Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms.

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Published in Nat Rev Cancer on November 01, 2013

Authors

Eran Elinav1, Roni Nowarski, Christoph A Thaiss, Bo Hu, Chengcheng Jin, Richard A Flavell

Author Affiliations

1: 1] Department of Immunology, Weizmann Institute of Science, 100 Herzl Street, Rehovot 76100, Israel. [2].

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Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19

Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med (2008) 3.15

JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (2012) 3.12

Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: the STRADIVARIUS randomized controlled trial. JAMA (2008) 3.09

The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08

Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation. J Immunol (2002) 3.04

Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nat Immunol (2005) 2.96

CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci U S A (2003) 2.94

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest (2008) 2.91

Regulation of the Th2 cytokine locus by a locus control region. Immunity (2003) 2.84

Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med (2004) 2.84

A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe (2010) 2.84

An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity (2009) 2.82

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77

Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proc Natl Acad Sci U S A (2006) 2.75

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol (2005) 2.75

The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat Immunol (2009) 2.73

Does Toll-like receptor 3 play a biological role in virus infections? Virology (2004) 2.73

Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell (2008) 2.68

Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity (2009) 2.66

The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol (2006) 2.65

Molecular mechanism of NLRP3 inflammasome activation. J Clin Immunol (2010) 2.61

Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med (2009) 2.61

Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J Exp Med (2002) 2.60

Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe (2009) 2.58

Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity (2003) 2.56

STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity (2003) 2.54

Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity (2012) 2.54

TH2, allergy and group 2 innate lymphoid cells. Nat Immunol (2013) 2.52

Longitudinal progression trajectory of GFR among patients with CKD. Am J Kidney Dis (2012) 2.51