PubRank

C D Sigmund

Author PubWeight™ 78.44‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli. Nucleic Acids Res 1984 3.94
2 Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coli. Methods Enzymol 1988 3.60
3 Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products. Mol Cell Biol 1992 2.51
4 Differential expression of angiotensin receptor 1A and 1B in mouse. Am J Physiol 1994 1.91
5 RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. Kidney Int 2006 1.88
6 The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem 1997 1.78
7 Erythromycin resistance due to a mutation in a ribosomal RNA operon of Escherichia coli. Proc Natl Acad Sci U S A 1982 1.73
8 The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes. Circ Res 1998 1.73
9 Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. J Biol Chem 2001 1.72
10 Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiol Genomics 1999 1.60
11 Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest 2000 1.59
12 Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. J Clin Invest 1996 1.59
13 Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. Am J Physiol 1998 1.57
14 Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circ Res 2001 1.50
15 Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. J Hypertens 1999 1.42
16 Differential requirement for SLP-76 domains in T cell development and function. Immunity 2001 1.36
17 Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. J Clin Invest 1997 1.29
18 Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo. J Biol Chem 1999 1.28
19 Retinoic acid-mediated activation of the mouse renin enhancer. J Biol Chem 2000 1.25
20 Role of proximal promoter elements in regulation of renin gene transcription. J Biol Chem 1996 1.22
21 Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter. Circ Res 2001 1.22
22 Functional expression of the human angiotensinogen gene in transgenic mice. J Biol Chem 1994 1.22
23 Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice. Am J Physiol Renal Physiol 2001 1.19
24 Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice. Am J Physiol 1999 1.12
25 Spectinomycin resistance due to a mutation in an rRNA operon of Escherichia coli. J Bacteriol 1983 1.11
26 Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation. Physiol Genomics 2000 1.11
27 Highly regulated cell type-restricted expression of human renin in mice containing 140- or 160-kilobase pair P1 phage artificial chromosome transgenes. J Biol Chem 1999 1.09
28 Identification of cis elements in the cardiac troponin T gene conferring specific expression in cardiac muscle of transgenic mice. Circ Res 2000 1.08
29 Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination. J Biol Chem 2000 1.05
30 Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle. J Biol Chem 2000 1.04
31 Transgenic mice expressing an intracellular fluorescent fusion of angiotensin II demonstrate renal thrombotic microangiopathy and elevated blood pressure. Am J Physiol Heart Circ Physiol 2010 1.01
32 Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both cAMP-responsive element binding protein-1 (CREB)-dependent and CREB-independent mechanisms in Calu-6 cells. J Biol Chem 1997 0.99
33 The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system. Brain Res 1999 0.98
34 Expression of murine renin genes during fetal development. Mol Endocrinol 1990 0.97
35 NF-Y antagonizes renin enhancer function by blocking stimulatory transcription factors. Hypertension 2001 0.97
36 Vectors for high-level expression of cDNAs controlled by tissue-specific promoters in transgenic mice. Biotechniques 2001 0.96
37 Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein e knockout mice but not in C57BL/6 mice. Arterioscler Thromb Vasc Biol 2001 0.95
38 Species-specific differences in positive and negative regulatory elements in the renin gene enhancer. Circ Res 1999 0.94
39 Impaired endothelial function in transgenic mice expressing both human renin and human angiotensinogen. Stroke 2000 0.93
40 Conserved enhancer elements in human and mouse renin genes have different transcriptional effects in As4.1 cells. Circ Res 1997 0.92
41 Endogenous human renin expression and promoter activity in CALU-6, a pulmonary carcinoma cell line. Hypertension 1995 0.91
42 Allele-specific expression of the murine Ren-1 genes. J Biol Chem 1989 0.91
43 Vascular biology in genetically altered mice : smaller vessels, bigger insight. Circ Res 2000 0.89
44 Genetic evidence that lethality in angiotensinogen-deficient mice is due to loss of systemic but not renal angiotensinogen. J Biol Chem 2000 0.89
45 Expression of the DBA/2J Ren-2 gene in the adrenal gland of transgenic mice. EMBO J 1989 0.88
46 Biosynthesis of renin in mouse kidney tumor As4.1 cells. Eur J Biochem 1997 0.87
47 JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter. Am J Physiol 1999 0.87
48 Transcriptional and posttranscriptional mechanisms regulate human renin gene expression in Calu-6 cells. Am J Physiol 1996 0.85
49 Understanding hypertension through genetic manipulation in mice. Kidney Int 2000 0.83
50 Regulation of human renin mRNA expression and protein release in transgenic mice. Hypertension 1996 0.83
51 Modifiable gene expression in mice: kidney-specific deletion of a target gene via the cre-loxP system. Exp Nephrol 1999 0.82
52 Kidney is the only source of human plasma renin in 45-kb human renin transgenic mice. Circ Res 1999 0.82
53 Human renin mRNA stability is increased in response to cAMP in Calu-6 cells. Hypertension 1999 0.82
54 Transgenic mice for studies of the renin-angiotensin system in hypertension. Acta Physiol Scand 2004 0.81
55 Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). Endocrinology 1995 0.80
56 Regulatory elements required for human angiotensinogen expression in HepG2 cells are dispensable in transgenic mice. Hypertension 1998 0.80
57 Transgenic and knockout mice to study the renin-angiotensin system and other interacting vasoactive pathways. Curr Hypertens Rep 2000 0.79
58 Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia. Hypertension 1991 0.78
59 Studies on the regulation of renin genes using transgenic mice. Clin Exp Hypertens A 1988 0.78
60 Developmental expression of human angiotensinogen in transgenic mice. Am J Physiol 1998 0.78
61 Transgenic models as tools for studying the regulation of human renin expression. Regul Pept 2000 0.77
62 Chromosome 8 alterations accompany tumorigenesis in renin-SV40 T antigen transgenic mice. Cancer Res 1994 0.76
63 Downregulation of renin gene expression by interleukin-1. Hypertension 1997 0.76
64 Paradoxical regulation of short promoter human renin transgene by angiotensin ii. Hypertension 2001 0.76
65 Physiological insights from genetic manipulation of the renin-angiotensin system. News Physiol Sci 2001 0.75
66 Use of transgenic and gene-targeted mice to model the genetic basis of hypertensive disorders. Proc Assoc Am Physicians 1997 0.75
67 Inappropriate splicing of a chimeric gene containing a large internal exon results in exon skipping in transgenic mice. Nucleic Acids Res 1996 0.75
68 Human renin 5'-flanking DNA to nucleotide-2750. DNA Seq 1995 0.75
69 Transgenic animal models as tools for studying renal developmental physiology. Pediatr Nephrol 1996 0.75
70 Transgenic animals in the study of blood pressure regulation and hypertension. Am J Physiol 1995 0.75
71 Transgenesis and gene targeting in the mouse; tools for studying genetic determinants of hypertension. Trends Cardiovasc Med 1998 0.75
72 Transgenic animals as tools in hypertension research. Proc Soc Exp Biol Med 1994 0.75