The exchanged EF-hands in calmodulin and troponin C chimeras impair the Ca²⁺-induced hydrophobicity and alter the interaction with Orai1: a spectroscopic, thermodynamic and kinetic study.

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Published in BMC Biochem on February 15, 2015

Authors

Drake Jensen1, Nicole Reynolds2, Ya-Ping Yang3, Shubha Shakya4, Zhi-Qiang Wang5, Dennis J Stuehr6, Chin-Chuan Wei7

Author Affiliations

1: Department of Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL, 62026, USA. djensen@siue.edu.
2: Department of Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL, 62026, USA. nreynol82@gmail.com.
3: Department of Pathobiology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA. yyny@yahoo.com.
4: Department of Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL, 62026, USA. sshakya@siue.edu.
5: Department of Chemistry, Kent State University at Tuscarawas, New Philadelphia, OH, 44663, USA. zwang3@kent.edu.
6: Department of Pathobiology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA. stuehrd@ccf.org.
7: Department of Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL, 62026, USA. cwei@siue.edu.

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