Published in Bioessays on January 30, 2015
Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair. Redox Biol (2015) 0.88
NF-κB oscillations translate into functionally related patterns of gene expression. Elife (2016) 0.82
Anatomy of a negative feedback loop: the case of IκBα. J R Soc Interface (2015) 0.79
MicroRNA analysis suggests an additional level of feedback regulation in the NF-κB signaling cascade. Oncotarget (2015) 0.78
Late-phase synthesis of IκBα insulates the TLR4-activated canonical NF-κB pathway from noncanonical NF-κB signaling in macrophages. Sci Signal (2016) 0.75
Kinase Inhibition Leads to Hormesis in a Dual Phosphorylation-Dephosphorylation Cycle. PLoS Comput Biol (2016) 0.75
Global quantification of mammalian gene expression control. Nature (2011) 22.36
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell (1995) 21.15
Signaling to NF-kappaB. Genes Dev (2004) 19.78
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
The control of flux. Symp Soc Exp Biol (1973) 12.14
Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol (2009) 11.76
The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol (2004) 10.85
Oscillations in NF-kappaB signaling control the dynamics of gene expression. Science (2004) 8.44
Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet (2004) 8.30
A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. Eur J Biochem (1974) 6.65
Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature (2010) 5.27
Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science (2005) 5.14
Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha. Proc Natl Acad Sci U S A (1993) 4.99
Oscillations and variability in the p53 system. Mol Syst Biol (2006) 4.59
Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression. Oncogene (2006) 4.53
Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription. Science (2009) 4.14
IkappaB kinase complexes: gateways to NF-kappaB activation and transcription. Oncogene (2006) 3.84
A fourth IkappaB protein within the NF-kappaB signaling module. Cell (2007) 3.34
Oncogenic activation of NF-kappaB. Cold Spring Harb Perspect Biol (2010) 3.30
p53 dynamics control cell fate. Science (2012) 3.30
Non-canonical NF-κB signaling pathway. Cell Res (2010) 3.03
Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96
Animal transcription networks as highly connected, quantitative continua. Dev Cell (2011) 2.87
Mathematical model of NF-kappaB regulatory module. J Theor Biol (2004) 2.75
Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell (2008) 2.70
Dynamics and variability of ERK2 response to EGF in individual living cells. Mol Cell (2009) 2.42
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell (2010) 2.40
IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression. J Cell Biol (2006) 2.38
Return to homeostasis: downregulation of NF-κB responses. Nat Immunol (2011) 2.17
A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity. Mol Syst Biol (2007) 2.13
Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Mol Cell (2009) 2.11
A20: from ubiquitin editing to tumour suppression. Nat Rev Cancer (2010) 2.08
Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol (2011) 2.02
Signal-dependent dynamics of transcription factor translocation controls gene expression. Nat Struct Mol Biol (2011) 1.94
A noisy paracrine signal determines the cellular NF-kappaB response to lipopolysaccharide. Sci Signal (2009) 1.91
A single NFκB system for both canonical and non-canonical signaling. Cell Res (2010) 1.88
Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles. PLoS One (2009) 1.81
Understanding NF-kappaB signaling via mathematical modeling. Mol Syst Biol (2008) 1.79
Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter. J Biol Chem (2005) 1.57
NF-kappaB in solid tumors. Biochem Pharmacol (2006) 1.57
Understanding the temporal codes of intra-cellular signals. Curr Opin Genet Dev (2010) 1.48
NF-kappa B as a therapeutic target in neurodegenerative diseases. Expert Opin Ther Targets (2007) 1.25
Lessons from mathematically modeling the NF-κB pathway. Immunol Rev (2012) 1.22
It takes two to tango: IκBs, the multifunctional partners of NF-κB. Immunol Rev (2012) 1.17
Fold change of nuclear NF-κB determines TNF-induced transcription in single cells. Mol Cell (2014) 1.16
Sources of cell-to-cell variability in canonical nuclear factor-κB (NF-κB) signaling pathway inferred from single cell dynamic images. J Biol Chem (2011) 1.13
Dual delayed feedback provides sensitivity and robustness to the NF-κB signaling module. PLoS Comput Biol (2013) 0.90
Quantitative dissection and modeling of the NF-κB p100-p105 module reveals interdependent precursor proteolysis. Cell Rep (2014) 0.88
Generalization of the theory of transition times in metabolic pathways: a geometrical approach. Biophys J (1999) 0.87
Dynamic signal encoding--from cells to organisms. Semin Cell Dev Biol (2014) 0.83
Global quantification of mammalian gene expression control. Nature (2011) 22.36
Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors. J Exp Med (2008) 1.94
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J (2007) 1.55
Modeling feedback loops of the Mammalian circadian oscillator. Biophys J (2004) 1.45
Temperature dependency and temperature compensation in a model of yeast glycolytic oscillations. Biophys Chem (2003) 1.10
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J (2011) 1.10
Corrigendum: Global quantification of mammalian gene expression control. Nature (2013) 1.08
A modelling approach to quantify dynamic crosstalk between the pheromone and the starvation pathway in baker's yeast. FEBS J (2006) 1.00
Synthesis and degradation jointly determine the responsiveness of the cellular proteome. Bioessays (2013) 0.87
Mathematical modelling of Wnt/β-catenin signalling. Biochem Soc Trans (2010) 0.86
The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells. J Clin Invest (2009) 0.84
Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions. Front Physiol (2013) 0.83
A model of the mammalian circadian oscillator including the REV-ERBalpha module. Genome Inform (2004) 0.79
Metabolic synchronization by traveling waves in yeast cell layers. Biophys J (2011) 0.79
Spatio-temporal dynamics of glycolysis in cell layers. A mathematical model. Biosystems (2009) 0.79
Mathematical modelling suggests a differential impact of β-transducin repeat-containing protein paralogues on Wnt/β-catenin signalling dynamics. FEBS J (2015) 0.76