Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics.

PubWeight™: 1.24‹?› | Rank: Top 10%

🔗 View Article (PMC 3919211)

Published in Gastroenterology on June 08, 2013

Authors

Nicholas T Ventham1, Nicholas A Kennedy, Elaine R Nimmo, Jack Satsangi

Author Affiliations

1: Gastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland. nventham@staffmail.ed.ac.uk

Articles citing this

Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives. Gastroenterology (2013) 1.24

MicroRNAs: new players in IBD. Gut (2014) 1.07

Inflammatory Bowel Disease: Genetics, Epigenetics, and Pathogenesis. Front Immunol (2015) 0.98

Role of the enteric microbiota in intestinal homeostasis and inflammation. Free Radic Biol Med (2013) 0.98

Differential diagnosis in inflammatory bowel disease colitis: state of the art and future perspectives. World J Gastroenterol (2015) 0.95

Natural history and long-term clinical course of Crohn's disease. World J Gastroenterol (2014) 0.92

Epigenetic control of intestinal barrier function and inflammation in zebrafish. Proc Natl Acad Sci U S A (2015) 0.91

Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci. Inflamm Bowel Dis (2014) 0.89

Mucosal healing and deep remission: what does it mean? World J Gastroenterol (2013) 0.87

Gastrointestinal mucosal barrier function and diseases. J Gastroenterol (2016) 0.85

Genome-wide analysis of DNA methylation and gene expression defines molecular characteristics of Crohn's disease-associated fibrosis. Clin Epigenetics (2016) 0.81

Characteristics of Japanese inflammatory bowel disease susceptibility loci. J Gastroenterol (2013) 0.81

Changing incidence of inflammatory bowel disease: environmental influences and lessons learnt from the South asian population. Front Pediatr (2013) 0.81

Pathogenesis of Crohn's disease. F1000Prime Rep (2015) 0.81

Interaction of dietary fatty acids with tumour necrosis factor family cytokines during colon inflammation and cancer. Mediators Inflamm (2014) 0.80

Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory Diseases. Inflamm Bowel Dis (2015) 0.80

Fibrogenesis and fibrosis in inflammatory bowel diseases: Good and bad side of same coin? World J Gastrointest Pathophysiol (2013) 0.80

DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis. J Crohns Colitis (2015) 0.80

Influence of environmental factors in the development of inflammatory bowel diseases. World J Gastrointest Pharmacol Ther (2016) 0.80

Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases? Curr Opin Immunol (2014) 0.79

Biomarkers in Search of Precision Medicine in IBD. Am J Gastroenterol (2016) 0.79

Microbiome-Epigenome Interactions and the Environmental Origins of Inflammatory Bowel Diseases. J Pediatr Gastroenterol Nutr (2016) 0.78

Protective and pro-inflammatory roles of intestinal bacteria. Pathophysiology (2016) 0.77

Intestinal Microbiota and the Innate Immune System - A Crosstalk in Crohn's Disease Pathogenesis. Front Immunol (2015) 0.77

Systematic meta-analyses and field synopsis of genetic and epigenetic studies in paediatric inflammatory bowel disease. Sci Rep (2016) 0.77

Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease. Mucosal Immunol (2015) 0.77

Mucosal transcriptomics implicates under expression of BRINP3 in the pathogenesis of ulcerative colitis. Inflamm Bowel Dis (2014) 0.77

Mucosal Immune Development in Early Life: Setting the Stage. Arch Immunol Ther Exp (Warsz) (2015) 0.77

Common NOD2/CARD15 and TLR4 Polymorphisms Are Associated with Crohn's Disease Phenotypes in Southeastern Brazilians. Dig Dis Sci (2016) 0.77

Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents. J Immunol Res (2016) 0.76

The histone deacetylase Hdac1 regulates inflammatory signalling in intestinal epithelial cells. J Inflamm (Lond) (2014) 0.76

Nutritional Modulation of Gene Expression: Might This be of Benefit to Individuals with Crohn's Disease? Front Immunol (2015) 0.76

Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease. Nat Commun (2016) 0.75

Effects of Herb-Partitioned Moxibustion on the miRNA Expression Profiles in Colon from Rats with DSS-Induced Ulcerative Colitis. Evid Based Complement Alternat Med (2017) 0.75

Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease. Gut Microbes (2017) 0.75

Genetic and epigenetic regulation of intestinal fibrosis. United European Gastroenterol J (2016) 0.75

A Potential Role of Salmonella Infection in the Onset of Inflammatory Bowel Diseases. Front Immunol (2017) 0.75

Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease. Nutrients (2016) 0.75

Increased duodenal expression of miR-146a and -155 in pediatric Crohn's disease. World J Gastroenterol (2016) 0.75

A Genome-Wide Methylation Approach Identifies a New Hypermethylated Gene Panel in Ulcerative Colitis. Int J Mol Sci (2016) 0.75

How to Apply for and Secure EU Funding for Collaborative IBD Research Projects. J Crohns Colitis (2016) 0.75

Gender differences in paediatric patients of the swiss inflammatory bowel disease cohort study. Pediatr Gastroenterol Hepatol Nutr (2014) 0.75

The IBD interactome: an integrated view of aetiology, pathogenesis and therapy. Nat Rev Gastroenterol Hepatol (2017) 0.75

Diet, Gut Microbiome and Epigenetics: Emerging Links with Inflammatory Bowel Diseases and Prospects for Management and Prevention. Nutrients (2017) 0.75

Articles cited by this

(truncated to the top 100)

MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59

An integrated encyclopedia of DNA elements in the human genome. Nature (2012) 64.73

Chromatin modifications and their function. Cell (2007) 55.98

The impact of microRNAs on protein output. Nature (2008) 32.39

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20

Unravelling the pathogenesis of inflammatory bowel disease. Nature (2007) 18.52

Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet (2008) 18.28

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62

Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology (2011) 12.09

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med (2007) 9.80

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet (2006) 9.56

Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol (2003) 9.30

Epigenetic inheritance at the agouti locus in the mouse. Nat Genet (1999) 9.14

Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. Genet Med (2011) 9.03

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98

Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96

Genetics and pathogenesis of inflammatory bowel disease. Nature (2011) 7.79

Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol (2010) 7.75

Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med (2009) 7.53

Functions of site-specific histone acetylation and deacetylation. Annu Rev Biochem (2007) 7.49

Epigenetic modifications and human disease. Nat Biotechnol (2010) 7.29

Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene (2007) 7.13

Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science (2001) 6.79

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1) Nature (1996) 6.72

Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med (2007) 6.61

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol (2013) 5.89

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol (2009) 5.83

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med (2009) 5.43

An epigenetic mutation responsible for natural variation in floral symmetry. Nature (1999) 5.32

CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet (2002) 5.31

Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis (2003) 5.19

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet (2008) 5.05

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61

Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med (2012) 4.41

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet (2009) 4.25

The molecular classification of the clinical manifestations of Crohn's disease. Gastroenterology (2002) 4.20

Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature (2010) 4.04

Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet (2010) 4.03

Predicting lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res (2000) 3.65

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nat Genet (2011) 3.59

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut (2009) 3.55

MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha. Gastroenterology (2008) 3.29

Transgenerational epigenetic effects. Annu Rev Genomics Hum Genet (2008) 3.16

Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res (2001) 3.02

New IBD genetics: common pathways with other diseases. Gut (2011) 2.95

Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum Mol Genet (2009) 2.85

Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J Exp Med (2005) 2.72

Lack of common NOD2 variants in Japanese patients with Crohn's disease. Gastroenterology (2002) 2.71

Increasing incidence of paediatric inflammatory bowel disease in Ontario, Canada: evidence from health administrative data. Gut (2009) 2.62

Genomics and the multifactorial nature of human autoimmune disease. N Engl J Med (2011) 2.52

Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood. Hum Mol Genet (2011) 2.48

Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains. PLoS Pathog (2009) 2.35

Plasma miR-21: a potential diagnostic marker of colorectal cancer. Ann Surg (2012) 2.35

DNA methylation and gene silencing in cancer: which is the guilty party? Oncogene (2002) 2.23

Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment. PLoS Med (2010) 2.20

Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients. Cancer Res (2001) 2.18

Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNFα therapy: results from the COIN study. Gut (2012) 2.15

Recent insights into the genetics of inflammatory bowel disease. Gastroenterology (2011) 2.12

Infant colitis--it's in the genes. Lancet (2010) 2.10

Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes. Genes Dev (2002) 2.10

Histone hyperacetylation is associated with amelioration of experimental colitis in mice. J Immunol (2006) 2.09

Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice. PLoS Genet (2006) 2.07

Allele-specific DNA methylation: beyond imprinting. Hum Mol Genet (2010) 1.98

Insulin gene expression is regulated by DNA methylation. PLoS One (2009) 1.97

MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function. Gastroenterology (2010) 1.95

Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS One (2010) 1.93

Identification of microRNAs associated with ileal and colonic Crohn's disease. Inflamm Bowel Dis (2010) 1.89

Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway. Inflamm Bowel Dis (2011) 1.88

Topical butyrate improves efficacy of 5-ASA in refractory distal ulcerative colitis: results of a multicentre trial. Eur J Clin Invest (2003) 1.86

Geographical variability and environmental risk factors in inflammatory bowel disease. Gut (2013) 1.84

The genetic and epigenetic basis of type 2 diabetes and obesity. Clin Pharmacol Ther (2012) 1.84

New therapies for inflammatory bowel disease: from the bench to the bedside. Gut (2011) 1.84

The epigenome: archive of the prenatal environment. Epigenetics (2009) 1.82

Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet (2010) 1.81

Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology (2009) 1.81

Methylation changes in faecal DNA: a marker for colorectal cancer screening? Lancet (2004) 1.80

Fidelity of the methylation pattern and its variation in the genome. Genome Res (2003) 1.71

Timing is everything: the when and how of environmentally induced changes in the epigenome of animals. Epigenetics (2011) 1.67

De novo DNA methylation: a germ cell perspective. Trends Genet (2011) 1.66

Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. PLoS One (2010) 1.54

STAT4: genetics, mechanisms, and implications for autoimmunity. Curr Allergy Asthma Rep (2008) 1.53

Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum (2011) 1.52

Butyrate inhibits NF-kappaB activation in lamina propria macrophages of patients with ulcerative colitis. Scand J Gastroenterol (2002) 1.52

Histone deacetylase inhibitors in inflammatory disease. Curr Top Med Chem (2009) 1.46

HLA-DRB1*1502 allele, subtype of DR15, is associated with susceptibility to ulcerative colitis and its progression. Dig Dis Sci (1995) 1.45

STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk. Ann Rheum Dis (2008) 1.42

Peripheral blood microRNAs distinguish active ulcerative colitis and Crohn's disease. Inflamm Bowel Dis (2010) 1.38

Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis. J Gastroenterol Hepatol (2010) 1.38

Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformation. Inflamm Bowel Dis (2011) 1.33

Transgenerational epigenetic inheritance: how important is it? Nat Rev Genet (2013) 1.32

Gene-environment interactions in chronic inflammatory disease. Nat Immunol (2011) 1.30

Circulating microRNA is a biomarker of pediatric Crohn disease. J Pediatr Gastroenterol Nutr (2011) 1.29

Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer. Gut (2001) 1.29

Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat. Gut (1996) 1.28

Epigenetic regulation of TLR4 gene expression in intestinal epithelial cells for the maintenance of intestinal homeostasis. J Immunol (2009) 1.28

Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes. Hum Mol Genet (2011) 1.26

Articles by these authors

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27

Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol (2005) 10.16

Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98

Guidelines for the management of inflammatory bowel disease in adults. Gut (2011) 5.42

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet (2008) 4.96

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61

Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology (2008) 4.05

Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet (2009) 3.82

Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31

Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet (2009) 3.19

IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology (2007) 2.97

New genes in inflammatory bowel disease: lessons for complex diseases? Lancet (2006) 2.72

Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype. Am J Gastroenterol (2004) 2.53

NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut (2011) 2.26

Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection. Hepatology (2003) 2.23

Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. Gastroenterology (2008) 2.17

Prevalence of CARD15/NOD2 mutations in Caucasian healthy people. Am J Gastroenterol (2007) 2.14

The hedgehog signalling pathway in the gastrointestinal tract: implications for development, homeostasis, and disease. Gastroenterology (2005) 2.12

The genetics of Crohn's disease. Annu Rev Genomics Hum Genet (2009) 2.07

Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway. Inflamm Bowel Dis (2011) 1.88

Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease. Hum Mol Genet (2010) 1.82

Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet (2010) 1.81

Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature (2013) 1.79

Genotype-phenotype analysis in childhood-onset Crohn's disease: NOD2/CARD15 variants consistently predict phenotypic characteristics of severe disease. Inflamm Bowel Dis (2005) 1.55

Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis. Gastroenterology (2005) 1.49

Does cigarette smoking influence the phenotype of Crohn's disease? Analysis using the Montreal classification. Am J Gastroenterol (2007) 1.43

Incidence of juvenile-onset Crohn's disease in Scotland: association with northern latitude and affluence. Gastroenterology (2004) 1.36

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet (2011) 1.30

Smoking habit and load influence age at diagnosis and disease extent in ulcerative colitis. Am J Gastroenterol (2007) 1.24

The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease. Gastroenterology (2005) 1.21

The diagnostic accuracy of fecal calprotectin during the investigation of suspected pediatric inflammatory bowel disease. Am J Gastroenterol (2012) 1.16

Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history. Expert Rev Gastroenterol Hepatol (2009) 1.15

The genetics of inflammatory bowel disease. Am J Gastroenterol (2007) 1.14

Systematic review: the role of breastfeeding in the development of pediatric inflammatory bowel disease. J Pediatr (2009) 1.13

Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis. Inflamm Bowel Dis (2010) 1.10

Molecular genetics of Crohn's disease. Curr Opin Genet Dev (2004) 1.06

PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. Inflamm Bowel Dis (2009) 1.06

Genetics of the innate immune response in inflammatory bowel disease. Inflamm Bowel Dis (2007) 1.05

Disease location, anti-Saccharomyces cerevisiae antibody, and NOD2/CARD15 genotype influence the progression of disease behavior in Crohn's disease. Inflamm Bowel Dis (2004) 1.03

Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. PLoS Med (2008) 1.02

Rising incidence of pediatric inflammatory bowel disease in Scotland. Inflamm Bowel Dis (2011) 1.02

Dysregulation of human beta-defensin-2 protein in inflammatory bowel disease. PLoS One (2009) 1.01

Genetics of childhood-onset inflammatory bowel disease. Inflamm Bowel Dis (2011) 1.00

Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin G glycome. Inflamm Bowel Dis (2015) 1.00

Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis. Gastroenterology (2011) 0.97

Potential role for the common cystic fibrosis DeltaF508 mutation in Crohn's disease. Inflamm Bowel Dis (2007) 0.91

The intermediate filament protein, vimentin, is a regulator of NOD2 activity. Gut (2012) 0.91

Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci. Inflamm Bowel Dis (2014) 0.89

Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study. Inflamm Bowel Dis (2010) 0.88

Resolution of non-small-cell lung cancer after withdrawal of anti-TNF therapy. N Engl J Med (2008) 0.87

Investigation of NOD1/CARD4 variation in inflammatory bowel disease using a haplotype-tagging strategy. Hum Mol Genet (2007) 0.86

The clinical course of ulcerative colitis after orthotopic liver transplantation for primary sclerosing cholangitis: further appraisal of immunosuppression post transplantation. Eur J Gastroenterol Hepatol (2005) 0.86

Does nicotine influence cytokine profile and subsequent cell cycling/apoptotic responses in inflammatory bowel disease? Inflamm Bowel Dis (2008) 0.85

Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis. PLoS One (2009) 0.85

Infliximab use in Crohn's disease: impact on health care resources in the UK. Eur J Gastroenterol Hepatol (2005) 0.85

Characterisation of osteoprotegerin autoantibodies in coeliac disease. Calcif Tissue Int (2015) 0.85

TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease. Gastroenterology (2011) 0.84

Predicting the need for colectomy in severe ulcerative colitis: a critical appraisal of clinical parameters and currently available biomarkers. Gut (2011) 0.83

Detailed haplotype-tagging study of germline variation of MUC19 in inflammatory bowel disease. Inflamm Bowel Dis (2010) 0.82

Esophageal adenocarcinoma and hypertrophic osteoarthropathy with improvement following resection of esophageal cancer. J Clin Rheumatol (2011) 0.82

Association of DLG5 and inflammatory bowel disease across populations. Eur J Hum Genet (2006) 0.82

Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells. PLoS One (2011) 0.81

Contribution of CARD15 variants in determining susceptibility to Crohn's disease in Sweden. Scand J Gastroenterol (2006) 0.81

Novel susceptibility genes in inflammatory bowel disease. World J Gastroenterol (2006) 0.81

Technology insight: the application of proteomics in gastrointestinal disease. Nat Clin Pract Gastroenterol Hepatol (2007) 0.81

Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway. FEBS J (2010) 0.81