Published in Age (Dordr) on February 01, 2014
NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats. J Neuroinflammation (2015) 1.43
Situational awareness: regulation of the myb transcription factor in differentiation, the cell cycle and oncogenesis. Cancers (Basel) (2014) 0.85
Protective Effect of Ginsenoside Rg1 on Hematopoietic Stem/Progenitor Cells through Attenuating Oxidative Stress and the Wnt/β-Catenin Signaling Pathway in a Mouse Model of d-Galactose-induced Aging. Int J Mol Sci (2016) 0.79
Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging. Age (Dordr) (2016) 0.78
Global gene profiling of aging lungs in Atp8b1 mutant mice. Aging (Albany NY) (2016) 0.75
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature (2003) 12.81
The genetics of ageing. Nature (2010) 12.08
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99
Ink4a/Arf expression is a biomarker of aging. J Clin Invest (2004) 8.30
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science (2007) 8.07
Augmented Wnt signaling in a mammalian model of accelerated aging. Science (2007) 5.62
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci U S A (2003) 4.76
Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A (2005) 4.48
Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol (2003) 4.31
LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science (2007) 4.27
Fat tissue, aging, and cellular senescence. Aging Cell (2010) 3.34
Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell (2009) 3.02
DNA damage response and cellular senescence in tissues of aging mice. Aging Cell (2009) 2.91
Stem cells in the skin: waste not, Wnt not. Genes Dev (2003) 2.80
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45
Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription. J Biol Chem (2007) 2.37
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol (2013) 2.04
Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol Cell (2007) 1.87
Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing. J Cell Biol (2001) 1.86
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proc Natl Acad Sci U S A (2007) 1.84
Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle. Nat Cell Biol (2011) 1.68
Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells. Gastroenterology (2007) 1.66
Wnt signaling: relevance to beta-cell biology and diabetes. Trends Endocrinol Metab (2008) 1.28
The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem Soc Trans (2012) 1.04
Wnts as essential growth factors for the adult small intestine and colon. Cell Cycle (2004) 1.04
The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair. Int J Biol Sci (2012) 0.94
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell (2004) 6.48
Cellular senescence in aging primates. Science (2006) 6.24
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell (2005) 4.83
Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrest. Mol Cell (2003) 3.23
Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev (2006) 3.14
A large scale genetic analysis of c-Myc-regulated gene expression patterns. J Biol Chem (2003) 2.69
Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol (2007) 2.56
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol Cell (2011) 2.40
A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism. Mol Cell Biol (2002) 2.27
Global regulation of nucleotide biosynthetic genes by c-Myc. PLoS One (2008) 2.12
The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry. Cell Cycle (2008) 2.09
Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity. Mol Cell (2011) 2.07
Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). Proc Natl Acad Sci U S A (2006) 2.06
Structure and function of the conserved core of histone deposition protein Asf1. Curr Biol (2003) 2.02
Cellular senescence and organismal aging. Mech Ageing Dev (2008) 1.92
Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol Cell (2007) 1.87
Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis. Aging Cell (2004) 1.87
Targeted inactivation of p53 in human cells does not result in aneuploidy. Cancer Res (2002) 1.86
Proteomic profiling of Myc-associated proteins. Cell Cycle (2010) 1.80
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Genes Dev (2013) 1.78
Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements. Aging Cell (2013) 1.62
Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol Cell Biol (2007) 1.62
RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. J Biol Chem (2004) 1.61
Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly. Nat Struct Mol Biol (2006) 1.58
Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology (2006) 1.49
Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity. Mol Cell Biol (2002) 1.49
Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation. EMBO J (2005) 1.41
HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. Mol Cell Biol (2006) 1.40
Lysosome-mediated processing of chromatin in senescence. J Cell Biol (2013) 1.38
Loss of protooncogene c-Myc function impedes G1 phase progression both before and after the restriction point. Mol Biol Cell (2003) 1.34
Senescent cells harbour features of the cancer epigenome. Nat Cell Biol (2013) 1.34
Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell (2010) 1.33
Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts. Mol Cell Biol (2003) 1.32
Involvement of the INK4a/Arf gene locus in senescence. Aging Cell (2003) 1.28
Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. Mol Cell Biol (2002) 1.26
Formation of higher-order nuclear Rad51 structures is functionally linked to p21 expression and protection from DNA damage-induced apoptosis. J Cell Sci (2002) 1.26
Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues. Aging (Albany NY) (2013) 1.26
Aging by epigenetics--a consequence of chromatin damage? Exp Cell Res (2008) 1.25
Regulation of growth arrest in senescence: telomere damage is not the end of the story. Mech Ageing Dev (2005) 1.25
Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Mol Cell Biol (2008) 1.23
The number of p16INK4a positive cells in human skin reflects biological age. Aging Cell (2012) 1.23
Identification of a functional network of human epigenetic silencing factors. J Biol Chem (2009) 1.20
Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene. Cancer Res (2003) 1.18
Placing the HIRA histone chaperone complex in the chromatin landscape. Cell Rep (2013) 1.16
Analysis of cell cycle phases and progression in cultured mammalian cells. Methods (2007) 1.12
Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts. EMBO Rep (2003) 1.10
A proposal to sequence genomes of unique interest for research on aging. J Gerontol A Biol Sci Med Sci (2007) 1.10
Heterochromatin and its relationship to cell senescence and cancer therapy. Cell Cycle (2007) 1.09
The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progression. J Biol Chem (2002) 1.06
Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response. J Virol (2007) 1.06
Varicella-zoster virus immediate-early 63 protein interacts with human antisilencing function 1 protein and alters its ability to bind histones h3.1 and h3.3. J Virol (2008) 1.06
Telomerase expression in normal human fibroblasts stabilizes DNA 5-methylcytosine transferase I. J Biol Chem (2003) 1.06
Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci. Cell Div (2010) 1.05
Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction. Cell Signal (2007) 1.04
Epigenetic control of aging. Antioxid Redox Signal (2010) 1.02
Transcriptional landscape of repetitive elements in normal and cancer human cells. BMC Genomics (2014) 1.01
Reconstructing networks of pathways via significance analysis of their intersections. BMC Bioinformatics (2008) 1.01
Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. Mol Cell Biol (2011) 1.00
Nuclear protein accumulation in cellular senescence and organismal aging revealed with a novel single-cell resolution fluorescence microscopy assay. Aging (Albany NY) (2011) 0.99
NFAT4 is required for JC virus infection of glial cells. J Virol (2006) 0.99
A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells. J Cell Mol Med (2010) 0.99
A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging. Age (Dordr) (2014) 0.98
Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit. Brain Res Bull (2006) 0.97
DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML. Genome Biol (2014) 0.95
Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex. Biochemistry (2012) 0.89
The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK. Cell Signal (2008) 0.89
c-Myc localization within the nucleus: evidence for association with the PML nuclear body. J Cell Biochem (2004) 0.89
Mice lacking Raf kinase inhibitor protein-1 (RKIP-1) have altered sperm capacitation and reduced reproduction rates with a normal response to testicular injury. J Androl (2007) 0.88
Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence. Aging Cell (2003) 0.88
Senescence at a glance. J Cell Sci (2013) 0.88
Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position. FEBS Lett (2004) 0.88
Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation. J Biol Chem (2006) 0.87
Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment. Stem Cell Res Ther (2013) 0.87
How to measure RNA expression in rare senescent cells expressing any specific protein such as p16Ink4a. Aging (Albany NY) (2013) 0.86
Cellular senescence, epigenetic switches and c-Myc. Cell Cycle (2006) 0.86
Random mutagenesis of PDZ(Omi) domain and selection of mutants that specifically bind the Myc proto-oncogene and induce apoptosis. Oncogene (2003) 0.86
Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death. Mamm Genome (2009) 0.86
Wnt signaling potentiates nevogenesis. Proc Natl Acad Sci U S A (2013) 0.86
Activation of Wnt signalling promotes development of dysplasia in Barrett's oesophagus. J Pathol (2012) 0.85
Surprise ending. Nat Genet (2003) 0.84
Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion. BMC Physiol (2012) 0.83
Lessons from senescence: Chromatin maintenance in non-proliferating cells. Biochim Biophys Acta (2011) 0.82
Probing the depths of cellular senescence. J Cell Biol (2013) 0.81
Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters. Cell Cycle (2011) 0.80
Regulation of RKIP function by Helicobacter pylori in gastric cancer. PLoS One (2012) 0.80
Signalling the end of the line. Nat Cell Biol (2012) 0.80
A damage limitation exercise. Nat Cell Biol (2011) 0.80
Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy. Small GTPases (2011) 0.79