Published in Pharmaceuticals (Basel) on February 06, 2013
The impact of extracellular vesicle-encapsulated circulating microRNAs in lung cancer research. Biomed Res Int (2014) 0.96
Silencing VDAC1 Expression by siRNA Inhibits Cancer Cell Proliferation and Tumor Growth In Vivo. Mol Ther Nucleic Acids (2014) 0.92
Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis. J Extracell Vesicles (2015) 0.87
miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells. Cancer Gene Ther (2015) 0.86
Development of small RNA delivery systems for lung cancer therapy. Int J Mol Sci (2015) 0.85
Poly(amidoamine) dendrimer nanocarriers and their aerosol formulations for siRNA delivery to the lung epithelium. Mol Pharm (2014) 0.84
siRNA delivery to the lung: what's new? Adv Drug Deliv Rev (2014) 0.83
Novel insights into miRNA in lung and heart inflammatory diseases. Mediators Inflamm (2014) 0.81
Acid-Sensitive Sheddable PEGylated PLGA Nanoparticles Increase the Delivery of TNF-α siRNA in Chronic Inflammation Sites. Mol Ther Nucleic Acids (2016) 0.80
Extracellular Vesicle: An Unknown Environmental Factor for Causing Airway Disease. Allergy Asthma Immunol Res (2016) 0.79
Translational Nano-Medicines: Targeted Therapeutic Delivery for Cancer and Inflammatory Diseases. AAPS J (2015) 0.77
Role of Exosomal Noncoding RNAs in Lung Carcinogenesis. Biomed Res Int (2015) 0.77
Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer. Oncotarget (2015) 0.76
BMP type II receptor as a therapeutic target in pulmonary arterial hypertension. Cell Mol Life Sci (2017) 0.76
Advanced Therapeutic Strategies for Chronic Lung Disease Using Nanoparticle-Based Drug Delivery. J Clin Med (2016) 0.76
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RAS is regulated by the let-7 microRNA family. Cell (2005) 30.24
Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol (2003) 16.63
Requirement of bic/microRNA-155 for normal immune function. Science (2007) 16.24
Control of stress-dependent cardiac growth and gene expression by a microRNA. Science (2007) 12.08
Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol (2009) 11.50
LNA-mediated microRNA silencing in non-human primates. Nature (2008) 11.45
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science (2009) 10.30
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci U S A (2008) 9.86
Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med (2005) 9.47
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med (2011) 6.85
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol (2008) 6.81
Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet (2003) 6.49
Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol (2001) 5.80
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Strategies for silencing human disease using RNA interference. Nat Rev Genet (2007) 5.19
MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science (2009) 5.17
The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle (2008) 4.95
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med (2010) 4.71
RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nat Med (2004) 4.63
RNAi therapeutics: a potential new class of pharmaceutical drugs. Nat Chem Biol (2006) 4.38
Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med (2009) 4.27
The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules. Nat Immunol (2009) 3.85
Alveolar wall apoptosis causes lung destruction and emphysematous changes. Am J Respir Cell Mol Biol (2003) 3.83
Inhibition of respiratory viruses by nasally administered siRNA. Nat Med (2004) 3.69
MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One (2009) 3.66
Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med (2001) 3.59
Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. Cancer Res (2010) 3.21
Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Physiol Rev (2007) 3.03
Inhibition and role of let-7d in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2010) 3.02
MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol (2009) 2.89
miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am J Respir Cell Mol Biol (2010) 2.87
Regression of murine lung tumors by the let-7 microRNA. Oncogene (2009) 2.83
Nonviral delivery of synthetic siRNAs in vivo. J Clin Invest (2007) 2.78
The promise of microRNA replacement therapy. Cancer Res (2010) 2.68
RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther (2005) 2.68
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol (2003) 2.66
Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo. Mol Ther (2008) 2.66
Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke. FASEB J (2008) 2.58
Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. Nat Med (2005) 2.55
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MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci U S A (2009) 2.37
MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes. Circ Res (2011) 2.32
Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy. Mol Ther (2010) 2.30
Lipid-based systemic delivery of siRNA. Adv Drug Deliv Rev (2009) 2.28
Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease. Proc Natl Acad Sci U S A (2009) 2.28
Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells. Mol Pharm (2006) 2.28
Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. Proc Natl Acad Sci U S A (2005) 2.23
Asthma and allergic inflammation. Cell (2010) 2.21
Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc Natl Acad Sci U S A (2004) 2.21
Delivery of siRNA therapeutics: barriers and carriers. AAPS J (2010) 2.15
Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice. J Clin Invest (2009) 2.13
Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV). Antiviral Res (2007) 2.06
siRNA and isRNA: two edges of one sword. Mol Ther (2006) 2.02
RNA interference therapy in lung transplant patients infected with respiratory syncytial virus. Am J Respir Crit Care Med (2010) 1.94
A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus. Proc Natl Acad Sci U S A (2010) 1.92
Protection against lethal influenza virus challenge by RNA interference in vivo. Proc Natl Acad Sci U S A (2004) 1.91
Cationic liposome-mediated delivery of siRNAs in adult mice. Biochem Biophys Res Commun (2003) 1.87
Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1. Gene Ther (2006) 1.86
Genetics of COPD. Chest (2004) 1.85
Small interfering RNA inhibits hepatitis B virus replication in mice. Mol Ther (2003) 1.76
Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta. Genes Dev (2010) 1.75
Targeting the NF-kappaB pathway in asthma and chronic obstructive pulmonary disease. Pharmacol Ther (2008) 1.74
Lack of interferon response in animals to naked siRNAs. Nat Biotechnol (2004) 1.71
Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial-mesenchymal interactions. PLoS One (2009) 1.70
COPD as a lung disease with systemic consequences--clinical impact, mechanisms, and potential for early intervention. COPD (2008) 1.65
Tumor necrosis factor-alpha gene polymorphism in chronic bronchitis. Am J Respir Crit Care Med (1997) 1.63
Gene expression networks in COPD: microRNA and mRNA regulation. Thorax (2011) 1.62
COPD: current therapeutic interventions and future approaches. Eur Respir J (2005) 1.61
Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis. Am J Pathol (2005) 1.60
Role of microRNA in anticancer drug resistance. Int J Cancer (2010) 1.48
Cellular siRNA delivery using cell-penetrating peptides modified for endosomal escape. Adv Drug Deliv Rev (2009) 1.46
MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy. PLoS One (2009) 1.44
Participation of miR-200 in pulmonary fibrosis. Am J Pathol (2011) 1.43
MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 1.42
Cigarette smoke induces senescence in alveolar epithelial cells. Am J Respir Cell Mol Biol (2004) 1.41
Non-invasive pulmonary aerosol delivery in mice by the endotracheal route. Eur J Pharm Biopharm (2005) 1.39
Gene silencing by adenovirus-delivered siRNA. FEBS Lett (2003) 1.37
COPD, a multicomponent disease: implications for management. Respir Med (2005) 1.36
Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD. Thorax (2011) 1.35
Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression. Cancer Res (2008) 1.34
Lipidic systems for in vivo siRNA delivery. AAPS J (2009) 1.33
Reduced miR-146a increases prostaglandin E₂in chronic obstructive pulmonary disease fibroblasts. Am J Respir Crit Care Med (2010) 1.33
Effect of adenovirus-mediated RNA interference on endogenous microRNAs in a mouse model of multidrug resistance protein 2 gene silencing. J Virol (2006) 1.32
MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1. Cardiovasc Res (2011) 1.32
In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury. J Leukoc Biol (2005) 1.32
Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Histopathology (2002) 1.31
The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice. J Cancer Res Clin Oncol (2009) 1.26
Down-regulation of miR-133a contributes to up-regulation of Rhoa in bronchial smooth muscle cells. Am J Respir Crit Care Med (2009) 1.25
The lung as a route for systemic delivery of therapeutic proteins and peptides. Respir Res (2001) 1.25
MicroRNAs in inflammatory lung disease--master regulators or target practice? Respir Res (2010) 1.24
Drug delivery trends in clinical trials and translational medicine: challenges and opportunities in the delivery of nucleic acid-based therapeutics. J Pharm Sci (2011) 1.24
Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis. Thorax (2010) 1.23
Extracellular barriers in respiratory gene therapy. Adv Drug Deliv Rev (2008) 1.22
Syk tyrosine kinase participates in beta1-integrin signaling and inflammatory responses in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.21
Intratracheal versus intravenous liposomal delivery of siRNA, antisense oligonucleotides and anticancer drug. Pharm Res (2008) 1.19
Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer. Int J Oncol (2005) 1.15
Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance. Mol Pharm (2009) 1.12
Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect. Am J Physiol Lung Cell Mol Physiol (2004) 1.10
Delivering silence: advancements in developing siRNA therapeutics. Curr Opin Drug Discov Devel (2008) 1.10
Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem (2010) 8.09
Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci (2010) 5.17
Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc Natl Acad Sci U S A (2005) 3.24
Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes. Mol Ther (2009) 2.92
microRNA as a new immune-regulatory agent in breast milk. Silence (2010) 2.20
Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol Ther (2012) 2.15
Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. Hepatology (2007) 2.14
Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction. Biochem Biophys Res Commun (2003) 2.00
The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families. PLoS One (2011) 1.81
miR-22 represses cancer progression by inducing cellular senescence. J Cell Biol (2011) 1.78
MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression. Mol Ther (2011) 1.77
IFATS collection: in vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury. Stem Cells (2008) 1.75
Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure. J Gastroenterol Hepatol (2008) 1.68
Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. Nucleic Acids Res (2004) 1.67
Secretory microRNAs as a versatile communication tool. Commun Integr Biol (2010) 1.64
Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J Biol Chem (2013) 1.62
Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. Proc Natl Acad Sci U S A (2012) 1.61
Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer. Gastroenterology (2006) 1.60
Generation of genetically modified rats from embryonic stem cells. Proc Natl Acad Sci U S A (2010) 1.59
Dicer is required for maintaining adult pancreas. PLoS One (2009) 1.59
One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation. Genomics (2007) 1.56
MOZ is essential for maintenance of hematopoietic stem cells. Genes Dev (2006) 1.56
TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells. J Immunol (2002) 1.50
Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol (2004) 1.49
Therapeutic potential of RNA interference against cancer. Cancer Sci (2006) 1.49
Competitive interactions of cancer cells and normal cells via secretory microRNAs. J Biol Chem (2011) 1.48
Combined functional genome survey of therapeutic targets for hepatocellular carcinoma. Clin Cancer Res (2010) 1.47
The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Proteomics (2013) 1.39
RPN2 gene confers docetaxel resistance in breast cancer. Nat Med (2008) 1.38
LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution. Stem Cells (2012) 1.36
MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma. Biomarkers (2009) 1.35
The role of high mobility group box1 in pulmonary fibrosis. Am J Respir Cell Mol Biol (2008) 1.34
Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models. Adv Drug Deliv Rev (2012) 1.34
Insufficient autophagy in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2012) 1.30
Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes. Sci Rep (2013) 1.28
Comprehensive miRNA expression analysis in peripheral blood can diagnose liver disease. PLoS One (2012) 1.28
Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol (2010) 1.27
Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice. J Immunol (2005) 1.27
Trash or Treasure: extracellular microRNAs and cell-to-cell communication. Front Genet (2013) 1.25
Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application. Hepatology (2003) 1.24
miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells. Hepatology (2013) 1.22
Therapeutic effects of microRNA-582-5p and -3p on the inhibition of bladder cancer progression. Mol Ther (2013) 1.19
MAP kinase activation and apoptosis in lung tissues from patients with idiopathic pulmonary fibrosis. J Pathol (2002) 1.18
Development and biological analysis of peritoneal metastasis mouse models for human scirrhous stomach cancer. Cancer Sci (2005) 1.16
Establishment of rat embryonic stem cells and making of chimera rats. PLoS One (2008) 1.14
Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease. Oncoimmunology (2012) 1.12
Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations. J Clin Invest (2013) 1.12
Dual-immunohistochemistry provides little evidence for epithelial-mesenchymal transition in pulmonary fibrosis. Histochem Cell Biol (2008) 1.10
The roles of extracellular vesicles in cancer biology: toward the development of novel cancer biomarkers. Proteomics (2014) 1.10
Enhanced skin carcinogenesis in cyclin D1-conditional transgenic mice: cyclin D1 alters keratinocyte response to calcium-induced terminal differentiation. Cancer Res (2002) 1.09
A randomized, single-blind study of lansoprazole for the prevention of exacerbations of chronic obstructive pulmonary disease in older patients. J Am Geriatr Soc (2009) 1.07
EGFR tyrosine kinase inhibition worsens acute lung injury in mice with repairing airway epithelium. Am J Respir Crit Care Med (2010) 1.07
Direct hepatic fate specification from mouse embryonic stem cells. Hepatology (2005) 1.07
Comparative marker analysis of extracellular vesicles in different human cancer types. J Extracell Vesicles (2013) 1.06
An integrative genomic analysis revealed the relevance of microRNA and gene expression for drug-resistance in human breast cancer cells. Mol Cancer (2011) 1.05
Amphiregulin attenuates bleomycin-induced pneumopathy in mice. Am J Physiol Lung Cell Mol Physiol (2009) 1.05
Stem cells for hepatic regeneration: the role of adipose tissue derived mesenchymal stem cells. Curr Stem Cell Res Ther (2010) 1.05
Atelocollagen for protein and gene delivery. Adv Drug Deliv Rev (2003) 1.04
Unraveling the Mystery of Cancer by Secretory microRNA: Horizontal microRNA Transfer between Living Cells. Front Genet (2012) 1.04
Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation. EMBO J (2002) 1.00
miR-29 represses the activities of DNA methyltransferases and DNA demethylases. Int J Mol Sci (2013) 1.00
Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β. Sci Rep (2013) 1.00
Efficacy of a novel class of RNA interference therapeutic agents. PLoS One (2012) 0.99
Micromanaging Iron Homeostasis: hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteins. J Biol Chem (2012) 0.98
Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice. Antimicrob Agents Chemother (2006) 0.98
Exosomal tumor-suppressive microRNAs as novel cancer therapy: "exocure" is another choice for cancer treatment. Adv Drug Deliv Rev (2012) 0.98
Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol (2013) 0.97
Potential of atelocollagen-mediated systemic antisense therapeutics for inflammatory disease. Hum Gene Ther (2004) 0.96
Identification of erythropoietin-induced microRNAs in haematopoietic cells during erythroid differentiation. Br J Haematol (2008) 0.96
Effects of adipose-derived mesenchymal cells on ischemia-reperfusion injury in kidney. Clin Exp Nephrol (2012) 0.95
Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection. PLoS One (2013) 0.95
Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer. Int J Oncol (2006) 0.95
Cancer-related microRNAs and their role as tumor suppressors and oncogenes in hepatocellular carcinoma. Histol Histopathol (2012) 0.95
Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence. Am J Physiol Lung Cell Mol Physiol (2013) 0.95
A photon counting technique for quantitatively evaluating progression of peritoneal tumor dissemination. Cancer Res (2006) 0.94
Susceptibility of Snark-deficient mice to azoxymethane-induced colorectal tumorigenesis and the formation of aberrant crypt foci. Cancer Sci (2007) 0.94
RNAi therapeutics and applications of microRNAs in cancer treatment. Jpn J Clin Oncol (2013) 0.93
Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity. Sci Rep (2012) 0.93