Published in Zhongguo Zhong Xi Yi Jie He Za Zhi on July 01, 2013
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science (2012) 10.47
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature (2012) 9.89
The specific and essential role of MAVS in antiviral innate immune responses. Immunity (2006) 6.74
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42
Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell (2010) 5.83
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med (2014) 5.37
A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature (2012) 5.02
Novel mutations target distinct subgroups of medulloblastoma. Nature (2012) 4.82
Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature (2008) 4.76
Direct activation of protein kinases by unanchored polyubiquitin chains. Nature (2009) 4.65
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. Cancer Cell (2012) 4.41
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet (2009) 3.59
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet (2013) 3.51
The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat Genet (2013) 3.43
Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood (2011) 3.40
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature (2008) 3.11
Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response. Immunity (2012) 3.07
A distinct role for norepinephrine in memory retrieval. Cell (2004) 2.68
Association of age at diagnosis and genetic mutations in patients with neuroblastoma. JAMA (2012) 2.49
Two calcium-dependent protein kinases, CPK4 and CPK11, regulate abscisic acid signal transduction in Arabidopsis. Plant Cell (2007) 2.40
Quantitative measurement of interocular suppression in anisometropic amblyopia: a case-control study. Ophthalmology (2013) 2.17
Electronic signatures of all four DNA nucleosides in a tunneling gap. Nano Lett (2010) 1.83
Expression of high mobility group box chromosomal protein 1 and its modulating effects on downstream cytokines in systemic lupus erythematosus. J Rheumatol (2010) 1.78
MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus. Proc Natl Acad Sci U S A (2008) 1.74
Activation of MAPK kinase 9 induces ethylene and camalexin biosynthesis and enhances sensitivity to salt stress in Arabidopsis. J Biol Chem (2008) 1.64
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades. Elife (2013) 1.63
Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol (2009) 1.57
Cellulose synthase interactive protein 1 (CSI1) links microtubules and cellulose synthase complexes. Proc Natl Acad Sci U S A (2011) 1.57
Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts. Int J Cancer (2002) 1.56
A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans. J Immunol (2010) 1.55
Possible genomic imprinting of three human obesity-related genetic loci. Am J Hum Genet (2005) 1.54
Deletion of Nf1 in neurons induces increased axon collateral branching after dorsal root injury. J Neurosci (2007) 1.54
Mice deficient in MyD88 Develop a Th2-dominant response and severe pathology in the upper genital tract following Chlamydia muridarum infection. J Immunol (2010) 1.49
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Am J Hum Genet (2012) 1.49
Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project. Blood (2012) 1.47
Retroperitoneal laparoscopic dismembered pyeloplasty with a novel technique of JJ stenting in children. BJU Int (2011) 1.45
Decrease in rate of myopia progression with a contact lens designed to reduce relative peripheral hyperopia: one-year results. Invest Ophthalmol Vis Sci (2011) 1.41
scFv-mediated delivery of truncated BID suppresses HER2-positive osteosarcoma growth and metastasis. Cancer Biol Ther (2008) 1.40
A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J Immunol (2009) 1.39
Chlamydia vaccine candidates and tools for chlamydial antigen discovery. Expert Rev Vaccines (2009) 1.34
Characterization of Chlamydia trachomatis plasmid-encoded open reading frames. J Bacteriol (2013) 1.31
Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system. Mol Cell Biol (2005) 1.31
Identification of alpha-enolase as an autoantigen in lung cancer: its overexpression is associated with clinical outcomes. Clin Cancer Res (2006) 1.29
CD147/basigin promotes progression of malignant melanoma and other cancers. J Dermatol Sci (2010) 1.29
Hydrogen sulphide enhances photosynthesis through promoting chloroplast biogenesis, photosynthetic enzyme expression, and thiol redox modification in Spinacia oleracea seedlings. J Exp Bot (2011) 1.27
Intra/intermolecular direct allylic alkylation via Pd(II)-catalyzed allylic C-H activation. J Am Chem Soc (2008) 1.26
Wnt signaling in bone formation and its therapeutic potential for bone diseases. Ther Adv Musculoskelet Dis (2013) 1.25
Improvement of Aspergillus sulphureus endo-beta-1,4-xylanase expression in Pichia pastoris by codon optimization and analysis of the enzymic characterization. Appl Biochem Biotechnol (2009) 1.22
Characterization of Pgp3, a Chlamydia trachomatis plasmid-encoded immunodominant antigen. J Bacteriol (2010) 1.18
Effect of surface roughness on stain resistance of dental resin composites. J Esthet Restor Dent (2005) 1.17
Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance. Biochem Pharmacol (2008) 1.16
A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis. Cancer Lett (2008) 1.16
Glutathione-indole-3-acetonitrile is required for camalexin biosynthesis in Arabidopsis thaliana. Plant Cell (2011) 1.15
A novel two-step strategy for in vitro culture of early-stage ovarian follicles in the mouse. Fertil Steril (2009) 1.15
Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms. Int Immunopharmacol (2011) 1.14
Spectacle lenses designed to reduce progression of myopia: 12-month results. Optom Vis Sci (2010) 1.13
Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome. Hum Reprod (2010) 1.13
ATG16L1 T300A polymorphism and Crohn's disease susceptibility: evidence from 13,022 cases and 17,532 controls. Hum Genet (2009) 1.11
Conditionally immortalized mouse embryonic fibroblasts retain proliferative activity without compromising multipotent differentiation potential. PLoS One (2012) 1.11
RNA interference targeting the CD147 induces apoptosis of multi-drug resistant cancer cells related to XIAP depletion. Cancer Lett (2008) 1.10
Antibodies from women urogenitally infected with C. trachomatis predominantly recognized the plasmid protein pgp3 in a conformation-dependent manner. BMC Microbiol (2008) 1.10
PKCλ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP. EMBO J (2013) 1.10
Never smokers and lung cancer risk: a case-control study of epidemiological factors. Int J Cancer (2006) 1.10
Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance. Biochem Pharmacol (2009) 1.09
Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin. J Mol Biol (2007) 1.09
Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10). PLoS One (2009) 1.09
Protective effect of Ulinastatin against murine models of sepsis: inhibition of TNF-α and IL-6 and augmentation of IL-10 and IL-13. Exp Toxicol Pathol (2010) 1.09
Frequency and distribution in East Asia of 12 mutations identified in the SLC25A13 gene of Japanese patients with citrin deficiency. J Hum Genet (2005) 1.09
Rhodium-catalyzed direct addition of aryl C-H bonds to N-sulfonyl aldimines. Angew Chem Int Ed Engl (2011) 1.09
A sign-component-based framework for Chinese sign language recognition using accelerometer and sEMG data. IEEE Trans Biomed Eng (2012) 1.08
Optofluidic planar reactors for photocatalytic water treatment using solar energy. Biomicrofluidics (2010) 1.08
Secretion of the chlamydial virulence factor CPAF requires the Sec-dependent pathway. Microbiology (2010) 1.08
Growth hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells. J Bone Miner Res (2012) 1.08
A genome-wide association analysis of Framingham Heart Study longitudinal data using multivariate adaptive splines. BMC Proc (2009) 1.08
Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1. J Biol Chem (2006) 1.07
Chlamydia trachomatis secretion of hypothetical protein CT622 into host cell cytoplasm via a secretion pathway that can be inhibited by the type III secretion system inhibitor compound 1. Microbiology (2011) 1.07
Early evaluation of cancer response by a new functional biomarker: apparent diffusion coefficient. AJR Am J Roentgenol (2011) 1.06
Oviduct infection and hydrosalpinx in DBA1/j mice is induced by intracervical but not intravaginal inoculation with Chlamydia muridarum. PLoS One (2013) 1.06
Apple sucrose transporter SUT1 and sorbitol transporter SOT6 interact with cytochrome b5 to regulate their affinity for substrate sugars. Plant Physiol (2009) 1.06
Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier. Mol Vis (2007) 1.06
Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events. Stem Cell Res (2012) 1.05
ED handoffs: observed practices and communication errors. Am J Emerg Med (2010) 1.04
Maximal conditional chi-square importance in random forests. Bioinformatics (2010) 1.04
The chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosol. BMC Microbiol (2011) 1.04
The effectiveness of progressive addition lenses on the progression of myopia in Chinese children. Ophthalmic Physiol Opt (2009) 1.02
Complexes with mixed primary and secondary cellulose synthases are functional in Arabidopsis plants. Plant Physiol (2012) 1.01
Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. Development (2003) 1.01
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol (2012) 1.01
Expression and localization of Hsps in the heart and blood vessel of heat-stressed broilers. Cell Stress Chaperones (2008) 1.01
miR-33a functions as a tumor suppressor in melanoma by targeting HIF-1α. Cancer Biol Ther (2015) 1.00
Protein kinase C isoforms differentially phosphorylate Ca(v)1.2 alpha(1c). Biochemistry (2009) 1.00
Negative regulation of transcription factor FoxM1 by p53 enhances oxaliplatin-induced senescence in hepatocellular carcinoma. Cancer Lett (2012) 1.00
Willows: a memory efficient tree and forest construction package. BMC Bioinformatics (2009) 1.00
Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity. Exp Mol Med (2008) 1.00
Autoprocessing and self-activation of the secreted protease CPAF in Chlamydia-infected cells. Microb Pathog (2010) 1.00
BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells. J Cell Sci (2012) 0.99
Prevalence and severity of chronic kidney disease and anemia in the nursing home population. J Am Med Dir Assoc (2009) 0.99