Published in Nat Struct Mol Biol on September 01, 2014
DNA-guided genome editing using the Natronobacterium gregoryi Argonaute. Nat Biotechnol (2016) 3.71
Noncoding RNA. piRNA-guided slicing specifies transcripts for Zucchini-dependent, phased piRNA biogenesis. Science (2015) 1.58
Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages. PLoS Biol (2015) 1.50
A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions. Cell (2016) 1.43
Argonaute of the archaeon Pyrococcus furiosus is a DNA-guided nuclease that targets cognate DNA. Nucleic Acids Res (2015) 0.94
Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells. EMBO J (2016) 0.89
Origin of eukaryotes from within archaea, archaeal eukaryome and bursts of gene gain: eukaryogenesis just made easier? Philos Trans R Soc Lond B Biol Sci (2015) 0.87
A prokaryotic twist on argonaute function. Life (Basel) (2015) 0.86
ssDNA and the Argonautes: The Quest for the Next Golden Editor. Hum Gene Ther (2016) 0.82
Evolutionary Ecology of Prokaryotic Immune Mechanisms. Microbiol Mol Biol Rev (2016) 0.82
Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute. Nat Commun (2016) 0.81
Immunity, suicide or both? Ecological determinants for the combined evolution of anti-pathogen defense systems. BMC Evol Biol (2015) 0.80
Duplication and Diversification of Dipteran Argonaute Genes, and the Evolutionary Divergence of Piwi and Aubergine. Genome Biol Evol (2016) 0.79
A Small RNA-Based Immune System Defends Germ Cells against Mobile Genetic Elements. Stem Cells Int (2015) 0.77
From early lessons to new frontiers: the worm as a treasure trove of small RNA biology. Front Genet (2014) 0.77
Human nuclear ARGONAUTE 2 interacts in vivo only with small RNAs and not with DNA. Cell Cycle (2015) 0.77
A bacterial Argonaute with noncanonical guide RNA specificity. Proc Natl Acad Sci U S A (2016) 0.76
Variation and Evolution in the Glutamine-Rich Repeat Region of Drosophila Argonaute-2. G3 (Bethesda) (2016) 0.76
Effects of Argonaute on Gene Expression in Thermus thermophilus. PLoS One (2015) 0.76
The miRNA biogenesis in marine bivalves. PeerJ (2016) 0.76
Conformational Dynamics of Ago-Mediated Silencing Processes. Int J Mol Sci (2015) 0.76
The evolutionary origin of plant and animal microRNAs. Nat Ecol Evol (2017) 0.76
A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes. Elife (2016) 0.75
RNA. Complete pairing not needed. Science (2014) 0.75
An NgAgo tool for genome editing: did CRISPR/Cas9 just find a competitor? Genes Dis (2016) 0.75
Evolution and Functional Trajectory of Sir1 in Gene Silencing. Mol Cell Biol (2016) 0.75
Bacteriophage exclusion, a new defense system. EMBO J (2014) 0.75
Mechanistic Insights into Archaeal and Human Argonaute Substrate Binding and Cleavage Properties. PLoS One (2016) 0.75
A Primary Sequence Analysis of the ARGONAUTE Protein Family in Plants. Front Plant Sci (2016) 0.75
Reconstruction of the evolution of microbial defense systems. BMC Evol Biol (2017) 0.75
The small non-coding RNA processing machinery of two living fossil species, lungfish and coelacanth, gives new insights into the evolution of the Argonaute protein family. Genome Biol Evol (2017) 0.75
Profile of Dinshaw J. Patel. Proc Natl Acad Sci U S A (2015) 0.75
The LBD12-1 transcription factor suppresses apical meristem size by repressing Argonaute 10 expression. Plant Physiol (2016) 0.75
Evolution of RNA- and DNA-guided antivirus defense systems in prokaryotes and eukaryotes: common ancestry vs convergence. Biol Direct (2017) 0.75
Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes. Nucleic Acids Res (2017) 0.75
Mechanisms and consequences of diversity-generating immune strategies. Nat Rev Immunol (2017) 0.75
RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding. Nat Struct Mol Biol (2017) 0.75
Recruitment of CRISPR-Cas systems by Tn7-like transposons. Proc Natl Acad Sci U S A (2017) 0.75
MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17
FastTree 2--approximately maximum-likelihood trees for large alignments. PLoS One (2010) 26.15
Asymmetry in the assembly of the RNAi enzyme complex. Cell (2003) 22.18
Functional siRNAs and miRNAs exhibit strand bias. Cell (2003) 19.15
Crystal structure of Argonaute and its implications for RISC slicer activity. Science (2004) 12.48
RNA silencing in plants. Nature (2004) 11.12
Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell (2008) 9.02
Argonaute proteins: key players in RNA silencing. Nat Rev Mol Cell Biol (2008) 8.96
Small RNAs as guardians of the genome. Cell (2009) 8.88
Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature (2004) 7.63
Methylation as a crucial step in plant microRNA biogenesis. Science (2005) 7.16
Distinct populations of primary and secondary effectors during RNAi in C. elegans. Science (2006) 7.15
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Cell (2006) 7.14
Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature (2005) 7.12
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol (2003) 6.90
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature (2010) 6.37
A three-dimensional view of the molecular machinery of RNA interference. Nature (2009) 6.31
Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. Nature (2005) 6.23
A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science (2010) 5.84
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature (2008) 5.78
AGO1 defines a novel locus of Arabidopsis controlling leaf development. EMBO J (1998) 5.62
Secondary siRNAs result from unprimed RNA synthesis and form a distinct class. Science (2006) 5.49
Structure of the guide-strand-containing argonaute silencing complex. Nature (2008) 5.36
The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Curr Biol (2007) 5.35
Structure and conserved RNA binding of the PAZ domain. Nature (2003) 5.28
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature (2009) 5.24
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22
Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature (2003) 4.92
Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat Struct Mol Biol (2004) 4.38
The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster. Genes Dev (2006) 4.26
Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol Cell (2005) 4.11
The crystal structure of human Argonaute2. Science (2012) 4.03
Target RNA-directed trimming and tailing of small silencing RNAs. Science (2010) 3.98
Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain. Trends Biochem Sci (2000) 3.96
Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems. Biol Direct (2011) 3.92
Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature (2010) 3.77
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J (2004) 3.57
The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nat Struct Mol Biol (2012) 3.42
The mammalian Mediator complex and its role in transcriptional regulation. Trends Biochem Sci (2005) 3.25
Argonaute proteins: functional insights and emerging roles. Nat Rev Genet (2013) 3.09
Antiviral RNA interference in mammalian cells. Science (2013) 2.89
The structure of human argonaute-2 in complex with miR-20a. Cell (2012) 2.83
The Argonaute protein family. Genome Biol (2008) 2.83
RNA interference functions as an antiviral immunity mechanism in mammals. Science (2013) 2.77
A Dicer-like protein in Tetrahymena has distinct functions in genome rearrangement, chromosome segregation, and meiotic prophase. Genes Dev (2004) 2.75
DNA-guided DNA interference by a prokaryotic Argonaute. Nature (2014) 2.75
Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription. Nature (2010) 2.74
Biogenesis, turnover, and mode of action of plant microRNAs. Plant Cell (2013) 2.65
Comparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packaging. Nucleic Acids Res (2004) 2.62
RNA interference in Trypanosoma brucei: cloning of small interfering RNAs provides evidence for retroposon-derived 24-26-nucleotide RNAs. RNA (2001) 2.61
DNA-binding proteins and evolution of transcription regulation in the archaea. Nucleic Acids Res (1999) 2.53
Bacterial argonaute samples the transcriptome to identify foreign DNA. Mol Cell (2013) 2.47
Structure of yeast Argonaute with guide RNA. Nature (2012) 2.38
Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein. Mol Cell (2009) 2.27
Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release. EMBO J (2006) 2.23
Origins and evolution of eukaryotic RNA interference. Trends Ecol Evol (2008) 2.15
Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell (2012) 2.07
3' end formation of PIWI-interacting RNAs in vitro. Mol Cell (2011) 2.05
ATP-dependent human RISC assembly pathways. Nat Struct Mol Biol (2009) 2.04
Structural determinants of miRNAs for RISC loading and slicer-independent unwinding. Nat Struct Mol Biol (2009) 2.01
Retroviral integrase superfamily: the structural perspective. EMBO Rep (2009) 1.97
The many faces of RNAi. Dev Cell (2011) 1.94
CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs. Cell (2009) 1.94
PIWI-interacting RNAs: from generation to transgenerational epigenetics. Nat Rev Genet (2013) 1.92
The helicases DinG, Rep and UvrD cooperate to promote replication across transcription units in vivo. EMBO J (2009) 1.91
Structure and function of Zucchini endoribonuclease in piRNA biogenesis. Nature (2012) 1.90
Comparative genomics of defense systems in archaea and bacteria. Nucleic Acids Res (2013) 1.82
Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int Immunol (2004) 1.76
Argonaute proteins at a glance. J Cell Sci (2010) 1.66
The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression. Dev Cell (2013) 1.60
Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements. Biol Direct (2009) 1.58
Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proc Natl Acad Sci U S A (2011) 1.56
The N domain of Argonaute drives duplex unwinding during RISC assembly. Nat Struct Mol Biol (2012) 1.55
Protection of germline gene expression by the C. elegans Argonaute CSR-1. Dev Cell (2013) 1.55
Structure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nuclease. Proc Natl Acad Sci U S A (2005) 1.47
Identification of novel restriction endonuclease-like fold families among hypothetical proteins. Nucleic Acids Res (2005) 1.44
Signalling of toll-like receptors. Handb Exp Pharmacol (2008) 1.40
Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains. Proc Natl Acad Sci U S A (2010) 1.40
Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep (2010) 1.39
Recognition of 2'-O-methylated 3'-end of piRNA by the PAZ domain of a Piwi protein. Structure (2011) 1.37
Realm of PD-(D/E)XK nuclease superfamily revisited: detection of novel families with modified transitive meta profile searches. BMC Struct Biol (2007) 1.33
How to slice: snapshots of Argonaute in action. Silence (2010) 1.26
Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc Natl Acad Sci U S A (2013) 1.26
An unusual Dicer-like1 protein fuels the RNA interference pathway in Trypanosoma brucei. RNA (2006) 1.25
The CRISPR associated protein Cas4 Is a 5' to 3' DNA exonuclease with an iron-sulfur cluster. PLoS One (2012) 1.22
Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs. EMBO J (2012) 1.21
Building an immune system from nine domains. Biochem Soc Trans (2007) 1.19
Eukaryotic Argonautes come into focus. Trends Biochem Sci (2013) 1.19
The making of a slicer: activation of human Argonaute-1. Cell Rep (2013) 1.15
Turning catalytically inactive human Argonaute proteins into active slicer enzymes. Nat Struct Mol Biol (2013) 1.14
Distinct and overlapping roles for two Dicer-like proteins in the RNA interference pathways of the ancient eukaryote Trypanosoma brucei. Proc Natl Acad Sci U S A (2009) 1.11
Structure of Aquifex aeolicus argonaute highlights conformational flexibility of the PAZ domain as a potential regulator of RNA-induced silencing complex function. J Biol Chem (2006) 1.10
Functional diversification of Dicer-like proteins and small RNAs required for genome sculpting. Dev Cell (2014) 1.09
Eukaryote-specific insertion elements control human ARGONAUTE slicer activity. Cell Rep (2013) 1.08
The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Nucleic Acids Res (2012) 1.07
Planting the seed: target recognition of short guide RNAs. Trends Microbiol (2014) 1.05
The functions of plant TIR domains. Sci STKE (2007) 1.05
Structural features of Argonaute-GW182 protein interactions. Proc Natl Acad Sci U S A (2013) 1.01
Regulation of Argonaute slicer activity by guide RNA 3' end interactions with the N-terminal lobe. J Biol Chem (2013) 0.98
Small interfering RNA-producing loci in the ancient parasitic eukaryote Trypanosoma brucei. BMC Genomics (2012) 0.96
Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis. Nat Struct Mol Biol (2013) 2.14
A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks. Nat Struct Mol Biol (2015) 1.09
c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets. Nat Chem Biol (2014) 1.07
Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt. Nat Struct Mol Biol (2015) 0.81
On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires. MBio (2017) 0.75
Proposed Role for KaiC-Like ATPases as Major Signal Transduction Hubs in Archaea. MBio (2017) 0.75
TRF2 binds branched DNA to safeguard telomere integrity. Nat Struct Mol Biol (2017) 0.75