Published in Mol Cell Biol on September 01, 1989
A Sm-like protein complex that participates in mRNA degradation. EMBO J (2000) 5.08
The small nucleolar RNP protein NOP1 (fibrillarin) is required for pre-rRNA processing in yeast. EMBO J (1991) 4.93
Genome-wide protein interaction screens reveal functional networks involving Sm-like proteins. Yeast (2000) 3.85
A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction. EMBO J (1994) 3.17
The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus. J Cell Biol (1990) 2.82
Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. Mol Cell Biol (2003) 2.77
A U3 snoRNP protein with homology to splicing factor PRP4 and G beta domains is required for ribosomal RNA processing. EMBO J (1993) 2.71
PRP5: a helicase-like protein required for mRNA splicing in yeast. Proc Natl Acad Sci U S A (1990) 2.33
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Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A (1999) 2.15
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The yeast PRP6 gene encodes a U4/U6 small nuclear ribonucleoprotein particle (snRNP) protein, and the PRP9 gene encodes a protein required for U2 snRNP binding. Mol Cell Biol (1990) 2.06
Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing. Mol Cell Biol (1992) 2.01
Cloning of a yeast U1 snRNP 70K protein homologue: functional conservation of an RNA-binding domain between humans and yeast. EMBO J (1991) 1.97
The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome. Proc Natl Acad Sci U S A (1989) 1.87
Functional association of essential splicing factor(s) with PRP19 in a protein complex. EMBO J (1994) 1.86
Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins. EMBO J (2002) 1.82
The yeast PRP19 protein is not tightly associated with small nuclear RNAs, but appears to associate with the spliceosome after binding of U2 to the pre-mRNA and prior to formation of the functional spliceosome. Mol Cell Biol (1993) 1.77
Roles of PRP8 protein in the assembly of splicing complexes. EMBO J (1992) 1.75
A U5 small nuclear ribonucleoprotein particle protein involved only in the second step of pre-mRNA splicing in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.75
U4 small nuclear RNA dissociates from a yeast spliceosome and does not participate in the subsequent splicing reaction. Mol Cell Biol (1991) 1.73
Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex. Genes Dev (1999) 1.71
PRP38 encodes a yeast protein required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels. Mol Cell Biol (1992) 1.67
Electron microscopy of small nuclear ribonucleoprotein (snRNP) particles U2 and U5: evidence for a common structure-determining principle in the major U snRNP family. Proc Natl Acad Sci U S A (1990) 1.65
Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing. EMBO J (1998) 1.56
PRP18, a protein required for the second reaction in pre-mRNA splicing. Mol Cell Biol (1990) 1.48
PRP19: a novel spliceosomal component. Mol Cell Biol (1993) 1.43
The PRP4 (RNA4) protein of Saccharomyces cerevisiae is associated with the 5' portion of the U4 small nuclear RNA. Mol Cell Biol (1990) 1.42
Genetic depletion indicates a late role for U5 snRNP during in vitro spliceosome assembly. Nucleic Acids Res (1991) 1.40
Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociation. EMBO J (1998) 1.38
LACHESIS restricts gametic cell fate in the female gametophyte of Arabidopsis. PLoS Biol (2007) 1.38
Evidence for a Prp24 binding site in U6 snRNA and in a putative intermediate in the annealing of U6 and U4 snRNAs. EMBO J (1995) 1.35
Snt309p, a component of the Prp19p-associated complex that interacts with Prp19p and associates with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p. Mol Cell Biol (1998) 1.32
A novel gene, spp91-1, suppresses the splicing defect and the pre-mRNA nuclear export in the prp9-1 mutant. EMBO J (1992) 1.31
The yeast PRP8 protein interacts directly with pre-mRNA. Nucleic Acids Res (1991) 1.27
Reconstitution of functional mammalian U4 small nuclear ribonucleoprotein: Sm protein binding is not essential for splicing in vitro. Mol Cell Biol (1992) 1.25
The biochemical defects of prp4-1 and prp6-1 yeast splicing mutants reveal that the PRP6 protein is required for the accumulation of the [U4/U6.U5] tri-snRNP. Nucleic Acids Res (1993) 1.21
Identification and characterization of a yeast homolog of U1 snRNP-specific protein C. EMBO J (1997) 1.21
Conserved domains of human U4 snRNA required for snRNP and spliceosome assembly. Nucleic Acids Res (1990) 1.20
Prp31p promotes the association of the U4/U6 x U5 tri-snRNP with prespliceosomes to form spliceosomes in Saccharomyces cerevisiae. Mol Cell Biol (1997) 1.19
The Saccharomyces cerevisiae PRP21 gene product is an integral component of the prespliceosome. Proc Natl Acad Sci U S A (1993) 1.15
A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing. Mol Cell Biol (1999) 1.15
Identification and characterization of a yeast gene encoding the U2 small nuclear ribonucleoprotein particle B" protein. Mol Cell Biol (1996) 1.13
STP1, a gene involved in pre-tRNA processing, encodes a nuclear protein containing zinc finger motifs. Mol Cell Biol (1992) 1.02
Mutational analysis of the PRP4 protein of Saccharomyces cerevisiae suggests domain structure and snRNP interactions. Nucleic Acids Res (1994) 0.99
Mutational analysis of Saccharomyces cerevisiae U4 small nuclear RNA identifies functionally important domains. Mol Cell Biol (1995) 0.94
A new U6 small nuclear ribonucleoprotein-specific protein conserved between cis- and trans-splicing systems. Mol Cell Biol (1991) 0.92
Reassembly and protection of small nuclear ribonucleoprotein particles by heat shock proteins in yeast cells. RNA (1999) 0.92
Assembly and dynamics of the U4/U6 di-snRNP by single-molecule FRET. Nucleic Acids Res (2015) 0.85
A U6 snRNA gene with an internal promoter is juxtaposed to an snRNP protein sequence within an intron of a human G protein gene. Nucleic Acids Res (1991) 0.81
New nucleotide sequence data on the EMBL File Server. Nucleic Acids Res (1989) 0.75
Workflow for Genome-Wide Determination of Pre-mRNA Splicing Efficiency from Yeast RNA-seq Data. Biomed Res Int (2016) 0.75
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Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J Mol Biol (1986) 55.34
A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. Proc Natl Acad Sci U S A (1985) 46.59
Macromolecule synthesis in temperature-sensitive mutants of yeast. J Bacteriol (1967) 21.34
U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing. Cell (1985) 8.85
The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing. Nature (1987) 8.28
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Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs. Cell (1986) 8.06
Splicing of messenger RNA precursors. Science (1987) 7.61
Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences. Cell (1985) 7.49
Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes. Cell (1987) 7.44
Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell (1985) 6.85
A multicomponent complex is involved in the splicing of messenger RNA precursors. Cell (1985) 6.27
Spliceosome assembly in yeast. Genes Dev (1987) 6.00
The "spliceosome": yeast pre-messenger RNA associates with a 40S complex in a splicing-dependent reaction. Science (1985) 5.82
Heterogeneous nuclear ribonucleoproteins: role in RNA splicing. Science (1986) 5.52
Spliceosomal RNA U6 is remarkably conserved from yeast to mammals. Nature (1988) 5.48
Yeast mRNA splicing in vitro. J Biol Chem (1985) 5.48
Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes. Nature (1987) 5.13
An early hierarchic role of U1 small nuclear ribonucleoprotein in spliceosome assembly. Science (1988) 4.16
Compilation and comparison of the sequence context around the AUG startcodons in Saccharomyces cerevisiae mRNAs. Nucleic Acids Res (1987) 3.76
Pre-mRNA splicing in vitro requires intact U4/U6 small nuclear ribonucleoprotein. Cell (1986) 3.62
U4 and U6 RNAs coexist in a single small nuclear ribonucleoprotein particle. Nucleic Acids Res (1984) 3.61
Identification of a yeast snRNP protein and detection of snRNP-snRNP interactions. Cell (1987) 3.46
Evidence for the existence of snRNAs U4 and U6 in a single ribonucleoprotein complex and for their association by intermolecular base pairing. EMBO J (1984) 3.25
An essential yeast snRNA with a U5-like domain is required for splicing in vivo. Cell (1987) 3.22
Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes. Mol Cell Biol (1987) 3.00
Splicing of yeast nuclear pre-mRNA in vitro requires a functional 40S spliceosome and several extrinsic factors. Genes Dev (1987) 3.00
U2 RNA from yeast is unexpectedly large and contains homology to vertebrate U4, U5, and U6 small nuclear RNAs. Cell (1986) 2.77
Molecular consequences of specific intron mutations on yeast mRNA splicing in vivo and in vitro. Cell (1985) 2.75
Maximizing gene expression from plasmid vectors containing the lambda PL promoter: strategies for overproducing transcription termination factor rho. Proc Natl Acad Sci U S A (1985) 2.70
Saccharomyces cerevisiae has a U1-like small nuclear RNA with unexpected properties. Science (1987) 2.64
The yeast RNA gene products are essential for mRNA splicing in vitro. Cell (1986) 2.49
S. cerevisiae U1 RNA is large and has limited primary sequence homology to metazoan U1 snRNA. Cell (1987) 2.48
Saccharomyces cerevisiae tRNA ligase. Purification of the protein and isolation of the structural gene. J Biol Chem (1986) 2.42
The subnuclear localization of tRNA ligase in yeast. J Cell Biol (1987) 2.28
An essential snRNA from S. cerevisiae has properties predicted for U4, including interaction with a U6-like snRNA. Cell (1987) 2.07
RNA11 protein is associated with the yeast spliceosome and is localized in the periphery of the cell nucleus. Mol Cell Biol (1988) 2.01
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5'-terminal caps of snRNAs are accessible for reaction with 2,2,7-trimethylguanosine-specific antibody in intact snRNPs. J Biol Chem (1983) 1.75
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