Published in Genes Dev on December 14, 2004
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action. Biol Direct (2006) 11.31
Small RNAs as guardians of the genome. Cell (2009) 8.88
Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci U S A (2005) 8.35
On the road to reading the RNA-interference code. Nature (2009) 4.33
On the origin and functions of RNA-mediated silencing: from protists to man. Curr Genet (2006) 3.05
A novel class of bacteria-induced small RNAs in Arabidopsis. Genes Dev (2007) 2.29
RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena. Genes Dev (2007) 2.26
Microarray analyses of gene expression during the Tetrahymena thermophila life cycle. PLoS One (2009) 2.11
Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline. Genes Dev (2006) 2.09
Two classes of endogenous small RNAs in Tetrahymena thermophila. Genes Dev (2005) 2.08
Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms. Annu Rev Genet (2011) 2.07
Germ line transcripts are processed by a Dicer-like protein that is essential for developmentally programmed genome rearrangements of Tetrahymena thermophila. Mol Cell Biol (2005) 2.06
Study of an RNA helicase implicates small RNA-noncoding RNA interactions in programmed DNA elimination in Tetrahymena. Genes Dev (2008) 1.82
2'-O-methylation stabilizes Piwi-associated small RNAs and ensures DNA elimination in Tetrahymena. RNA (2009) 1.76
Gene silencing in the marine diatom Phaeodactylum tricornutum. Nucleic Acids Res (2009) 1.67
Maternal noncoding transcripts antagonize the targeting of DNA elimination by scanRNAs in Paramecium tetraurelia. Genes Dev (2008) 1.60
PIWI proteins and PIWI-interacting RNAs in the soma. Nature (2014) 1.53
Evolution and diversification of RNA silencing proteins in fungi. J Mol Evol (2006) 1.44
A domesticated piggyBac transposase plays key roles in heterochromatin dynamics and DNA cleavage during programmed DNA deletion in Tetrahymena thermophila. Mol Biol Cell (2010) 1.42
The evolutionary journey of Argonaute proteins. Nat Struct Mol Biol (2014) 1.41
Pdsg1 and Pdsg2, novel proteins involved in developmental genome remodelling in Paramecium. PLoS One (2014) 1.40
Tetrahymena Genome Database (TGD): a new genomic resource for Tetrahymena thermophila research. Nucleic Acids Res (2006) 1.40
Dogma derailed: the many influences of RNA on the genome. Mol Cell (2013) 1.36
Silencing-associated and meiosis-specific small RNA pathways in Paramecium tetraurelia. Nucleic Acids Res (2008) 1.34
Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila. Genes Dev (2009) 1.34
Regulation of small RNA stability: methylation and beyond. Cell Res (2012) 1.33
A growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo. Genes Dev (2010) 1.30
Ancestral roles of small RNAs: an Ago-centric perspective. Cold Spring Harb Perspect Biol (2011) 1.27
The Tetrahymena argonaute-binding protein Giw1p directs a mature argonaute-siRNA complex to the nucleus. Cell (2010) 1.25
An unusual Dicer-like1 protein fuels the RNA interference pathway in Trypanosoma brucei. RNA (2006) 1.25
Dynamic nuclear reorganization during genome remodeling of Tetrahymena. Biochim Biophys Acta (2008) 1.25
Molecular evolution of piRNA and transposon control pathways in Drosophila. Cold Spring Harb Symp Quant Biol (2010) 1.21
Genome-Scale Analysis of Programmed DNA Elimination Sites in Tetrahymena thermophila. G3 (Bethesda) (2011) 1.16
Induction of gene silencing by hairpin RNA expression in Tetrahymena thermophila reveals a second small RNA pathway. Mol Cell Biol (2006) 1.15
Epigenetics of ciliates. Cold Spring Harb Perspect Biol (2013) 1.14
The evolution of core proteins involved in microRNA biogenesis. BMC Evol Biol (2008) 1.14
Argonaute and the nuclear RNAs: new pathways for RNA-mediated control of gene expression. Nucleic Acid Ther (2012) 1.10
Biased transcription and selective degradation of small RNAs shape the pattern of DNA elimination in Tetrahymena. Genes Dev (2012) 1.10
piRNA clusters and open chromatin structure. Mob DNA (2014) 1.08
The small RNA repertoire of Dictyostelium discoideum and its regulation by components of the RNAi pathway. Nucleic Acids Res (2007) 1.07
RNA-Mediated Epigenetic Programming of Genome Rearrangements. Annu Rev Genomics Hum Genet (2011) 1.06
Mating of the stichotrichous ciliate Oxytricha trifallax induces production of a class of 27 nt small RNAs derived from the parental macronucleus. PLoS One (2012) 1.03
Spatial and temporal plasticity of chromatin during programmed DNA-reorganization in Stylonychia macronuclear development. Epigenetics Chromatin (2008) 1.00
Lia1p, a novel protein required during nuclear differentiation for genome-wide DNA rearrangements in Tetrahymena thermophila. Eukaryot Cell (2007) 0.99
Dicer independent small RNAs associate with telomeric heterochromatin. RNA (2009) 0.99
Untangling the web: the diverse functions of the PIWI/piRNA pathway. Mol Reprod Dev (2013) 0.98
Centromeric histone H3 is essential for vegetative cell division and for DNA elimination during conjugation in Tetrahymena thermophila. Mol Cell Biol (2006) 0.98
Programmed DNA elimination in Tetrahymena: a small RNA-mediated genome surveillance mechanism. Adv Exp Med Biol (2011) 0.97
An essential role for the DNA breakage-repair protein Ku80 in programmed DNA rearrangements in Tetrahymena thermophila. Mol Biol Cell (2012) 0.97
Tudor nuclease genes and programmed DNA rearrangements in Tetrahymena thermophila. Eukaryot Cell (2007) 0.97
Two GW repeat proteins interact with Tetrahymena thermophila argonaute and promote genome rearrangement. Mol Cell Biol (2009) 0.97
MicroRNAs and essential components of the microRNA processing machinery are not encoded in the genome of the ctenophore Mnemiopsis leidyi. BMC Genomics (2012) 0.96
Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila. Mol Cell Biol (2007) 0.95
The conjugation-specific Die5 protein is required for development of the somatic nucleus in both Paramecium and Tetrahymena. Eukaryot Cell (2010) 0.94
Epigenetic inheritance in ciliates. Curr Opin Microbiol (2009) 0.94
The germ line limited M element of Tetrahymena is targeted for elimination from the somatic genome by a homology-dependent mechanism. Nucleic Acids Res (2006) 0.93
RNA-directed epigenetic regulation of DNA rearrangements. Essays Biochem (2010) 0.93
The highly conserved family of Tetrahymena thermophila chromosome breakage elements contains an invariant 10-base-pair core. Eukaryot Cell (2006) 0.93
Use of HAPPY mapping for the higher order assembly of the Tetrahymena genome. Genomics (2006) 0.90
A Tetrahymena Hsp90 co-chaperone promotes siRNA loading by ATP-dependent and ATP-independent mechanisms. EMBO J (2015) 0.89
Tetrahymena thermophila JMJD3 homolog regulates H3K27 methylation and nuclear differentiation. Eukaryot Cell (2012) 0.89
The SUMO pathway is developmentally regulated and required for programmed DNA elimination in Paramecium tetraurelia. Eukaryot Cell (2006) 0.88
Small-RNA-Mediated Genome-wide trans-Recognition Network in Tetrahymena DNA Elimination. Mol Cell (2015) 0.88
Keeping the soma free of transposons: programmed DNA elimination in ciliates. J Biol Chem (2011) 0.88
Gene network landscape of the ciliate Tetrahymena thermophila. PLoS One (2011) 0.88
Modules for C-terminal epitope tagging of Tetrahymena genes. J Microbiol Methods (2010) 0.88
DNA rearrangements directed by non-coding RNAs in ciliates. Wiley Interdiscip Rev RNA (2011) 0.88
LIA5 is required for nuclear reorganization and programmed DNA rearrangements occurring during tetrahymena macronuclear differentiation. PLoS One (2013) 0.87
Zygotic expression of the double-stranded RNA binding motif protein Drb2p is required for DNA elimination in the ciliate Tetrahymena thermophila. Eukaryot Cell (2011) 0.87
Chromatin-associated ncRNA activities. Chromosome Res (2013) 0.86
Developmentally programmed, RNA-directed genome rearrangement in Tetrahymena. Dev Growth Differ (2011) 0.85
Comprehensive Annotation of Physcomitrella patens Small RNA Loci Reveals That the Heterochromatic Short Interfering RNA Pathway Is Largely Conserved in Land Plants. Plant Cell (2015) 0.85
A developmentally regulated gene, ASI2, is required for endocycling in the macronuclear anlagen of Tetrahymena. Eukaryot Cell (2010) 0.85
Genome-wide analysis of genetic and epigenetic control of programmed DNA deletion. Nucleic Acids Res (2014) 0.83
Spliced DNA sequences in the Paramecium germline: their properties and evolutionary potential. Genome Biol Evol (2013) 0.81
Loading and pre-loading processes generate a distinct siRNA population in Tetrahymena. Biochem Biophys Res Commun (2013) 0.80
Stemming epigenetics in marine stramenopiles. Curr Genomics (2011) 0.80
RNA interference has a role in regulating Drosophila telomeres. Genome Biol (2006) 0.79
Nuclear Noncoding RNAs and Genome Stability. Mol Cell (2016) 0.79
LIA4 encodes a chromoshadow domain protein required for genomewide DNA rearrangements in Tetrahymena thermophila. Eukaryot Cell (2014) 0.79
Subtraction by addition: domesticated transposases in programmed DNA elimination. Genes Dev (2009) 0.78
Tetrahymena Pot2 is a developmentally regulated paralog of Pot1 that localizes to chromosome breakage sites but not to telomeres. Eukaryot Cell (2014) 0.77
The piRNA Pathway Guards the Germline Genome Against Transposable Elements. Adv Exp Med Biol (2016) 0.77
Chromodomain protein Tcd1 is required for macronuclear genome rearrangement and repair in Tetrahymena. Sci Rep (2015) 0.77
Strand-asymmetric endogenous Tetrahymena small RNA production requires a previously uncharacterized uridylyltransferase protein partner. RNA (2012) 0.76
Small RNAs and RNAi pathways in meiotic prophase I. Chromosome Res (2007) 0.76
DRH1, a p68-related RNA helicase, is required for chromosome breakage in Tetrahymena. Biol Open (2016) 0.75
The piggyBac transposon-derived genes TPB1 and TPB6 mediate essential transposon-like excision during the developmental rearrangement of key genes in Tetrahymena thermophila. Genes Dev (2016) 0.75
Checkpoint Activation of an Unconventional DNA Replication Program in Tetrahymena. PLoS Genet (2015) 0.75
Intercepting noncoding messages between germline and soma. Genes Dev (2012) 0.75
Negative Regulators of an RNAi-Heterochromatin Positive Feedback Loop Safeguard Somatic Genome Integrity in Tetrahymena. Cell Rep (2017) 0.75
Trans-generational function of Tetrahymena Piwi protein Twi8p at distinctive non-coding RNA loci. RNA (2017) 0.75
Paramecium tetraurelia chromatin assembly factor-1-like protein PtCAF-1 is involved in RNA-mediated control of DNA elimination. Nucleic Acids Res (2014) 0.75
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science (2002) 17.04
Mechanisms of gene silencing by double-stranded RNA. Nature (2004) 16.82
ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Science (2003) 9.54
Establishment and maintenance of a heterochromatin domain. Science (2002) 9.34
Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science (2004) 6.35
Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. Cell (2002) 6.25
Isolation of micro- and macronuclei of Tetrahymena pyriformis. Methods Cell Biol (1975) 6.06
Small RNAs correspond to centromere heterochromatic repeats. Science (2002) 5.96
Dicer is essential for formation of the heterochromatin structure in vertebrate cells. Nat Cell Biol (2004) 5.92
The DNA of ciliated protozoa. Microbiol Rev (1994) 5.79
Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena. Cell (2002) 5.78
Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena. Proc Natl Acad Sci U S A (1999) 5.33
RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol (2004) 4.01
RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast. Proc Natl Acad Sci U S A (2002) 3.52
RNA interference is required for normal centromere function in fission yeast. Chromosome Res (2003) 3.46
Methylation of histone h3 at lysine 9 targets programmed DNA elimination in tetrahymena. Cell (2002) 3.16
Germline and somatic transformation of mating Tetrahymena thermophila by particle bombardment. Genetics (1997) 3.04
Programmed DNA deletion as an RNA-guided system of genome defense. Science (2003) 3.02
A bouquet makes ends meet. Nat Rev Mol Cell Biol (2001) 2.79
Block in anaphase chromosome separation caused by a telomerase template mutation. Science (1997) 2.65
Small RNAs in genome rearrangement in Tetrahymena. Curr Opin Genet Dev (2004) 2.56
Cellular RNA-dependent RNA polymerase involved in posttranscriptional gene silencing has two distinct activity modes. Mol Cell (2002) 2.47
A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. Proc Natl Acad Sci U S A (2002) 2.46
Conjugation-specific small RNAs in Tetrahymena have predicted properties of scan (scn) RNAs involved in genome rearrangement. Genes Dev (2004) 2.19
Genome downsizing during ciliate development: nuclear division of labor through chromosome restructuring. Annu Rev Genet (1996) 2.15
Histone H3 lysine 9 methylation is required for DNA elimination in developing macronuclei in Tetrahymena. Proc Natl Acad Sci U S A (2004) 2.10
Nongenic, bidirectional transcription precedes and may promote developmental DNA deletion in Tetrahymena thermophila. Genes Dev (2001) 2.08
Dicer is required for chromosome segregation and gene silencing in fission yeast cells. Proc Natl Acad Sci U S A (2002) 1.97
Pdd1p, a novel chromodomain-containing protein, links heterochromatin assembly and DNA elimination in Tetrahymena. Cell (1996) 1.95
Temporal and spatial association of histone H2A variant hv1 with transcriptionally competent chromatin during nuclear development in Tetrahymena thermophila. Genes Dev (1993) 1.87
Tetrahymena genetics: two nuclei are better than one. Methods Cell Biol (2000) 1.78
Parental expression of the chromodomain protein Pdd1p is required for completion of programmed DNA elimination and nuclear differentiation. Mol Cell (1999) 1.78
Oryzalin, a dinitroaniline herbicide, binds to plant tubulin and inhibits microtubule polymerization in vitro. Planta (1987) 1.77
Sequence structures of two developmentally regulated, alternative DNA deletion junctions in Tetrahymena thermophila. Mol Cell Biol (1988) 1.75
Genome remodeling in ciliated protozoa. Annu Rev Microbiol (2002) 1.71
Cytologic and autoradiographic studies of the micronucleus at meiotic prophase in Tetrahymena pyriformis. J Protozool (1974) 1.70
hv1 is an evolutionarily conserved H2A variant that is preferentially associated with active genes. J Biol Chem (1986) 1.51
RNA and protein synthesis during meiotic prophase in Tetrahymena thermophila. J Protozool (1985) 1.50
Nullisomic Tetrahymena. II. a Set of Nullisomics Define the Germinal Chromosomes. Genetics (1983) 1.50
Excision of micronuclear-specific DNA requires parental expression of pdd2p and occurs independently from DNA replication in Tetrahymena thermophila. Genes Dev (1999) 1.36
An HP1-like protein is missing from transcriptionally silent micronuclei of Tetrahymena. Proc Natl Acad Sci U S A (1998) 1.26
A novel chromodomain protein, pdd3p, associates with internal eliminated sequences during macronuclear development in Tetrahymena thermophila. Mol Cell Biol (2000) 1.19
Pdd1p associates with germline-restricted chromatin and a second novel anlagen-enriched protein in developmentally programmed DNA elimination structures. Development (1997) 1.17
TATA-binding protein and nuclear differentiation in Tetrahymena thermophila. Mol Cell Biol (1994) 1.07
RNA polymerase II localizes in Tetrahymena thermophila meiotic micronuclei when micronuclear transcription associated with genome rearrangement occurs. Eukaryot Cell (2004) 1.02
A mutational analysis of conjugation in Tetrahymena thermophila. 1. Phenotypes affecting early development: meiosis to nuclear selection. Dev Biol (1997) 0.98
STUDIES ON NUCLEAR STRUCTURE AND FUNCTION IN TETRAHYMENA PYRIFORMIS: I. RNA Synthesis in Macro- and Micronuclei. J Cell Biol (1969) 0.95
Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena. Cell (2002) 5.78
Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol (2006) 5.44
Small RNAs in genome rearrangement in Tetrahymena. Curr Opin Genet Dev (2004) 2.56
A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. Proc Natl Acad Sci U S A (2002) 2.46
Conjugation-specific small RNAs in Tetrahymena have predicted properties of scan (scn) RNAs involved in genome rearrangement. Genes Dev (2004) 2.19
Microarray analyses of gene expression during the Tetrahymena thermophila life cycle. PLoS One (2009) 2.11
Histone H3 lysine 9 methylation is required for DNA elimination in developing macronuclei in Tetrahymena. Proc Natl Acad Sci U S A (2004) 2.10
A unified phylogeny-based nomenclature for histone variants. Epigenetics Chromatin (2012) 1.82
Study of an RNA helicase implicates small RNA-noncoding RNA interactions in programmed DNA elimination in Tetrahymena. Genes Dev (2008) 1.82
Phosphorylation and an ATP-dependent process increase the dynamic exchange of H1 in chromatin. J Cell Biol (2002) 1.55
Tetrahymena thermophila contains a conventional gamma-tubulin that is differentially required for the maintenance of different microtubule-organizing centers. J Cell Biol (2002) 1.42
Tetrahymena thermophila. Curr Biol (2005) 1.25
The Tetrahymena argonaute-binding protein Giw1p directs a mature argonaute-siRNA complex to the nucleus. Cell (2010) 1.25
Deposition and function of histone H3 variants in Tetrahymena thermophila. Mol Cell Biol (2006) 1.22
Glutamylation on alpha-tubulin is not essential but affects the assembly and functions of a subset of microtubules in Tetrahymena thermophila. Eukaryot Cell (2008) 1.20
Genome-Scale Analysis of Programmed DNA Elimination Sites in Tetrahymena thermophila. G3 (Bethesda) (2011) 1.16
Both carboxy-terminal tails of alpha- and beta-tubulin are essential, but either one will suffice. Curr Biol (2002) 1.13
Different effects of Tetrahymena IFT172 domains on anterograde and retrograde intraflagellar transport. Mol Biol Cell (2008) 1.09
Tetrahymena IFT122A is not essential for cilia assembly but plays a role in returning IFT proteins from the ciliary tip to the cell body. J Cell Sci (2008) 1.08
Elimination of foreign DNA during somatic differentiation in Tetrahymena thermophila shows position effect and is dosage dependent. Eukaryot Cell (2005) 1.04
Cell context-specific effects of the beta-tubulin glycylation domain on assembly and size of microtubular organelles. Mol Biol Cell (2004) 1.03
RNA polymerase II localizes in Tetrahymena thermophila meiotic micronuclei when micronuclear transcription associated with genome rearrangement occurs. Eukaryot Cell (2004) 1.02
The nonessential H2A N-terminal tail can function as an essential charge patch on the H2A.Z variant N-terminal tail. Mol Cell Biol (2003) 1.02
Centromeric histone H3 is essential for vegetative cell division and for DNA elimination during conjugation in Tetrahymena thermophila. Mol Cell Biol (2006) 0.98
Two GW repeat proteins interact with Tetrahymena thermophila argonaute and promote genome rearrangement. Mol Cell Biol (2009) 0.97
Mutational analyses reveal a novel function of the nucleotide-binding domain of gamma-tubulin in the regulation of basal body biogenesis. J Cell Biol (2005) 0.96
Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila. Mol Cell Biol (2007) 0.95
Regulation of transcription by H1 phosphorylation in Tetrahymena is position independent and requires clustered sites. Proc Natl Acad Sci U S A (2002) 0.91
Histone H2B ubiquitylation is not required for histone H3 methylation at lysine 4 in tetrahymena. J Biol Chem (2009) 0.85
Endoplasmic reticulum retention signal-dependent glycylation of the Hsp70/Grp170-related Pgp1p in Tetrahymena. Eukaryot Cell (2006) 0.85
The H1 phosphorylation state regulates expression of CDC2 and other genes in response to starvation in Tetrahymena thermophila. Mol Cell Biol (2005) 0.84
Unphosphorylated H1 is enriched in a specific region of the promoter when CDC2 is down-regulated during starvation. Mol Cell Biol (2006) 0.80
The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation. Genes Dev (2012) 0.79
Nuclear dimorphism: two peas in a pod. Curr Biol (2009) 0.79
Bioinformatic and proteomic analysis of bulk histones reveals PTM crosstalk and chromatin features. J Proteome Res (2014) 0.77