Published in J Am Chem Soc on September 05, 2013
Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB-siRNA conjugates. Nucleic Acids Res (2014) 0.92
Direct cytosolic delivery of siRNA using nanoparticle-stabilized nanocapsules. Angew Chem Int Ed Engl (2014) 0.92
Therapeutic applications of an expanded genetic code. Chembiochem (2014) 0.82
Enhancing Accumulation and Penetration of HPMA Copolymer-Doxorubicin Conjugates in 2D and 3D Prostate Cancer Cells via iRGD Conjugation with an MMP-2 Cleavable Spacer. J Am Chem Soc (2015) 0.81
EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex. J Biomed Sci (2015) 0.80
A specific aptamer-cell penetrating peptides complex delivered siRNA efficiently and suppressed prostate tumor growth in vivo. Cancer Biol Ther (2016) 0.75
In Vivo Evaluation of Site-Specifically PEGylated Chemically Self-Assembled Protein Nanostructures. Mol Pharm (2016) 0.75
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RNAi-mediated gene silencing in non-human primates. Nature (2006) 7.60
Expanding the genetic code of Escherichia coli. Science (2001) 7.25
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol (2005) 6.40
Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat Biotechnol (2006) 6.30
The HER-2 receptor and breast cancer: ten years of targeted anti-HER-2 therapy and personalized medicine. Oncologist (2009) 6.00
The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters. Proc Natl Acad Sci U S A (2000) 5.81
Arming antibodies: prospects and challenges for immunoconjugates. Nat Biotechnol (2005) 5.80
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nat Biotechnol (2008) 5.54
RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu Rev Pharmacol Toxicol (2010) 4.86
T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell (2008) 4.32
Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Nat Biotechnol (2008) 4.29
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nat Biotechnol (2007) 4.02
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat Biotechnol (2009) 3.78
Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science (2008) 3.51
Genetic incorporation of unnatural amino acids into proteins in mammalian cells. Nat Methods (2007) 3.45
Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes. Proc Natl Acad Sci U S A (2007) 3.30
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nat Nanotechnol (2012) 3.09
Addition of the keto functional group to the genetic code of Escherichia coli. Proc Natl Acad Sci U S A (2002) 2.84
Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell (2012) 2.83
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses. Nat Biotechnol (2009) 2.76
Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles. Proc Natl Acad Sci U S A (2009) 2.72
Single-stranded siRNAs activate RNAi in animals. Cell (2012) 2.64
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates. Nat Biotechnol (2012) 2.43
Targeted quantum dot conjugates for siRNA delivery. Bioconjug Chem (2007) 2.31
Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy. Mol Ther (2010) 2.30
Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1. Proc Natl Acad Sci U S A (2007) 2.27
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids. Proc Natl Acad Sci U S A (2012) 1.99
Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Sci Transl Med (2012) 1.86
Silencing disease genes in the laboratory and the clinic. J Pathol (2011) 1.72
siRNA conjugate delivery systems. Bioconjug Chem (2009) 1.69
Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers. Nucleic Acids Res (2012) 1.47
Antibody-linked spherical nucleic acids for cellular targeting. J Am Chem Soc (2012) 1.34
Cellular uptake of aminoglycosides, guanidinoglycosides, and poly-arginine. J Am Chem Soc (2003) 1.31
Special delivery: targeted therapy with small RNAs. Gene Ther (2011) 1.22
Synthesis of bispecific antibodies using genetically encoded unnatural amino acids. J Am Chem Soc (2012) 1.14
Novel binding and efficient cellular uptake of guanidine-based peptide nucleic acids (GPNA). J Am Chem Soc (2003) 1.12
Synthesis at the interface of chemistry and biology. J Am Chem Soc (2009) 1.11
Site-specific DNA-antibody conjugates for specific and sensitive immuno-PCR. Proc Natl Acad Sci U S A (2012) 1.11
Cell-specific aptamer-mediated targeted drug delivery. Oligonucleotides (2010) 1.10
Site-specific coupling and sterically controlled formation of multimeric antibody fab fragments with unnatural amino acids. J Mol Biol (2011) 1.08
Medicinal chemistry of siRNA delivery. J Med Chem (2010) 1.04
LHRH receptor-mediated delivery of siRNA using polyelectrolyte complex micelles self-assembled from siRNA-PEG-LHRH conjugate and PEI. Bioconjug Chem (2008) 0.93
Receptor-mediated delivery of siRNAs by tethered nucleic acid base-paired interactions. RNA (2008) 0.92
Ligand-targeted delivery of small interfering RNAs to malignant cells and tissues. Ann N Y Acad Sci (2009) 0.90
Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing. Mol Ther Nucleic Acids (2012) 0.88
Self-assembled antibody multimers through peptide nucleic acid conjugation. J Am Chem Soc (2012) 0.86
T cell-specific siRNA delivery using antibody-conjugated chitosan nanoparticles. Bioconjug Chem (2012) 0.84
Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47
The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
The genetic architecture of maize flowering time. Science (2009) 9.27
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature (2007) 7.12
Adding new chemistries to the genetic code. Annu Rev Biochem (2010) 6.32
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A (2009) 5.86
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science (2010) 5.50
Genomic analysis of the host response to hepatitis C virus infection. Proc Natl Acad Sci U S A (2002) 5.28
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A (2008) 4.80
An expanded eukaryotic genetic code. Science (2003) 4.66
Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells. Nano Lett (2007) 4.37
Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A (2006) 3.83
Addition of a photocrosslinking amino acid to the genetic code of Escherichiacoli. Proc Natl Acad Sci U S A (2002) 3.77
Maize HapMap2 identifies extant variation from a genome in flux. Nat Genet (2012) 3.74
GAPIT: genome association and prediction integrated tool. Bioinformatics (2012) 3.66
Genetic incorporation of unnatural amino acids into proteins in mammalian cells. Nat Methods (2007) 3.45
Expanding the genetic code. Annu Rev Biophys Biomol Struct (2006) 3.36
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol (2008) 3.23
A stem cell-based approach to cartilage repair. Science (2012) 3.22
An enhanced system for unnatural amino acid mutagenesis in E. coli. J Mol Biol (2009) 3.20
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest (2009) 3.17
The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. Proc Natl Acad Sci U S A (2008) 3.13
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (2011) 3.07
Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. J Am Chem Soc (2002) 2.88
Addition of the keto functional group to the genetic code of Escherichia coli. Proc Natl Acad Sci U S A (2002) 2.84
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A (2009) 2.80
Expanding the genetic code. Angew Chem Int Ed Engl (2004) 2.78
Genomically recoded organisms expand biological functions. Science (2013) 2.73
Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A (2006) 2.65
An efficient rapid system for profiling the cellular activities of molecular libraries. Proc Natl Acad Sci U S A (2006) 2.51
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A (2013) 2.49
Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proc Natl Acad Sci U S A (2003) 2.45
A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. Proc Natl Acad Sci U S A (2008) 2.39
A chemical toolkit for proteins--an expanded genetic code. Nat Rev Mol Cell Biol (2006) 2.39
Improvement in oncology practice performance through voluntary participation in the Quality Oncology Practice Initiative. J Clin Oncol (2008) 2.39
Recombinant expression of selectively sulfated proteins in Escherichia coli. Nat Biotechnol (2006) 2.31
Genome-wide functional analysis of human cell-cycle regulators. Proc Natl Acad Sci U S A (2006) 2.31
Efficient incorporation of unnatural amino acids into proteins in Escherichia coli. Nat Methods (2006) 2.24
Genetic architecture of maize kernel composition in the nested association mapping and inbred association panels. Plant Physiol (2011) 2.20
Oxysterols direct immune cell migration via EBI2. Nature (2011) 2.19
Substrate recognition by the AAA+ chaperone ClpB. Nat Struct Mol Biol (2004) 2.19
An expanded genetic code with a functional quadruplet codon. Proc Natl Acad Sci U S A (2004) 2.09
Synthetic small molecules that control stem cell fate. Proc Natl Acad Sci U S A (2003) 2.06
A facile system for encoding unnatural amino acids in mammalian cells. Angew Chem Int Ed Engl (2009) 2.02
Control of protein phosphorylation with a genetically encoded photocaged amino acid. Nat Chem Biol (2007) 1.99
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids. Proc Natl Acad Sci U S A (2012) 1.99
Identification of small molecule activators of cryptochrome. Science (2012) 1.95
A role for chemistry in stem cell biology. Nat Biotechnol (2004) 1.95
A genetically encoded fluorescent amino acid. J Am Chem Soc (2006) 1.93
The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination. Nat Biotechnol (2004) 1.93
Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiae. J Am Chem Soc (2003) 1.93
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents. Clin Cancer Res (2012) 1.92
Exploring the limits of codon and anticodon size. Chem Biol (2002) 1.89
Distinct genetic architectures for male and female inflorescence traits of maize. PLoS Genet (2011) 1.88
A combinatorial scaffold approach toward kinase-directed heterocycle libraries. J Am Chem Soc (2002) 1.79
Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex. Science (2008) 1.79
A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. Proc Natl Acad Sci U S A (2006) 1.78
A small molecule primes embryonic stem cells for differentiation. Cell Stem Cell (2009) 1.78
A general approach to site-specific antibody drug conjugates. Proc Natl Acad Sci U S A (2014) 1.77
Directed evolution of the site specificity of Cre recombinase. Proc Natl Acad Sci U S A (2002) 1.77
Profiling protein function with small molecule microarrays. Proc Natl Acad Sci U S A (2002) 1.77
BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. Neuropsychopharmacology (2005) 1.74
An efficient system for the evolution of aminoacyl-tRNA synthetase specificity. Nat Biotechnol (2002) 1.73
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol (2009) 1.73
Accuracy and precision of the Pediatric Evaluation of Disability Inventory computer-adaptive tests (PEDI-CAT). Dev Med Child Neurol (2011) 1.73
A genetically encoded metabolically stable analogue of phosphotyrosine in Escherichia coli. ACS Chem Biol (2007) 1.72
An approach to genomewide screens of expressed small interfering RNAs in mammalian cells. Proc Natl Acad Sci U S A (2003) 1.71
A genetically encoded infrared probe. J Am Chem Soc (2006) 1.71
VisANT 4.0: Integrative network platform to connect genes, drugs, diseases and therapies. Nucleic Acids Res (2013) 1.71
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Proc Natl Acad Sci U S A (2003) 1.68
Progress toward an expanded eukaryotic genetic code. Chem Biol (2003) 1.66
A genetically encoded fluorescent amino acid. Proc Natl Acad Sci U S A (2006) 1.66
Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening. J Biol Chem (2007) 1.65
A genetically encoded photocaged amino acid. J Am Chem Soc (2004) 1.65
Site-directed spin labeling of a genetically encoded unnatural amino acid. Proc Natl Acad Sci U S A (2009) 1.65
A small-molecule inducer of the antioxidant response element. Chem Biol (2010) 1.65
Identification of a novel protein regulating microtubule stability through a chemical approach. Chem Biol (2004) 1.64
Small molecules that induce cardiomyogenesis in embryonic stem cells. J Am Chem Soc (2004) 1.63
Tom40 protein import channel binds to non-native proteins and prevents their aggregation. Nat Struct Biol (2003) 1.62
Generation of a bacterium with a 21 amino acid genetic code. J Am Chem Soc (2003) 1.62
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem Biol (2004) 1.60
A genetically encoded bidentate, metal-binding amino acid. Angew Chem Int Ed Engl (2007) 1.57
In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy. J Am Chem Soc (2008) 1.57
Dedifferentiation of lineage-committed cells by a small molecule. J Am Chem Soc (2004) 1.56
A genetically encoded photocaged tyrosine. Angew Chem Int Ed Engl (2006) 1.56
A general and efficient method for the site-specific dual-labeling of proteins for single molecule fluorescence resonance energy transfer. J Am Chem Soc (2008) 1.56
A genetically encoded boronate-containing amino acid. Angew Chem Int Ed Engl (2008) 1.54
Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation. J Am Chem Soc (2007) 1.54
Maternal mosaicism is a significant contributor to discordant sex chromosomal aneuploidies associated with noninvasive prenatal testing. Clin Chem (2013) 1.54
Beyond the canonical 20 amino acids: expanding the genetic lexicon. J Biol Chem (2010) 1.53
A new strategy for the site-specific modification of proteins in vivo. Biochemistry (2003) 1.52
Bispecific small molecule-antibody conjugate targeting prostate cancer. Proc Natl Acad Sci U S A (2013) 1.52
Enthalpy arrays. Proc Natl Acad Sci U S A (2004) 1.52
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc Natl Acad Sci U S A (2013) 1.51
Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice. Proc Natl Acad Sci U S A (2002) 1.51