Published in J Biol Chem on February 18, 2014
IQGAPs choreograph cellular signaling from the membrane to the nucleus. Trends Cell Biol (2015) 1.02
The biology of IQGAP proteins: beyond the cytoskeleton. EMBO Rep (2015) 0.97
IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes. J Cell Biol (2015) 0.80
Differential transcriptome profile of peripheral white cells to identify biomarkers involved in oxaliplatin induced neuropathy. J Pers Med (2014) 0.79
Shigella Effector OspB Activates mTORC1 in a Manner That Depends on IQGAP1 and Promotes Cell Proliferation. PLoS Pathog (2015) 0.76
The Structural Basis for Cdc42-Induced Dimerization of IQGAPs. Structure (2016) 0.76
Calmodulin Lobes Facilitate Dimerization and Activation of Estrogen Receptor-α. J Biol Chem (2017) 0.75
IQGAP1 Binds to Yes-associated Protein (YAP) and Modulates Its Transcriptional Activity. J Biol Chem (2016) 0.75
Absence of IQGAP1 leads to insulin resistance. J Biol Chem (2017) 0.75
Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells. Sci Rep (2016) 0.75
Wnt/β-catenin signaling and disease. Cell (2012) 16.05
A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature (1997) 11.15
Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA (2003) 8.07
Estrogen receptors: how do they signal and what are their targets. Physiol Rev (2007) 5.27
Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion. Science (1998) 3.39
Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7. Proc Natl Acad Sci U S A (1984) 3.25
IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J (1996) 2.90
IQGAP1: a key regulator of adhesion and migration. J Cell Sci (2005) 2.65
IQGAP1 in cellular signaling: bridging the GAP. Trends Cell Biol (2006) 2.63
The different roles of ER subtypes in cancer biology and therapy. Nat Rev Cancer (2011) 2.56
IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis. FEBS Lett (2009) 2.35
Functional synergy between the transcription factor Sp1 and the estrogen receptor. Mol Endocrinol (1997) 1.87
IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation. Circ Res (2004) 1.85
Identification of protein-protein interactions using in vivo cross-linking and mass spectrometry. Proteomics (2004) 1.81
IQGAP1 and its binding proteins control diverse biological functions. Cell Signal (2011) 1.77
IQGAP1 promotes cell motility and invasion. J Biol Chem (2003) 1.72
IQGAP1 integrates Ca2+/calmodulin and Cdc42 signaling. J Biol Chem (1999) 1.72
IQGAP1 modulates activation of B-Raf. Proc Natl Acad Sci U S A (2007) 1.57
IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly. J Cell Sci (2007) 1.49
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci U S A (2011) 1.47
IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells. J Biol Chem (2007) 1.46
IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin. J Biol Chem (2001) 1.36
Progesterone receptor regulation in uterine cells: stimulation by estrogen, cyclic adenosine 3',5'-monophosphate, and insulin-like growth factor I and suppression by antiestrogens and protein kinase inhibitors. Endocrinology (1991) 1.34
Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1. J Biol Chem (2002) 1.27
Membrane oestrogen receptor alpha signalling to cell functions. J Physiol (2009) 1.25
Post-translational modifications of nuclear receptors and human disease. Nucl Recept Signal (2012) 1.23
Estrogen receptors and human disease: an update. Arch Toxicol (2012) 1.22
IQGAP1 binds Rap1 and modulates its activity. J Biol Chem (2007) 1.11
Allosteric modulators of steroid hormone receptors: structural dynamics and gene regulation. Endocr Rev (2012) 1.11
Binding of myosin essential light chain to the cytoskeleton-associated protein IQGAP1. Biochem Biophys Res Commun (1998) 1.11
Estradiol increases and anti-estrogens antagonize the growth factor-induced activator protein-1 activity in MCF7 breast cancer cells without affecting c-fos and c-jun synthesis. J Biol Chem (1993) 1.10
MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation. J Biol Chem (2011) 1.09
Self-association of IQGAP1: characterization and functional sequelae. J Biol Chem (2005) 1.09
The zinc- and calcium-binding S100B interacts and co-localizes with IQGAP1 during dynamic rearrangement of cell membranes. J Biol Chem (2002) 1.09
Modulation of steroid hormone receptor activity. Prog Brain Res (2010) 1.07
IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver. J Clin Invest (2013) 1.06
E6AP and calmodulin reciprocally regulate estrogen receptor stability. J Biol Chem (2005) 1.04
Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms. J Biol Chem (2011) 1.01
Calmodulin enhances the stability of the estrogen receptor. J Biol Chem (2001) 1.01
Derailed estrogen signaling and breast cancer: an authentic couple. Endocr Rev (2012) 1.01
ERα-associated protein networks. Trends Endocrinol Metab (2011) 1.00
The transcriptional activity of estrogen receptor-alpha is dependent on Ca2+/calmodulin. J Biol Chem (2005) 0.98
Ligand-independent antiapoptotic function of estrogen receptor-beta in lung cancer cells. Mol Endocrinol (2010) 0.97
IQGAP1 protein binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance. J Biol Chem (2011) 0.96
IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest. Int J Biochem Cell Biol (2010) 0.95
Structural basis for Ca2+-induced activation and dimerization of estrogen receptor α by calmodulin. J Biol Chem (2012) 0.90
IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling. PLoS One (2013) 0.89
Identification and functional studies of a new Nrf2 partner IQGAP1: a critical role in the stability and transactivation of Nrf2. Antioxid Redox Signal (2012) 0.88
A new look at screening and diagnosing diabetes mellitus. J Clin Endocrinol Metab (2008) 4.97
Trends in prevalence and control of diabetes in the United States, 1988-1994 and 1999-2010. Ann Intern Med (2014) 4.00
Tests of glycemia in diabetes. Diabetes Care (2004) 3.35
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature (2012) 2.87
IQGAP1 in cellular signaling: bridging the GAP. Trends Cell Biol (2006) 2.63
Global standardization of glycated hemoglobin measurement: the position of the IFCC Working Group. Clin Chem Lab Med (2007) 2.46
Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years. Pediatrics (2009) 2.43
IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis. FEBS Lett (2009) 2.35
Executive summary. The National Academy of Clinical Biochemistry Laboratory Medicine Practice Guideline: evidence-based practice for point-of-care testing. Clin Chim Acta (2007) 2.23
Syphilis treatment response among HIV-discordant couples in Zambia and Rwanda. Clin Infect Dis (2013) 2.22
IQGAP proteins are integral components of cytoskeletal regulation. EMBO Rep (2003) 2.17
IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Mol Cell Biol (2005) 2.16
IQGAP1 binds ERK2 and modulates its activity. J Biol Chem (2004) 1.99
Status of hemoglobin A1c measurement and goals for improvement: from chaos to order for improving diabetes care. Clin Chem (2010) 1.95
Protein scaffolds in MAP kinase signalling. Cell Signal (2008) 1.94
Tight glucose control in the intensive care unit: are glucose meters up to the task? Clin Chem (2008) 1.90
IQGAP1 and its binding proteins control diverse biological functions. Cell Signal (2011) 1.77
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Mol Cell Biol (2006) 1.75
IQGAP1 promotes cell motility and invasion. J Biol Chem (2003) 1.72
The IFCC Reference Measurement System for HbA1c: a 6-year progress report. Clin Chem (2008) 1.70
HbA1c: how do we measure it and what does it mean? Curr Opin Endocrinol Diabetes Obes (2009) 1.65
IQGAP1 modulates activation of B-Raf. Proc Natl Acad Sci U S A (2007) 1.57
Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22. J Hepatol (2010) 1.48
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci U S A (2011) 1.47
IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells. J Biol Chem (2007) 1.46
Prenatal exposure to airborne polycyclic aromatic hydrocarbons and children's intelligence at 5 years of age in a prospective cohort study in Poland. Environ Health Perspect (2010) 1.44
IQGAP1 is a component of Cdc42 signaling to the cytoskeleton. J Biol Chem (2002) 1.39
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton. FEBS Lett (2003) 1.38
IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin. J Biol Chem (2001) 1.36
Global harmonization of hemoglobin A1c. Clin Chem (2005) 1.36
In utero arsenic exposure and infant infection in a United States cohort: a prospective study. Environ Res (2013) 1.31
The Salmonella SPI2 effector SseI mediates long-term systemic infection by modulating host cell migration. PLoS Pathog (2009) 1.30
Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1. J Biol Chem (2002) 1.27
miR-223 regulates migration and invasion by targeting Artemin in human esophageal carcinoma. J Biomed Sci (2011) 1.27
Hand-held arthroscopic optical coherence tomography for in vivo high-resolution imaging of articular cartilage. J Biomed Opt (2003) 1.24
IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis. PLoS One (2008) 1.22
Constitutive expression of a miR319 gene alters plant development and enhances salt and drought tolerance in transgenic creeping bentgrass. Plant Physiol (2013) 1.21
High-performance, stable organic thin-film field-effect transistors based on bis-5'-alkylthiophen-2'-yl-2,6-anthracene semiconductors. J Am Chem Soc (2005) 1.18
The impact of stress on the life history strategies of African American adolescents: cognitions, genetic moderation, and the role of discrimination. Dev Psychol (2012) 1.18
IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. J Biol Chem (2005) 1.13
IQGAP1 binds Rap1 and modulates its activity. J Biol Chem (2007) 1.11
MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation. J Biol Chem (2011) 1.09
Self-association of IQGAP1: characterization and functional sequelae. J Biol Chem (2005) 1.09
Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis. PLoS One (2013) 1.09
Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns. Cancer Epidemiol Biomarkers Prev (2008) 1.09
Dkk-1 inhibits intestinal epithelial cell migration by attenuating directional polarization of leading edge cells. Mol Biol Cell (2009) 1.08
Wnt5a directs polarized calcium gradients by recruiting cortical endoplasmic reticulum to the cell trailing edge. Dev Cell (2013) 1.07
Comparative analysis of the genomes of two field isolates of the rice blast fungus Magnaporthe oryzae. PLoS Genet (2012) 1.05
Hemoglobin variants and hemoglobin A1c analysis: problem solved? Clin Chem (2003) 1.05
A new G6PD knockdown tumor-cell line with reduced proliferation and increased susceptibility to oxidative stress. Cancer Biother Radiopharm (2009) 1.05
Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study. Environ Health (2013) 1.04
E6AP and calmodulin reciprocally regulate estrogen receptor stability. J Biol Chem (2005) 1.04
A multicomponent motivational intervention to improve adherence among adolescents with poorly controlled type 1 diabetes: a pilot study. J Pediatr Psychol (2013) 1.04
IQGAP1 mediates the disruption of adherens junctions to promote Escherichia coli K1 invasion of brain endothelial cells. Cell Microbiol (2012) 1.03
The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes. J Biol Chem (2007) 1.03
Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2. Biochem Biophys Res Commun (2003) 1.03
IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1, and Cdc42. J Biol Chem (2007) 1.03
Multiple proteins mediate IQGAP1-stimulated cell migration. Cell Signal (2007) 1.01
IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling. J Biol Chem (2008) 1.00
Epitaxial ZnO nanowire-on-nanoplate structures as efficient and transferable field emitters. Adv Mater (2013) 1.00
A population-based case-control study of urinary arsenic species and squamous cell carcinoma in New Hampshire, USA. Environ Health Perspect (2013) 0.99
Rapid assessment of trachoma in Hainan Province, China: validation of the new World Health Organization methodology. Ophthalmic Epidemiol (2002) 0.98
Therapy: Intensive glucose control in the ICU: is sugar nice? Nat Rev Endocrinol (2009) 0.98
IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma. BMC Gastroenterol (2010) 0.98
The transcriptional activity of estrogen receptor-alpha is dependent on Ca2+/calmodulin. J Biol Chem (2005) 0.98
IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton. FEBS Lett (2011) 0.97
IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration. EMBO J (2013) 0.96
Actin pedestal formation by enteropathogenic Escherichia coli is regulated by IQGAP1, calcium, and calmodulin. J Biol Chem (2008) 0.96
IQGAP1 protein binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance. J Biol Chem (2011) 0.96
β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1. PLoS One (2013) 0.95
Clinicopathological and prognostic significance of survivin over-expression in patients with esophageal squamous cell carcinoma: a meta-analysis. PLoS One (2012) 0.95
OCT4 positively regulates Survivin expression to promote cancer cell proliferation and leads to poor prognosis in esophageal squamous cell carcinoma. PLoS One (2012) 0.95
Interleukin-6 cytokine: a multifunctional glycoprotein for cancer. Immunome Res (2013) 0.95
Head impact accelerations for brain strain-related responses in contact sports: a model-based investigation. Biomech Model Mechanobiol (2014) 0.94
Identification and characterization of the Cdc42-binding site of IQGAP1. Biochem Biophys Res Commun (2003) 0.94
Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy. Oncotarget (2014) 0.94
P16 reactivation induces anoikis and exhibits antitumour potency by downregulating Akt/survivin signalling in hepatocellular carcinoma cells. Gut (2010) 0.93