Published in Proc Natl Acad Sci U S A on March 31, 2014
Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity (2014) 1.87
Th17 cells in cancer: the ultimate identity crisis. Front Immunol (2014) 1.33
Neutrophils in cancer: neutral no more. Nat Rev Cancer (2016) 1.06
Pathogenesis beyond the cancer clone(s) in multiple myeloma. Blood (2015) 1.04
Aerosolized Ebola vaccine protects primates and elicits lung-resident T cell responses. J Clin Invest (2015) 0.99
Inflammation in chronic obstructive pulmonary disease and its role in cardiovascular disease and lung cancer. Clin Transl Med (2015) 0.95
IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer. Cancer Res (2016) 0.92
IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia. J Immunol (2014) 0.89
Interleukin-17 promotes angiogenesis by stimulating VEGF production of cancer cells via the STAT3/GIV signaling pathway in non-small-cell lung cancer. Sci Rep (2015) 0.88
Th17 Cell Plasticity and Functions in Cancer Immunity. Biomed Res Int (2015) 0.88
COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link. Br J Pharmacol (2015) 0.87
Promotion of lung tumor growth by interleukin-17. Am J Physiol Lung Cell Mol Physiol (2014) 0.87
The relationship between COPD and lung cancer. Lung Cancer (2015) 0.85
The ratio of Th17/Treg cells as a risk indicator in early acute respiratory distress syndrome. Crit Care (2015) 0.83
Functional and Phenotypic Plasticity of CD4(+) T Cell Subsets. Biomed Res Int (2015) 0.83
Interleukin-17 promotes prostate cancer via MMP7-induced epithelial-to-mesenchymal transition. Oncogene (2016) 0.82
Disturbed Th17/Treg Balance in Patients with Non-small Cell Lung Cancer. Inflammation (2015) 0.80
IL-17/miR-192/IL-17Rs regulatory feedback loop facilitates multiple myeloma progression. PLoS One (2014) 0.80
Cellular and molecular immunology of lung cancer: therapeutic implications. Expert Rev Clin Immunol (2014) 0.79
The roles and functional mechanisms of interleukin-17 family cytokines in mucosal immunity. Cell Mol Immunol (2016) 0.79
Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner. PLoS One (2016) 0.78
Lung Cancer Subtypes Generate Unique Immune Responses. J Immunol (2016) 0.78
Hypoxia-inducible factors: a central link between inflammation and cancer. J Clin Invest (2016) 0.78
NFAT5/STAT3 interaction mediates synergism of high salt with IL-17 towards induction of VEGF-A expression in breast cancer cells. Oncol Lett (2016) 0.78
Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis. Mol Cancer (2016) 0.77
IL-17 induces EMT via Stat3 in lung adenocarcinoma. Am J Cancer Res (2016) 0.77
Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma. Proc Natl Acad Sci U S A (2016) 0.77
Preferential expansion of pro-inflammatory Tregs in human non-small cell lung cancer. Cancer Immunol Immunother (2015) 0.77
Tumorigenic Th17 cells in oncogenic Kras-driven and inflammation-accelerated lung cancer. Oncoimmunology (2015) 0.77
Preconditioning with VEGF Enhances Angiogenic and Neuroprotective Effects of Bone Marrow Mononuclear Cell Transplantation in a Rat Model of Chronic Cerebral Hypoperfusion. Mol Neurobiol (2015) 0.77
Involvement of IL17A, IL17F and IL23R Polymorphisms in Colorectal Cancer Therapy. PLoS One (2015) 0.76
Multiple criteria optimization joint analyses of microarray experiments in lung cancer: from existing microarray data to new knowledge. Cancer Med (2015) 0.76
Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer. Oncoimmunology (2015) 0.75
IL-17A weakens the antitumor immuity by inhibiting apoptosis of MDSCs in Lewis lung carcinoma bearing mice. Oncotarget (2017) 0.75
Th17 cytokines in non-melanoma skin cancer. Eur J Immunol (2015) 0.75
Interluekin-17A (IL17A). Gene (2017) 0.75
The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis. Mucosal Immunol (2016) 0.75
Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment. Oncoimmunology (2016) 0.75
The Role of Interleukin-17 in Lung Cancer. Mediators Inflamm (2016) 0.75
IL-17A-producing T cells are associated with the progression of lung adenocarcinoma. Oncol Rep (2016) 0.75
IL-17C mediates the recruitment of tumor-associated neutrophils and lung tumor growth. Oncogene (2017) 0.75
The role of toll-like receptor 4 in tumor microenvironment. Oncotarget (2017) 0.75
The prognostic value of interleukin-17 in lung cancer: A systematic review with meta-analysis based on Chinese patients. PLoS One (2017) 0.75
Interleukin-17A Promotes Lung Tumor Progression Through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade. J Thorac Oncol (2017) 0.75
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol (2005) 30.22
Immunity, inflammation, and cancer. Cell (2010) 28.27
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17
Interleukin-17 family members and inflammation. Immunity (2004) 16.16
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev (2001) 15.97
Lung cancer. N Engl J Med (2008) 13.49
Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol (2012) 12.19
The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer (2012) 10.90
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med (2009) 7.45
The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer (2008) 7.40
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell (2012) 7.36
Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood (2008) 6.81
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell (2012) 5.77
Regulation of inflammatory responses by IL-17F. J Exp Med (2008) 5.56
IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med (2009) 5.05
Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature (2009) 4.93
A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell (2012) 4.89
Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood (2009) 4.80
T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity (2009) 4.69
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature (2012) 4.41
A risk model for prediction of lung cancer. J Natl Cancer Inst (2007) 4.25
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell (2012) 4.16
Endogenous IL-17 contributes to reduced tumor growth and metastasis. Blood (2009) 4.13
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer (2013) 4.02
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med (2010) 4.00
Interleukin-17 inhibits tumor cell growth by means of a T-cell-dependent mechanism. Blood (2002) 3.17
Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. Cancer Cell (2010) 2.89
K-ras activation generates an inflammatory response in lung tumors. Oncogene (2006) 2.78
Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer. Sci Transl Med (2012) 2.62
High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras. Cancer Res (2006) 1.84
Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.73
IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS One (2011) 1.61
Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema. Sci Transl Med (2009) 1.61
Nontypeable Haemophilus influenzae in the lower respiratory tract of patients with chronic bronchitis. Am J Respir Crit Care Med (2001) 1.55
Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. Sci Transl Med (2012) 1.54
Increased IL-17-producing cells correlate with poor survival and lymphangiogenesis in NSCLC patients. Lung Cancer (2010) 1.49
Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model. Am J Respir Cell Mol Biol (2008) 1.44
The IL-17/IL-23 axis of inflammation in cancer: friend or foe? Curr Opin Investig Drugs (2009) 1.36
Interleukin-17 promotes formation and growth of prostate adenocarcinoma in mouse models. Cancer Res (2012) 1.26
A protective role by interleukin-17F in colon tumorigenesis. PLoS One (2012) 1.08
A role for T-bet-mediated tumour immune surveillance in anti-IL-17A treatment of lung cancer. Nat Commun (2011) 1.00
Cre-mediated recombination in mouse Clara cells. Genesis (2008) 1.00
Chronic obstructive pulmonary disease and lung cancer: common pathogenesis, shared clinical challenges. Proc Am Thorac Soc (2012) 0.92
Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase. Mol Cancer (2013) 0.89
IL-17 mediates resistance to anti-VEGF therapy. Nat Med (2013) 0.86
Human T(H)17 immune cells specific for the tumor antigen MAGE-A3 convert to IFN-γ-secreting cells as they differentiate into effector T cells in vivo. Cancer Res (2012) 0.86
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature (2007) 14.28
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity (2007) 13.29
STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem (2007) 10.41
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity (2008) 10.26
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity (2008) 9.61
Bcl6 mediates the development of T follicular helper cells. Science (2009) 8.50
Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity (2009) 6.87
Regulation of inflammatory responses by IL-17F. J Exp Med (2008) 5.56
T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity (2009) 4.69
Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med (2011) 4.50
Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres. Nature (2012) 4.00
Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med (2007) 3.91
The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol (2006) 3.76
IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med (2007) 3.66
CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol (2008) 3.51
Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol (2009) 3.42
Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes. Cell Res (2006) 3.41
ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. J Exp Med (2008) 3.39
B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity (2003) 3.18
Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor. J Biol Chem (2006) 3.16
Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J Biol Chem (2007) 3.14
Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease. Immunity (2010) 2.90
Characterization of mouse and human B7-H3 genes. J Immunol (2002) 2.86
Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity (2003) 2.56
A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res (2007) 2.50
A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A (2003) 2.47
Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E. Immunity (2011) 2.39
Murine B7-H3 is a negative regulator of T cells. J Immunol (2004) 2.33
TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease. J Exp Med (2008) 2.33
Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. J Immunol (2006) 2.15
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev (2003) 2.10
Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature (2004) 1.99
Retracted Inducible costimulator is essential for collagen-induced arthritis. J Clin Invest (2003) 1.94
T-cell tolerance or function is determined by combinatorial costimulatory signals. EMBO J (2006) 1.92
Regulation of IL-9 expression by IL-25 signaling. Nat Immunol (2010) 1.78
IL-17 family member cytokines: regulation and function in innate immunity. Cytokine Growth Factor Rev (2010) 1.76
B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction. Eur J Immunol (2009) 1.71
Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med (2012) 1.69
Signaling of interleukin-17 family cytokines in immunity and inflammation. Cell Signal (2010) 1.66
Regulation and function of proinflammatory TH17 cells. Ann N Y Acad Sci (2008) 1.65
IL-17F: regulation, signaling and function in inflammation. Cytokine (2009) 1.56
Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts. J Immunol (2009) 1.54
Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. Sci Transl Med (2012) 1.54
Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep (2002) 1.52
STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J Biol Chem (2012) 1.51
Cutting Edge: Programmed death (PD) ligand-1/PD-1 interaction is required for CD8+ T cell tolerance to tissue antigens. J Immunol (2006) 1.49
Regulation of T cell activation and tolerance by PDL2. Proc Natl Acad Sci U S A (2006) 1.46
BTNL2, a butyrophilin-like molecule that functions to inhibit T cell activation. J Immunol (2006) 1.45
CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation. Genes Dev (2007) 1.45
Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. J Biol Chem (2011) 1.43
Yin-Yang of costimulation: crucial controls of immune tolerance and function. Immunol Rev (2009) 1.39
Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation. J Biol Chem (2009) 1.38
Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease. Immunity (2011) 1.38
The IL-17/IL-23 axis of inflammation in cancer: friend or foe? Curr Opin Investig Drugs (2009) 1.36
MAP kinases in immune responses. Cell Mol Immunol (2005) 1.34
Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc Natl Acad Sci U S A (2012) 1.32
B7h is required for T cell activation, differentiation, and effector function. Proc Natl Acad Sci U S A (2003) 1.32
NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25. J Immunol (2010) 1.32
The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity (2010) 1.31
Repression of photosynthesis gene expression by formation of a disulfide bond in CrtJ. Proc Natl Acad Sci U S A (2002) 1.31
Transcriptional regulation of follicular T-helper (Tfh) cells. Immunol Rev (2013) 1.28
The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol (2013) 1.26
Heterogeneous nuclear ribonuclear protein K interacts with Sindbis virus nonstructural proteins and viral subgenomic mRNA. Virology (2007) 1.26
Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression. J Biol Chem (2010) 1.25
Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma. Nat Immunol (2009) 1.25
Laboratory-based surveillance for hepatitis E virus infection, United States, 2005-2012. Emerg Infect Dis (2013) 1.25
IL-17A produced by γδ T cells promotes tumor growth in hepatocellular carcinoma. Cancer Res (2014) 1.24
A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes. J Immunol (2007) 1.21
Molecular mechanisms of T-cell tolerance. Immunol Rev (2011) 1.21
Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. Nat Immunol (2012) 1.20
Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol (2009) 1.19
An NKT-mediated autologous vaccine generates CD4 T-cell dependent potent antilymphoma immunity. Blood (2007) 1.18
Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2. Immunity (2012) 1.18
Smad2 positively regulates the generation of Th17 cells. J Biol Chem (2010) 1.17
Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo. J Immunol (2007) 1.16
CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis. J Immunol (2008) 1.16
Graphene oxide: structural analysis and application as a highly transparent support for electron microscopy. ACS Nano (2009) 1.16
Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation. Proc Natl Acad Sci U S A (2012) 1.15
Melanoma cells express ICOS ligand to promote the activation and expansion of T-regulatory cells. Cancer Res (2010) 1.14
Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ γδ T cells. J Immunol (2011) 1.13
MKP-1 is necessary for T cell activation and function. J Biol Chem (2009) 1.13
Interleukin-25 (IL-25) promotes efficient protective immunity against Trichinella spiralis infection by enhancing the antigen-specific IL-9 response. Infect Immun (2013) 1.13
SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation. Mol Cell (2012) 1.11
PCA3 noncoding RNA is involved in the control of prostate-cancer cell survival and modulates androgen receptor signaling. BMC Cancer (2012) 1.11
Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction. J Immunol (2009) 1.10
Innate signals from Nod2 block respiratory tolerance and program T(H)2-driven allergic inflammation. J Allergy Clin Immunol (2010) 1.10
A protective role by interleukin-17F in colon tumorigenesis. PLoS One (2012) 1.08
IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation. Cell Res (2009) 1.08
Toll-like receptor regulation of effector T lymphocyte function. Trends Immunol (2013) 1.06
Highlights of 10 years of immunology in Nature Reviews Immunology. Nat Rev Immunol (2011) 1.06
A critical role of costimulation during intrathymic development of invariant NK T cells. J Immunol (2008) 1.05
Strain mapping in a graphene monolayer nanocomposite. ACS Nano (2011) 1.05
Cross talk between follicular Th cells and tumor cells in human follicular lymphoma promotes immune evasion in the tumor microenvironment. J Immunol (2013) 1.04
A butyrophilin family member critically inhibits T cell activation. J Immunol (2010) 1.04
IL-21 regulates Th17 cells in rheumatoid arthritis. Hum Immunol (2010) 1.03
USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. J Exp Med (2013) 1.02
High poly(β-hydroxybutyrate) production by Pseudomonas fluorescens A2a5 from inexpensive substrates. Enzyme Microb Technol (2007) 1.00