Published in Science on May 24, 1985
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An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly. EMBO J (1987) 4.52
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The yeast homologue of U3 snRNA. EMBO J (1987) 3.74
Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particles. Mol Cell Biol (1988) 3.56
Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein. Proc Natl Acad Sci U S A (1988) 3.38
Mutations in conserved intron sequences affect multiple steps in the yeast splicing pathway, particularly assembly of the spliceosome. EMBO J (1986) 3.35
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Native mRNA editing complexes from Trypanosoma brucei mitochondria. EMBO J (1992) 2.78
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Identification of Prp40, a novel essential yeast splicing factor associated with the U1 small nuclear ribonucleoprotein particle. Mol Cell Biol (1996) 2.65
Early commitment of yeast pre-mRNA to the spliceosome pathway. Mol Cell Biol (1988) 2.64
Solid phase synthesis of oligoribonucleotides using o-nitrobenzyl protection of 2'-hydroxyl via a phosphite triester approach. Nucleic Acids Res (1986) 2.64
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cDNA cloning of human hnRNP protein A1 reveals the existence of multiple mRNA isoforms. Nucleic Acids Res (1988) 2.32
The DEAH-box protein PRP22 is an ATPase that mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes. EMBO J (1998) 2.31
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Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicing. Mol Cell Biol (1996) 2.23
Pre-mRNA splicing and the nuclear matrix. Mol Cell Biol (1987) 2.22
Regulated production of mu m and mu s mRNA requires linkage of the poly(A) addition sites and is dependent on the length of the mu s-mu m intron. Proc Natl Acad Sci U S A (1986) 2.19
Spontaneous splicing mutations at the dihydrofolate reductase locus in Chinese hamster ovary cells. Mol Cell Biol (1986) 2.19
Autogenous regulation of splicing of the transcript of a yeast ribosomal protein gene. Proc Natl Acad Sci U S A (1986) 2.12
Splicing with inverted order of exons occurs proximal to large introns. EMBO J (1992) 2.10
SLU7 and a novel activity, SSF1, act during the PRP16-dependent step of yeast pre-mRNA splicing. EMBO J (1995) 2.09
Resolution of the mammalian E complex and the ATP-dependent spliceosomal complexes on native agarose mini-gels. RNA (1999) 2.06
RNA11 protein is associated with the yeast spliceosome and is localized in the periphery of the cell nucleus. Mol Cell Biol (1988) 2.01
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PRP4 (RNA4) from Saccharomyces cerevisiae: its gene product is associated with the U4/U6 small nuclear ribonucleoprotein particle. Mol Cell Biol (1989) 1.95
Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2. Genes Dev (2005) 1.90
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U1 small nuclear ribonucleoproteins are required early during spliceosome assembly. Mol Cell Biol (1987) 1.83
Nonconsensus branch-site sequences in the in vitro splicing of transcripts of mutant rabbit beta-globin genes. Proc Natl Acad Sci U S A (1985) 1.82
Accurate in vitro splicing of two pre-mRNA plant introns in a HeLa cell nuclear extract. EMBO J (1986) 1.80
Interactions of PRP2 protein with pre-mRNA splicing complexes in Saccharomyces cerevisiae. Nucleic Acids Res (1990) 1.80
Yeast precursor mRNA processing protein PRP19 associates with the spliceosome concomitant with or just after dissociation of U4 small nuclear RNA. Proc Natl Acad Sci U S A (1993) 1.77
The yeast PRP19 protein is not tightly associated with small nuclear RNAs, but appears to associate with the spliceosome after binding of U2 to the pre-mRNA and prior to formation of the functional spliceosome. Mol Cell Biol (1993) 1.77
A U5 small nuclear ribonucleoprotein particle protein involved only in the second step of pre-mRNA splicing in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.75
Formation of mRNA 3' termini: stability and dissociation of a complex involving the AAUAAA sequence. EMBO J (1987) 1.73
RNA splicing products formed with isolated fractions from HeLa cells are associated with fast-sedimenting complexes. Proc Natl Acad Sci U S A (1986) 1.67
Purification of a protein required for the splicing of pre-mRNA and its separation from the lariat debranching enzyme. EMBO J (1985) 1.56
Fractionation and characterization of a yeast mRNA splicing extract. Proc Natl Acad Sci U S A (1986) 1.56
The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors. EMBO J (1990) 1.53
Specific accessory sequences in Saccharomyces cerevisiae introns control assembly of pre-mRNAs into spliceosomes. EMBO J (1987) 1.53
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Autonomous splicing and complementation of in vivo-assembled spliceosomes. J Cell Biol (1989) 1.49
Association of U2, U4, U5, and U6 small nuclear ribonucleoproteins in a spliceosome-type complex in absence of precursor RNA. Proc Natl Acad Sci U S A (1988) 1.49
PRP18, a protein required for the second reaction in pre-mRNA splicing. Mol Cell Biol (1990) 1.48
Sedimentation analysis of polyadenylation-specific complexes. Mol Cell Biol (1988) 1.46
The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. J Biol Chem (2008) 1.43
PRP19: a novel spliceosomal component. Mol Cell Biol (1993) 1.43
Assembly and disassembly of spliceosomes along a specific pre-messenger RNP fiber. EMBO J (1994) 1.42
Identification and nuclear localization of yeast pre-messenger RNA processing components: RNA2 and RNA3 proteins. J Cell Biol (1986) 1.41
RNA splicing and intron turnover are greatly diminished by a mutant yeast branch point. Proc Natl Acad Sci U S A (1986) 1.39
Thiophosphates in yeast U6 snRNA specifically affect pre-mRNA splicing in vitro. Nucleic Acids Res (1992) 1.39
Inhibition of a spliceosome turnover pathway suppresses splicing defects. Proc Natl Acad Sci U S A (2006) 1.37
Introduction of functional artificial introns into the naturally intronless ura4 gene of Schizosaccharomyces pombe. Mol Cell Biol (1989) 1.35
U2AF35 is encoded by an essential gene clustered in an operon with RRM/cyclophilin in Caenorhabditis elegans. RNA (1999) 1.32
Uridine branch acceptor is a cis-acting element involved in regulation of the alternative processing of calcitonin/CGRP-l pre-mRNA. Nucleic Acids Res (1990) 1.31
Requirements for U2 snRNP addition to yeast pre-mRNA. Nucleic Acids Res (1992) 1.31
Assembly of pre-mRNA splicing complex is cap dependent. Nucleic Acids Res (1987) 1.30
Serine/threonine phosphorylation regulates binding of C hnRNP proteins to pre-mRNA. Proc Natl Acad Sci U S A (1993) 1.28
The differential interaction of snRNPs with pre-mRNA reveals splicing kinetics in living cells. J Cell Biol (2010) 1.26
Assembly in an in vitro splicing reaction of a mouse insulin messenger RNA precursor into a 60-40S ribonucleoprotein complex. Nucleic Acids Res (1986) 1.23
Maturation of polycistronic pre-mRNA in Trypanosoma brucei: analysis of trans splicing and poly(A) addition at nascent RNA transcripts from the hsp70 locus. Mol Cell Biol (1991) 1.23
Identification of cis-acting intron and exon regions in influenza virus NS1 mRNA that inhibit splicing and cause the formation of aberrantly sedimenting presplicing complexes. Mol Cell Biol (1992) 1.23
Yeast pre-messenger RNA splicing efficiency depends on critical spacing requirements between the branch point and 3' splice site. EMBO J (1986) 1.22
Effects on mRNA splicing of mutations in the 3' region of the Saccharomyces cerevisiae actin intron. Mol Cell Biol (1987) 1.21
cis-acting sequences involved in exon selection in the chicken beta-tropomyosin gene. Mol Cell Biol (1992) 1.21
Combinatorial splicing of exon pairs by two-site binding of U1 small nuclear ribonucleoprotein particle. Mol Cell Biol (1991) 1.19
In vitro splicing of adenovirus E1A transcripts: characterization of novel reactions and of multiple branch points abnormally far from the 3' splice site. Nucleic Acids Res (1988) 1.19
Prp31p promotes the association of the U4/U6 x U5 tri-snRNP with prespliceosomes to form spliceosomes in Saccharomyces cerevisiae. Mol Cell Biol (1997) 1.19
Requirement of ATP in the second step of the pre-mRNA splicing reaction. Nucleic Acids Res (1988) 1.18
In vitro processing of a plant pre-mRNA in a HeLa cell nuclear extract. Nucleic Acids Res (1986) 1.18
A novel splicing factor is an integral component of 200S large nuclear ribonucleoprotein (InRNP) particles. EMBO J (1991) 1.17
Assembly of a tRNA splicing complex: evidence for concerted excision and joining steps in splicing in vitro. Mol Cell Biol (1986) 1.17
Molecular consequences of truncations of the first exon for in vitro splicing of yeast actin pre-mRNA. Nucleic Acids Res (1988) 1.16
The fission yeast prp4+ gene involved in pre-mRNA splicing codes for a predicted serine/threonine kinase and is essential for growth. Nucleic Acids Res (1993) 1.15
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PRP28, a 'DEAD-box' protein, is required for the first step of mRNA splicing in vitro. Nucleic Acids Res (1994) 1.13
Assembly and localization of the U1-specific snRNP C protein in the amphibian oocyte. J Cell Biol (1992) 1.12
More than half of yeast U1 snRNA is dispensable for growth. Nucleic Acids Res (1991) 1.11
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In vitro cleavage of the simian virus 40 early polyadenylation site adjacent to a required downstream TG sequence. Mol Cell Biol (1986) 1.08
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The 5' splice site consensus RNA oligonucleotide induces assembly of U2/U4/U5/U6 small nuclear ribonucleoprotein complexes. Proc Natl Acad Sci U S A (1992) 1.05
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