Published in Nature on July 17, 2013
Sphingolipid metabolites in inflammatory disease. Nature (2014) 2.19
Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts. J Lipid Res (2014) 0.96
Use of proteins as biomarkers and their role in carcinogenesis. J Cancer (2015) 0.93
Sphingomyelinase D/ceramide 1-phosphate in cell survival and inflammation. Toxins (Basel) (2015) 0.91
Cellular and molecular interactions of phosphoinositides and peripheral proteins. Chem Phys Lipids (2014) 0.89
Arabidopsis accelerated cell death 11, ACD11, is a ceramide-1-phosphate transfer protein and intermediary regulator of phytoceramide levels. Cell Rep (2014) 0.87
Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation. Nat Cell Biol (2016) 0.86
Ceramide induced mitophagy and tumor suppression. Biochim Biophys Acta (2015) 0.84
Autophagy in the light of sphingolipid metabolism. Apoptosis (2015) 0.84
The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and cancer cells. Expert Opin Ther Targets (2013) 0.82
Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex. EMBO Rep (2015) 0.81
Glucosylceramide Contained in Koji Mold-Cultured Cereal Confers Membrane and Flavor Modification and Stress Tolerance to Saccharomyces cerevisiae during Coculture Fermentation. Appl Environ Microbiol (2015) 0.80
Phosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells. J Biol Chem (2014) 0.80
Anaplasma phagocytophilum Rab10-dependent parasitism of the trans-Golgi network is critical for completion of the infection cycle. Cell Microbiol (2015) 0.79
Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis. Biochim Biophys Acta (2015) 0.79
Lipid Mediators of Allergic Disease: Pathways, Treatments, and Emerging Therapeutic Targets. Curr Allergy Asthma Rep (2016) 0.78
Resolution of sterile inflammation: role for vitamin C. Mediators Inflamm (2014) 0.78
Computational modeling of sphingolipid metabolism. BMC Syst Biol (2015) 0.78
Arachidonic acid-derived signaling lipids and functions in impaired healing. Wound Repair Regen (2015) 0.77
Trafficking and Functions of Bioactive Sphingolipids: Lessons from Cells and Model Membranes. Lipid Insights (2015) 0.77
Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells. J Biol Chem (2015) 0.76
Sphingolipid transfer proteins defined by the GLTP-fold. Q Rev Biophys (2015) 0.76
Membrane-spanning lipids for an uncompromised monitoring of membrane fusion and intermembrane lipid transfer. J Lipid Res (2015) 0.76
Profile of Dinshaw J. Patel. Proc Natl Acad Sci U S A (2015) 0.75
Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis. Cancer Res (2016) 0.75
Investigation of the biophysical properties of a fluorescently modified ceramide-1-phosphate. Chem Phys Lipids (2016) 0.75
Phosphatidylserine stimulates ceramide-1-phosphate (C1P) intermembrane transfer by C1P transfer proteins. J Biol Chem (2016) 0.75
Sphingolipids and Lipoproteins in Health and Metabolic Disorders. Trends Endocrinol Metab (2017) 0.75
Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients. J Lipid Res (2017) 0.75
Lipidomics in translational research and the clinical significance of lipid-based biomarkers. Transl Res (2017) 0.75
Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol (2008) 12.34
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov (2008) 5.78
Molecular machinery for non-vesicular trafficking of ceramide. Nature (2003) 5.19
Lipid signalling in disease. Nat Rev Mol Cell Biol (2008) 4.85
Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopy. J Cell Sci (1992) 4.64
Sphingosine-1-phosphate signaling and its role in disease. Trends Cell Biol (2011) 2.97
Protein families and their evolution-a structural perspective. Annu Rev Biochem (2005) 2.45
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J Cell Sci (2005) 2.07
Structure of human phosphatidylcholine transfer protein in complex with its ligand. Nat Struct Biol (2002) 2.01
Non-vesicular lipid transport by lipid-transfer proteins and beyond. Nat Rev Mol Cell Biol (2010) 1.84
Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology. Trends Mol Med (2008) 1.77
Divergence and convergence in enzyme evolution. J Biol Chem (2011) 1.56
The interface of protein structure, protein biophysics, and molecular evolution. Protein Sci (2012) 1.54
Structural basis for glycosphingolipid transfer specificity. Nature (2004) 1.46
Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc Natl Acad Sci U S A (2008) 1.39
Lipidomic analysis of dynamic eicosanoid responses during the induction and resolution of Lyme arthritis. J Biol Chem (2009) 1.36
Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease. Prog Lipid Res (2010) 1.28
Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels. J Lipid Res (2009) 1.21
Lipid trafficking sans vesicles: where, why, how? Cell (2010) 1.19
Phosphate recognition in structural biology. Angew Chem Int Ed Engl (2007) 1.17
Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis. J Lipid Res (2007) 1.14
Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase: comparative analysis to glucosylceramide and sphingomyelin. J Biol Chem (2007) 1.13
Ceramide 1-phosphate is required for the translocation of group IVA cytosolic phospholipase A2 and prostaglandin synthesis. J Biol Chem (2009) 1.10
Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex. J Biol Chem (2005) 1.04
For whom the bell tolls? DING proteins in health and disease. Cell Mol Life Sci (2009) 1.02
Localization and function of cytosolic phospholipase A2alpha at the Golgi. Biochimie (2010) 1.01
Tektin 2 is required for central spindle microtubule organization and the completion of cytokinesis. J Cell Biol (2008) 1.00
Amphiastral mitotic spindle assembly in vertebrate cells lacking centrosomes. Curr Biol (2011) 0.99
Ceramide kinase: the first decade. Cell Signal (2010) 0.97
Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. Structure (2010) 0.94
Ceramide kinase and the ceramide-1-phosphate/cPLA2alpha interaction as a therapeutic target. Curr Drug Targets (2008) 0.91
Human glycolipid transfer protein (GLTP) genes: organization, transcriptional status and evolution. BMC Genomics (2008) 0.87
A PLA1-2 punch regulates the Golgi complex. Trends Cell Biol (2011) 0.86
Enhanced selectivity for sulfatide by engineered human glycolipid transfer protein. Structure (2011) 0.82
Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature (2006) 7.70
Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature (2005) 7.12
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature (2008) 5.78
Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chem Biol (2004) 5.44
Structure of the guide-strand-containing argonaute silencing complex. Nature (2008) 5.36
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature (2009) 5.24
Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol Cell (2005) 4.11
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature (2012) 4.08
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell (2013) 3.92
Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch. Nature (2006) 3.90
Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell (2006) 3.87
Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense. Genes Dev (2006) 3.77
Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. J Am Chem Soc (2004) 3.74
Recognition of small interfering RNA by a viral suppressor of RNA silencing. Nature (2003) 3.36
Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold. J Am Chem Soc (2006) 3.26
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature (2009) 3.13
TRIM24 links a non-canonical histone signature to breast cancer. Nature (2010) 2.99
Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science (2010) 2.98
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature (2008) 2.86
Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta (2002) 2.69
Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell (2011) 2.68
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature (2013) 2.67
Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. Mol Cell (2006) 2.63
Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: distinct topologies, thermodynamic properties, and folding/unfolding kinetics. J Am Chem Soc (2003) 2.52
Ribozymes, riboswitches and beyond: regulation of gene expression without proteins. Nat Rev Genet (2007) 2.52
Knockout of Arabidopsis accelerated-cell-death11 encoding a sphingosine transfer protein causes activation of programmed cell death and defense. Genes Dev (2002) 2.51
Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat Struct Mol Biol (2005) 2.50
Dicer recognizes the 5' end of RNA for efficient and accurate processing. Nature (2011) 2.49
Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger. Mol Cell (2007) 2.47
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell (2010) 2.44
Structural insights into amino acid binding and gene control by a lysine riboswitch. Nature (2008) 2.41
The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x. J Cell Biol (2007) 2.39
Structure of yeast Argonaute with guide RNA. Nature (2012) 2.38
Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat Struct Mol Biol (2006) 2.29
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J Am Chem Soc (2007) 2.26
Dual binding of chromomethylase domains to H3K9me2-containing nucleosomes directs DNA methylation in plants. Cell (2012) 2.19
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nat Struct Mol Biol (2011) 2.18
Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I. Nat Struct Mol Biol (2010) 2.13
The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J (2003) 2.10
Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution. Nucleic Acids Res (2007) 2.09
The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome. Nature (2012) 2.07
Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1. Nat Struct Mol Biol (2008) 2.00
Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter. Nat Chem Biol (2005) 2.00
Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution. Nucleic Acids Res (2006) 1.98
DNA architecture: from G to Z. Curr Opin Struct Biol (2006) 1.97
Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch. Nature (2009) 1.90
Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion. PLoS Biol (2006) 1.89
RNA-Puzzles: a CASP-like evaluation of RNA three-dimensional structure prediction. RNA (2012) 1.88
Concerted motions in HIV-1 TAR RNA may allow access to bound state conformations: RNA dynamics from NMR residual dipolar couplings. J Mol Biol (2002) 1.86
Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell (2013) 1.82
Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature (2013) 1.82
A poised chromatin platform for TGF-β access to master regulators. Cell (2011) 1.81
A site-specific low-enrichment (15)N,(13)C isotope-labeling approach to unambiguous NMR spectral assignments in nucleic acids. J Am Chem Soc (2002) 1.77
Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. J Biol Chem (2003) 1.76
Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers. J Am Chem Soc (2009) 1.74
An interlocked dimeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integrase. Proc Natl Acad Sci U S A (2005) 1.71
The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure. PLoS Biol (2006) 1.70
Structural insights into RNA recognition by the alternate-splicing regulator CUG-binding protein 1. Structure (2010) 1.67
Structural insights into ligand recognition by a sensing domain of the cooperative glycine riboswitch. Mol Cell (2010) 1.66
DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition. Nature (2012) 1.65
SAP155 Binds to ceramide-responsive RNA cis-element 1 and regulates the alternative 5' splice site selection of Bcl-x pre-mRNA. FASEB J (2006) 1.65
Structure-based mechanistic insights into DNMT1-mediated maintenance DNA methylation. Science (2012) 1.64
Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis. J Cell Biol (2008) 1.64
Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases. Structure (2009) 1.59
Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets. Structure (2003) 1.56
Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers. J Biol Chem (2003) 1.52
(3 + 1) Assembly of three human telomeric repeats into an asymmetric dimeric G-quadruplex. J Am Chem Soc (2005) 1.51
Metabolite recognition principles and molecular mechanisms underlying riboswitch function. Annu Rev Biophys (2012) 1.47
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem (2003) 1.47
Structural basis for glycosphingolipid transfer specificity. Nature (2004) 1.46
Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation. Mol Biol Cell (2005) 1.45
Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery. Biopolymers (2002) 1.43
A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes Dev (2011) 1.43
An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol Cell (2012) 1.43
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood (2006) 1.41
Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains. Proc Natl Acad Sci U S A (2010) 1.40
Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction. Nat Struct Mol Biol (2011) 1.38
Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a. Cancer Res (2010) 1.34
The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol Pharmacol (2005) 1.33
Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2 alpha and enhances the interaction of the enzyme with phosphatidylcholine. J Biol Chem (2005) 1.30
Phase diagrams of lipid mixtures relevant to the study of membrane rafts. Biochim Biophys Acta (2008) 1.29
Ceramide-1-phosphate binds group IVA cytosolic phospholipase a2 via a novel site in the C2 domain. J Biol Chem (2007) 1.27
Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc Natl Acad Sci U S A (2013) 1.26
Fluoride ion encapsulation by Mg2+ ions and phosphates in a fluoride riboswitch. Nature (2012) 1.26
Lesion processing: high-fidelity versus lesion-bypass DNA polymerases. Trends Biochem Sci (2008) 1.24
Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension. Circ Heart Fail (2012) 1.23
SRp30a (ASF/SF2) regulates the alternative splicing of caspase-9 pre-mRNA and is required for ceramide-responsiveness. J Lipid Res (2006) 1.23
A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia. Nucleic Acids Res (2010) 1.22
Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels. J Lipid Res (2009) 1.21