Published in Mol Cell on April 15, 2005
Effects of sister chromatid cohesion proteins on cut gene expression during wing development in Drosophila. Development (2005) 2.25
Cohesin: a catenase with separate entry and exit gates? Nat Cell Biol (2011) 2.11
Cohesin's DNA exit gate is distinct from its entrance gate and is regulated by acetylation. Cell (2012) 1.75
Clustering of phosphorylation site recognition motifs can be exploited to predict the targets of cyclin-dependent kinase. Genome Biol (2007) 1.63
How cohesin and CTCF cooperate in regulating gene expression. Chromosome Res (2009) 1.62
Cohesion fatigue induces chromatid separation in cells delayed at metaphase. Curr Biol (2011) 1.60
The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells. EMBO J (2009) 1.58
Sororin cooperates with the acetyltransferase Eco2 to ensure DNA replication-dependent sister chromatid cohesion. Proc Natl Acad Sci U S A (2010) 1.41
Cerebellum development and medulloblastoma. Curr Top Dev Biol (2011) 1.40
Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis. Nat Cell Biol (2012) 1.38
The Smc complexes in DNA damage response. Cell Biosci (2012) 1.31
Age-related aneuploidy through cohesion exhaustion. EMBO Rep (2012) 1.31
Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion. Nat Struct Mol Biol (2014) 1.30
Sister chromatid cohesion. Cold Spring Harb Perspect Biol (2012) 1.30
Cancer biomarker discovery: the entropic hallmark. PLoS One (2010) 1.26
Sister acts: coordinating DNA replication and cohesion establishment. Genes Dev (2010) 1.24
PIASgamma is required for faithful chromosome segregation in human cells. PLoS One (2006) 1.21
Structural insights into anaphase-promoting complex function and mechanism. Philos Trans R Soc Lond B Biol Sci (2011) 1.17
Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion. EMBO J (2009) 1.15
Regulation of sororin by Cdk1-mediated phosphorylation. J Cell Sci (2011) 1.08
A matter of choice: the establishment of sister chromatid cohesion. EMBO Rep (2009) 1.07
Cohesin-independent segregation of sister chromatids in budding yeast. Mol Biol Cell (2011) 1.06
Diverse developmental disorders from the one ring: distinct molecular pathways underlie the cohesinopathies. Front Genet (2012) 1.06
Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin. Proc Natl Acad Sci U S A (2013) 1.05
DNA damage associated with mitosis and cytokinesis failure. Oncogene (2013) 1.04
Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion. J Biol Chem (2011) 1.03
Pds5 promotes and protects cohesin acetylation. Proc Natl Acad Sci U S A (2013) 1.03
Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl. Genes Dev (2012) 1.02
A conserved motif at the C terminus of sororin is required for sister chromatid cohesion. J Biol Chem (2010) 0.99
A fast workflow for identification and quantification of proteomes. Mol Cell Proteomics (2013) 0.98
Sororin is a master regulator of sister chromatid cohesion and separation. Cell Cycle (2012) 0.98
Gas2l3, a novel constriction site-associated protein whose regulation is mediated by the APC/C Cdh1 complex. PLoS One (2013) 0.96
Cohesin's ATPase activity couples cohesin loading onto DNA with Smc3 acetylation. Curr Biol (2014) 0.96
Mechanism of APC/CCDC20 activation by mitotic phosphorylation. Proc Natl Acad Sci U S A (2016) 0.96
Structure of the human cohesin inhibitor Wapl. Proc Natl Acad Sci U S A (2013) 0.95
Processive ubiquitin chain formation by the anaphase-promoting complex. Semin Cell Dev Biol (2011) 0.95
Cohesin is dispensable for centromere cohesion in human cells. PLoS One (2007) 0.94
Cohesin codes - interpreting chromatin architecture and the many facets of cohesin function. J Cell Sci (2013) 0.94
Releasing Activity Disengages Cohesin's Smc3/Scc1 Interface in a Process Blocked by Acetylation. Mol Cell (2016) 0.94
Complex elaboration: making sense of meiotic cohesin dynamics. FEBS J (2015) 0.93
Functional genomics identifies a requirement of pre-mRNA splicing factors for sister chromatid cohesion. EMBO J (2014) 0.91
SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs. EMBO J (2014) 0.91
Sororin pre-mRNA splicing is required for proper sister chromatid cohesion in human cells. EMBO Rep (2014) 0.90
Characterization of the interaction between the cohesin subunits Rad21 and SA1/2. PLoS One (2013) 0.89
Shugoshins: tension-sensitive pericentromeric adaptors safeguarding chromosome segregation. Mol Cell Biol (2014) 0.89
Cohesin acetylation promotes sister chromatid cohesion only in association with the replication machinery. J Biol Chem (2012) 0.88
Deducing protein function by forensic integrative cell biology. PLoS Biol (2013) 0.87
C-terminus of Sororin interacts with SA2 and regulates sister chromatid cohesion. Cell Cycle (2015) 0.86
CDCA5 overexpression is an indicator of poor prognosis in patients with urothelial carcinomas of the upper urinary tract and urinary bladder. Am J Transl Res (2015) 0.86
Crystal Structure of the Cohesin Gatekeeper Pds5 and in Complex with Kleisin Scc1. Cell Rep (2016) 0.85
Replication factor C complexes play unique pro- and anti-establishment roles in sister chromatid cohesion. PLoS One (2010) 0.85
UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells. EMBO Rep (2014) 0.85
Cohesin gene mutations in tumorigenesis: from discovery to clinical significance. BMB Rep (2014) 0.85
The roles of cohesins in mitosis, meiosis, and human health and disease. Methods Mol Biol (2014) 0.82
Borealin is repressed in response to p53/Rb signaling. Cell Biol Int (2007) 0.82
Drosophila Dalmatian combines sororin and shugoshin roles in establishment and protection of cohesion. EMBO J (2017) 0.81
Sororin actively maintains sister chromatid cohesion. EMBO J (2016) 0.80
Quantitative analysis of cohesin complex stoichiometry and SMC3 modification-dependent protein interactions. J Proteome Res (2011) 0.80
Nonparametric Bayesian evaluation of differential protein quantification. J Proteome Res (2013) 0.79
Linking chromosome duplication and segregation via sister chromatid cohesion. Methods Mol Biol (2014) 0.79
A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly. Sci Rep (2015) 0.79
Sororin loads to the synaptonemal complex central region independently of meiotic cohesin complexes. EMBO Rep (2016) 0.79
The Xenopus ORFeome: A resource that enables functional genomics. Dev Biol (2015) 0.78
Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome. Dis Model Mech (2015) 0.76
Post-Translational Modification Profiling-a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems. Curr Protoc Protein Sci (2014) 0.76
Therapeutic potential of targeting cell division cycle associated 5 for oral squamous cell carcinoma. Oncotarget (2016) 0.76
Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA. EMBO J (2016) 0.75
Opposing Functions of the N-terminal Acetyltransferases Naa50 and NatA in Sister-chromatid Cohesion. J Biol Chem (2016) 0.75
Sororin is enriched at the central region of synapsed meiotic chromosomes. Chromosome Res (2017) 0.75
SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A-B56. Cell Cycle (2015) 0.75
The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex. Biol Open (2014) 0.75
Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse. Cell Rep (2016) 0.75
Sororin is tethered to Cohesin SA2. Cell Cycle (2015) 0.75
Involvement of the Cohesin Cofactor PDS5 (SPO76) During Meiosis and DNA Repair in Arabidopsis thaliana. Front Plant Sci (2015) 0.75
Age-Related Loss of Cohesion: Causes and Effects. Int J Mol Sci (2017) 0.75
Enzyme-substrate relationships in the ubiquitin system: approaches for identifying substrates of ubiquitin ligases. Cell Mol Life Sci (2017) 0.75
In Favor of Establishment: Regulation of Chromatid Cohesion in Plants. Front Plant Sci (2017) 0.75
Esco1 and Esco2 regulate distinct cohesin functions during cell cycle progression. Proc Natl Acad Sci U S A (2017) 0.75
Rescuing US biomedical research from its systemic flaws. Proc Natl Acad Sci U S A (2014) 14.78
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc Natl Acad Sci U S A (2003) 10.82
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science (2012) 6.79
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature (2002) 6.26
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol (2002) 5.58
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol (2003) 4.89
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell (2004) 4.21
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
Cell growth and size homeostasis in proliferating animal cells. Science (2009) 3.89
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature (2004) 3.63
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature (2004) 3.62
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature (2012) 3.44
The incoherent feedforward loop can provide fold-change detection in gene regulation. Mol Cell (2009) 3.38
An actin-based wave generator organizes cell motility. PLoS Biol (2007) 3.36
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell (2006) 2.91
Using buoyant mass to measure the growth of single cells. Nat Methods (2010) 2.67
Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol (2004) 2.36
Direct observation of mammalian cell growth and size regulation. Nat Methods (2012) 2.34
Purification and architecture of the ubiquitous Wave complex. Proc Natl Acad Sci U S A (2004) 2.25
UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex. Proc Natl Acad Sci U S A (2010) 2.15
Phosphorylation analysis by mass spectrometry: myths, facts, and the consequences for qualitative and quantitative measurements. Mol Cell Proteomics (2005) 2.12
Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Mol Cell (2009) 2.11
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol (2004) 2.11
Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A (2004) 2.08
Activation of the WAVE complex by coincident signals controls actin assembly. Mol Cell (2009) 2.08
Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions. Nature (2013) 2.02
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol (2004) 1.99
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J (2003) 1.98
Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell (2007) 1.97
A general lack of compensation for gene dosage in yeast. Mol Syst Biol (2010) 1.96
Self-assembly of filopodia-like structures on supported lipid bilayers. Science (2010) 1.87
Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS. Proc Natl Acad Sci U S A (2005) 1.83
Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. Proc Natl Acad Sci U S A (2003) 1.77
Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility. Dev Cell (2011) 1.76
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes Dev (2010) 1.74
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell (2003) 1.56
Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature (2013) 1.50
A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J Biol Chem (2002) 1.40
Optimizing optical flow cytometry for cell volume-based sorting and analysis. PLoS One (2011) 1.39
Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. J Cell Biol (2004) 1.39
Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev (2010) 1.38
The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm. Development (2003) 1.35
Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis. Proc Natl Acad Sci U S A (2008) 1.34
Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts. Mol Cell (2010) 1.25
Need-based up-regulation of protein levels in response to deletion of their duplicate genes. PLoS Biol (2010) 1.24
Kinetic responses of β-catenin specify the sites of Wnt control. Science (2012) 1.23
Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays. Proc Natl Acad Sci U S A (2009) 1.23
A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis. Development (2005) 1.20
Timing of events in mitosis. Curr Biol (2002) 1.20
The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus. Development (2009) 1.15
Gap 1 phase length and mouse embryonic stem cell self-renewal. Proc Natl Acad Sci U S A (2012) 1.15
FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides. J Proteome Res (2009) 1.15
Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem Biol (2006) 1.12
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. J Biol Chem (2012) 1.12
Remodeling of the metabolome during early frog development. PLoS One (2011) 1.12
Profiling of ubiquitin-like modifications reveals features of mitotic control. Cell (2013) 1.12
Cell cycle adaptations of embryonic stem cells. Proc Natl Acad Sci U S A (2011) 1.11
Size homeostasis in adherent cells studied by synthetic phase microscopy. Proc Natl Acad Sci U S A (2013) 1.07
Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex. Nat Cell Biol (2013) 1.06
Graded positional information: interpretation for both fate and guidance. Cell (2003) 1.05
The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. J Cell Sci (2007) 1.04
Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrula. Development (2003) 1.02
Anaphase specific auto-cleavage of separase. FEBS Lett (2002) 1.01
The relationship between evolutionary and physiological variation in hemoglobin. Proc Natl Acad Sci U S A (2007) 1.01
Redundant ubiquitin ligase activities regulate wee1 degradation and mitotic entry. Cell Cycle (2007) 1.00
Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster. Anal Chem (2012) 0.98
Domain structure of separase and its binding to securin as determined by EM. Nat Struct Mol Biol (2005) 0.98
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9. Proc Natl Acad Sci U S A (2013) 0.96
SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Rep (2013) 0.93
Exploiting polypharmacology for drug target deconvolution. Proc Natl Acad Sci U S A (2014) 0.93
Activation domain-dependent degradation of somatic Wee1 kinase. J Biol Chem (2009) 0.92
The anaphase promoting complex induces substrate degradation during neuronal differentiation. J Biol Chem (2008) 0.90
Identification of ubiquitin ligase substrates by in vitro expression cloning. Methods Enzymol (2005) 0.89
Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Dev Cell (2005) 0.88
In vitro reconstitution of cdc42-mediated actin assembly using purified components. Methods Enzymol (2006) 0.87
An ultra-high throughput cell-based screen for wee1 degradation inhibitors. J Biomol Screen (2010) 0.87
Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts. Methods Enzymol (2006) 0.87
Epigenetic pathways and glioblastoma treatment. Epigenetics (2013) 0.85
Protein microarrays for genome-wide posttranslational modification analysis. Wiley Interdiscip Rev Syst Biol Med (2010) 0.84
Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated. J Am Chem Soc (2014) 0.84
Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. Proc Natl Acad Sci U S A (2013) 0.83
Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway. Cancer Res (2002) 0.80
Post-Translational Modification Profiling-a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems. Curr Protoc Protein Sci (2014) 0.76
Epigenetic pathways and glioblastoma treatment: insights from signaling cascades. J Cell Biochem (2015) 0.75
GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Cell Cycle (2015) 0.75
Screening of cell cycle fusion proteins to identify kinase signaling networks. Cell Cycle (2015) 0.75