability. Mol Cancer Ther (2008) 0.88
Phosphorylation of mixed lineage leukemia 5 by CDC2 affects its cellular distribution and is required for mitotic entry. J Biol Chem (2010) 0.86
Cell-Size Control. Cold Spring Harb Perspect Biol (2016) 0.86
Punctuated cyclin synthesis drives early embryonic cell cycle oscillations. Mol Biol Cell (2011) 0.84
Simple rules for complex processes: new lessons from the budding yeast cell cycle. Mol Cell (2011) 0.83
The coupling of pathways and processes through shared components. BMC Syst Biol (2011) 0.80
PP2A(Cdc55) Phosphatase Imposes Ordered Cell-Cycle Phosphorylation by Opposing Threonine Phosphorylation. Mol Cell (2017) 0.78
Positive Feedback Keeps Duration of Mitosis Temporally Insulated from Upstream Cell-Cycle Events. Mol Cell (2016) 0.77
Rescuing US biomedical research from its systemic flaws. Proc Natl Acad Sci U S A (2014) 14.78
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc Natl Acad Sci U S A (2003) 10.82
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae. Nat Biotechnol (2002) 8.37
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science (2012) 6.79
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol (2004) 6.61
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature (2002) 6.26
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol (2002) 5.58
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol (2003) 4.89
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell (2004) 4.21
Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr Biol (2004) 4.20
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
Cell growth and size homeostasis in proliferating animal cells. Science (2009) 3.89
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature (2008) 3.77
Protein architecture of the human kinetochore microtubule attachment site. Cell (2009) 3.68
The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Mol Cell (2002) 3.65
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature (2004) 3.63
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature (2004) 3.62
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature (2012) 3.44
The incoherent feedforward loop can provide fold-change detection in gene regulation. Mol Cell (2009) 3.38
An actin-based wave generator organizes cell motility. PLoS Biol (2007) 3.36
Aurora B is enriched at merotelic attachment sites, where it regulates MCAK. Curr Biol (2006) 3.22
Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis. Curr Biol (2002) 3.17
Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Mol Cell (2005) 3.14
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. Science (2010) 3.13
The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes Dev (2003) 3.04
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell (2006) 2.91
Using buoyant mass to measure the growth of single cells. Nat Methods (2010) 2.67
Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell (2002) 2.56
Kinetochore attachments require an interaction between unstructured tails on microtubules and Ndc80(Hec1). Curr Biol (2008) 2.38
Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol (2004) 2.36
Direct observation of mammalian cell growth and size regulation. Nat Methods (2012) 2.34
The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. Curr Biol (2004) 2.31
Phosphorylation regulates SIRT1 function. PLoS One (2008) 2.30
Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation. Science (2008) 2.28
Purification and architecture of the ubiquitous Wave complex. Proc Natl Acad Sci U S A (2004) 2.25
The reversibility of mitotic exit in vertebrate cells. Nature (2006) 2.16
UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex. Proc Natl Acad Sci U S A (2010) 2.15
Phosphorylation analysis by mass spectrometry: myths, facts, and the consequences for qualitative and quantitative measurements. Mol Cell Proteomics (2005) 2.12
Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Mol Cell (2009) 2.11
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol (2004) 2.11
Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A (2004) 2.08
Activation of the WAVE complex by coincident signals controls actin assembly. Mol Cell (2009) 2.08
Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Mol Cell (2005) 2.05
Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions. Nature (2013) 2.02
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol (2004) 1.99
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J (2003) 1.98
Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell (2007) 1.97
A general lack of compensation for gene dosage in yeast. Mol Syst Biol (2010) 1.96
Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly. J Cell Biol (2008) 1.91
Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. Curr Biol (2005) 1.88
Self-assembly of filopodia-like structures on supported lipid bilayers. Science (2010) 1.87
Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS. Proc Natl Acad Sci U S A (2005) 1.83
Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. Proc Natl Acad Sci U S A (2003) 1.77
Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility. Dev Cell (2011) 1.76
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes Dev (2010) 1.74
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila. Dev Cell (2006) 1.71
Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function. Mol Biol Cell (2007) 1.66
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal (2011) 1.62
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell (2003) 1.56
Measuring the stoichiometry and physical interactions between components elucidates the architecture of the vertebrate kinetochore. Mol Biol Cell (2005) 1.52
Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein. Proc Natl Acad Sci U S A (2004) 1.51
Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature (2013) 1.50
Complement activation on B lymphocytes opsonized with rituximab or ofatumumab produces substantial changes in membrane structure preceding cell lysis. J Immunol (2008) 1.46
A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J Biol Chem (2002) 1.40
Optimizing optical flow cytometry for cell volume-based sorting and analysis. PLoS One (2011) 1.39
Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. J Cell Biol (2004) 1.39
Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev (2010) 1.38
The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm. Development (2003) 1.35
Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis. Proc Natl Acad Sci U S A (2008) 1.34
Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin. Chromosoma (2007) 1.32
Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts. Mol Cell (2010) 1.25
Spindle poisons and cell fate: a tale of two pathways. Mol Interv (2011) 1.24
Need-based up-regulation of protein levels in response to deletion of their duplicate genes. PLoS Biol (2010) 1.24
Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae. Eukaryot Cell (2005) 1.24
Kinetic responses of β-catenin specify the sites of Wnt control. Science (2012) 1.23
Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays. Proc Natl Acad Sci U S A (2009) 1.23
Linking kinetochore-microtubule binding to the spindle checkpoint. Dev Cell (2008) 1.21
A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis. Development (2005) 1.20
Xenopus Cep57 is a novel kinetochore component involved in microtubule attachment. Cell (2007) 1.17
The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus. Development (2009) 1.15
Multimodal microtubule binding by the Ndc80 kinetochore complex. Nat Struct Mol Biol (2012) 1.15
FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides. J Proteome Res (2009) 1.15
Gap 1 phase length and mouse embryonic stem cell self-renewal. Proc Natl Acad Sci U S A (2012) 1.15
Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem Biol (2006) 1.12
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. J Biol Chem (2012) 1.12
Remodeling of the metabolome during early frog development. PLoS One (2011) 1.12
Profiling of ubiquitin-like modifications reveals features of mitotic control. Cell (2013) 1.12
Cell cycle adaptations of embryonic stem cells. Proc Natl Acad Sci U S A (2011) 1.11
The Ndc80 complex: integrating the kinetochore's many movements. Chromosome Res (2011) 1.11
ICIS and Aurora B coregulate the microtubule depolymerase Kif2a. Curr Biol (2009) 1.08
Size homeostasis in adherent cells studied by synthetic phase microscopy. Proc Natl Acad Sci U S A (2013) 1.07
The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein. J Cell Biol (2011) 1.07
Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex. Nat Cell Biol (2013) 1.06
Cep57, a multidomain protein with unique microtubule and centrosomal localization domains. Biochem J (2008) 1.06
Graded positional information: interpretation for both fate and guidance. Cell (2003) 1.05
The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement. Mol Biol Cell (2011) 1.05
The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. J Cell Sci (2007) 1.04