Published in Biophys J on November 04, 2014
Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant. Nat Commun (2015) 0.87
Molecular-scale GPS: positioning a biosensor peptide on RyR. Biophys J (2014) 0.77
CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol (2016) 0.77
Structural mapping of divergent regions in the type 1 ryanodine receptor using fluorescence resonance energy transfer. Structure (2014) 0.77
S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex. J Biol Chem (2016) 0.75
Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into Ca(2+) (mis)handling. Clin Med Insights Cardiol (2017) 0.75
High-Throughput Spectral and Lifetime-Based FRET Screening in Living Cells to Identify Small-Molecule Effectors of SERCA. J Biomol Screen (2016) 0.75
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47
The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res (2005) 21.68
Cardiac excitation-contraction coupling. Nature (2002) 18.48
Version 1.2 of the Crystallography and NMR system. Nat Protoc (2007) 13.01
Fluorescence energy transfer as a spectroscopic ruler. Annu Rev Biochem (1978) 11.41
Ryanodine receptor calcium release channels. Physiol Rev (2002) 5.14
Databases in protein crystallography. Acta Crystallogr D Biol Crystallogr (1998) 4.18
Slow-cooling protocols for crystallographic refinement by simulated annealing. Acta Crystallogr A (1990) 4.11
Using Situs for the integration of multi-resolution structures. Biophys Rev (2010) 3.07
Cryo-electron microscopy and three-dimensional reconstruction of the calcium release channel/ryanodine receptor from skeletal muscle. J Cell Biol (1994) 2.58
The geometry of the ribosomal polypeptide exit tunnel. J Mol Biol (2006) 2.53
Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions. J Struct Biol (2010) 2.48
Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb Perspect Biol (2010) 2.46
Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure. Circulation (2005) 2.42
DNA-binding orientation and domain conformation of the E. coli rep helicase monomer bound to a partial duplex junction: single-molecule studies of fluorescently labeled enzymes. J Mol Biol (2004) 2.40
Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29
Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor. J Am Coll Cardiol (2009) 2.21
Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex. Nat Struct Mol Biol (2010) 2.10
A nano-positioning system for macromolecular structural analysis. Nat Methods (2008) 1.84
The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule. Nature (2010) 1.79
Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating. PLoS Biol (2009) 1.77
Apocalmodulin and Ca2+-calmodulin bind to neighboring locations on the ryanodine receptor. J Biol Chem (2001) 1.75
Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure. Cardiovasc Res (2010) 1.73
Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion. Nat Struct Mol Biol (2010) 1.64
Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor. Circ Res (2010) 1.61
Dantrolene stabilizes domain interactions within the ryanodine receptor. J Biol Chem (2004) 1.52
Cardiac sarcoplasmic reticulum calcium leak: basis and roles in cardiac dysfunction. Annu Rev Physiol (2013) 1.46
Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations. Structure (2009) 1.31
Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts. Circulation (2008) 1.30
Ryanodine receptors: structure and function. J Biol Chem (2012) 1.30
Structural characterization of the RyR1-FKBP12 interaction. J Mol Biol (2005) 1.30
FRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channel. Proc Natl Acad Sci U S A (2009) 1.29
Ryanodine receptor structure: progress and challenges. J Biol Chem (2008) 1.29
Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts. Cardiovasc Res (2008) 1.27
X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies. J Mol Biol (2000) 1.26
Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure. J Am Coll Cardiol (2007) 1.24
Peptide probe study of the critical regulatory domain of the cardiac ryanodine receptor. Biochem Biophys Res Commun (2002) 1.22
Cryoelectron microscopy and image analysis of the cardiac ryanodine receptor. J Biol Chem (1998) 1.22
Spectroscopic monitoring of local conformational changes during the intramolecular domain-domain interaction of the ryanodine receptor. Biochemistry (2002) 1.15
Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain. Structure (2012) 1.09
Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor. J Cell Sci (2010) 1.07
Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer. J Biol Chem (2010) 1.05
Structural determinants of skeletal muscle ryanodine receptor gating. J Biol Chem (2013) 1.03
FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel. Biophys J (2011) 1.00
Application of the nano-positioning system to the analysis of fluorescence resonance energy transfer networks. J Phys Chem B (2011) 0.98
Förster resonance energy transfer measurements of ryanodine receptor type 1 structure using a novel site-specific labeling method. PLoS One (2009) 0.95
Calmodulin-binding locations on the skeletal and cardiac ryanodine receptors. J Biol Chem (2012) 0.95
A structural model of the pore-forming region of the skeletal muscle ryanodine receptor (RyR1). PLoS Comput Biol (2009) 0.94
N-terminal and central segments of the type 1 ryanodine receptor mediate its interaction with FK506-binding proteins. J Biol Chem (2013) 0.87
In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding. Circ Res (2012) 0.84
Modeling a ryanodine receptor N-terminal domain connecting the central vestibule and the corner clamp region. J Biol Chem (2012) 0.82
Ryanodine receptor patents. Recent Pat Biotechnol (2012) 0.76