Published in PLoS One on July 20, 2009
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis (2010) 1.84
Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease. Hum Mol Genet (2010) 1.82
Antimicrobial peptides and gut microbiota in homeostasis and pathology. EMBO Mol Med (2013) 1.17
Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. PLoS One (2009) 1.16
Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implications. J Physiol Pharmacol (2009) 1.13
Irritable bowel syndrome: emerging paradigm in pathophysiology. World J Gastroenterol (2014) 1.03
Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing. BMC Genomics (2010) 0.93
Inflammatory bowel disease: an impaired barrier disease. Langenbecks Arch Surg (2012) 0.91
Antimicrobial proteins in intestine and inflammatory bowel diseases. Intest Res (2014) 0.88
Antimicrobial peptides in gastrointestinal inflammation. Int J Inflam (2010) 0.86
Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin. PLoS One (2014) 0.85
Host defense peptide resistance contributes to colonization and maximal intestinal pathology by Crohn's disease-associated adherent-invasive Escherichia coli. Infect Immun (2014) 0.83
Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells. PLoS One (2011) 0.81
Differential regulation of interleukin-8 and human beta-defensin 2 in Pseudomonas aeruginosa-infected intestinal epithelial cells. BMC Microbiol (2014) 0.81
Association studies of the copy-number variable ß-defensin cluster on 8p23.1 in adenocarcinoma and chronic pancreatitis. BMC Res Notes (2012) 0.81
Modulation of porcine β-defensins 1 and 2 upon individual and combined Fusarium toxin exposure in a swine jejunal epithelial cell line. Appl Environ Microbiol (2013) 0.80
Growth of M. avium subspecies paratuberculosis in culture is enhanced by nicotinic acid, nicotinamide, and α and β nicotinamide adenine dinucleotide. Dig Dis Sci (2010) 0.77
De Novo sphingolipid synthesis is essential for Salmonella-induced autophagy and human beta-defensin 2 expression in intestinal epithelial cells. Gut Pathog (2016) 0.76
Narrowing down the distal border of the copy number variable beta-defensin gene cluster on human 8p23. BMC Res Notes (2014) 0.76
The N-terminal fragment of chromogranin A, vasostatin-1 protects mice from acute or chronic colitis upon oral administration. Dig Dis Sci (2012) 0.76
Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period. PLoS Pathog (2016) 0.75
Recent Trends in Pharmacological Activity of Alkaloids in Animal Colitis: Potential Use for Inflammatory Bowel Disease. Evid Based Complement Alternat Med (2017) 0.75
Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function. Cell Mol Gastroenterol Hepatol (2017) 0.75
The Interplay between Defensins and Microbiota in Crohn's Disease. Mediators Inflamm (2017) 0.75
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell (1989) 11.19
Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol (2005) 10.16
Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl (1989) 9.56
Psoriasis is associated with increased beta-defensin genomic copy number. Nat Genet (2007) 8.07
A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet (2006) 5.10
Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A (2005) 5.05
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet (2008) 4.96
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut (2004) 4.39
Effects of cigarette smoke on the immune system. Nat Rev Immunol (2002) 4.38
Activation of nuclear factor kappa B inflammatory bowel disease. Gut (1998) 4.14
IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J Immunol (2004) 3.84
Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster. Am J Hum Genet (2003) 3.27
Molecular analysis of the gut microbiota of identical twins with Crohn's disease. ISME J (2008) 2.96
Transdermal nicotine for active ulcerative colitis. N Engl J Med (1994) 2.90
Accurate, high-throughput typing of copy number variation using paralogue ratios from dispersed repeats. Nucleic Acids Res (2006) 2.64
Human beta-defensins. Cell Mol Life Sci (2006) 2.57
IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut (2008) 2.50
NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium. Infect Immun (2004) 2.47
Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis (2003) 2.06
NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. J Biol Chem (2005) 2.06
Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. J Immunol (2004) 2.05
Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23. Genomics (2005) 1.97
NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe? Genes Immun (2004) 1.94
Correlation between beta-defensin expression and induction profiles in gingival keratinocytes. Mol Immunol (2004) 1.90
Inflammatory bowel disease: epidemiology and management in an English general practice population. Aliment Pharmacol Ther (2000) 1.84
Increased expression of antimicrobial peptides and lysozyme in colonic epithelial cells of patients with ulcerative colitis. Clin Exp Immunol (2003) 1.70
Inflammatory bowel disease and smoking: a review of epidemiology, pathophysiology, and therapeutic implications. Inflamm Bowel Dis (2004) 1.65
Probiotic lactobacilli and VSL#3 induce enterocyte beta-defensin 2. Clin Exp Immunol (2008) 1.57
Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis. Gut (2008) 1.53
Nicotine administration and withdrawal affect survival in systemic inflammation models. J Appl Physiol (1985) (2008) 1.48
Does cigarette smoking influence the phenotype of Crohn's disease? Analysis using the Montreal classification. Am J Gastroenterol (2007) 1.43
Defining complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes. Inflamm Bowel Dis (2003) 1.42
Incidence of juvenile-onset Crohn's disease in Scotland: association with northern latitude and affluence. Gastroenterology (2004) 1.36
ADP ribosylation of human neutrophil peptide-1 regulates its biological properties. Proc Natl Acad Sci U S A (2002) 1.34
Allelic recombination between distinct genomic locations generates copy number diversity in human beta-defensins. Proc Natl Acad Sci U S A (2009) 1.33
Paneth cells: their role in innate immunity and inflammatory disease. Gut (2005) 1.32
Impact of cessation of smoking on the course of ulcerative colitis. Am J Gastroenterol (2001) 1.27
Effects of current and former cigarette smoking on the clinical course of Crohn's disease. Aliment Pharmacol Ther (1999) 1.27
High-resolution mapping of the 8p23.1 beta-defensin cluster reveals strictly concordant copy number variation of all genes. Hum Mutat (2008) 1.25
Smoking habit and load influence age at diagnosis and disease extent in ulcerative colitis. Am J Gastroenterol (2007) 1.24
Nicotine and cotinine in the cervical mucus of smokers, passive smokers, and nonsmokers. Cancer Epidemiol Biomarkers Prev (1993) 1.14
Reduced mucosal antimicrobial activity in Crohn's disease of the colon. Gut (2007) 1.11
Transdermal nicotine for induction of remission in ulcerative colitis. Cochrane Database Syst Rev (2004) 1.08
Nicotine and oxidative cigarette smoke constituents induce immune-modulatory and pro-inflammatory dendritic cell responses. Mol Immunol (2008) 1.08
Effects of nicotine on the immune response. I. Chronic exposure to nicotine impairs antigen receptor-mediated signal transduction in lymphocytes. Toxicol Appl Pharmacol (1995) 1.07
Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin. PLoS One (2009) 1.06
ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. J Biol Chem (2006) 1.01
Chronic nicotine administration differentially alters jejunal and colonic inflammation in interleukin-10 deficient mice. Eur J Gastroenterol Hepatol (2002) 0.97
NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation. Trends Microbiol (2006) 0.95
The pharmacological actions of nicotine on the gastrointestinal tract. J Pharmacol Sci (2004) 0.95
Nicotine inhibits cytokine synthesis by mouse colonic mucosa. Eur J Pharmacol (1995) 0.94
IL-12, IL-23, and IL-27 enhance human beta-defensin-2 production in human keratinocytes. Eur J Immunol (2008) 0.92
Dual effect of chronic nicotine administration: augmentation of jejunitis and amelioration of colitis induced by iodoacetamide in rats. Int J Colorectal Dis (2001) 0.88
Defensin expression in chronic pouchitis in patients with ulcerative colitis or familial adenomatous polyposis coli. World J Gastroenterol (2006) 0.87
Does nicotine influence cytokine profile and subsequent cell cycling/apoptotic responses in inflammatory bowel disease? Inflamm Bowel Dis (2008) 0.85
Antimicrobial peptides in chronic anal fistula epithelium. Scand J Gastroenterol (2007) 0.84
An exuberant inflammatory response to E coli: implications for the pathogenesis of ulcerative colitis and pyoderma gangrenosum. Gut (2006) 0.83
Differential effects of Staphylococcal enterotoxin B-mediated immune activation on intestinal defensins. Clin Exp Immunol (2009) 0.82
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol (2005) 10.16
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Guidelines for the management of inflammatory bowel disease in adults. Gut (2011) 5.42
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet (2008) 4.96
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61
Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology (2008) 4.05
Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet (2009) 3.82
Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31
Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet (2009) 3.19
IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology (2007) 2.97
New genes in inflammatory bowel disease: lessons for complex diseases? Lancet (2006) 2.72
Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype. Am J Gastroenterol (2004) 2.53
NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut (2011) 2.26
Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection. Hepatology (2003) 2.23
Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. Gastroenterology (2008) 2.17
Prevalence of CARD15/NOD2 mutations in Caucasian healthy people. Am J Gastroenterol (2007) 2.14
The hedgehog signalling pathway in the gastrointestinal tract: implications for development, homeostasis, and disease. Gastroenterology (2005) 2.12
The genetics of Crohn's disease. Annu Rev Genomics Hum Genet (2009) 2.07
Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway. Inflamm Bowel Dis (2011) 1.88
Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease. Hum Mol Genet (2010) 1.82
Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet (2010) 1.81
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature (2013) 1.79
Genotype-phenotype analysis in childhood-onset Crohn's disease: NOD2/CARD15 variants consistently predict phenotypic characteristics of severe disease. Inflamm Bowel Dis (2005) 1.55
Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis. Gastroenterology (2005) 1.49
Does cigarette smoking influence the phenotype of Crohn's disease? Analysis using the Montreal classification. Am J Gastroenterol (2007) 1.43
Incidence of juvenile-onset Crohn's disease in Scotland: association with northern latitude and affluence. Gastroenterology (2004) 1.36
Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet (2011) 1.30
Smoking habit and load influence age at diagnosis and disease extent in ulcerative colitis. Am J Gastroenterol (2007) 1.24
Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics. Gastroenterology (2013) 1.24
The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease. Gastroenterology (2005) 1.21
Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history. Expert Rev Gastroenterol Hepatol (2009) 1.15
The genetics of inflammatory bowel disease. Am J Gastroenterol (2007) 1.14
Systematic review: the role of breastfeeding in the development of pediatric inflammatory bowel disease. J Pediatr (2009) 1.13
Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis. Inflamm Bowel Dis (2010) 1.10
Molecular genetics of Crohn's disease. Curr Opin Genet Dev (2004) 1.06
PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. Inflamm Bowel Dis (2009) 1.06
Genetics of the innate immune response in inflammatory bowel disease. Inflamm Bowel Dis (2007) 1.05
Disease location, anti-Saccharomyces cerevisiae antibody, and NOD2/CARD15 genotype influence the progression of disease behavior in Crohn's disease. Inflamm Bowel Dis (2004) 1.03
Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. PLoS Med (2008) 1.02
Rising incidence of pediatric inflammatory bowel disease in Scotland. Inflamm Bowel Dis (2011) 1.02
Genetics of childhood-onset inflammatory bowel disease. Inflamm Bowel Dis (2011) 1.00
Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin G glycome. Inflamm Bowel Dis (2015) 1.00
Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis. Gastroenterology (2011) 0.97
Three-dimensional representation software as image enhancement tool in small-bowel capsule endoscopy: a feasibility study. Dig Liver Dis (2013) 0.96
Potential role for the common cystic fibrosis DeltaF508 mutation in Crohn's disease. Inflamm Bowel Dis (2007) 0.91
The intermediate filament protein, vimentin, is a regulator of NOD2 activity. Gut (2012) 0.91
Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci. Inflamm Bowel Dis (2014) 0.89
Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study. Inflamm Bowel Dis (2010) 0.88
Resolution of non-small-cell lung cancer after withdrawal of anti-TNF therapy. N Engl J Med (2008) 0.87
Investigation of NOD1/CARD4 variation in inflammatory bowel disease using a haplotype-tagging strategy. Hum Mol Genet (2007) 0.86
The clinical course of ulcerative colitis after orthotopic liver transplantation for primary sclerosing cholangitis: further appraisal of immunosuppression post transplantation. Eur J Gastroenterol Hepatol (2005) 0.86
Does nicotine influence cytokine profile and subsequent cell cycling/apoptotic responses in inflammatory bowel disease? Inflamm Bowel Dis (2008) 0.85
Infliximab use in Crohn's disease: impact on health care resources in the UK. Eur J Gastroenterol Hepatol (2005) 0.85
Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis. PLoS One (2009) 0.85
Characterisation of osteoprotegerin autoantibodies in coeliac disease. Calcif Tissue Int (2015) 0.85
TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease. Gastroenterology (2011) 0.84
Predicting the need for colectomy in severe ulcerative colitis: a critical appraisal of clinical parameters and currently available biomarkers. Gut (2011) 0.83
Detailed haplotype-tagging study of germline variation of MUC19 in inflammatory bowel disease. Inflamm Bowel Dis (2010) 0.82
Association of DLG5 and inflammatory bowel disease across populations. Eur J Hum Genet (2006) 0.82
Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells. PLoS One (2011) 0.81
Technology insight: the application of proteomics in gastrointestinal disease. Nat Clin Pract Gastroenterol Hepatol (2007) 0.81
Novel susceptibility genes in inflammatory bowel disease. World J Gastroenterol (2006) 0.81
Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway. FEBS J (2010) 0.81
Contribution of CARD15 variants in determining susceptibility to Crohn's disease in Sweden. Scand J Gastroenterol (2006) 0.81
Association of FcgR2a, but not FcgR3a, with inflammatory bowel diseases across three Caucasian populations. Inflamm Bowel Dis (2010) 0.80
Use of methotrexate in refractory Crohn's disease: the Edinburgh experience. Inflamm Bowel Dis (2008) 0.79
Genes in inflammatory bowel disease: lessons from complex diseases. Clin Med (2011) 0.79
A role for vimentin in Crohn disease. Autophagy (2012) 0.79
Serum C-reactive protein and CRP genotype in pediatric inflammatory bowel disease: influence on phenotype, natural history, and response to therapy. Inflamm Bowel Dis (2015) 0.79
Contribution of the IBD5 locus to Crohn's disease in the Swedish population. Scand J Gastroenterol (2007) 0.78
Hedgehog, paneth cells, and colon cancer: a cautionary note for the use of systemic agonists/antagonists. Gastroenterology (2006) 0.77
More pediatric NOD2/CARD data. Am J Gastroenterol (2004) 0.76
Haplotype-tagging analysis of common variants of the IL23R gene demonstrates gene-wide extent of association with IBD. Inflamm Bowel Dis (2013) 0.76
Role of infliximab in ulcerative colitis: further questions. Inflamm Bowel Dis (2006) 0.76
Multidrug resistance (MDR1) gene in inflammatory bowel disease: a key player? Inflamm Bowel Dis (2005) 0.76
Pharmacogenetics and inflammatory bowel disease: progress and prospects. Inflamm Bowel Dis (2004) 0.76
Azathioprine and anti-TNF alpha therapies in Crohn's disease: a review of pharmacology, clinical efficacy and safety. Pharmacol Res (2003) 0.76
Barrett's esophagus: evolutionary insights from genomics. Gastroenterology (2013) 0.76
Correction: changes to serum sample tube and processing methodology does not cause inter-individual variation in automated whole serum N-glycan profiling in health and disease. PLoS One (2015) 0.75
Early combined immunosuppression in Crohn's disease. Lancet (2008) 0.75
Killing of Escherichia coli by Crohn's Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D. Inflamm Bowel Dis (2015) 0.75
Variation in ICOSLG influences Crohn's disease susceptibility. Gut (2011) 0.75
Therapeutic options in acute severe ulcerative colitis. Expert Rev Gastroenterol Hepatol (2008) 0.75
Nationwide linkage analysis in Scotland-Has mortality following hospital admission for Crohn's disease changed in the early 21st century? J Crohns Colitis (2014) 0.75
Predicting outcomes in acute severe ulcerative colitis. Expert Rev Gastroenterol Hepatol (2014) 0.75
Sight-threatening keratopathy complicating anti-TNF therapy in Crohn's disease: a case report. Inflamm Bowel Dis (2014) 0.75