PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

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Published in Mol Cell on December 12, 2013

Authors

Alexandre Maréchal1, Ju-Mei Li2, Xiao Ye Ji1, Ching-Shyi Wu1, Stephanie A Yazinski1, Hai Dang Nguyen1, Shizhou Liu1, Amanda E Jiménez1, Jianping Jin2, Lee Zou1,3

Author Affiliations

1: Massachusetts General Hospital Cancer Center Harvard Medical School Charlestown, MA 02129.
2: Department of Biochemistry and Molecular Biology The University of Texas Health Science Center at Houston Houston, TX 77030.
3: Department of Pathology Massachusetts General Hospital Harvard Medical School Boston, MA 02114.

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