Published in Pediatr Crit Care Med on September 01, 2013
Pediatric severe sepsis in U.S. children's hospitals. Pediatr Crit Care Med (2014) 2.43
Epidemiology of severe sepsis. Virulence (2013) 2.26
Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. Am J Respir Crit Care Med (2015) 2.09
Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis. Crit Care Med (2014) 1.81
Mitochondrial dysfunction in peripheral blood mononuclear cells in pediatric septic shock. Pediatr Crit Care Med (2015) 1.59
Time for a neonatal-specific consensus definition for sepsis. Pediatr Crit Care Med (2014) 1.56
Gene expression profiling in sepsis: timing, tissue, and translational considerations. Trends Mol Med (2014) 1.25
Timing of antibiotics, volume, and vasoactive infusions in children with sepsis admitted to intensive care. Crit Care (2015) 0.95
The clinical application value of cytokines in treating infectious diseases. PLoS One (2014) 0.92
Development of metabolic and inflammatory mediator biomarker phenotyping for early diagnosis and triage of pediatric sepsis. Crit Care (2015) 0.92
Differential expression of the nuclear-encoded mitochondrial transcriptome in pediatric septic shock. Crit Care (2014) 0.91
Pediatric sepsis: important considerations for diagnosing and managing severe infections in infants, children, and adolescents. Virulence (2013) 0.91
Postnatal Age Is a Critical Determinant of the Neonatal Host Response to Sepsis. Mol Med (2015) 0.88
Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study. Crit Care (2015) 0.87
Could Biomarkers Direct Therapy for the Septic Patient? J Pharmacol Exp Ther (2016) 0.84
Plasma exchange, methylprednisolone, IV immune globulin, and now anakinra support continued PICU equipoise in management of hyperferritinemia-associated sepsis/multiple organ dysfunction syndrome/macrophage activation syndrome/secondary hemophagocytic lymphohistiocytosis syndrome*. Pediatr Crit Care Med (2014) 0.83
Early adaptive immune suppression in children with septic shock: a prospective observational study. Crit Care (2014) 0.82
Therapeutic plasma exchange may improve hemodynamics and organ failure among children with sepsis-induced multiple organ dysfunction syndrome receiving extracorporeal life support. Pediatr Crit Care Med (2015) 0.81
Decreased ADAMTS 13 Activity is Associated With Disease Severity and Outcome in Pediatric Severe Sepsis. Medicine (Baltimore) (2016) 0.80
Sepsis in Canadian children: a national analysis using administrative data. Clin Epidemiol (2014) 0.79
Why children with severe bacterial infection die: a population-based study of determinants and consequences of suboptimal care with a special emphasis on methodological issues. PLoS One (2014) 0.79
Differential expression of the Nrf2-linked genes in pediatric septic shock. Crit Care (2015) 0.78
Nonhematopoietic Peroxisome Proliferator-Activated Receptor-α Protects Against Cardiac Injury and Enhances Survival in Experimental Polymicrobial Sepsis. Crit Care Med (2016) 0.78
Epidemiology and cost of heart failure in children. Cardiol Young (2015) 0.78
Effectiveness of physical exam signs for early detection of critical illness in pediatric systemic inflammatory response syndrome. BMC Emerg Med (2014) 0.78
Extracorporeal therapies in pediatric severe sepsis: findings from the pediatric health-care information system. Crit Care (2015) 0.78
Pediatric heart failure: current state and future possibilities. Korean Circ J (2015) 0.78
Is the developmentally immature immune response in paediatric sepsis a recapitulation of immune tolerance? Immunology (2015) 0.77
Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs. Pediatr Crit Care Med (2016) 0.77
Optimism and no longer foolishness? Haematology/oncology and the PICU. Intensive Care Med (2014) 0.76
Interleukin-27: a novel biomarker in predicting bacterial infection among the critically ill. Crit Care (2015) 0.76
Identifying Pediatric Severe Sepsis and Septic Shock: Accuracy of Diagnosis Codes. J Pediatr (2015) 0.76
What's New in Paediatric Sepsis. Curr Pediatr Rep (2016) 0.75
Rolipram Improves Outcome in a Rat Model of Infant Sepsis-Induced Cardiorenal Syndrome. Front Pharmacol (2017) 0.75
Sepsis After Cardiac Surgery Early in Infancy and Adverse 4.5-Year Neurocognitive Outcomes. J Am Heart Assoc (2015) 0.75
Pediatric sepsis-light at the end of the tunnel?*. Pediatr Crit Care Med (2013) 0.75
Pediatric sepsis. Curr Opin Pediatr (2016) 0.75
Prospective evaluation of SeptiFast Multiplex PCR in children with systemic inflammatory response syndrome under antibiotic treatment. BMC Infect Dis (2016) 0.75
Fluid Resuscitation in Pediatric Sepsis: Lack of Data Versus Lack of Equipoise. Pediatr Crit Care Med (2015) 0.75
Etiology and prognostic factors of sepsis among children and adolescents admitted to the intensive care unit. Rev Bras Ter Intensiva (2015) 0.75
Activation of α2 adrenoceptor attenuates lipopolysaccharide-induced hepatic injury. Int J Clin Exp Pathol (2015) 0.75
The common prophylactic therapy for bowel surgery is ineffective for clearing Bacteroidetes, the primary inducers of systemic inflammation, and causes faster death in response to intestinal barrier damage in mice. BMJ Open Gastroenterol (2015) 0.75
Epidemiology and Outcomes of Pediatric Multiple Organ Dysfunction Syndrome. Pediatr Crit Care Med (2017) 0.75
Clinical Trials in Pediatric Sepsis: What's the (End) Point? Pediatr Crit Care Med (2017) 0.75
Initial resuscitation and management of pediatric septic shock. Minerva Pediatr (2015) 0.75
2016 Update for the Rogers' Textbook of Pediatric Intensive Care: Recognition and Initial Management of Shock. Pediatr Crit Care Med (2016) 0.75
Association of Delayed Antimicrobial Therapy with One-Year Mortality in Pediatric Sepsis. Shock (2017) 0.75
Morbidity associated with 30-day surgical site infection following nonshunt pediatric neurosurgery. J Neurosurg Pediatr (2017) 0.75
Improving Recognition of Pediatric Severe Sepsis in the Emergency Department: Contributions of a Vital Sign-Based Electronic Alert and Bedside Clinician Identification. Ann Emerg Med (2017) 0.75
Validation of the Vasoactive-Inotropic Score in Pediatric Sepsis. Pediatr Crit Care Med (2017) 0.75
Prediction of pediatric sepsis mortality within 1 h of intensive care admission. Intensive Care Med (2017) 0.75
Adherence to surviving sepsis guidelines among pediatric intensivists. A national survey. Saudi Med J (2017) 0.75
Increased serum thrombomodulin level is associated with disease severity and mortality in pediatric sepsis. PLoS One (2017) 0.75
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med (2013) 39.56
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med (2013) 17.37
A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
Unexpected increased mortality after implementation of a commercially sold computerized physician order entry system. Pediatrics (2005) 15.40
Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review. JAMA (2002) 9.89
RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care (2006) 9.29
Use of intensive care at the end of life in the United States: an epidemiologic study. Crit Care Med (2004) 9.06
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med (2010) 6.69
National estimates of severe sepsis in United States emergency departments. Crit Care Med (2007) 5.99
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65
Nighttime intensivist staffing and mortality among critically ill patients. N Engl J Med (2012) 5.22
Variation in critical care services across North America and Western Europe. Crit Care Med (2008) 5.00
The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med (2002) 4.72
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
Duration of cardiopulmonary resuscitation and illness category impact survival and neurologic outcomes for in-hospital pediatric cardiac arrests. Circulation (2013) 4.46
The effect of multidisciplinary care teams on intensive care unit mortality. Arch Intern Med (2010) 4.41
Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis. Crit Care Med (2003) 4.04
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78
Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome. Pediatrics (2003) 3.49
Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia. Ann Emerg Med (2008) 3.44
Severe sepsis in pre-hospital emergency care: analysis of incidence, care, and outcome. Am J Respir Crit Care Med (2012) 3.36
The epidemiology of mechanical ventilation use in the United States. Crit Care Med (2010) 3.28
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18
Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital characteristics. Am J Respir Crit Care Med (2007) 3.17
The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17
Intensive care unit quality improvement: a "how-to" guide for the interdisciplinary team. Crit Care Med (2006) 3.15
Pneumonia: still the old man's friend? Arch Intern Med (2003) 3.12
Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes. Kidney Int (2002) 3.07
Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States. Am J Respir Crit Care Med (2002) 3.02
Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival. Kidney Int (2009) 2.97
Prospective meta-analysis using individual patient data in intensive care medicine. Intensive Care Med (2009) 2.93
Organizational characteristics, outcomes, and resource use in 78 Brazilian intensive care units: the ORCHESTRA study. Intensive Care Med (2015) 2.92
Three-year outcomes for Medicare beneficiaries who survive intensive care. JAMA (2010) 2.87
The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med (2006) 2.84
The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. Am J Respir Crit Care Med (2012) 2.72
Critical care medicine training and certification for emergency physicians. Ann Emerg Med (2005) 2.67
End-of-life care for the critically ill: A national intensive care unit survey. Crit Care Med (2006) 2.61
Disability among elderly survivors of mechanical ventilation. Am J Respir Crit Care Med (2010) 2.50
Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med (2003) 2.44
Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe. Intensive Care Med (2013) 2.44
Prioritizing the organization and management of intensive care services in the United States: the PrOMIS Conference. Crit Care Med (2007) 2.42
Relationship between staff perceptions of hospital norms and hospital-level end-of-life treatment intensity. J Palliat Med (2007) 2.39
Long-term mortality and medical care charges in patients with severe sepsis. Crit Care Med (2003) 2.39
Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis. Am J Respir Crit Care Med (2008) 2.37
Is survival better at hospitals with higher "end-of-life" treatment intensity? Med Care (2010) 2.35
A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med (2010) 2.31
Survival after liver transplantation in the United States: a disease-specific analysis of the UNOS database. Liver Transpl (2004) 2.31
Growth of intensive care unit resource use and its estimated cost in Medicare. Crit Care Med (2008) 2.31
Severe sepsis epidemiology: sampling, selection, and society. Crit Care (2004) 2.28
Healthcare costs and long-term outcomes after acute respiratory distress syndrome: A phase III trial of inhaled nitric oxide. Crit Care Med (2006) 2.27
Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis. JAMA (2010) 2.27
Incidence, cost, and mortality of neutropenia hospitalization associated with chemotherapy. Cancer (2005) 2.25
Perceptions of safety culture vary across the intensive care units of a single institution. Crit Care Med (2007) 2.24
Hospital deaths in patients with sepsis from 2 independent cohorts. JAMA (2014) 2.23
Plasma neutrophil gelatinase-associated lipocalin predicts recovery from acute kidney injury following community-acquired pneumonia. Kidney Int (2011) 2.22
Posttraumatic stress and complicated grief in family members of patients in the intensive care unit. J Gen Intern Med (2008) 2.12
Critical care medicine training and certification for emergency physicians. Crit Care Med (2005) 2.12
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Crit Care Med (2005) 2.11
Severe sepsis and septic shock. N Engl J Med (2013) 2.10
A comparison of critical care research funding and the financial burden of critical illness in the United States. Crit Care Med (2012) 2.07
Do hospitals provide lower quality of care to black patients for pneumonia? Crit Care Med (2010) 2.07
Forging a critical alliance: Addressing the research needs of the United States critical illness and injury community. Crit Care Med (2009) 2.03
Relationship Between ICU Length of Stay and Long-Term Mortality for Elderly ICU Survivors. Crit Care Med (2016) 2.03
Use of intensive care services during terminal hospitalizations in England and the United States. Am J Respir Crit Care Med (2009) 2.00
Assessing the feasibility of the American College of Surgeons' benchmarks for the triage of trauma patients. Arch Surg (2011) 1.95
Critical care bed growth in the United States. A comparison of regional and national trends. Am J Respir Crit Care Med (2015) 1.93
How does lack of insurance affect use of intensive care? A population-based study. Crit Care Med (2006) 1.92
Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United States. Pediatrics (2003) 1.92
A tertiary care center's experience with therapeutic hypothermia after pediatric cardiac arrest. Pediatr Crit Care Med (2010) 1.90
Temporal changes in management and outcome of septic shock in patients with malignancies in the intensive care unit. Crit Care Med (2008) 1.89
The first international consensus conference on continuous renal replacement therapy. Kidney Int (2002) 1.89
Pediatric specialized transport teams are associated with improved outcomes. Pediatrics (2009) 1.87
A retrospective cohort study of prognostic factors associated with outcome in pediatric severe sepsis: what is the role of steroids? Pediatr Crit Care Med (2005) 1.87
The effects of trauma center care, admission volume, and surgical volume on paralysis after traumatic spinal cord injury. Ann Surg (2009) 1.86
Using simulation to isolate physician variation in intensive care unit admission decision making for critically ill elders with end-stage cancer: a pilot feasibility study. Crit Care Med (2008) 1.81
Influence of comorbid conditions on long-term mortality after pneumonia in older people. J Am Geriatr Soc (2007) 1.79
Physician attitudes toward regionalization of adult critical care: a national survey. Crit Care Med (2009) 1.79
Medicare intensive care unit use: analysis of incidence, cost, and payment. Crit Care Med (2004) 1.79
Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis Forum. Crit Care Med (2005) 1.77
Understanding the potential role of statins in pneumonia and sepsis. Crit Care Med (2011) 1.77