PubRank

Jean-Pierre Changeux

Author PubWeight™ 129.21‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature 2008 5.77
2 Conscious, preconscious, and subliminal processing: a testable taxonomy. Trends Cogn Sci 2006 4.66
3 Experimental and theoretical approaches to conscious processing. Neuron 2011 4.28
4 Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov 2009 3.26
5 A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature 2006 3.04
6 X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel. Nature 2011 3.00
7 Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J Neurosci 2003 2.85
8 A neuronal network model linking subjective reports and objective physiological data during conscious perception. Proc Natl Acad Sci U S A 2003 2.79
9 Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors. Neuron 2006 2.69
10 Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism. Biophys J 2005 2.33
11 The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences. J Neurobiol 2002 2.20
12 Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice. J Neurosci 2002 2.05
13 Nicotine upregulates its own receptors through enhanced intracellular maturation. Neuron 2005 1.89
14 One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue. Proc Natl Acad Sci U S A 2010 1.81
15 Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites. Proc Natl Acad Sci U S A 2002 1.78
16 The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice. Psychopharmacology (Berl) 2006 1.76
17 Structure and pharmacology of pentameric receptor channels: from bacteria to brain. Structure 2012 1.69
18 Molecular tuning of fast gating in pentameric ligand-gated ion channels. Proc Natl Acad Sci U S A 2005 1.58
19 A neuronal model of predictive coding accounting for the mismatch negativity. J Neurosci 2012 1.48
20 Ongoing spontaneous activity controls access to consciousness: a neuronal model for inattentional blindness. PLoS Biol 2005 1.47
21 Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine. Proc Natl Acad Sci U S A 2011 1.44
22 Executive and social behaviors under nicotinic receptor regulation. Proc Natl Acad Sci U S A 2003 1.44
23 Altered map of visual space in the superior colliculus of mice lacking early retinal waves. J Neurosci 2005 1.38
24 Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors. Proc Natl Acad Sci U S A 2006 1.32
25 Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation. Proc Natl Acad Sci U S A 2013 1.32
26 Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor. Proc Natl Acad Sci U S A 2002 1.32
27 Conformational selection or induced fit? 50 years of debate resolved. F1000 Biol Rep 2011 1.31
28 Pore conformations and gating mechanism of a Cys-loop receptor. Proc Natl Acad Sci U S A 2005 1.31
29 Nicotine and serotonin in immune regulation and inflammatory processes: a perspective. J Leukoc Biol 2006 1.22
30 An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors. EMBO J 2003 1.19
31 Localization of [3H]nicotine, [3H]cytisine, [3H]epibatidine, and [125I]alpha-bungarotoxin binding sites in the brain of Macaca mulatta. J Comp Neurol 2003 1.18
32 Monitoring protein interactions in the living cell through the fluorescence decays of the cyan fluorescent protein. Chemphyschem 2006 1.18
33 Rapsyn escorts the nicotinic acetylcholine receptor along the exocytic pathway via association with lipid rafts. J Neurosci 2002 1.17
34 Nicotine activates immature "silent" connections in the developing hippocampus. Proc Natl Acad Sci U S A 2003 1.17
35 An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine. J Biol Chem 2004 1.15
36 Intracellular complexes of the beta2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomics. Proc Natl Acad Sci U S A 2007 1.15
37 A gating mechanism of pentameric ligand-gated ion channels. Proc Natl Acad Sci U S A 2013 1.15
38 α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release. FASEB J 2010 1.12
39 Nicotinic modulation of network and synaptic transmission in the immature hippocampus investigated with genetically modified mice. J Physiol 2006 1.12
40 Prefrontal nicotinic receptors control novel social interaction between mice. FASEB J 2011 1.11
41 Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors. Proc Natl Acad Sci U S A 2010 1.10
42 Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: dependence on cholinergic nicotinic and dopaminergic D1 receptors. Neuropharmacology 2006 1.08
43 Interplay of beta2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion. Proc Natl Acad Sci U S A 2008 1.08
44 Long-term effects of chronic nicotine exposure on brain nicotinic receptors. Proc Natl Acad Sci U S A 2007 1.08
45 Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function. Proc Natl Acad Sci U S A 2005 1.08
46 Knockout and knockin mice to investigate the role of nicotinic receptors in the central nervous system. Prog Brain Res 2004 1.05
47 Heterogeneity and selective targeting of neuronal nicotinic acetylcholine receptor (nAChR) subtypes expressed on retinal afferents of the superior colliculus and lateral geniculate nucleus: identification of a new native nAChR subtype alpha3beta2(alpha5 or beta3) enriched in retinocollicular afferents. Mol Pharmacol 2005 1.05
48 The emergence of human consciousness: from fetal to neonatal life. Pediatr Res 2009 1.04
49 Electron microscopic evidence for nucleation and growth of 3D acetylcholine receptor microcrystals in structured lipid-detergent matrices. Proc Natl Acad Sci U S A 2003 1.03
50 Beta2-containing nicotinic receptors contribute to the organization of sleep and regulate putative micro-arousals in mice. J Neurosci 2004 1.02
51 Nicotine enhances intracellular nicotinic receptor maturation: a novel mechanism of neural plasticity? J Physiol Paris 2006 1.01
52 A chimera encoding the fusion of an acetylcholine-binding protein to an ion channel is stabilized in a state close to the desensitized form of ligand-gated ion channels. C R Biol 2005 1.01
53 Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb. Proc Natl Acad Sci U S A 2004 1.01
54 Monoamine oxidase inhibitors allow locomotor and rewarding responses to nicotine. Neuropsychopharmacology 2005 1.00
55 {alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation. Am J Pathol 2009 0.97
56 Live imaging of neural structure and function by fibred fluorescence microscopy. EMBO Rep 2006 0.96
57 Analysis of the cellular expression pattern of beta-CGRP in alpha-CGRP-deficient mice. J Comp Neurol 2004 0.96
58 Nicotine differentially activates inhibitory and excitatory neurons in the dorsal spinal cord. Pain 2004 0.96
59 Allosteric transitions of Torpedo acetylcholine receptor in lipids, detergent and amphipols: molecular interactions vs. physical constraints. FEBS Lett 2002 0.96
60 Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration. PLoS Comput Biol 2008 0.95
61 Expression of mutant Ets protein at the neuromuscular synapse causes alterations in morphology and gene expression. EMBO Rep 2002 0.95
62 Nicotinic receptors regulate B lymphocyte activation and immune response. Eur J Pharmacol 2005 0.93
63 Inhibition of both alpha7* and beta2* nicotinic acetylcholine receptors is necessary to prevent development of sensitization to cocaine-elicited increases in extracellular dopamine levels in the ventral striatum. Psychopharmacology (Berl) 2006 0.93
64 beta 2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure. Proc Natl Acad Sci U S A 2002 0.92
65 A neurocomputational hypothesis for nicotine addiction. Proc Natl Acad Sci U S A 2006 0.92
66 14-3-3 gamma associates with muscle specific kinase and regulates synaptic gene transcription at vertebrate neuromuscular synapse. Proc Natl Acad Sci U S A 2004 0.92
67 Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe. Eur J Biochem 2002 0.91
68 Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice. Psychopharmacology (Berl) 2011 0.91
69 Attention-deficit/hyperactivity disorder: a plausible mouse model? Acta Paediatr 2006 0.91
70 Mechanism of Cl- selection by a glutamate-gated chloride (GluCl) receptor revealed through mutations in the selectivity filter. J Biol Chem 2006 0.90
71 Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries. FASEB J 2002 0.89
72 Functional nicotinic acetylcholine receptors are expressed in B lymphocyte-derived cell lines. Mol Pharmacol 2003 0.89
73 A versatile system for the neuronal subtype specific expression of lentiviral vectors. FASEB J 2009 0.89
74 Object memory in young and aged mice after sevoflurane anaesthesia. Neuroreport 2009 0.88
75 Transcription in neuromuscular junction formation: who turns on whom? J Neurocytol 2004 0.86
76 A non-radioactive ligand-binding assay for detection of cyanobacterial anatoxins using Torpedo electrocyte membranes. Toxicon 2008 0.86
77 Phosphorylation-elicited quaternary changes of GA binding protein in transcriptional activation. Mol Cell Biol 2003 0.86
78 The concept of allosteric modulation: an overview. Drug Discov Today Technol 2013 0.85
79 Relationships between structural dynamics and functional kinetics in oligomeric membrane receptors. Biophys J 2010 0.84
80 Distinct subcellular targeting of fluorescent nicotinic alpha 3 beta 4 and serotoninergic 5-HT3A receptors in hippocampal neurons. Eur J Neurosci 2004 0.84
81 The role of nicotinic acetylcholine receptors in lymphocyte development. J Neuroimmunol 2005 0.84
82 Rational understanding of nicotinic receptors drug binding. Curr Top Med Chem 2004 0.84
83 Altered paralimbic interaction in behavioral addiction. Proc Natl Acad Sci U S A 2013 0.83
84 Deciding between conflicting motivations: what mice make of their prefrontal cortex. Behav Brain Res 2011 0.82
85 Reduction of withdrawal signs after chronic nicotine exposure of alpha-calcitonin gene-related peptide knock-out mice. Neurosci Lett 2004 0.82
86 Long-term exposure to nicotine modulates the level and activity of acetylcholine receptors in white blood cells of smokers and model mice. Mol Pharmacol 2004 0.81
87 Basic consciousness of the newborn. Semin Perinatol 2010 0.80
88 Modulation of the mouse prefrontal cortex activation by neuronal nicotinic receptors during novelty exploration but not by exploration of a familiar environment. Cereb Cortex 2011 0.80
89 Allosteric regulation of pentameric ligand-gated ion channels: an emerging mechanistic perspective. Channels (Austin) 2014 0.80
90 Antibodies against extracellular domains of α4 and α7 subunits alter the levels of nicotinic receptors in the mouse brain and affect memory: possible relevance to Alzheimer's pathology. J Alzheimers Dis 2011 0.79
91 Functional organization and conformational dynamics of the nicotinic receptor: a plausible structural interpretation of myasthenic mutations. Ann N Y Acad Sci 2008 0.79
92 Chronic nicotine exposure has dissociable behavioural effects on control and beta2-/- mice. Behav Genet 2008 0.79
93 Docking of alpha-cobratoxin suggests a basal conformation of the nicotinic receptor. Biochem Biophys Res Commun 2007 0.79
94 Intermediate closed state for glycine receptor function revealed by cysteine cross-linking. Proc Natl Acad Sci U S A 2013 0.78
95 Acquisition and performance of delayed-response tasks: a neural network model. Cereb Cortex 2004 0.78
96 Loss of high-affinity nicotinic receptors increases the vulnerability to excitotoxic lesion and decreases the positive effects of an enriched environment. FASEB J 2007 0.78
97 Abnormal response of dopaminergic neurons to nicotine without perturbation of nicotinic receptors in alphaCGRP knock-out mice. Brain Res 2008 0.77
98 Regional differential effects of chronic nicotine on brain alpha 4-containing and alpha 6-containing receptors. Neuroreport 2008 0.77
99 Identification of two critical residues within the Cys-loop sequence that determine fast-gating kinetics in a pentameric ligand-gated ion channel. J Mol Neurosci 2006 0.76
100 Immunoreactive Calcitonin Gene-Related Peptide, Vasoactive Intestinal Polypeptide, and Somatostatin in Developing Chicken Spinal Cord Motoneurons. Eur J Neurosci 1989 0.75
101 Sevoflurane anesthesia alters exploratory and anxiety-like behavior in mice lacking the beta2 nicotinic acetylcholine receptor subunit. Anesthesiology 2008 0.75
102 [The 2000 years]. Med Sci (Paris) 2015 0.75
103 Jean-Pierre Changeux: allostery as neuro-enlightenment. Mol Interv 2009 0.75
104 Historical perspective: An INTERVIEW WITH JEAN-PIERRE CHANGEUX by Ernesto Carafoli. Biochem Biophys Res Commun 2015 0.75
105 Regional changes in the cholinergic system in mice lacking monoamine oxidase A. Brain Res Bull 2008 0.75
106 α7 and β2 nicotinic receptors control monoamine-mediated locomotor response. Neuroreport 2010 0.75