Published in Protein Sci on March 01, 1998
Exploring steric constraints on protein mutations using MAGE/PROBE. Protein Sci (2000) 1.96
Lessons from the lysozyme of phage T4. Protein Sci (2010) 1.85
Decoys for docking. J Med Chem (2005) 1.43
The molecular basis of N-end rule recognition. Mol Cell (2008) 1.36
Molecular basis of substrate selection by the N-end rule adaptor protein ClpS. Proc Natl Acad Sci U S A (2009) 1.05
Increasing protein stability by polar surface residues: domain-wide consequences of interactions within a loop. Biophys J (2002) 0.99
Interatomic potentials and solvation parameters from protein engineering data for buried residues. Protein Sci (2002) 0.96
Thermodynamic effects of noncoded and coded methionine substitutions in calmodulin. Biophys J (2009) 0.88
Alanine-scanning mutagenesis of the beta-sheet region of phage T4 lysozyme suggests that tertiary context has a dominant effect on beta-sheet formation. Protein Sci (2004) 0.86
Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme. Protein Sci (2009) 0.83
Nonnatural amino acid incorporation into the methionine 214 position of the metzincin Pseudomonas aeruginosa alkaline protease. BMC Biochem (2005) 0.79
Fundamental processes of protein folding: measuring the energetic balance between helix formation and hydrophobic interactions. Protein Sci (2006) 0.79
New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers. J Lipid Res (2009) 0.78
The exchanged EF-hands in calmodulin and troponin C chimeras impair the Ca²⁺-induced hydrophobicity and alter the interaction with Orai1: a spectroscopic, thermodynamic and kinetic study. BMC Biochem (2015) 0.77
Site Saturation Mutagenesis Applications on Candida methylica Formate Dehydrogenase. Scientifica (Cairo) (2016) 0.75
Impact of novel SNPs identified in Cynara cardunculus genes on functionality of proteins regulating phenylpropanoid pathway and their association with biological activities. BMC Genomics (2017) 0.75
Adaptive Evolution of Toll-Like Receptors (TLRs) in the Family Suidae. PLoS One (2015) 0.75
Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol (1987) 66.52
Solvent-accessible surfaces of proteins and nucleic acids. Science (1983) 11.29
Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect. Science (1992) 6.51
Structural and genetic analysis of protein stability. Annu Rev Biochem (1993) 3.34
A mutant T4 lysozyme displays five different crystal conformations. Nature (1990) 3.07
Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance. Methods Enzymol (1989) 2.95
Control of enzyme activity by an engineered disulfide bond. Science (1989) 2.70
Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J Mol Biol (1993) 2.50
Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme. Biochemistry (1991) 2.31
Temperature-sensitive mutations of bacteriophage T4 lysozyme occur at sites with low mobility and low solvent accessibility in the folded protein. Biochemistry (1987) 2.12
Multiwire area X-ray diffractometers. Methods Enzymol (1985) 2.04
Second-site revertants of an inactive T4 lysozyme mutant restore activity by restructuring the active site cleft. Biochemistry (1991) 2.03
Nucleotide sequence of the lysozyme gene of bacteriophage T4. Analysis of mutations involving repeated sequences. J Mol Biol (1983) 1.89
Large increases in general stability for subtilisin BPN' through incremental changes in the free energy of unfolding. Biochemistry (1989) 1.77
Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme. J Mol Biol (1992) 1.73
Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive. Protein Eng (1995) 1.68
A test of the "jigsaw puzzle" model for protein folding by multiple methionine substitutions within the core of T4 lysozyme. Proc Natl Acad Sci U S A (1996) 1.56
A covalent enzyme-substrate intermediate with saccharide distortion in a mutant T4 lysozyme. Science (1993) 1.50
Engineering an enzyme by site-directed mutagenesis to be resistant to chemical oxidation. J Biol Chem (1985) 1.43
Structure and thermal stability of phage T4 lysozyme. Methods Enzymol (1987) 1.18
The M32L substitution of staphylococcal nuclease: disagreement between theoretical prediction and experimental protein stability. J Mol Biol (1996) 0.94
Estimation of stabilities of staphylococcal nuclease mutants (Met32-->Ala and Met32-->Leu) using molecular dynamics/free energy perturbation. Biochim Biophys Acta (1993) 0.79
Solvent content of protein crystals. J Mol Biol (1968) 106.07
Comparison of the predicted and observed secondary structure of T4 phage lysozyme. Biochim Biophys Acta (1975) 17.03
The helix-turn-helix DNA binding motif. J Biol Chem (1989) 6.87
Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect. Science (1992) 6.51
Structure of the cro repressor from bacteriophage lambda and its interaction with DNA. Nature (1981) 5.24
Structural basis of amino acid alpha helix propensity. Science (1993) 4.36
Enhancement of the method of molecular replacement by incorporation of known structural information. Acta Crystallogr D Biol Crystallogr (1994) 4.26
Structural basis of DNA-protein recognition. Trends Biochem Sci (1989) 3.95
Three-dimensional structure of tosyl-alpha-chymotrypsin. Nature (1967) 3.57
DNA-binding proteins. Science (1983) 3.56
The molecular basis of DNA-protein recognition inferred from the structure of cro repressor. Nature (1982) 3.56
Three-dimensional structure of beta-galactosidase from E. coli. Nature (1994) 3.46
A relationship between protein stability and protein function. Proc Natl Acad Sci U S A (1995) 3.44
A mutant T4 lysozyme displays five different crystal conformations. Nature (1990) 3.07
Structure of bacteriophage T4 lysozyme refined at 1.7 A resolution. J Mol Biol (1987) 3.02
Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. Proc Natl Acad Sci U S A (1992) 2.89
Structural similarity in the DNA-binding domains of catabolite gene activator and cro repressor proteins. Proc Natl Acad Sci U S A (1982) 2.84
Structure of thermolysin refined at 1.6 A resolution. J Mol Biol (1982) 2.84
Structure of crystalline -chymotrypsin. II. A preliminary report including a hypothesis for the activation mechanism. J Mol Biol (1968) 2.72
Accurate calculation of the density of proteins. Acta Crystallogr D Biol Crystallogr (2000) 2.70
Control of enzyme activity by an engineered disulfide bond. Science (1989) 2.70
Protein flexibility and adaptability seen in 25 crystal forms of T4 lysozyme. J Mol Biol (1995) 2.55
Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J Mol Biol (1993) 2.50
Structure and X-ray amino acid sequence of a bacteriochlorophyll A protein from Prosthecochloris aestuarii refined at 1.9 A resolution. J Mol Biol (1986) 2.45
Hydrophobic stabilization in T4 lysozyme determined directly by multiple substitutions of Ile 3. Nature (1988) 2.32
Protein-DNA interaction. No code for recognition. Nature (1988) 2.31
Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme. Biochemistry (1991) 2.31
Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme. Proc Natl Acad Sci U S A (2000) 2.25
The conformation of thermolysin. J Biol Chem (1974) 2.25
Structural analysis of zinc substitutions in the active site of thermolysin. Protein Sci (1995) 2.24
Stabilization of phage T4 lysozyme by engineered disulfide bonds. Proc Natl Acad Sci U S A (1989) 2.17
Covalent structure of a group-specific protease from rat small intestine. Appendix: crystallographic data for a group specific protease from rat intestine. Biochemistry (1978) 2.17
Ancestral lysozymes reconstructed, neutrality tested, and thermostability linked to hydrocarbon packing. Nature (1990) 2.14
Toroidal structure of lambda-exonuclease. Science (1997) 2.14
An omega protein from Drosophila melanogaster. Biochemistry (1974) 2.12
Temperature-sensitive mutations of bacteriophage T4 lysozyme occur at sites with low mobility and low solvent accessibility in the folded protein. Biochemistry (1987) 2.12
Specificity of ligand binding in a buried nonpolar cavity of T4 lysozyme: linkage of dynamics and structural plasticity. Biochemistry (1995) 2.10
A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene. Nature (1992) 2.10
Structure of the DNA-binding region of lac repressor inferred from its homology with cro repressor. Proc Natl Acad Sci U S A (1982) 2.09
Structure and function of the methionine aminopeptidases. Biochim Biophys Acta (2000) 2.09
Substantial increase of protein stability by multiple disulphide bonds. Nature (1989) 2.08
Second-site revertants of an inactive T4 lysozyme mutant restore activity by restructuring the active site cleft. Biochemistry (1991) 2.03
The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect. Protein Sci (1998) 2.02
Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme. Nature (1987) 2.01
Intrahelical hydrogen bonding of serine, threonine and cysteine residues within alpha-helices and its relevance to membrane-bound proteins. J Mol Biol (1984) 2.00
Structural studies of protein-nucleic acid interactions. Annu Rev Biophys Bioeng (1983) 1.95
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme. J Mol Biol (1994) 1.95
Three-dimensional structure of human basic fibroblast growth factor. Proc Natl Acad Sci U S A (1991) 1.94
Enhanced protein thermostability from designed mutations that interact with alpha-helix dipoles. Nature (1988) 1.89
Kinetic studies on Cro repressor-operator DNA interaction. J Mol Biol (1987) 1.85
A structural basis for processivity. Protein Sci (2001) 1.85
Structure of the cobalt-dependent methionine aminopeptidase from Escherichia coli: a new type of proteolytic enzyme. Biochemistry (1993) 1.80
Many gene-regulatory proteins appear to have a similar alpha-helical fold that binds DNA and evolved from a common precursor. J Mol Evol (1983) 1.80
Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme. Biochemistry (1991) 1.79
Type II restriction endonucleases: structural, functional and evolutionary relationships. Curr Opin Chem Biol (1999) 1.79
The structure of thermolysin: an electron density map at 2-3 A resolution. J Mol Biol (1972) 1.77
Low-temperature unfolding of a mutant of phage T4 lysozyme. 2. Kinetic investigations. Biochemistry (1989) 1.76
Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes. Proc Natl Acad Sci U S A (1995) 1.76
Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase. Proc Natl Acad Sci U S A (2000) 1.76
Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis. Biochemistry (1991) 1.76
Energetic origins of specificity of ligand binding in an interior nonpolar cavity of T4 lysozyme. Biochemistry (1995) 1.75
Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme. J Mol Biol (1992) 1.73
Structure-based design of a lysozyme with altered catalytic activity. Nat Struct Biol (1995) 1.73
Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme. Biochemistry (2000) 1.72
Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive. Protein Eng (1995) 1.68
Atomic co-ordinates for tosyl-alpha-chymotrypsin. Biochem Biophys Res Commun (1969) 1.67
Circular dichroism and DNA secondary structure. Nucleic Acids Res (1979) 1.67
Molecular basis of thermostability in the lysozyme from bacteriophage T4. Nature (1979) 1.66
A crystallographic study of the complex of phosphoramidon with thermolysin. A model for the presumed catalytic transition state and for the binding of extended substances. J Mol Biol (1977) 1.65
Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex. Proc Natl Acad Sci U S A (1990) 1.63
Reversible lattice repacking illustrates the temperature dependence of macromolecular interactions. J Mol Biol (2001) 1.60
An interactive computer graphics study of thermolysin-catalyzed peptide cleavage and inhibition by N-carboxymethyl dipeptides. Biochemistry (1984) 1.59
Comparison of the crystal structure of bacteriophage T4 lysozyme at low, medium, and high ionic strengths. Proteins (1991) 1.57
A test of the "jigsaw puzzle" model for protein folding by multiple methionine substitutions within the core of T4 lysozyme. Proc Natl Acad Sci U S A (1996) 1.56
Structure of Escherichia coli exonuclease I suggests how processivity is achieved. Nat Struct Biol (2000) 1.55
Structure of a bacteriochlorophyll a-protein from the green photosynthetic bacterium Prosthecochloris aestuarii. J Mol Biol (1979) 1.54
The three dimensional structure of the lysozyme from bacteriophage T4. Proc Natl Acad Sci U S A (1974) 1.52
Domain motions of EF-G bound to the 70S ribosome: insights from a hand-shaking between multi-resolution structures. Biophys J (2000) 1.52
A covalent enzyme-substrate intermediate with saccharide distortion in a mutant T4 lysozyme. Science (1993) 1.50
Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants. Proc Natl Acad Sci U S A (1989) 1.50
Folding and function of a T4 lysozyme containing 10 consecutive alanines illustrate the redundancy of information in an amino acid sequence. Proc Natl Acad Sci U S A (1992) 1.49
Corepressor-induced organization and assembly of the biotin repressor: a model for allosteric activation of a transcriptional regulator. Proc Natl Acad Sci U S A (2001) 1.49
Comparison of the structures of cro and lambda repressor proteins from bacteriophage lambda. J Mol Biol (1983) 1.48
Relation between hen egg white lysozyme and bacteriophage T4 lysozyme: evolutionary implications. J Mol Biol (1981) 1.46
A structural role for arginine in proteins: multiple hydrogen bonds to backbone carbonyl oxygens. Protein Sci (1994) 1.46
Comparison of the structures of carboxypeptidase A and thermolysin. J Biol Chem (1977) 1.46