Published in Elife on May 06, 2014
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation. Cancer Cell (2015) 1.73
SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair. Oncogene (2015) 1.65
Dual Chromatin and Cytoskeletal Remodeling by SETD2. Cell (2016) 1.44
Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination. Genes Dev (2015) 1.17
LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2. Oncotarget (2015) 1.03
High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma. Oncogene (2015) 1.01
New strategies in renal cell carcinoma: targeting the genetic and metabolic basis of disease. Clin Cancer Res (2015) 0.98
miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma. Oncotarget (2015) 0.93
Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma. Elife (2015) 0.90
The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer. Cancer Genet (2015) 0.85
The Genetic Basis of Hepatosplenic T-cell Lymphoma. Cancer Discov (2017) 0.84
Histone H3 mutations--a special role for H3.3 in tumorigenesis? Chromosoma (2015) 0.83
SET-ting the stage for DNA repair. Nat Struct Mol Biol (2014) 0.83
Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation. EMBO J (2015) 0.81
DNA double strand break repair pathway choice: a chromatin based decision? Nucleus (2015) 0.81
Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma. Sci Rep (2017) 0.81
The epigenetic landscape of renal cancer. Nat Rev Nephrol (2016) 0.81
Selective suppression of antisense transcription by Set2-mediated H3K36 methylation. Nat Commun (2016) 0.81
Genomic aberrations frequently alter chromatin regulatory genes in chordoma. Genes Chromosomes Cancer (2016) 0.80
Precision medicine from the renal cancer genome. Nat Rev Nephrol (2016) 0.80
Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model. Clin Epigenetics (2016) 0.80
Reading chromatin signatures after DNA double-strand breaks. Philos Trans R Soc Lond B Biol Sci (2017) 0.78
SETD2: an epigenetic modifier with tumor suppressor functionality. Oncotarget (2016) 0.78
Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia. Leukemia (2016) 0.78
Crosstalk between the H3K36me3 and H4K16ac histone epigenetic marks in DNA double-strand break repair. J Biol Chem (2017) 0.77
Marked for death: targeting epigenetic changes in cancer. Nat Rev Drug Discov (2017) 0.76
Shaping the cellular landscape with Set2/SETD2 methylation. Cell Mol Life Sci (2017) 0.76
MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress. Proc Natl Acad Sci U S A (2017) 0.76
The epigenetic landscape of clear-cell renal cell carcinoma. J Kidney Cancer VHL (2015) 0.75
MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents. Oncogene (2016) 0.75
Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes. Nat Struct Mol Biol (2017) 0.75
Genomic alterations in DNA repair and chromatin remodeling genes in estrogen receptor-positive metastatic breast cancer patients with exceptional responses to capecitabine. Cancer Med (2015) 0.75
Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma. Neoplasia (2016) 0.75
Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme. Mob DNA (2016) 0.75
In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites. Genome Res (2017) 0.75
SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing. Nucleic Acids Res (2016) 0.75
Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation. J Biol Chem (2016) 0.75
JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity. PLoS Genet (2017) 0.75
Increased expression of SET domain-containing proteins and decreased expression of Rad51 in different classes of renal cell carcinoma. Biosci Rep (2016) 0.75
The PPARγ-SETD8 axis constitutes an epigenetic, p53-independent checkpoint on p21-mediated cellular senescence. Aging Cell (2017) 0.75
Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription. Cell Rep (2017) 0.75
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 57.23
Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature (1997) 44.55
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem (1998) 28.13
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science (2007) 20.11
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem (2004) 14.93
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature (2010) 14.50
Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature (2013) 13.60
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature (2011) 13.30
Cell-cycle checkpoints and cancer. Nature (2004) 13.19
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (1998) 11.90
The DNA damage response: ten years after. Mol Cell (2007) 11.80
Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89
Human CtIP promotes DNA end resection. Nature (2007) 10.63
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell (1997) 10.52
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature (2012) 9.89
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev (1999) 9.50
Mechanism of eukaryotic homologous recombination. Annu Rev Biochem (2008) 8.86
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell (2010) 8.70
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem (2001) 7.35
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res (2004) 6.38
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol (2010) 5.59
DNA double-strand break repair: all's well that ends well. Annu Rev Genet (2006) 5.59
Playing the end game: DNA double-strand break repair pathway choice. Mol Cell (2012) 5.42
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol (2010) 5.35
Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet (2013) 4.61
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance. Nat Cell Biol (2011) 4.23
Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation. EMBO J (2007) 3.81
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO J (1999) 3.13
Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Mol Cell (2009) 3.12
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature (2011) 3.10
The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell (2013) 2.87
DNA damage checkpoints in stem cells, ageing and cancer. Nat Rev Mol Cell Biol (2012) 2.39
Prime, repair, restore: the active role of chromatin in the DNA damage response. Mol Cell (2012) 2.04
Histone methyltransferase gene SETD2 is a novel tumor suppressor gene in clear cell renal cell carcinoma. Cancer Res (2010) 2.03
Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair. J Biol Chem (2007) 1.94
Chromatin and the genome integrity network. Nat Rev Genet (2013) 1.72
Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas. Acta Neuropathol (2013) 1.54
p53 pathway in renal cell carcinoma is repressed by a dominant mechanism. Cancer Res (2004) 1.47
Targeting histone modifications--epigenetics in cancer. Curr Opin Cell Biol (2013) 1.36
LEDGF (p75) promotes DNA-end resection and homologous recombination. Nat Struct Mol Biol (2012) 1.27
Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes. Cell Signal (2008) 1.18
Free radical mechanisms in neocarzinostatin-induced DNA damage. Free Radic Biol Med (1987) 1.18
Topoisomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes. J Biol Chem (1996) 1.17
Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas. Genes Chromosomes Cancer (2013) 1.12
Internucleosomal cleavage and chromosomal degradation by bleomycin and phleomycin in yeast. Cancer Res (1988) 1.12
Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription. Nucleic Acids Res (2013) 1.12
Proteolytic digestion studies of chromatin core-histone structure. Identification of the limit peptides of histones H3 and H4. Eur J Biochem (1981) 1.00
Histone acetyltransferase 1 promotes homologous recombination in DNA repair by facilitating histone turnover. J Biol Chem (2013) 0.95
The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair. Cell Cycle (2011) 0.94
Histone chaperone FACT regulates homologous recombination by chromatin remodeling through interaction with RNF20. J Cell Sci (2013) 0.93
Histone tails: Directing the chromatin response to DNA damage. FEBS Lett (2011) 0.90
Reciprocal regulatory links between cotranscriptional splicing and chromatin. Semin Cell Dev Biol (2014) 0.82