Published in Cell on July 03, 2014
Complement activation, regulation, and molecular basis for complement-related diseases. EMBO J (2015) 1.12
A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling. Nat Commun (2015) 0.86
The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanism. Structure (2014) 0.84
Role of VGF-derived carboxy-terminal peptides in energy balance and reproduction: analysis of "humanized" knockin mice expressing full-length or truncated VGF. Endocrinology (2015) 0.84
Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming. Genes Dev (2014) 0.81
Altered Plasma Profile of Antioxidant Proteins as an Early Correlate of Pancreatic β Cell Dysfunction. J Biol Chem (2016) 0.78
The somatotropic axis and aging: Benefits of endocrine defects. Growth Horm IGF Res (2016) 0.78
Type 2 diabetes mellitus coincident with pulmonary or latent tuberculosis results in modulation of adipocytokines. Cytokine (2016) 0.77
Replacing SNAP-25b with SNAP-25a expression results in metabolic disease. Proc Natl Acad Sci U S A (2015) 0.76
Multiple Sclerosis and Obesity: Possible Roles of Adipokines. Mediators Inflamm (2016) 0.76
Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia. Sci Rep (2016) 0.75
The Safety Limits Of An Extended Fast: Lessons from a Non-Model Organism. Sci Rep (2016) 0.75
Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation. PLoS One (2016) 0.75
Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery. J Obes (2016) 0.75
Liver ubiquitome uncovers nutrient-stress-mediated trafficking and secretion of complement C3. Cell Death Dis (2016) 0.75
Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus. Sci Rep (2015) 0.75
Adipose-Derived Mesenchymal Stem Cells Ameliorate Lipid Metabolic Disturbance in Mice. Stem Cells Transl Med (2016) 0.75
The neuropeptide TLQP-21 opposes obesity via C3aR1-mediated enhancement of adrenergic-induced lipolysis. Mol Metab (2016) 0.75
Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders. Mol Metab (2017) 0.75
Genetic Determination of Serum Levels of Diabetes-Associated Adipokines. Rev Diabet Stud (2016) 0.75
Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Subcutaneous Adipose Tissue and Adipocytes in Acquired Obesity. Front Immunol (2017) 0.75
Macrophage functions in lean and obese adipose tissue. Metabolism (2017) 0.75
Protective role of complement C3 against cytokine-mediated β-cell apoptosis. Endocrinology (2017) 0.75
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
Inflammation and metabolic disorders. Nature (2006) 33.33
Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med (2006) 19.09
Inflammation and insulin resistance. J Clin Invest (2006) 18.76
Complement: a key system for immune surveillance and homeostasis. Nat Immunol (2010) 10.37
Adipocytes as regulators of energy balance and glucose homeostasis. Nature (2006) 9.52
Mechanisms linking obesity with cardiovascular disease. Nature (2006) 9.07
U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group. Diabetes (1995) 8.95
Adipokines in inflammation and metabolic disease. Nat Rev Immunol (2011) 8.92
Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest (2007) 8.71
Islet beta cell failure in type 2 diabetes. J Clin Invest (2006) 7.67
Inflammatory links between obesity and metabolic disease. J Clin Invest (2011) 6.73
Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol (2008) 6.23
Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science (1996) 4.61
Insulin-sensitive obesity. Am J Physiol Endocrinol Metab (2010) 3.46
Diabetes mellitus and the β cell: the last ten years. Cell (2012) 3.31
Increased number of islet-associated macrophages in type 2 diabetes. Diabetes (2007) 3.01
Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med (2008) 2.78
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature (2013) 2.74
Characterizing the profile of obese patients who are metabolically healthy. Int J Obes (Lond) (2010) 2.71
United Kingdom Prospective Diabetes Study 17: a 9-year update of a randomized, controlled trial on the effect of improved metabolic control on complications in non-insulin-dependent diabetes mellitus. Ann Intern Med (1996) 2.41
The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study. Diabetes (2006) 2.40
UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group. Diabet Med (1998) 2.20
Adipokines as novel biomarkers and regulators of the metabolic syndrome. Ann N Y Acad Sci (2010) 2.16
MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. Nat Med (2012) 2.13
Severely impaired adipsin expression in genetic and acquired obesity. Science (1987) 2.03
Metabolic signaling in fuel-induced insulin secretion. Cell Metab (2013) 2.00
Adipsin and an endogenous pathway of complement from adipose cells. J Biol Chem (1992) 1.88
Adipsin and complement factor D activity: an immune-related defect in obesity. Science (1989) 1.87
Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve. Science (1987) 1.77
Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. J Biol Chem (1992) 1.74
The stunned beta cell: a brief history. Cell Metab (2010) 1.61
Insulin resistance and pancreatic beta cell failure. J Clin Invest (2006) 1.60
The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology. Endocr Rev (2006) 1.59
Complement activation in factor D-deficient mice. Proc Natl Acad Sci U S A (2001) 1.59
Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat. Diabetes (2006) 1.49
Role for the alternative complement pathway in ischemia/reperfusion injury. Am J Pathol (2003) 1.49
Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. J Immunol (2001) 1.47
The dual control of insulin secretion by glucose involves triggering and amplifying pathways in β-cells. Diabetes Res Clin Pract (2011) 1.42
The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation. Diabetes (2009) 1.32
Regulation of calcium in pancreatic α- and β-cells in health and disease. Cell Calcium (2011) 1.29
The immune system's involvement in obesity-driven type 2 diabetes. Semin Immunol (2013) 1.25
The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis. J Clin Invest (1993) 1.25
Effect of body weight and caloric restriction on serum complement proteins, including Factor D/adipsin: studies in anorexia nervosa and obesity. Clin Exp Immunol (1997) 1.16
The role of adipokines in β-cell failure of type 2 diabetes. J Endocrinol (2013) 1.15
Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration. Diabetologia (2008) 1.11
Dual action of adiponectin on insulin secretion in insulin-resistant mice. Biochem Biophys Res Commun (2004) 1.10
Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes. Diabetes Obes Metab (2009) 1.10
Alterations of the classic pathway of complement in adipose tissue of obesity and insulin resistance. Am J Physiol Endocrinol Metab (2007) 1.10
Regulation of ATP production by mitochondrial Ca(2+). Cell Calcium (2012) 1.07
Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes. Nat Clin Pract Endocrinol Metab (2008) 1.07
The role of FOXO1 in β-cell failure and type 2 diabetes mellitus. Nat Rev Endocrinol (2013) 1.07
Activated Ask1-MKK4-p38MAPK/JNK stress signaling pathway in human omental fat tissue may link macrophage infiltration to whole-body Insulin sensitivity. J Clin Endocrinol Metab (2009) 1.00
Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis. J Clin Endocrinol Metab (2005) 0.99
Mitochondrial function and insulin secretion. Mol Cell Endocrinol (2013) 0.97
C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling. FASEB J (2012) 0.97
Genetic deficiency of acylation stimulating protein (ASP(C3ades-Arg)) does not cause hyperapobetalipoproteinemia in mice. J Biol Chem (1999) 0.93
Acylation stimulating protein stimulates insulin secretion. Int J Obes Relat Metab Disord (2003) 0.87
Concentrations of adipsin in blood and rates of adipsin secretion by adipose tissue in humans with normal, elevated and diminished adipose tissue mass. Int J Obes Relat Metab Disord (1994) 0.87
Distinct different contributions of the alternative and classical complement activation pathway for the innate host response during sepsis. J Immunol (2011) 0.84
Independent regulation of adipose tissue-specificity and obesity response of the adipsin promoter in transgenic mice. J Biol Chem (1994) 0.76