Published in Angew Chem Int Ed Engl on August 05, 2014
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The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell (2005) 2.85
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Proc Natl Acad Sci U S A (2003) 2.73
En bloc vascular resection for locally advanced pancreatic malignancies infiltrating major blood vessels: perioperative outcome and long-term survival in 136 patients. Ann Surg (2008) 2.64
The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation. J Biol Chem (2005) 2.01
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Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation. EMBO J (2002) 1.81
Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature (2002) 1.80
siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells. Oncogene (2003) 1.78
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Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. Mol Cell Biol (2006) 1.31
UBE1L2, a novel E1 enzyme specific for ubiquitin. J Biol Chem (2007) 1.25
KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry. Nat Chem Biol (2012) 1.24
The role of the ubiquitin ligase E6-AP in human papillomavirus E6-mediated degradation of PDZ domain-containing proteins. J Biol Chem (2006) 1.23
Improved LNA probe-based assay for the detection of African and South American yellow fever virus strains. J Clin Virol (2010) 1.22
Novel strategies for the site-specific covalent labelling of nucleic acids. Chem Commun (Camb) (2008) 1.18
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Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. Cancer Res (2009) 1.12
RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma. Int J Cancer (2012) 1.10
Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2. J Biol Chem (2007) 1.08
Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome. Proc Natl Acad Sci U S A (2010) 1.07
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Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc. Proc Natl Acad Sci U S A (2013) 0.99
Mutation of HERC2 causes developmental delay with Angelman-like features. J Med Genet (2012) 0.98
Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2. J Biol Chem (2011) 0.98
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Expression and prognostic relevance of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of patients with multiple myeloma. Exp Mol Pathol (2010) 0.96
Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system. Mol Cell Proteomics (2012) 0.93
Prolonged intrathecal release of soluble Fas following severe traumatic brain injury in humans. J Neuroimmunol (2002) 0.92
Implications of active site constraints on varied DNA polymerase selectivity. J Am Chem Soc (2002) 0.92
Evolving a thermostable DNA polymerase that amplifies from highly damaged templates. Angew Chem Int Ed Engl (2007) 0.92
A molecular beacon for quantitative monitoring of the DNA polymerase reaction in real-time. Angew Chem Int Ed Engl (2002) 0.92
Enhanced fidelity in mismatch extension by DNA polymerase through directed combinatorial enzyme design. Angew Chem Int Ed Engl (2005) 0.91
Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53. J Virol (2005) 0.91
DNA-templated synthesis: more versatile than expected. Angew Chem Int Ed Engl (2002) 0.90
New light-sensitive nucleosides for caged DNA strand breaks. Chembiochem (2002) 0.90
Ubiquitin ligase E6-AP and its role in human disease. Biochem Soc Trans (2008) 0.90
Opposed steric constraints in human DNA polymerase beta and E. coli DNA polymerase I. J Am Chem Soc (2008) 0.89
A nucleoside triphosphate for site-specific labelling of DNA by the Staudinger ligation. Chem Commun (Camb) (2007) 0.89
Evaluation of the stereotactic 8G vacuum-assisted breast biopsy in the histologic evaluation of suspicious mammography findings (BI-RADS IV). Invest Radiol (2005) 0.89
Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases. Mol Cell (2013) 0.88
The ubiquitin-protein ligase activity of Hdm2 is inhibited by nucleic acids. FEBS Lett (2003) 0.88
Generation of a mono-ubiquitinated PCNA mimic by click chemistry. Chembiochem (2011) 0.88
Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. J Gen Virol (2007) 0.87
Crossing the Rubicon: when pancreatic resection with curative intent ends in an R2 status. Impact of "desmoplastic pseudo-pancreatitis" and anatomical site of irresectability. Ann Surg Oncol (2009) 0.87
Structures of KOD and 9°N DNA polymerases complexed with primer template duplex. Chembiochem (2013) 0.87
A DNA polymerase with increased reactivity for ribonucleotides and C5-modified deoxyribonucleotides. Chembiochem (2010) 0.87
Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase. Proc Natl Acad Sci U S A (2010) 0.86
Evolving thermostable reverse transcriptase activity in a DNA polymerase scaffold. Angew Chem Int Ed Engl (2006) 0.86
Direct sensing of 5-methylcytosine by polymerase chain reaction. Angew Chem Int Ed Engl (2014) 0.86
Rapid labeling of metabolically engineered cell-surface glycoconjugates with a carbamate-linked cyclopropene reporter. Bioconjug Chem (2013) 0.86
An efficient method for the construction of functionalized DNA bearing amino acid groups through cross-coupling reactions of nucleoside triphosphates followed by primer extension or PCR. Chemistry (2007) 0.86
GFAP-independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells. Glia (2011) 0.86
Turning the RING domain protein MdmX into an active ubiquitin-protein ligase. J Biol Chem (2010) 0.86
Functional ubiquitin conjugates with lysine-epsilon-amino-specific linkage by thioether ligation of cysteinyl-ubiquitin peptide building blocks. Bioconjug Chem (2009) 0.85
Cytogenetics of extramedullary manifestations in multiple myeloma. Br J Haematol (2013) 0.84
Poly(ADP-ribose)-mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function. FEBS J (2014) 0.84
BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl (2009) 0.84
Engineered DNA polymerases in biotechnology. Chembiochem (2010) 0.84
Specific incorporation of an artificial nucleotide opposite a mutagenic DNA adduct by a DNA polymerase. J Am Chem Soc (2014) 0.83
Enzymatic synthesis of multiple spin-labeled DNA. Angew Chem Int Ed Engl (2008) 0.83
Roles of larval sea urchin spicule SM50 domains in organic matrix self-assembly and calcium carbonate mineralization. J Struct Biol (2013) 0.83
A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein. J Mol Med (Berl) (2008) 0.83
Lesion bypass activity of DNA polymerase A from the extremely radioresistant organism Deinococcus radiodurans. J Biol Chem (2007) 0.83
Anterior, thoracoscopic-assisted reduction and stabilization of a thoracic burst fracture (T8) in a pregnant woman. Eur Spine J (2011) 0.83
Taking fingerprints of DNA polymerases: multiplex enzyme profiling on DNA arrays. Angew Chem Int Ed Engl (2009) 0.83
Structures of KlenTaq DNA polymerase caught while incorporating C5-modified pyrimidine and C7-modified 7-deazapurine nucleoside triphosphates. J Am Chem Soc (2012) 0.83
Dissecting ubiquitin signaling with linkage-defined and protease resistant ubiquitin chains. Angew Chem Int Ed Engl (2014) 0.83
Learning from directed evolution: Thermus aquaticus DNA polymerase mutants with translesion synthesis activity. Chembiochem (2011) 0.82
Novel DNA catalysts based on G-quadruplex recognition. Chembiochem (2008) 0.82
Screening mutant libraries of T7 RNA polymerase for candidates with increased acceptance of 2'-modified nucleotides. Chem Commun (Camb) (2012) 0.82
A class of mild surfactants that keep integral membrane proteins water-soluble for functional studies and crystallization. Mol Membr Biol (2011) 0.82
Similar incidences of TP53 deletions in extramedullary organ infiltrations, soft tissue and osteolyses of patients with multiple myeloma. Anticancer Res (2012) 0.82
Synthesis and stability of phosphate modified ATP analogues. J Org Chem (2012) 0.82
Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancer. Mol Ther (2005) 0.82
Differentiation of compact and extended conformations of di-ubiquitin conjugates with lysine-specific isopeptide linkages by ion mobility-mass spectrometry. J Am Soc Mass Spectrom (2011) 0.81
Ubiquitin-fusion protein system: a powerful tool for ectopic protein expression in mammalian cells. Biotechniques (2009) 0.81
Structures of DNA polymerases caught processing size-augmented nucleotide probes. Angew Chem Int Ed Engl (2010) 0.81
A new photoactive building block for investigation of DNA backbone interactions: photoaffinity labeling of human DNA polymerase beta. Chembiochem (2006) 0.81
PTEN deletion is rare but often homogeneous in gastric cancer. J Clin Pathol (2012) 0.81
Replacing 32 proline residues by a noncanonical amino acid results in a highly active DNA polymerase. J Am Chem Soc (2010) 0.81
Amino acid templating mechanisms in selection of nucleotides opposite abasic sites by a family a DNA polymerase. J Biol Chem (2012) 0.80
Directed evolution of DNA polymerases: construction and screening of DNA polymerase mutant libraries. Curr Protoc Chem Biol (2010) 0.80
c-Abl phosphorylates E6AP and regulates its E3 ubiquitin ligase activity. Biochemistry (2013) 0.80
Enzymatic synthesis of perfluoroalkylated DNA. Bioorg Med Chem (2009) 0.80
Small Molecule Inhibitors of Human DNA Polymerase λ. ACS Chem Biol (2011) 0.80
Sustained complete hematologic remission after administration of the tyrosine kinase inhibitor imatinib mesylate in a patient with refractory, secondary AML. Blood (2002) 0.80
Diamondoid-modified DNA. Org Biomol Chem (2011) 0.79
Low N-acetyltransferase 2 activity in isoniazid-associated acute hepatitis requiring liver transplantation. Transpl Int (2009) 0.79
The use of enzymes for construction of DNA-based objects and assemblies. Chem Soc Rev (2011) 0.79
Tuning PCR specificity by chemically modified primer probes. Angew Chem Int Ed Engl (2002) 0.79