Published in Plant Cell on October 05, 2007
Guard cell signal transduction network: advances in understanding abscisic acid, CO2, and Ca2+ signaling. Annu Rev Plant Biol (2010) 3.87
Differential innate immune signalling via Ca(2+) sensor protein kinases. Nature (2010) 3.03
ABA-mediated transcriptional regulation in response to osmotic stress in plants. J Plant Res (2011) 2.98
Calcium signals: the lead currency of plant information processing. Plant Cell (2010) 2.87
Early abscisic acid signal transduction mechanisms: newly discovered components and newly emerging questions. Genes Dev (2010) 2.60
Guard cell anion channel SLAC1 is regulated by CDPK protein kinases with distinct Ca2+ affinities. Proc Natl Acad Sci U S A (2010) 2.36
PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J (2009) 2.29
Temperature stress and plant sexual reproduction: uncovering the weakest links. J Exp Bot (2010) 2.24
Coping with stresses: roles of calcium- and calcium/calmodulin-regulated gene expression. Plant Cell (2011) 2.08
Evolution of abscisic acid synthesis and signaling mechanisms. Curr Biol (2011) 2.01
Abscisic Acid synthesis and response. Arabidopsis Book (2013) 1.75
MAP kinases MPK9 and MPK12 are preferentially expressed in guard cells and positively regulate ROS-mediated ABA signaling. Proc Natl Acad Sci U S A (2009) 1.61
Quantitative phosphoproteomics identifies SnRK2 protein kinase substrates and reveals the effectors of abscisic acid action. Proc Natl Acad Sci U S A (2013) 1.60
Arabidopsis calcium-dependent protein kinase CPK10 functions in abscisic acid- and Ca2+-mediated stomatal regulation in response to drought stress. Plant Physiol (2010) 1.45
The Ca(2+) -dependent protein kinase CPK3 is required for MAPK-independent salt-stress acclimation in Arabidopsis. Plant J (2010) 1.40
CDPKs in immune and stress signaling. Trends Plant Sci (2012) 1.35
The Arabidopsis calcium-dependent protein kinase, CPK6, functions as a positive regulator of methyl jasmonate signaling in guard cells. Plant Physiol (2010) 1.29
The Clickable Guard Cell, Version II: Interactive Model of Guard Cell Signal Transduction Mechanisms and Pathways. Arabidopsis Book (2008) 1.27
Central functions of bicarbonate in S-type anion channel activation and OST1 protein kinase in CO2 signal transduction in guard cell. EMBO J (2011) 1.25
Plant organellar calcium signalling: an emerging field. J Exp Bot (2011) 1.24
The Arabidopsis ABA-activated kinase OST1 phosphorylates the bZIP transcription factor ABF3 and creates a 14-3-3 binding site involved in its turnover. PLoS One (2010) 1.16
AtCPK6, a functionally redundant and positive regulator involved in salt/drought stress tolerance in Arabidopsis. Planta (2010) 1.14
Antisense inhibition of the iron-sulphur subunit of succinate dehydrogenase enhances photosynthesis and growth in tomato via an organic acid-mediated effect on stomatal aperture. Plant Cell (2011) 1.12
Chemical genetics reveals negative regulation of abscisic acid signaling by a plant immune response pathway. Curr Biol (2011) 1.12
Alteration of substrate specificity: the variable N-terminal domain of tobacco Ca(2+)-dependent protein kinase is important for substrate recognition. Plant Cell (2010) 1.12
Enhancing crop resilience to combined abiotic and biotic stress through the dissection of physiological and molecular crosstalk. Front Plant Sci (2014) 1.11
Antagonism between abscisic acid and ethylene in Arabidopsis acts in parallel with the reciprocal regulation of their metabolism and signaling pathways. Plant Mol Biol (2009) 1.11
Calcium-dependent protein kinases: hubs in plant stress signaling and development. Plant Physiol (2013) 1.11
Regulation of Arabidopsis defense responses against Spodoptera littoralis by CPK-mediated calcium signaling. BMC Plant Biol (2010) 1.10
Cross-talk between abscisic acid-dependent and abscisic acid-independent pathways during abiotic stress. Plant Cell Rep (2013) 1.10
Transcriptome analysis reveals absence of unintended effects in drought-tolerant transgenic plants overexpressing the transcription factor ABF3. BMC Genomics (2010) 1.09
Modulation of protein phosphorylation, N-glycosylation and Lys-acetylation in grape (Vitis vinifera) mesocarp and exocarp owing to Lobesia botrana infection. Mol Cell Proteomics (2012) 1.08
The SWI2/SNF2 chromatin remodeling ATPase BRAHMA represses abscisic acid responses in the absence of the stress stimulus in Arabidopsis. Plant Cell (2012) 1.07
Apple sucrose transporter SUT1 and sorbitol transporter SOT6 interact with cytochrome b5 to regulate their affinity for substrate sugars. Plant Physiol (2009) 1.06
Tobacco calcium-dependent protein kinases are differentially phosphorylated in vivo as part of a kinase cascade that regulates stress response. J Biol Chem (2010) 1.06
The Arabidopsis mitogen-activated protein kinase phosphatase PP2C5 affects seed germination, stomatal aperture, and abscisic acid-inducible gene expression. Plant Physiol (2010) 1.05
Silencing MPK4 in Nicotiana attenuata enhances photosynthesis and seed production but compromises abscisic acid-induced stomatal closure and guard cell-mediated resistance to Pseudomonas syringae pv tomato DC3000. Plant Physiol (2011) 1.05
A PIIB-type Ca2+-ATPase is essential for stress adaptation in Physcomitrella patens. Proc Natl Acad Sci U S A (2008) 1.02
Silencing Nicotiana attenuata calcium-dependent protein kinases, CDPK4 and CDPK5, strongly up-regulates wound- and herbivory-induced jasmonic acid accumulations. Plant Physiol (2012) 1.02
Overexpression of pigeonpea stress-induced cold and drought regulatory gene (CcCDR) confers drought, salt, and cold tolerance in Arabidopsis. J Exp Bot (2014) 1.01
Overexpression of a Calcium-Dependent Protein Kinase Confers Salt and Drought Tolerance in Rice by Preventing Membrane Lipid Peroxidation. Plant Physiol (2014) 1.01
CDPK-mediated abiotic stress signaling. Plant Signal Behav (2012) 1.00
Osmotic stress signaling via protein kinases. Cell Mol Life Sci (2012) 0.99
Expressional analysis and role of calcium regulated kinases in abiotic stress signaling. Curr Genomics (2010) 0.99
Genome-wide identification and expression analysis of calcium-dependent protein kinase in maize. BMC Genomics (2013) 0.99
Cross talk among calcium, hydrogen peroxide, and nitric oxide and activation of gene expression involving calmodulins and calcium-dependent protein kinases in Ulva compressa exposed to copper excess. Plant Physiol (2012) 0.99
Cross-talk of calcium-dependent protein kinase and MAP kinase signaling. Plant Signal Behav (2011) 0.98
Ancient signals: comparative genomics of green plant CDPKs. Trends Plant Sci (2013) 0.97
The Brassica napus calcineurin B-Like 1/CBL-interacting protein kinase 6 (CBL1/CIPK6) component is involved in the plant response to abiotic stress and ABA signalling. J Exp Bot (2012) 0.97
Common and distinct functions of Arabidopsis class A1 and A2 heat shock factors in diverse abiotic stress responses and development. Plant Physiol (2013) 0.96
A rice calcium-dependent protein kinase OsCPK9 positively regulates drought stress tolerance and spikelet fertility. BMC Plant Biol (2014) 0.96
ZmCPK11 is involved in abscisic acid-induced antioxidant defence and functions upstream of ZmMPK5 in abscisic acid signalling in maize. J Exp Bot (2012) 0.96
Calcium-dependent protein kinases from Arabidopsis show substrate specificity differences in an analysis of 103 substrates. Front Plant Sci (2011) 0.95
A novel plant leucine-rich repeat receptor kinase regulates the response of Medicago truncatula roots to salt stress. Plant Cell (2009) 0.95
Calcium specificity signaling mechanisms in abscisic acid signal transduction in Arabidopsis guard cells. Elife (2015) 0.95
Abscisic acid regulates root elongation through the activities of auxin and ethylene in Arabidopsis thaliana. G3 (Bethesda) (2014) 0.95
Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium-dependent protein kinases (CDPKs). Mol Plant (2012) 0.94
Evidence that abscisic acid promotes degradation of SNF1-related protein kinase (SnRK) 1 in wheat and activation of a putative calcium-dependent SnRK2. J Exp Bot (2011) 0.94
Leaf responses to mild drought stress in natural variants of Arabidopsis. Plant Physiol (2015) 0.93
The myristoylated amino-terminus of an Arabidopsis calcium-dependent protein kinase mediates plasma membrane localization. Plant Mol Biol (2013) 0.92
Biochemical and physiological characterization of fut4 and fut6 mutants defective in arabinogalactan-protein fucosylation in Arabidopsis. J Exp Bot (2013) 0.92
Arabidopsis CALCIUM-DEPENDENT PROTEIN KINASE8 and CATALASE3 Function in Abscisic Acid-Mediated Signaling and H2O2 Homeostasis in Stomatal Guard Cells under Drought Stress. Plant Cell (2015) 0.91
Identification of proteins that interact with catalytically active calcium-dependent protein kinases from Arabidopsis. Mol Genet Genomics (2009) 0.91
Can prolonged exposure to low VPD disturb the ABA signalling in stomatal guard cells? J Exp Bot (2013) 0.89
Unique responsiveness of angiosperm stomata to elevated CO2 explained by calcium signalling. PLoS One (2013) 0.88
The variable domain of a plant calcium-dependent protein kinase (CDPK) confers subcellular localization and substrate recognition for NADPH oxidase. J Biol Chem (2013) 0.87
Ca2+-dependent protein kinase11 and 24 modulate the activity of the inward rectifying K+ channels in Arabidopsis pollen tubes. Plant Cell (2013) 0.87
Identification, expression and interaction analyses of calcium-dependent protein kinase (CPK) genes in canola (Brassica napus L.). BMC Genomics (2014) 0.86
Calcium-dependent protein kinases responsible for the phosphorylation of a bZIP transcription factor FD crucial for the florigen complex formation. Sci Rep (2015) 0.86
Association mapping of soybean seed germination under salt stress. Mol Genet Genomics (2015) 0.85
SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants. Elife (2015) 0.85
Arabidopsis ABA-Activated Kinase MAPKKK18 is Regulated by Protein Phosphatase 2C ABI1 and the Ubiquitin-Proteasome Pathway. Plant Cell Physiol (2015) 0.85
Differential expression of CPKs and cytosolic Ca2+ variation in resistant and susceptible apple cultivars (Malus x domestica) in response to the pathogen Erwinia amylovora and mechanical wounding. BMC Genomics (2013) 0.85
CDPK1 from ginger promotes salinity and drought stress tolerance without yield penalty by improving growth and photosynthesis in Nicotiana tabacum. PLoS One (2013) 0.85
Biotic and abiotic stress responses through calcium-dependent protein kinase (CDPK) signaling in wheat (Triticum aestivum L.). Plant Signal Behav (2008) 0.85
Genome-wide transcriptional analysis of two soybean genotypes under dehydration and rehydration conditions. BMC Genomics (2013) 0.84
Evaluation of the basic functions of six calcium-dependent protein kinases in Toxoplasma gondii using CRISPR-Cas9 system. Parasitol Res (2016) 0.84
Cyclin dependent protein kinases and stress responses in plants. Plant Signal Behav (2011) 0.84
Directly transforming PCR-amplified DNA fragments into plant cells is a versatile system that facilitates the transient expression assay. PLoS One (2013) 0.83
Calcium-dependent protein kinase CPK6 positively functions in induction by yeast elicitor of stomatal closure and inhibition by yeast elicitor of light-induced stomatal opening in Arabidopsis. Plant Physiol (2013) 0.83
Identification of cyclic GMP-activated nonselective Ca2+-permeable cation channels and associated CNGC5 and CNGC6 genes in Arabidopsis guard cells. Plant Physiol (2013) 0.83
Calcium-dependent and -independent stomatal signaling network and compensatory feedback control of stomatal opening via Ca2+ sensitivity priming. Plant Physiol (2013) 0.83
Plant stress surveillance monitored by ABA and disease signaling interactions. Mol Cells (2012) 0.83
Transcriptome of the inflorescence meristems of the biofuel plant Jatropha curcas treated with cytokinin. BMC Genomics (2014) 0.83
The mechanism of substrate recognition of Ca2+-dependent protein kinases. Plant Signal Behav (2011) 0.82
Reactive Oxygen Species in the Regulation of Stomatal Movements. Plant Physiol (2016) 0.82
A novel abi5 allele reveals the importance of the conserved Ala in the C3 domain for regulation of downstream genes and salt tolerance during germination in Arabidopsis. Plant Signal Behav (2013) 0.82
Characterization of StABF1, a stress-responsive bZIP transcription factor from Solanum tuberosum L. that is phosphorylated by StCDPK2 in vitro. Planta (2011) 0.82
Genome-wide Identification and Expression Analysis of the CDPK Gene Family in Grape, Vitis spp. BMC Plant Biol (2015) 0.82
CPK13, a noncanonical Ca2+-dependent protein kinase, specifically inhibits KAT2 and KAT1 shaker K+ channels and reduces stomatal opening. Plant Physiol (2014) 0.82
Hypersensitive to red and blue 1 and its modification by protein phosphatase 7 are implicated in the control of Arabidopsis stomatal aperture. PLoS Genet (2012) 0.81
Guard cell SLAC1-type anion channels mediate flagellin-induced stomatal closure. New Phytol (2015) 0.81
Golgi traffic and integrity depend on N-myristoyl transferase-1 in Arabidopsis. Plant Cell (2013) 0.81
CPK12: A Ca2+-dependent protein kinase balancer in abscisic acid signaling. Plant Signal Behav (2011) 0.80
Overexpression of bacterial mtlD gene in peanut improves drought tolerance through accumulation of mannitol. ScientificWorldJournal (2014) 0.80
Genome-wide identification of calcium-dependent protein kinases in soybean and analyses of their transcriptional responses to insect herbivory and drought stress. Sci Rep (2016) 0.80
Functions of Calcium-Dependent Protein Kinases in Plant Innate Immunity. Plants (Basel) (2014) 0.79
Transcriptome-wide functional characterization reveals novel relationships among differentially expressed transcripts in developing soybean embryos. BMC Genomics (2015) 0.79
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. Plant J (1998) 97.93
Salt and drought stress signal transduction in plants. Annu Rev Plant Biol (2002) 13.94
A novel cis-acting element in an Arabidopsis gene is involved in responsiveness to drought, low-temperature, or high-salt stress. Plant Cell (1994) 10.01
Abscisic acid signaling in seeds and seedlings. Plant Cell (2002) 9.02
A protein phosphatase 2C involved in ABA signal transduction in Arabidopsis thaliana. Science (1994) 8.71
Isolation of the Arabidopsis ABI3 gene by positional cloning. Plant Cell (1992) 8.36
Arabidopsis ABA response gene ABI1: features of a calcium-modulated protein phosphatase. Science (1994) 8.28
The Arabidopsis ABSCISIC ACID-INSENSITIVE2 (ABI2) and ABI1 genes encode homologous protein phosphatases 2C involved in abscisic acid signal transduction. Plant Cell (1997) 6.32
Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) function as transcriptional activators in abscisic acid signaling. Plant Cell (2003) 6.22
The Arabidopsis abscisic acid response gene ABI5 encodes a basic leucine zipper transcription factor. Plant Cell (2000) 6.18
ABSCISIC ACID SIGNAL TRANSDUCTION. Annu Rev Plant Physiol Plant Mol Biol (1998) 5.87
Arabidopsis OST1 protein kinase mediates the regulation of stomatal aperture by abscisic acid and acts upstream of reactive oxygen species production. Plant Cell (2002) 5.81
Integration of plant responses to environmentally activated phytohormonal signals. Science (2006) 5.46
Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under drought and high-salinity conditions. Proc Natl Acad Sci U S A (2000) 5.23
Regulatory network of gene expression in the drought and cold stress responses. Curr Opin Plant Biol (2003) 5.07
ABFs, a family of ABA-responsive element binding factors. J Biol Chem (2000) 4.98
A postgermination developmental arrest checkpoint is mediated by abscisic acid and requires the ABI5 transcription factor in Arabidopsis. Proc Natl Acad Sci U S A (2001) 4.95
The Arabidopsis abscisic acid response locus ABI4 encodes an APETALA 2 domain protein. Plant Cell (1998) 4.92
A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid. Science (2007) 4.61
ABI1 protein phosphatase 2C is a negative regulator of abscisic acid signaling. Plant Cell (1999) 4.46
Communicating with calcium Plant Cell (1999) 3.96
The Arabidopsis CDPK-SnRK superfamily of protein kinases. Plant Physiol (2003) 3.96
ABA-activated SnRK2 protein kinase is required for dehydration stress signaling in Arabidopsis. Plant Cell Physiol (2002) 3.90
Retracted The RNA-binding protein FCA is an abscisic acid receptor. Nature (2006) 3.63
Identification of two protein kinases required for abscisic acid regulation of seed germination, root growth, and gene expression in Arabidopsis. Plant Cell (2007) 3.62
Ca2+-dependent protein kinases and stress signal transduction in plants. Science (1996) 3.59
The ABI1 and ABI2 protein phosphatases 2C act in a negative feedback regulatory loop of the abscisic acid signalling pathway. Plant J (2001) 3.57
Arabidopsis basic leucine zipper proteins that mediate stress-responsive abscisic acid signaling. Plant Cell (2002) 3.36
CDPKs CPK6 and CPK3 function in ABA regulation of guard cell S-type anion- and Ca(2+)-permeable channels and stomatal closure. PLoS Biol (2006) 3.32
Abscisic acid-dependent multisite phosphorylation regulates the activity of a transcription activator AREB1. Proc Natl Acad Sci U S A (2006) 3.28
The Mg-chelatase H subunit is an abscisic acid receptor. Nature (2006) 3.28
The expression of a rab-related gene, rab18, is induced by abscisic acid during the cold acclimation process of Arabidopsis thaliana (L.) Heynh. Plant Mol Biol (1992) 3.20
Calmodulins and calcineurin B-like proteins: calcium sensors for specific signal response coupling in plants. Plant Cell (2002) 3.15
Regulation of abscisic acid-induced stomatal closure and anion channels by guard cell AAPK kinase. Science (2000) 3.15
Calcium signaling through protein kinases. The Arabidopsis calcium-dependent protein kinase gene family. Plant Physiol (2002) 2.99
AREB1 is a transcription activator of novel ABRE-dependent ABA signaling that enhances drought stress tolerance in Arabidopsis. Plant Cell (2005) 2.97
Structure and expression of kin2, one of two cold- and ABA-induced genes of Arabidopsis thaliana. Plant Mol Biol (1992) 2.74
A calcium-dependent protein kinase with a regulatory domain similar to calmodulin. Science (1991) 2.74
Mutational analysis of protein phosphatase 2C involved in abscisic acid signal transduction in higher plants. Proc Natl Acad Sci U S A (1998) 2.73
CDPKs - a kinase for every Ca2+ signal? Trends Plant Sci (2000) 2.66
The regulatory domain of SRK2E/OST1/SnRK2.6 interacts with ABI1 and integrates abscisic acid (ABA) and osmotic stress signals controlling stomatal closure in Arabidopsis. J Biol Chem (2005) 2.59
Calcium-dependent protein kinases play an essential role in a plant defence response. EMBO J (2001) 2.53
Relay and control of abscisic acid signaling. Curr Opin Plant Biol (2003) 2.51
Role of an Arabidopsis AP2/EREBP-type transcriptional repressor in abscisic acid and drought stress responses. Plant Cell (2005) 2.45
CALMODULIN AND CALMODULIN-BINDING PROTEINS IN PLANTS. Annu Rev Plant Physiol Plant Mol Biol (1998) 2.38
Calcium: a central regulator of plant growth and development. Plant Cell (2005) 2.33
Expression profiling of the whole Arabidopsis shaggy-like kinase multigene family by real-time reverse transcriptase-polymerase chain reaction. Plant Physiol (2002) 2.31
The abscisic acid-responsive kinase PKABA1 interacts with a seed-specific abscisic acid response element-binding factor, TaABF, and phosphorylates TaABF peptide sequences. Plant Physiol (2002) 2.05
CDPK-mediated signalling pathways: specificity and cross-talk. J Exp Bot (2003) 1.95
Guard cells: a dynamic signaling model. Curr Opin Plant Biol (2004) 1.94
The calcium sensor calcineurin B-like 9 modulates abscisic acid sensitivity and biosynthesis in Arabidopsis. Plant Cell (2004) 1.93
CIPK3, a calcium sensor-associated protein kinase that regulates abscisic acid and cold signal transduction in Arabidopsis. Plant Cell (2003) 1.92
A calcium sensor and its interacting protein kinase are global regulators of abscisic acid signaling in Arabidopsis. Dev Cell (2002) 1.92
Genetic identification of an autoinhibitor in CDPK, a protein kinase with a calmodulin-like domain. Biochemistry (1994) 1.81
A novel chloride channel in Vicia faba guard cell vacuoles activated by the serine/threonine kinase, CDPK. EMBO J (1996) 1.74
Arabidopsis calcium-dependent protein kinase AtCPK32 interacts with ABF4, a transcriptional regulator of abscisic acid-responsive gene expression, and modulates its activity. Plant Physiol (2005) 1.73
Identification of Ser-543 as the major regulatory phosphorylation site in spinach leaf nitrate reductase. Plant Cell (1996) 1.72
Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase. Nature (2002) 1.65
Identification of drought tolerance determinants by genetic analysis of root response to drought stress and abscisic Acid. Plant Physiol (2006) 1.61
Subcellular targeting of nine calcium-dependent protein kinase isoforms from Arabidopsis. Plant Physiol (2003) 1.56
Guard cells possess a calcium-dependent protein kinase that phosphorylates the KAT1 potassium channel. Plant Physiol (1998) 1.43
Characterization of two cDNAs (ERD10 and ERD14) corresponding to genes that respond rapidly to dehydration stress in Arabidopsis thaliana. Plant Cell Physiol (1994) 1.35
Spinach Leaf Sucrose-Phosphate Synthase and Nitrate Reductase Are Phosphorylated/Inactivated by Multiple Protein Kinases in Vitro. Plant Physiol (1995) 1.32
RNA interference identifies a calcium-dependent protein kinase involved in Medicago truncatula root development. Plant Cell (2005) 1.26
Abscisic acid stimulates a calcium-dependent protein kinase in grape berry. Plant Physiol (2006) 1.12
Partial Purification and Characterization of a Calcium-Dependent Protein Kinase and an Inhibitor Protein Required for Inactivation of Spinach Leaf Nitrate Reductase. Plant Physiol (1995) 1.09
A novel yeast two-hybrid approach to identify CDPK substrates: characterization of the interaction between AtCPK11 and AtDi19, a nuclear zinc finger protein. FEBS Lett (2006) 1.07
The Arabidopsis AtDi19 gene family encodes a novel type of Cys2/His2 zinc-finger protein implicated in ABA-independent dehydration, high-salinity stress and light signaling pathways. Plant Mol Biol (2006) 1.03
The calcium-dependent protein kinase HvCDPK1 mediates the gibberellic acid response of the barley aleurone through regulation of vacuolar function. Plant J (2004) 0.96
Expression of a grape calcium-dependent protein kinase ACPK1 in Arabidopsis thaliana promotes plant growth and confers abscisic acid-hypersensitivity in germination, postgermination growth, and stomatal movement. Plant Mol Biol (2007) 0.94
In vivo phosphorylation of a recombinant peptide substrate of CDPK suggests involvement of CDPK in plant stress responses. Plant Mol Biol (2003) 0.83
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature (2012) 18.23
The Genome sequence of the SARS-associated coronavirus. Science (2003) 16.68
Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA (2003) 16.08
Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature (2010) 10.66
Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature (2007) 10.40
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature (2006) 7.52
Modelling schizophrenia using human induced pluripotent stem cells. Nature (2011) 7.41
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42
A distinct lineage of influenza A virus from bats. Proc Natl Acad Sci U S A (2012) 6.27
Trends in survival after in-hospital cardiac arrest. N Engl J Med (2012) 5.67
Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis (2002) 5.64
Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med (2003) 5.45
CIP2A inhibits PP2A in human malignancies. Cell (2007) 5.28
Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study. Lancet (2007) 5.21
A high-resolution map of the three-dimensional chromatin interactome in human cells. Nature (2013) 5.18
Generation of human-induced pluripotent stem cells. Nat Protoc (2008) 4.85
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science (2006) 4.71
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med (2011) 4.68
Mechanisms of gamma oscillations. Annu Rev Neurosci (2012) 4.58
A recurrent network mechanism of time integration in perceptual decisions. J Neurosci (2006) 4.53
Cortico-basal ganglia circuit mechanism for a decision threshold in reaction time tasks. Nat Neurosci (2006) 4.36
Human illness from avian influenza H7N3, British Columbia. Emerg Infect Dis (2004) 4.29
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer: final results of a phase III randomized clinical trial. Ann Surg Oncol (2011) 4.16
Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen. Cell (2004) 4.14
New world bats harbor diverse influenza A viruses. PLoS Pathog (2013) 4.10
Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina). J Am Coll Cardiol (2013) 3.90
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell (2005) 3.89
Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada. PLoS Med (2010) 3.85
Long-term outcomes in elderly survivors of in-hospital cardiac arrest. N Engl J Med (2013) 3.85
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet (2009) 3.59
What determines the frequency of fast network oscillations with irregular neural discharges? I. Synaptic dynamics and excitation-inhibition balance. J Neurophysiol (2003) 3.54
Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung. Nat Biotechnol (2007) 3.54
Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol (2003) 3.51
Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol (2010) 3.49
AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. Science (2008) 3.44
Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome Study. Hypertension (2006) 3.42
Human Bocavirus infection, Canada. Emerg Infect Dis (2006) 3.30
The Mg-chelatase H subunit is an abscisic acid receptor. Nature (2006) 3.28
Pre-existing AAV capsid-specific CD8+ T cells are unable to eliminate AAV-transduced hepatocytes. Mol Ther (2007) 3.26
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat Biotechnol (2011) 3.25
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature (2004) 3.24
A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants. Cell Host Microbe (2007) 3.15
Neuronal basis of age-related working memory decline. Nature (2011) 3.15
Global analysis of the Deinococcus radiodurans proteome by using accurate mass tags. Proc Natl Acad Sci U S A (2002) 3.15
The scale of population structure in Arabidopsis thaliana. PLoS Genet (2010) 3.12
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J Cell Biol (2014) 3.12
Triple reassortant H3N2 influenza A viruses, Canada, 2005. Emerg Infect Dis (2006) 3.05
The importance of mixed selectivity in complex cognitive tasks. Nature (2013) 3.05
Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res (2007) 3.02
Label-free, normalized quantification of complex mass spectrometry data for proteomic analysis. Nat Biotechnol (2009) 3.01
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature (2013) 3.00
Identification of a novel astrovirus (astrovirus VA1) associated with an outbreak of acute gastroenteritis. J Virol (2009) 2.96
Cellular and network mechanisms of slow oscillatory activity (<1 Hz) and wave propagations in a cortical network model. J Neurophysiol (2003) 2.92
Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncol (2012) 2.91
Novel avian influenza H7N3 strain outbreak, British Columbia. Emerg Infect Dis (2004) 2.90
Masked hypertension in diabetes mellitus: treatment implications for clinical practice. Hypertension (2013) 2.89
Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen. Nature (2003) 2.87
Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature (2013) 2.85
Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Curr Biol (2007) 2.84
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell (2008) 2.84
Anterior chamber width measurement by high-speed optical coherence tomography. Ophthalmology (2005) 2.77
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nat Med (2013) 2.70
Interneuron Diversity series: Circuit complexity and axon wiring economy of cortical interneurons. Trends Neurosci (2004) 2.68
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. PLoS Genet (2005) 2.68
A distinct role for norepinephrine in memory retrieval. Cell (2004) 2.68
Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC Neurosci (2006) 2.68
Prognostic value of reading-to-reading blood pressure variability over 24 hours in 8938 subjects from 11 populations. Hypertension (2010) 2.64
Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer. Nat Med (2010) 2.62
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Nat Biotechnol (2004) 2.60
Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study. Lancet Neurol (2010) 2.60
Component-specific effectiveness of trivalent influenza vaccine as monitored through a sentinel surveillance network in Canada, 2006-2007. J Infect Dis (2009) 2.59
A decade's studies on metastasis of hepatocellular carcinoma. J Cancer Res Clin Oncol (2003) 2.50
Effectiveness of AS03 adjuvanted pandemic H1N1 vaccine: case-control evaluation based on sentinel surveillance system in Canada, autumn 2009. BMJ (2011) 2.50
Correlation of IHC and FISH for ALK gene rearrangement in non-small cell lung carcinoma: IHC score algorithm for FISH. J Thorac Oncol (2011) 2.50
Structural and biomechanical basis of sexual dimorphism in femoral neck fragility has its origins in growth and aging. J Bone Miner Res (2003) 2.48
Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. PLoS Pathog (2010) 2.48
miR-301a as an NF-κB activator in pancreatic cancer cells. EMBO J (2010) 2.47
NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex. Neuron (2013) 2.46
Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma. Genes Dev (2006) 2.46
A coastal cline in sodium accumulation in Arabidopsis thaliana is driven by natural variation of the sodium transporter AtHKT1;1. PLoS Genet (2010) 2.45
Prevention of stroke and myocardial infarction by amlodipine and Angiotensin receptor blockers: a quantitative overview. Hypertension (2007) 2.43
Variance as a signature of neural computations during decision making. Neuron (2011) 2.42
Smad7-induced beta-catenin degradation alters epidermal appendage development. Dev Cell (2006) 2.41
The role of default network deactivation in cognition and disease. Trends Cogn Sci (2012) 2.39
Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses. Anal Chem (2007) 2.38
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nat Biotechnol (2011) 2.37
Ambulatory blood pressure monitoring in 9357 subjects from 11 populations highlights missed opportunities for cardiovascular prevention in women. Hypertension (2011) 2.33
beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell (2002) 2.33
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nat Genet (2011) 2.32